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Article ; Online: Development of Yin-Yang ligand for cannabinoid receptors.

Qiu, Yanli / Zhao, Yitian / Hu, Tao / Yang, Meifang / Li, Fei / Li, Cuixia / Gu, Weiliang / Yang, Xiaodi / Zhao, Suwen / Tao, Houchao

Bioorganic chemistry

2023 Volume 133, Page(s) 106377

Abstract: ... effect, Yin-Yang ligands with opposite pharmacological activities simultaneously on two subtypes, offer ... unique therapeutic potential. Herein we report the development of a new Yin-Yang ligand which functions ... activities. As such, the ortho-morpholine substitution exerted the desired Yin-Yang bifunctionality ...

Abstract	Cannabinoid receptors (CBs), including CB1 and CB2, are the key components of a lipid signaling endocannabinoid system (ECS). Development of synthetic cannabinoids has been attractive to modulate ECS functions. CB1 and CB2 are structurally closely related subtypes but with distinct functions. While most efforts focus on the development of selective ligands for single subtype to circumvent the undesired off-target effect, Yin-Yang ligands with opposite pharmacological activities simultaneously on two subtypes, offer unique therapeutic potential. Herein we report the development of a new Yin-Yang ligand which functions as an antagonist for CB1 and concurrently an agonist for CB2. We found that in the pyrazole-cored scaffold, the arm of N1-phenyl group could be a switch, modification of which yielded various ligands with distinct activities. As such, the ortho-morpholine substitution exerted the desired Yin-Yang bifunctionality which, based on the docking study and molecular dynamic simulation, was proposed to be resulted from the hydrogen bonding with S173 and S285 in CB1 and CB2, respectively. Our results demonstrated the feasibility of structure guided ligand evolution for challenging Yin-Yang ligand.
MeSH term(s)	Cannabinoids/pharmacology ; Cannabinoids/chemistry ; Endocannabinoids ; Ligands ; Pyrazoles/chemistry ; Pyrazoles/pharmacology ; Receptor, Cannabinoid, CB1/chemistry ; Receptor, Cannabinoid, CB1/metabolism ; Receptors, Cannabinoid/chemistry ; Receptors, Cannabinoid/metabolism ; Yin-Yang
Chemical Substances	Cannabinoids ; Endocannabinoids ; Ligands ; Pyrazoles ; Receptor, Cannabinoid, CB1 ; Receptors, Cannabinoid
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2023.106377
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Zs.A 4207: Show issues

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Article ; Online: Yin Yang 1 impacts upon preeclampsia by regulating T

Li, Haowen / Yu, Ling / Ding, Yiling / Nie, Yanting / Yang, Mengyuan

Journal of immunotoxicology

2023 Volume 20, Issue 1, Page(s) 2228420

Abstract: ... The study here aimed to investigate the role of Yin Yang 1 (YY1) in PE, and to reveal any YY1-regulated ...

Abstract	Preeclampsia (PE) is a common obstetric syndrome with an unclear etiology and pathogenesis. The study here aimed to investigate the role of Yin Yang 1 (YY1) in PE, and to reveal any YY1-regulated mechanisms in PE. Peripheral blood, placenta, and endometrial tissues of PE patients, healthy volunteers, and patients who had undergone an elective Cesarean section and had a scarred uterus (control group) were collected for analyses. Rat PE models were established by lipopolysaccharide induction. Subsets of these rats were then made to over-express YY1. At 18 d after the PE was established, urine, blood, and placental tissues from all rats were collected. Levels of regulatory-T (T
MeSH term(s)	Humans ; Female ; Rats ; Pregnancy ; Animals ; Pre-Eclampsia ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; T-Lymphocytes, Regulatory ; Cesarean Section ; Yin-Yang ; Th17 Cells/metabolism ; Th17 Cells/pathology ; Placenta ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; RNA, Messenger/metabolism
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Forkhead Transcription Factors ; RNA, Messenger
Language	English
Publishing date	2023-07-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2205064-4
ISSN	1547-6901 ; 1547-691X
ISSN (online)	1547-6901
ISSN	1547-691X
DOI	10.1080/1547691X.2023.2228420
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Article ; Online: The role of transcription factor Yin Yang-1 in colorectal cancer.

Shao, Zhiying / Yang, Wendong / Meng, Xiannan / Li, Minle / Hou, Pingfu / Li, Zhongwei / Chu, Sufang / Zheng, Junnian / Bai, Jin

Cancer medicine

2023 Volume 12, Issue 10, Page(s) 11177–11190

Abstract: Background: Yin Yang-1 (YY1) is identified as a transcription factor with multiple functions ...

Abstract	Background: Yin Yang-1 (YY1) is identified as a transcription factor with multiple functions. However, the role of YY1 in tumorigenesis remains controversial and its regulatory effects may depend upon not only cancer types, but also its interacting partners, chromatin structure, and the context in which it acts. It has been detected that YY1 was highly expressed in colorectal cancer (CRC). Intriguingly, many YY1-repressed genes exhibit tumor suppressive potential while YY1 silencing is related to chemotherapy resistance. Therefore, it is crucial to meticulously explore YY1 protein structure and the dynamic alteration of its interactome in each cancer type. This review attempts to describe the structure of YY1, summarize the mechanism that influence the expression level of YY1 and also highlight the recent advances in our understanding of regulatory insights of YY1 functions in CRC. Methods: Related studies were identified through scoping search of PubMed, Web of science, Scopus and Emhase concerning the terms of "colorectal cancer", colorectal carcinoma" or CRC with "YY1". The retrieval strategy included title, abstract, and keywords with no language limitations. All the included articles were categorized depending on the mechanisms they explored. Results: In total, 170 articles were identified for further screening. After removing the duplication, not relevant outcomes and review articles, 34 were finally included in the review. Among them, 10 articles revealed the reasons of YY1 high expression in CRC, 13 articles explored YY1 function in CRC, and 11 articles fell into both aspects. In addition, we also summarized 10 clinical trials concerning the expression and activity of YY1 in various diseases, which offers a hint for future application. Conclusions: YY1 is highly expressed in CRC and broadly recognized as an oncogenic factor during the whole course of CRC. Sporadic controversial views are raised in term of CRC treatment, reminding us that future studies should take the influence of therapeutic regimens into concern.
MeSH term(s)	Humans ; Carcinogenesis/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; Transcription Factors/genetics ; YY1 Transcription Factor/genetics ; YY1 Transcription Factor/metabolism
Chemical Substances	Transcription Factors ; YY1 Transcription Factor
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.5745
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Article ; Online: The acute toxic effect of Chinese medicine Fuzi is exacerbated in kidney yang deficiency mice due to metabolic difference.

Jiang, Hui / Li, Xiaoyu / Fan, Yang / Wang, Junjie / Xie, Yiyi / Yu, Peilin

Journal of ethnopharmacology

2024 Volume 328, Page(s) 118036

Abstract: ... root of Aconitum carmichaelii Debx, is recognized as a panacea for kidney yang deficiency syndrome ... mechanisms.: Materials and methods: Firstly, the mouse model of kidney yang deficiency syndrome was ... Then, the acute toxicity of Fuzi in normal mice and kidney yang deficiency model mice was explored. Finally, the plasma ...

Abstract	Ethnopharmacological relevance: The proper application of toxic medicines is one of the characteristics of traditional Chinese medicines, and the use of traditional Chinese medicines follows the principle of dialectical treatment. It is necessary to combine different "syndrome" or "disease" states with the toxicity of traditional Chinese medicines to form a reliable toxicity evaluation system. Fuzi, the lateral root of Aconitum carmichaelii Debx, is recognized as a panacea for kidney yang deficiency syndrome, however, its toxic effects significantly limit its clinical application. Aim of the study: Herein, our research aimed to explore the toxic effects of Fuzi on syndrome models, and tried to reveal the underlying mechanisms. Materials and methods: Firstly, the mouse model of kidney yang deficiency syndrome was established through intramuscular injection of 25 mg/kg hydrocortisone per day for 10 consecutive days. Then, the acute toxicity of Fuzi in normal mice and kidney yang deficiency model mice was explored. Finally, the plasma metabolite concentrations and liver CYP3A4 enzyme activity were analyzed to reveal the possible mechanisms of the different pharmacological and toxicological effects of Fuzi in individuals with different physical constitutions. Results: It was found that the treatment with Fuzi (138 g/kg) had serious toxic effects on kidney yang deficiency mice, leading to the death of 80% of the mice, whereas it showed no lethal toxicity in normal mice. This indicates that Fuzi induced greater toxicity in kidney yang deficiency mice than in normal ones. The liver CYP3A4 enzyme activity in kidney yang deficiency mice was decreased by 20% compared to the controls, resulting in slower metabolism of the toxic diester diterpenoid alkaloids in Fuzi. Conclusion: In conclusion, our study showed that changes of the metabolic enzyme activity in individuals with different syndromes led to different toxic effects of Chinese medicines, emphasizing the crucial importance of considering individual physical syndromes in the clinical application of traditional Chinese medicine, and the significance of conducting safety evaluations and dose predictions on animal models with specific syndromes for traditional Chinese medicines.
MeSH term(s)	Mice ; Animals ; Medicine, Chinese Traditional ; Yang Deficiency/chemically induced ; Yang Deficiency/drug therapy ; Cytochrome P-450 CYP3A ; Drugs, Chinese Herbal/pharmacology ; Diterpenes/toxicity ; Diterpenes/therapeutic use ; Kidney ; Aconitum
Chemical Substances	fuzi drug herbal ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Drugs, Chinese Herbal ; Diterpenes
Language	English
Publishing date	2024-03-08
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118036
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Zs.A 1494: Show issues

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Article ; Online: Paeoniflorin mitigates MMP-12 inflammation in silicosis via Yang-Yin-Qing-Fei Decoction in murine models.

Li, Tian / Mao, Na / Xie, Zihao / Wang, Jianing / Jin, Fuyu / Li, Yaqian / Liu, Shupeng / Cai, Wenchen / Gao, Xuemin / Wei, Zhongqiu / Yang, Fang / Xu, Hong / Liu, Heliang / Zhang, Haibo / Xu, Dingjie

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 129, Page(s) 155616

Abstract: ... to elucidate the therapeutic role and mechanisms of the Yang-Yin-Qing-Fei Decoction (YYQFD) and its key ...

Abstract	Background: Silicosis presents a significant clinical challenges and economic burdens, with Traditional Chinese Medicine (TCM) emerging as a potential therapeutic avenue. However, the precise effects and mechanisms of TCM in treating silicosis remain uncertain and subject to debate. Objective: The study aims to elucidate the therapeutic role and mechanisms of the Yang-Yin-Qing-Fei Decoction (YYQFD) and its key component, paeoniflorin, in silicosis using a murine model. Methods: Silicotic mice were treated with YYQFD, pirfenidone (PFD), or paeoniflorin. RAW264.7 cells and mouse lung fibroblasts (MLF) were stimulated with silica, matrix metalloproteinase-12 (MMP-12), or TGF-β1, followed by treatment with paeoniflorin, PFD, or relevant inhibitors. YYQFD constituents were characterized using High-Performance Liquid Chromatography (HPLC). Lung fibrosis severity was assessed via histopathological examination, micro-CT imaging, lung functions, and Western blot analysis. Transcriptome sequencing and bioinformatics analysis were employed to delineate the gene expression profile and target genes modulated by YYQFD in silicosis. Results: Treatment with YYQFD ameliorated silica-induced lung fibrosis. Transcriptome sequencing identified MMP-12 as a potential common target of YYQFD and PFD. Additionally, a potential pro-inflammatory role of MMP-12, regulated by silica-induced TLR4 signaling pathways, was revealed. Paeoniflorin, one of the most distinctive compounds in YYQFD, attenuated silica-induced MMP-12 increase and its derived inflammatory factors in macrophages through a direct binding effect. Notably, paeoniflorin treatment exerted anti-fibrotic effects by inhibiting MMP-12-derived inflammatory factors and TGF-β1-induced myofibroblast differentiation in silica-exposed mice. Conclusions: This study underscores paeoniflorin as one of the most principal bioactive compounds in YYQFD, highlighting its capacity to attenuate lung inflammation driven by macrophage-derived MMP-12 and reduce lung fibrosis both in vivo and in vitro.
Language	English
Publishing date	2024-04-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2024.155616
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Zs.A 4115: Show issues

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Article ; Online: Kidney Yang Deficiency Syndrome Exacerbates Aβ

Jiang, Xia / Chen, Lin / Fu, Qing / Ma, Dan Li / Liu, Xue Ting / Wang, Xiao Yi

Current Alzheimer research

2023 Volume 20, Issue 1, Page(s) 48–58

Abstract: ... considered the consequence produced by Kidney Yang Deficiency Syndrome (KDS-Yang), which has similar clinical ... for 14 days was used to produce KDS-Yang. On the 15th day, Aβ: Results: Hyperphosphorylation of tau ... in Aβ: Conclusion: KDS-Yang might exacerbate AD pathological lesions. Importantly, G-Re is ...

Abstract	Background: Traditional Chinese medicine (TCM) indicates that Alzheimer's disease (AD) is considered the consequence produced by Kidney Yang Deficiency Syndrome (KDS-Yang), which has similar clinical characteristics to glucocorticoid withdrawal syndrome. Ginsenoside Re (G-Re) has been found to ameliorate the symptoms and pathological impairments of AD. However, it's not clear whether G-Re could protect memory and synapse lesions against kidney deficiency dementia. Methods: Subcutaneous injection of hydrocortisone for 14 days was used to produce KDS-Yang. On the 15th day, Aβ Results: Hyperphosphorylation of tau in Aβ Conclusion: KDS-Yang might exacerbate AD pathological lesions. Importantly, G-Re is a potential ingredient for protecting against memory and synapse deficits in kidney deficiency dementia.
MeSH term(s)	Rats ; Animals ; Amyloid beta-Peptides/toxicity ; Yang Deficiency ; Alzheimer Disease/metabolism ; Disks Large Homolog 4 Protein ; Kidney/metabolism ; Kidney/pathology ; Synapses/metabolism ; Disease Models, Animal ; Peptide Fragments/toxicity
Chemical Substances	Amyloid beta-Peptides ; ginsenoside Re (46F3R0BL3I) ; Disks Large Homolog 4 Protein ; Peptide Fragments
Language	English
Publishing date	2023-05-12
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205170-3
ISSN	1875-5828 ; 1567-2050
ISSN (online)	1875-5828
ISSN	1567-2050
DOI	10.2174/1567205020666230512094230
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Zs.A 6235: Show issues

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Article: [Clinical and genetic analysis of a child with Schaaf-Yang syndrome].

Luo, Juan / Chen, Xiaohong / Yao, Hui / Yang, Luhong / Du, Tingting / Li, Yakun

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

2022 Volume 40, Issue 1, Page(s) 53–56

Abstract: ... Yang syndrome (SYS).: Methods: Peripheral blood samples of the child and his parents were collected ...

Abstract	Objective: To explore the clinical characteristics and genetic etiology of a child with Schaaf-Yang syndrome (SYS). Methods: Peripheral blood samples of the child and his parents were collected and subjected to whole exome sequencing. Sanger sequencing was used for family constellation verification, and bioinformatic analysis was performed for the candidate variant. Results: The child, a 1-year-and-9-month-old boy, had clinical manifestations of retarded growth, small penis, and unusual facies. Genetic testing revealed that the child has harbored a novel heterozygous variant of c.3078dupG (p.Leu1027Valfs28) of the MAGEL2 gene. Sanger sequencing showed that neither parent of the child carried the same variant. The c.3078dupG(p.Leu1027Valfs28) variant of the MAGEL2 gene has not been included in the databases of ESP, 1000 Genomes and ExAC. According to the Standards and Guidelines for the Interpretation of Sequence Variants of the American College of Medical Genetics and Genomics (ACMG), the variant was judged to be pathogenic. Conclusion: The c.3078dupG (p.Leu1027Valfs*28) variant of the MAGEL2 gene probably underlay the SYS in this child, which has further expanded the spectrum of the MAGEL2 gene variants.
MeSH term(s)	Child ; Humans ; Infant ; Male ; Exome Sequencing ; Genetic Testing ; Heterozygote ; Mutation ; Proteins/genetics ; Developmental Disabilities/genetics
Chemical Substances	MAGEL2 protein, human ; Proteins
Language	Chinese
Publishing date	2022-12-30
Publishing country	China
Document type	Case Reports ; English Abstract ; Journal Article
ISSN	1003-9406
ISSN	1003-9406
DOI	10.3760/cma.j.cn511374-20210401-00293
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Article ; Online: Yin and yang regulation of stress granules by Caprin-1.

Song, Dan / Kuang, Lisha / Yang, Lin / Wang, Lei / Li, Hao / Li, Xiu / Zhu, Zhimin / Shi, Chaowei / Zhu, Haining / Gong, Weimin

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 44, Page(s) e2207975119

Abstract: ... terminal domains of Caprin-1 regulate SG formation in a "yin and yang" fashion, mediating the dynamic and ...

Abstract	Stress granules (SGs) are cytoplasmic biomolecular condensates containing proteins and RNAs in response to stress. Ras-GTPase-activating protein binding protein 1 (G3BP1) is a core SG protein. Caprin-1 and ubiquitin specific peptidase 10 (USP10) interact with G3BP1, facilitating and suppressing SG formation, respectively. The crystal structures of the nuclear transport factor 2-like (NTF2L) domain of G3BP1 in complex with the G3BP1-interacting motif (GIM) of Caprin-1 and USP10 show that both GIMs bind to the same hydrophobic pocket of G3BP1. Moreover, both GIMs suppressed the liquid-liquid phase separation (LLPS) of G3BP1, suggesting that Caprin-1 likely facilitates SG formation via other mechanisms. Thus, we dissected various domains of Caprin-1 and investigated their role in LLPS in vitro and SG formation in cells. The C-terminal domain of Caprin-1 underwent spontaneous LLPS, whereas the N-terminal domain and GIM of Caprin-1 suppressed LLPS of G3BP1. The opposing effect of the N- and C-terminal domains of Caprin-1 on SG formation were demonstrated in cells with or without the endogenous Caprin-1. We propose that the N- and C-terminal domains of Caprin-1 regulate SG formation in a "yin and yang" fashion, mediating the dynamic and reversible assembly of SGs.
MeSH term(s)	RNA Recognition Motif Proteins/metabolism ; Poly-ADP-Ribose Binding Proteins/metabolism ; RNA Helicases/metabolism ; DNA Helicases/metabolism ; Cytoplasmic Granules/metabolism ; Stress Granules ; GTPase-Activating Proteins/metabolism ; Ubiquitin-Specific Proteases/metabolism
Chemical Substances	RNA Recognition Motif Proteins ; Poly-ADP-Ribose Binding Proteins ; RNA Helicases (EC 3.6.4.13) ; DNA Helicases (EC 3.6.4.-) ; GTPase-Activating Proteins ; Ubiquitin-Specific Proteases (EC 3.4.19.12)
Language	English
Publishing date	2022-10-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2207975119
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Zs.A 1148: Show issues

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Article ; Online: The yin-yang of immunity: Immune dysregulation in myelodysplastic syndrome with different risk stratification.

Peng, Xiaohuan / Zhu, Xiaofeng / Di, Tianning / Tang, Futian / Guo, Xiaojia / Liu, Yang / Bai, Jun / Li, Yanhong / Li, Lijuan / Zhang, Liansheng

Frontiers in immunology

2022 Volume 13, Page(s) 994053

Abstract: ... Yin-Yang theory" in ancient China, meaning that the opposing forces may actually be interdependent and ...

Abstract	Myelodysplastic syndrome (MDS) is a heterogeneous group of myeloid clonal diseases with diverse clinical courses, and immune dysregulation plays an important role in the pathogenesis of MDS. However, immune dysregulation is complex and heterogeneous in the development of MDS. Lower-risk MDS (LR-MDS) is mainly characterized by immune hyperfunction and increased apoptosis, and the immunosuppressive therapy shows a good response. Instead, higher-risk MDS (HR-MDS) is characterized by immune suppression and immune escape, and the immune activation therapy may improve the survival of HR-MDS. Furthermore, the immune dysregulation of some MDS changes dynamically which is characterized by the coexistence and mutual transformation of immune hyperfunction and immune suppression. Taken together, the authors think that the immune dysregulation in MDS with different risk stratification can be summarized by an advanced philosophical thought "Yin-Yang theory" in ancient China, meaning that the opposing forces may actually be interdependent and interconvertible. Clarifying the mechanism of immune dysregulation in MDS with different risk stratification can provide the new basis for diagnosis and clinical treatment. This review focuses on the manifestations and roles of immune dysregulation in the different risk MDS, and summarizes the latest progress of immunotherapy in MDS.
MeSH term(s)	Humans ; Immunosuppression Therapy ; Immunotherapy/adverse effects ; Myelodysplastic Syndromes/therapy ; Risk Assessment ; Yin-Yang
Language	English
Publishing date	2022-09-23
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.994053
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Article: Validation of the Anticolitis Efficacy of the Jian-Wei-Yu-Yang Formula.

Yan, Jing / Tang, Yan / Yu, Wei / Jiang, Lu / Liu, Chen / Li, Qi / Zhang, Zhiqiang / Shao, Changlei / Zheng, Yang / Liu, Xihao / Liu, Xincheng

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 9110704

Abstract: ... to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application ...

Abstract	Background: Inflammatory bowel disease (IBD) is a major cause of morbidity and mortality due to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application in the clinic to combat gastrointestinal disorders. The investigation aimed to explore the molecular and cellular mechanisms of JW. Methods: 2% dextran sodium sulfate (DSS) was diluted in drinking water and given to mice for 5 days to establish murine models of experimental colitis, and different doses of JW solution were administered for 14 days. Network pharmacology analysis and weighted gene co-expression network analysis (WGCNA) were utilized to predict the therapeutic role of JW against experimental colitis and colitis-associated colorectal cancer (CAC). 16S rRNA sequencing and untargeted metabolomics were conducted using murine feces. Western blotting, immunocytochemistry, and wound healing experiments were performed to confirm the molecular mechanisms. Results: (1) Liquid chromatography with mass spectrometry was utilized to confirm the validity of the JW formula. The high dose of JW treatment markedly attenuated DSS-induced experimental colitis progression, and the targets were enriched in inflammation, infection, and tumorigenesis. (2) The JW targets were related to the survival probability in patients with colorectal cancer, underlying a potential therapeutic value in CRC intervention. (3) Moreover, the JW therapy successfully rescued the decreased richness and diversity of microbiota, suppressed the potentially pathogenic phenotype of the gut microorganisms, and increased cytochrome P450 activity in murine colitis models. (4) Our Conclusion: The JW capsule attenuated the progression of murine colitis by a prompt resolution of inflammation and bloody stool and by re-establishing a microbiome profile that favors re-epithelization and prevents carcinogenesis.
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/9110704
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