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Article ; Online: Prevalence of undiagnosed celiac disease in the adult general population of Italy in 1990: Baseline reference for testing current increasing incidence?

Bosi, Emanuele / Bazzigaluppi, Elena / Scavini, Marina / Calori, Giliola / Piemonti, Lorenzo / Lampasona, Vito

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2023 Volume 55, Issue 8, Page(s) 1156–1157

MeSH term(s)	Humans ; Adult ; Celiac Disease/diagnosis ; Celiac Disease/epidemiology ; Prevalence ; Incidence ; Italy/epidemiology ; Gliadin
Chemical Substances	Gliadin (9007-90-3)
Language	English
Publishing date	2023-06-07
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2023.05.009
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Article ; Online: Universal screening for early detection of chronic autoimmune, metabolic and cardiovascular diseases in the general population using capillary blood (UNISCREEN): low-risk interventional, single-centre, pilot study protocol.

Merolla, Aurora / De Lorenzo, Rebecca / Ferrannini, Giulia / Renzi, Cristina / Ulivi, Francesca / Bazzigaluppi, Elena / Lampasona, Vito / Bosi, Emanuele

BMJ open

2024 Volume 14, Issue 3, Page(s) e078983

Abstract: Introduction: Chronic autoimmune (type 1 diabetes and coeliac disease) and metabolic/cardiovascular (type 2 diabetes, dyslipidaemia, hypertension) diseases are highly prevalent across all age ranges representing a major public health burden. Universal ... ...

Abstract	Introduction: Chronic autoimmune (type 1 diabetes and coeliac disease) and metabolic/cardiovascular (type 2 diabetes, dyslipidaemia, hypertension) diseases are highly prevalent across all age ranges representing a major public health burden. Universal screening for prediction/early identification of these conditions is a potential tool for reducing their impact on the general population. The aim of this study is to assess whether universal screening using capillary blood sampling is feasible at a population-based level. Methods and analysis: This is a low-risk interventional, single-centre, pilot study for a population-based screening programme denominated UNISCREEN. Participants are volunteers aged 1-100 who reside in the town of Cantalupo (Milan, Italy) undergoing: (1) interview collecting demographics, anthropometrics and medical history; (2) capillary blood collection for measurement of type 1 diabetes and coeliac disease-specific autoantibodies and immediate measurement of glucose, glycated haemoglobin and lipid panel by point-of-care devices; (3) venous blood sampling to confirm autoantibody-positivity; (4) blood pressure measurement; (5) fulfilment of a feasibility and acceptability questionnaire. The outcomes are the assessment of feasibility and acceptability of capillary blood screening, the prevalence of presymptomatic type 1 diabetes and undiagnosed coeliac disease, distribution of glucose categories, lipid panel and estimate of cardiovascular risk in the study population. With approximately 3000 inhabitants, the screened population is expected to encompass at least half of its size, approaching nearly 1500 individuals. Ethics and dissemination: This protocol and the informed consent forms have been reviewed and approved by the San Raffaele Hospital Ethics Committee (approval number: 131/INT/2022). Written informed consent is obtained from all study participants or their parents if aged <18. Results will be published in scientific journals and presented at meetings. Conclusions: If proven feasible and acceptable, this universal screening model would pave the way for larger-scale programmes, providing an opportunity for the implementation of innovative public health programmes in the general population. Trial registration number: NCT05841719.
MeSH term(s)	Humans ; Autoantibodies ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Celiac Disease/diagnosis ; Celiac Disease/epidemiology ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 2 ; Glucose ; Lipids ; Pilot Projects
Chemical Substances	Autoantibodies ; Glucose (IY9XDZ35W2) ; Lipids
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-078983
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Article ; Online: Improved Specificity of Glutamate Decarboxylase 65 Autoantibody Measurement Using Luciferase-Based Immunoprecipitation System Assays.

Wyatt, Rebecca C / Grace, Sian L / Brigatti, Cristina / Marzinotto, Ilaria / Gillard, Ben T / Shoemark, Deborah K / Chandler, Kyla / Achenbach, Peter / Piemonti, Lorenzo / Long, Anna E / Gillespie, Kathleen M / Lampasona, Vito / Williams, Alistair J K

Diabetes

2024 Volume 73, Issue 4, Page(s) 565–571

MeSH term(s)	Humans ; Diabetes Mellitus, Type 1 ; Glutamate Decarboxylase ; Sensitivity and Specificity ; Autoantibodies ; Luciferases/genetics ; Immunoprecipitation
Chemical Substances	Glutamate Decarboxylase (EC 4.1.1.15) ; Autoantibodies ; Luciferases (EC 1.13.12.-)
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db23-0550
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Article ; Online: A novel, high-performance, low-volume, rapid luciferase immunoprecipitation system (LIPS) assay to detect autoantibodies to zinc transporter 8.

Williams, Claire L / Marzinotto, Ilaria / Brigatti, Cristina / Gillespie, Kathleen M / Lampasona, Vito / Williams, Alistair J K / Long, Anna E

Clinical and experimental immunology

2023 Volume 215, Issue 3, Page(s) 215–224

Abstract: Background: Zinc transporter 8 autoantibodies (ZnT8A) are thought to appear close to type 1 diabetes (T1D) onset and can identify high-risk multiple (≥2) autoantibody positive individuals. Radiobinding assays (RBA) are widely used for ZnT8A measurement ... ...

Abstract	Background: Zinc transporter 8 autoantibodies (ZnT8A) are thought to appear close to type 1 diabetes (T1D) onset and can identify high-risk multiple (≥2) autoantibody positive individuals. Radiobinding assays (RBA) are widely used for ZnT8A measurement but have limited sustainability. We sought to develop a novel, high-performance, non-radioactive luciferase immunoprecipitation system (LIPS) assay to replace RBA. Methods: A custom dual C-terminal ZnT8 (aa268-369; R325/W325) heterodimeric antigen, tagged with a NanoluciferaseTM (Nluc-ZnT8) reporter, and LIPS assay was developed. Assay performance was evaluated by testing sera from new onset T1D (n = 573), healthy schoolchildren (n = 521), and selected first-degree relatives (FDRs) from the Bart's Oxford family study (n = 617; 164 progressed to diabetes). Results: In new-onset T1D, ZnT8A levels by LIPS strongly correlated with RBA (Spearman's r = 0.89; P < 0.0001), and positivity was highly concordant (94.3%). At a high specificity (95%), LIPS and RBA had comparable assay performance [LIPS pROC-AUC(95) 0.032 (95% CI: 0.029-0.036); RBA pROC-AUC(95) 0.031 (95% CI: 0.028-0.034); P = 0.376]. Overall, FDRs found positive by LIPS or RBA had a comparable 20-year diabetes risk (52.6% and 59.7%, respectively), but LIPS positivity further stratified T1D risk in FDRs positive for at least one other islet autoantibody detected by RBA (P = 0.0346). Conclusion: This novel, high-performance, cheaper, quicker, higher throughput, low blood volume Nluc-ZnT8 LIPS assay is a safe, non-radioactive alternative to RBA with enhanced sensitivity and ability to discriminate T1D progressors. This method offers an advanced approach to current strategies to screen the general population for T1D risk for immunotherapy trials and to reduce rates of diabetic ketoacidosis at diagnosis.
MeSH term(s)	Humans ; Child ; Autoantibodies ; Zinc Transporter 8 ; Diabetes Mellitus, Type 1/diagnosis ; Lip ; Cation Transport Proteins ; Luciferases/metabolism ; Immunoprecipitation
Chemical Substances	Autoantibodies ; Zinc Transporter 8 ; Cation Transport Proteins ; Luciferases (EC 1.13.12.-)
Language	English
Publishing date	2023-12-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218531-3
ISSN	1365-2249 ; 0009-9104 ; 0964-2536
ISSN (online)	1365-2249
ISSN	0009-9104 ; 0964-2536
DOI	10.1093/cei/uxad139
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Article ; Online: Islet Autoantibodies.

Lampasona, Vito / Liberati, Daniela

Current diabetes reports

2016 Volume 16, Issue 6, Page(s) 53

Abstract: Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A), all antigens that ... ...

Abstract	Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A), all antigens that are found on secretory granules within pancreatic beta cells. Islet antibodies, measured by sensitive and specific liquid phase assays, are the key parameters of the autoimmune response monitored for diagnostics or prognostics in patients with T1D or for disease prediction in at-risk individuals before T1D onset. Islet autoantibodies have been the main tool used to explore the natural history of T1D; this review summarizes the current knowledge about the autoantigens and the phenotype of islets autoantibodies acquired in large prospective studies from birth in children at risk of developing T1D.
MeSH term(s)	Animals ; Autoantibodies/immunology ; Autoantigens/immunology ; Biomarkers/analysis ; Diabetes Mellitus, Type 1/immunology ; Humans ; Insulin/immunology ; Islets of Langerhans/immunology
Chemical Substances	Autoantibodies ; Autoantigens ; Biomarkers ; Insulin
Language	English
Publishing date	2016-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2065167-3
ISSN	1539-0829 ; 1534-4827
ISSN (online)	1539-0829
ISSN	1534-4827
DOI	10.1007/s11892-016-0738-2
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Zs.A 5628: Show issues

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Article ; Online: A/H1N1 hemagglutinin antibodies show comparable affinity in vaccine-related Narcolepsy type 1 and control and are unlikely to contribute to pathogenesis.

Lind, Alexander / Marzinotto, Ilaria / Brigatti, Cristina / Ramelius, Anita / Piemonti, Lorenzo / Lampasona, Vito

Scientific reports

2021 Volume 11, Issue 1, Page(s) 4063

Abstract: An increased incidence of narcolepsy type 1 (NT1) was observed in Scandinavia following the 2009-2010 influenza Pandemrix vaccination. The association between NT1 and HLA-DQB1*06:02:01 supported the view of the vaccine as an etiological agent. A/H1N1 ... ...

Abstract	An increased incidence of narcolepsy type 1 (NT1) was observed in Scandinavia following the 2009-2010 influenza Pandemrix vaccination. The association between NT1 and HLA-DQB106:02:01 supported the view of the vaccine as an etiological agent. A/H1N1 hemagglutinin (HA) is the main antigenic determinant of the host neutralization antibody response. Using two different immunoassays, the Luciferase Immunoprecipitation System (LIPS) and Radiobinding Assay (RBA), we investigated HA antibody levels and affinity in an exploratory and in a confirmatory cohort of Swedish NT1 patients and healthy controls vaccinated with Pandemrix. HA antibodies were increased in NT1 patients compared to controls in the exploratory (LIPS p = 0.0295, RBA p = 0.0369) but not in the confirmatory cohort (LIPS p = 0.55, RBA p = 0.625). HA antibody affinity, assessed by competition with Pandemrix vaccine, was comparable between patients and controls (LIPS: 48 vs. 39 ng/ml, p = 0.81; RBA: 472 vs. 491 ng/ml, p = 0.65). The LIPS assay also detected higher HA antibody titres as associated with HLA-DQB106:02:01 (p = 0.02). Our study shows that following Pandemrix vaccination, HA antibodies levels and affinity were comparable NT1 patients and controls and suggests that HA antibodies are unlikely to play a role in NT1 pathogenesis.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Antibodies, Viral/immunology ; Antibody Affinity/immunology ; Antigens, Viral/immunology ; Case-Control Studies ; Child ; Hemagglutinin Glycoproteins, Influenza Virus/immunology ; Humans ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza Vaccines/adverse effects ; Influenza Vaccines/immunology ; Middle Aged ; Narcolepsy/chemically induced ; Narcolepsy/immunology ; Young Adult
Chemical Substances	Antibodies, Viral ; Antigens, Viral ; H1N1 virus hemagglutinin ; Hemagglutinin Glycoproteins, Influenza Virus ; Influenza Vaccines ; pandemrix
Language	English
Publishing date	2021-02-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-83543-z
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Article ; Online: Gender-sex differences in autoimmune atrophic gastritis.

Lahner, Edith / Dilaghi, Emanuele / Cingolani, Sophia / Pivetta, Giulia / Dottori, Ludovica / Esposito, Gianluca / Marzinotto, Ilaria / Lampasona, Vito / Buzzetti, Raffaella / Annibale, Bruno

Translational research : the journal of laboratory and clinical medicine

2022 Volume 248, Page(s) 1–10

Abstract: Gender-sex differences in autoimmune diseases are gaining increasing attention due to their effects on prevalence and clinical features. Data on gender-sex differences in autoimmune atrophic gastritis (AAG), a chronic not-self-limiting inflammatory ... ...

Abstract	Gender-sex differences in autoimmune diseases are gaining increasing attention due to their effects on prevalence and clinical features. Data on gender-sex differences in autoimmune atrophic gastritis (AAG), a chronic not-self-limiting inflammatory condition characterized by corpus-oxyntic mucosa atrophy sparing the antrum, are lacking. This study aimed to assess possible gender-sex differences of clinical, serological, histological, and genetic features in AAG patients. Cross-sectional study on 435 patients with histological-AAG, stratified according to female-male gender. In subsets of patients, serum gastric-autoantibodies against intrinsic-factor (IFA) and parietal-cells (PCA) by luminescent-immunoprecipitation-system (LIPS) (n = 81) and of HLA-DRB1-genotyping (n = 89) were available and stratified according to sex. Female AAG-patients were preponderant: 69.2%vs30.8%, P < 0.0001(ratio 2.2:1). Females were more frequently PCA and/or IFA-positive than males (90.9%vs73.1%, P = 0.0361). HLA-DRB106-alleles were significantly more frequent in females [30%vs4%, P = 0.01, OR 10.1(95%CI 1.3-80.4); HLA-DRB104-alleles were more frequent and HLA-DRB103 and 05-alleles less frequent in females without reaching statistical significance. At logistic regression, iron-deficiency-anemia [OR 3.6(95%CI 1.9-7.0)], body-mass-index <25m
MeSH term(s)	Anemia ; Atrophy ; Autoantibodies ; Autoimmune Diseases ; Cross-Sectional Studies ; Dyspepsia ; Female ; Gastritis, Atrophic ; HLA-DRB1 Chains ; Humans ; Male ; Sex Characteristics
Chemical Substances	Autoantibodies ; HLA-DRB1 Chains
Language	English
Publishing date	2022-04-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2246684-8
ISSN	1878-1810 ; 1532-6543 ; 1931-5244
ISSN (online)	1878-1810 ; 1532-6543
ISSN	1931-5244
DOI	10.1016/j.trsl.2022.04.006
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Article ; Online: A public health antibody screening indicates a marked increase of SARS-CoV-2 exposure rate in children during the second wave.

Hippich, Markus / Sifft, Philipp / Zapardiel-Gonzalo, Jose / Böhmer, Merle M / Lampasona, Vito / Bonifacio, Ezio / Ziegler, Anette-Gabriele

Med (New York, N.Y.)

2021 Volume 2, Issue 5, Page(s) 571–572

MeSH term(s)	COVID-19/epidemiology ; Child ; Humans ; Immunologic Tests ; Public Health ; Public Health Surveillance ; SARS-CoV-2
Language	English
Publishing date	2021-04-03
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ISSN	2666-6340
ISSN (online)	2666-6340
DOI	10.1016/j.medj.2021.03.019
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Article: Post hoc

Sordi, Valeria / Monti, Paolo / Lampasona, Vito / Melzi, Raffaella / Pellegrini, Silvia / Keymeulen, Bart / Gillard, Pieter / Linn, Thomas / Bosi, Emanuele / Rose, Ludger / Pozzilli, Paolo / Giorgino, Francesco / Cossu, Efisio / Piemonti, Lorenzo

Frontiers in endocrinology

2023 Volume 14, Page(s) 1175640

Abstract: Aim: In a recent randomized, multicenter trial (NCT02814838) a short-term anti-inflammatory treatment with ladarixin (LDX; an inhibitor of the CXCR1/2 chemokine receptors) did not show benefit on preserving residual beta cell function in new-onset type ... ...

Abstract	Aim: In a recent randomized, multicenter trial (NCT02814838) a short-term anti-inflammatory treatment with ladarixin (LDX; an inhibitor of the CXCR1/2 chemokine receptors) did not show benefit on preserving residual beta cell function in new-onset type 1 diabetes. We present a Method: A double-blind, randomized (2:1), placebo-controlled study was conducted in 45 men and 31 women (aged 18-46 years) within 100 days of the first insulin administration. Patients received LDX (400 mg twice daily) for three cycles of 14 days on/14 days off, or placebo. The primary endpoint was the area under the curve for C-peptide [AUC (0-120 min)] in response to a 2-h mixed meal tolerance test (MMTT) at week 13 ± 1. Seventy-five patients completed the week 13 MMTT and were divided into three groups according to the DIR tertiles: lower, ≤ 0.23U/kg/die (n = 25); middle, 0.24-0.40 U/kg/die (n = 24); upper, ≥ 0.41 U/kg/die (n = 26). Results: When considering the patients in the upper tertile (HIGH-DIR), C-peptide AUC (0-120 min) at 13 weeks was higher in the LDX group (n = 16) than in the placebo (n = 10) group [difference: 0.72 nmol/L (95% CI 0.9-1.34), p = 0.027]. This difference reduced over time (0.71 nmol/L at 26 weeks, p = 0.04; 0.42 nmol/L at 52 weeks, p = 0.29), while it has never been significant at any time in patients in the lower and/or middle tertile (LOW-DIR). We characterized at baseline the HIGH-DIR and found that endo-metabolic (HOMA-B, adiponectin, and glucagon-to-C-peptide ratio) and immunologic (chemokine (C-C motif) ligand 2 (CCL2)/monocyte chemoattractant protein 1 (MCP1) and Vascular Endothelial Growth Factor (VEGF)) features distinguished this group from LOW-DIR. Conclusion: While LDX did not prevent the progressive loss of beta-cell function in the majority of treated subjects, the
MeSH term(s)	Male ; Humans ; Female ; Diabetes Mellitus, Type 1/drug therapy ; C-Peptide/metabolism ; Prospective Studies ; Vascular Endothelial Growth Factor A ; Insulin/therapeutic use
Chemical Substances	C-Peptide ; Vascular Endothelial Growth Factor A ; Insulin
Language	English
Publishing date	2023-06-20
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1175640
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Article ; Online: Analysis of a series of Italian APECED patients with autoimmune hepatitis and gastro-enteropathies.

Paldino, Giorgia / Faienza, Maria Felicia / Cappa, Marco / Pietrobattista, Andrea / Capalbo, Donatella / Valenzise, Mariella / Lampasona, Vito / Cudini, Annamaria / Carbone, Elena / Pagliarosi, Olivia / Maggiore, Giuseppe / Salerno, Mariacarolina / Betterle, Corrado / Fierabracci, Alessandra

Frontiers in immunology

2023 Volume 14, Page(s) 1172369

Abstract: Introduction: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) syndrome is a rare monogenic disease determined by biallelic mutations in : Patients and methods: We analyzed the clinical, genetic, and autoantibody (Ab) profiles ... ...

Abstract	Introduction: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) syndrome is a rare monogenic disease determined by biallelic mutations in Patients and methods: We analyzed the clinical, genetic, and autoantibody (Ab) profiles in a series of 14 pediatric Italian APECED patients with gastrointestinal manifestations (seven male and seven female patients). Ten patients presented hepatitis (APECED-associated hepatitis (APAH)), while seven were affected by constipation, diarrhea, and malabsorption. Four patients had developed APAH before classic triad symptoms. Results: Based on the age of appearance of non-endocrine manifestations including APAH and gastro-enteropathy, the Ferre-Lionakis criteria would have allowed an expedited diagnosis in 11/14 patients. Abs to tryptophan hydroxylase (TPHAb) and hepatic aromatic l-amino acid decarboxylase (AADC) were significantly associated with APECED patients of the present series. Abs to cP4501A2 were detectable in the serum of 4/8 patients with APAH, and Abs to cP4502A6 were detectable in 3/8 patients. AADC Abs tested positive in 5/7 patients, which is indicative of gastrointestinal dysfunction in APECED and TPHAb in 5/7 patients with gastrointestinal dysfunction. IFNAb was significantly associated with the syndrome. Conclusion: Although Ferre-Lionakis expanded criteria applied to the American cohorts of APECED patients would require validation in independent large cohorts of European patients, the results of this study emphasize the importance to evaluate the presence and the age of appearance of APAH and autoimmune enteropathy even in European cohorts for an earlier APECED diagnosis. An earlier APECED diagnosis would also allow the prevention of episodes of life-threatening hypocalcemic seizures and adrenal crisis, which are the main manifestations of undiagnosed APECED.
MeSH term(s)	Humans ; Male ; Child ; Female ; Hepatitis, Autoimmune/diagnosis ; Hepatitis, Autoimmune/genetics ; Polyendocrinopathies, Autoimmune/diagnosis ; Polyendocrinopathies, Autoimmune/genetics ; Mutation ; Italy/epidemiology ; Intestinal Diseases
Chemical Substances	7-(N-(3-aminopropyl)amino)heptan-2-one (122269-09-4)
Language	English
Publishing date	2023-06-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1172369
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