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  1. Article ; Online: Controlling supramolecular gels.

    Draper, Emily R / Adams, Dave J

    Nature materials

    2024  Volume 23, Issue 1, Page(s) 13–15

    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2088679-2
    ISSN 1476-4660 ; 1476-1122
    ISSN (online) 1476-4660
    ISSN 1476-1122
    DOI 10.1038/s41563-023-01765-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Recommended updates to the USEPA Framework for Metals Risk Assessment: Aquatic ecosystems.

    Adams, William J / Garman, Emily R

    Integrated environmental assessment and management

    2023  

    Abstract: In 2007, the USEPA issued its "Framework for Metals Risk Assessment." The framework provides technical guidance to risk assessors and regulators when performing human health and environmental risk assessments of metals. This article focuses on advances ... ...

    Abstract In 2007, the USEPA issued its "Framework for Metals Risk Assessment." The framework provides technical guidance to risk assessors and regulators when performing human health and environmental risk assessments of metals. This article focuses on advances in the science including assessing bioavailability in aquatic ecosystems, short- and long-term fate of metals in aquatic ecosystems, and advances in risk assessment of metals in sediments. Notable advances have occurred in the development of bioavailability models for assessing toxicity as a function of water chemistry in freshwater ecosystems. The biotic ligand model (BLM), the multiple linear regression model, and multimetal BLM now exist for most of the common mono- and divalent metals. Species sensitivity distributions for many metals exist, making it possible for many jurisdictions to develop or update their water quality criteria or guidelines. The understanding of the fate of metals in the environment has undergone significant scrutiny over the past 20 years. Transport and toxicity models have evolved including the Unit World Model allowing for estimation of concentrations of metals in various compartments as a function of loading and time. There has been significant focus on the transformation of metals in sediments into forms that are less bioavailable and on understanding conditions that result in resolubilization or redistribution of metals in and from sediments. Methods for spiking sediments have advanced such that the resulting chemistry in the laboratory mimics that in natural systems. Sediment bioavailability models are emerging including models that allow for prediction of toxicity in sediments for copper and nickel. Biodynamic models have been developed for several organisms and many metals. The models allow for estimates of transport of metals from sediments to organisms via their diet as well as their water exposure. All these advances expand the tool set available to risk assessors. Integr Environ Assess Manag 2023;00:1-28. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2234931-5
    ISSN 1551-3793 ; 1551-3777
    ISSN (online) 1551-3793
    ISSN 1551-3777
    DOI 10.1002/ieam.4827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7647: Show issues

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  3. Article ; Online: Genome sequence of Soos: a siphovirus of the CP cluster infecting

    Adams, Reese M / Britton, Holly A / Bruce, Emily D / De La Paz, Yucita / Kratz, Emily N / Pfeifer, Emma J / Priddy, Daisy E / Schotter, Brooklyn I / Stuffle, Wyatt A / Wagner, Jordyn / Weiss, Meredith R / Watt, Danielle K / Connerly, Pamela L / Rueschhoff, Elizabeth E

    Microbiology resource announcements

    2024  Volume 13, Issue 4, Page(s) e0120423

    Abstract: Novel actinobacteriophage Soos was isolated and purified from Southern Indiana soil using ... ...

    Abstract Novel actinobacteriophage Soos was isolated and purified from Southern Indiana soil using host
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.01204-23
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  4. Article ; Online: The Hidden Hand of Asymptomatic Infection Hinders Control of Neglected Tropical Diseases: A Modeling Analysis.

    Rock, Kat S / Chapman, Lloyd A C / Dobson, Andrew P / Adams, Emily R / Hollingsworth, T Déirdre

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  Volume 78, Issue Supplement_2, Page(s) S175–S182

    Abstract: Background: Neglected tropical diseases are responsible for considerable morbidity and mortality in low-income populations. International efforts have reduced their global burden, but transmission is persistent and case-finding-based interventions ... ...

    Abstract Background: Neglected tropical diseases are responsible for considerable morbidity and mortality in low-income populations. International efforts have reduced their global burden, but transmission is persistent and case-finding-based interventions rarely target asymptomatic individuals.
    Methods: We develop a generic mathematical modeling framework for analyzing the dynamics of visceral leishmaniasis in the Indian sub-continent (VL), gambiense sleeping sickness (gHAT), and Chagas disease and use it to assess the possible contribution of asymptomatics who later develop disease (pre-symptomatics) and those who do not (non-symptomatics) to the maintenance of infection. Plausible interventions, including active screening, vector control, and reduced time to detection, are simulated for the three diseases.
    Results: We found that the high asymptomatic contribution to transmission for Chagas and gHAT and the apparently high basic reproductive number of VL may undermine long-term control. However, the ability to treat some asymptomatics for Chagas and gHAT should make them more controllable, albeit over relatively long time periods due to the slow dynamics of these diseases. For VL, the toxicity of available therapeutics means the asymptomatic population cannot currently be treated, but combining treatment of symptomatics and vector control could yield a quick reduction in transmission.
    Conclusions: Despite the uncertainty in natural history, it appears there is already a relatively good toolbox of interventions to eliminate gHAT, and it is likely that Chagas will need improvements to diagnostics and their use to better target pre-symptomatics. The situation for VL is less clear, and model predictions could be improved by additional empirical data. However, interventions may have to improve to successfully eliminate this disease.
    MeSH term(s) Humans ; Neglected Diseases/prevention & control ; Neglected Diseases/epidemiology ; Chagas Disease/transmission ; Chagas Disease/prevention & control ; Chagas Disease/epidemiology ; Chagas Disease/drug therapy ; Asymptomatic Infections/epidemiology ; Leishmaniasis, Visceral/prevention & control ; Leishmaniasis, Visceral/epidemiology ; Leishmaniasis, Visceral/transmission ; Leishmaniasis, Visceral/drug therapy ; Models, Theoretical ; Trypanosomiasis, African/prevention & control ; Trypanosomiasis, African/epidemiology ; Trypanosomiasis, African/transmission ; Trypanosomiasis, African/drug therapy ; India/epidemiology ; Animals
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciae096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  5. Article ; Online: Investigating multigelator systems across multiple length scales.

    Marshall, Libby J / Bianco, Simona / Ginesi, Rebecca E / Doutch, James / Draper, Emily R / Adams, Dave J

    Soft matter

    2023  Volume 19, Issue 26, Page(s) 4972–4981

    Abstract: Preparation of multicomponent systems provides a method for changing the properties of low molecular weight gelator (LMWG)-based systems. Here we have prepared a variety of multicomponent systems where both components ... ...

    Abstract Preparation of multicomponent systems provides a method for changing the properties of low molecular weight gelator (LMWG)-based systems. Here we have prepared a variety of multicomponent systems where both components are
    Language English
    Publishing date 2023-07-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/d3sm00521f
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  6. Article ; Online: Atomic structures of naphthalene dipeptide micelles unravel mechanisms of assembly and gelation.

    Sonani, Ravi R / Bianco, Simona / Dietrich, Bart / Doutch, James / Draper, Emily R / Adams, Dave J / Egelman, Edward H

    Cell reports. Physical science

    2024  Volume 5, Issue 2

    Abstract: Peptide-based biopolymers have gained increasing attention due to their versatile applications. A naphthalene dipeptide (2NapFF) can form chirality-dependent tubular micelles, leading to supramolecular gels. The precise molecular arrangement within these ...

    Abstract Peptide-based biopolymers have gained increasing attention due to their versatile applications. A naphthalene dipeptide (2NapFF) can form chirality-dependent tubular micelles, leading to supramolecular gels. The precise molecular arrangement within these micelles and the mechanism governing gelation have remained enigmatic. We determined, at near-atomic resolution, cryoelectron microscopy structures of the 2NapFF micelles LL-tube and LD-tube, generated by the stereoisomers (l,l)-2NapFF and (l,d)-2NapFF, respectively. The structures reveal that the fundamental packing of dipeptides is driven by the systematic π-π stacking of aromatic rings and that same-charge repulsion between the carbonyl groups is responsible for the stiffness of both tubes. The structural analysis elucidates how a single residue's altered chirality gives rise to markedly distinct tubular structures and sheds light on the mechanisms underlying the pH-dependent gelation of LL- and LD-tubes. The understanding of dipeptide packing and gelation mechanisms provides insights for the rational design of 2NapFF derivatives, enabling the modulation of micellar dimensions.
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3864
    ISSN (online) 2666-3864
    DOI 10.1016/j.xcrp.2024.101812
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  7. Article ; Online: Photothermal Perylene Bisimide Hydrogels.

    Thomson, Lisa / Ginesi, Rebecca E / Osborne, Daniel D / Draper, Emily R / Adams, Dave J

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 37, Page(s) e202300663

    Abstract: Gels formed using a perylene bisimide (PBI) as a low molecular weight gelator can show the photothermal effect. Formation of the PBI radical anion results in new absorption bands forming, meaning that subsequent irradiation with a wavelength of light ... ...

    Abstract Gels formed using a perylene bisimide (PBI) as a low molecular weight gelator can show the photothermal effect. Formation of the PBI radical anion results in new absorption bands forming, meaning that subsequent irradiation with a wavelength of light overlapping with the new absorption band leads to heating of the gel. This approach can be used to heat the gel, as well as the surrounding milieu. We show how we can use electrochemical methods as well as multicomponent systems to form the radical anion without the need for UV light, and how we can use the photothermal effect to induce phase transitions in the solutions above the gels by exploiting photothermal behavior.
    Language English
    Publishing date 2023-05-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202300663
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  8. Article ; Online: Controlling the Assembly and Properties of Low-Molecular-Weight Hydrogelators.

    Draper, Emily R / Adams, Dave J

    Langmuir : the ACS journal of surfaces and colloids

    2019  Volume 35, Issue 20, Page(s) 6506–6521

    Abstract: Low-molecular-weight gels are formed by the self-assembly of small molecules into fibrous networks that can immobilize a significant amount of solvent. Here, we focus on our work with a specific class of gelator, the functionalized dipeptide. We discuss ... ...

    Abstract Low-molecular-weight gels are formed by the self-assembly of small molecules into fibrous networks that can immobilize a significant amount of solvent. Here, we focus on our work with a specific class of gelator, the functionalized dipeptide. We discuss the current state of the art in the area, focusing on how these materials can be controlled. We also highlight interesting and unusual observations and unanswered questions in the field.
    Language English
    Publishing date 2019-05-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.9b00716
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  9. Article: Case of an unreported genetic variant of salt losing 3-β-hydroxysteroid dehydrogenase deficiency.

    Alkhatib, Einas H / Adams, Stacie D / Miller, Emily R

    Oxford medical case reports

    2021  Volume 2021, Issue 5, Page(s) omab021

    Abstract: Salt losing 3-β-hydroxysteroid dehydrogenase deficiency (HSD3B2) is a rare form of congenital adrenal hyperplasia, seen in <0.5% of cases. We present a 7-year-old male diagnosed with HSD3B2 deficiency, not identified by state newborn screen, due to a ... ...

    Abstract Salt losing 3-β-hydroxysteroid dehydrogenase deficiency (HSD3B2) is a rare form of congenital adrenal hyperplasia, seen in <0.5% of cases. We present a 7-year-old male diagnosed with HSD3B2 deficiency, not identified by state newborn screen, due to a novel variant identified in the HSD3B2 gene (c.694C > G; p.His232Asp). This patient was referred to pediatric endocrinology and pediatric biochemical genetics following a fourth hospitalization for emesis and electrolyte derangements including hyponatremia, hyperkalemia, ketoacidosis and hypoglycemia. Endocrinology evaluation yielded elevated 17-hydroxyprogesterone (17-OHP), 17-hydroxypregnenolone (17-OHPreg), dehydroepiandrosterone and adrenocorticotropic hormone (ACTH). ACTH stimulation test indicated flat response. Sequencing of the HSD3B2 revealed a pathogenic variant inherited in trans with the novel c.694C > G (p.His232Asp) variant. The patient was started on daily glucocorticoid and mineralocorticoid replacement and has since had no further adrenal crises.
    Language English
    Publishing date 2021-05-24
    Publishing country England
    Document type Case Reports
    ZDB-ID 2766251-2
    ISSN 2053-8855
    ISSN 2053-8855
    DOI 10.1093/omcr/omab021
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  10. Article ; Online: Probing the self-assembled structures and pK

    Cross, Emily R / Adams, Dave J

    Soft matter

    2019  Volume 15, Issue 7, Page(s) 1522–1528

    Abstract: The surface chemistry of the aggregated structures that form the scaffold in self-assembled hydrogels - their charge, hydrophobicity and ion-binding dynamics - plays an important role in determining the gel properties and the gel's suitability for ... ...

    Abstract The surface chemistry of the aggregated structures that form the scaffold in self-assembled hydrogels - their charge, hydrophobicity and ion-binding dynamics - plays an important role in determining the gel properties and the gel's suitability for specific applications. However, there are limited methods available for the study of this surface chemistry. Here, we show that electrochemical techniques can be used to measure the surface chemical properties of the self-assembled aggregate structures and also to determine the pKa of the gelators. We also provide a method to quickly determine whether a functionalised-dipeptide will form a gel or not. This method has scope for use in high-throughput screening and further complex pH-triggered self-assembled gelation systems.
    Language English
    Publishing date 2019-01-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/c8sm02430h
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