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  1. Article ; Online: Nonreciprocal

    Wang, Zheng-Yang / He, Xiao-Wei / Han, Xue / Wang, Hong-Fu / Zhang, Shou

    Optics express

    2024  Volume 32, Issue 4, Page(s) 4987–4997

    Abstract: We propose a scheme to achieve nonreciprocal parity-time ( ...

    Abstract We propose a scheme to achieve nonreciprocal parity-time (
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.513536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Live-attenuated virus vaccine defective in RNAi suppression induces rapid protection in neonatal and adult mice lacking mature B and T cells.

    Chen, Gang / Han, Qingxia / Li, Wan-Xiang / Hai, Rong / Ding, Shou-Wei

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 17, Page(s) e2321170121

    Abstract: Global control of infectious diseases depends on the continuous development and deployment of diverse vaccination strategies. Currently available live-attenuated and killed virus vaccines typically take a week or longer to activate specific protection by ...

    Abstract Global control of infectious diseases depends on the continuous development and deployment of diverse vaccination strategies. Currently available live-attenuated and killed virus vaccines typically take a week or longer to activate specific protection by the adaptive immunity. The mosquito-transmitted Nodamura virus (NoV) is attenuated in mice by mutations that prevent expression of the B2 viral suppressor of RNA interference (VSR) and consequently, drastically enhance in vivo production of the virus-targeting small-interfering RNAs. We reported recently that 2 d after immunization with live-attenuated VSR-disabled NoV (NoVΔB2), neonatal mice become fully protected against lethal NoV challenge and develop no detectable infection. Using
    MeSH term(s) Animals ; Humans ; Mice ; T-Lymphocytes ; RNA Interference ; Vaccines, Attenuated ; Viral Vaccines ; Viruses ; Homeodomain Proteins ; Influenza Vaccines ; Antibodies, Viral
    Chemical Substances Vaccines, Attenuated ; Viral Vaccines ; Homeodomain Proteins ; Influenza Vaccines ; Antibodies, Viral
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2321170121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Conversion of

    Cheng, Yu-Chen / Huang, Wei-Han / Lo, Shou-Chen / Huang, Eugene / Chiang, En-Pei Isabel / Huang, Chieh-Chen / Yang, Ya-Tang

    Microorganisms

    2023  Volume 11, Issue 2

    Abstract: We report the mixotrophic growth ... ...

    Abstract We report the mixotrophic growth of
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11020253
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  4. Article ; Online: Infection Defects of RNA and DNA Viruses Induced by Antiviral RNA Interference.

    Liu, Si / Han, Yanhong / Li, Wan-Xiang / Ding, Shou-Wei

    Microbiology and molecular biology reviews : MMBR

    2023  Volume 87, Issue 2, Page(s) e0003522

    Abstract: Immune recognition of viral genome-derived double-stranded RNA (dsRNA) molecules and their subsequent processing into small interfering RNAs (siRNAs) in plants, invertebrates, and mammals trigger specific antiviral immunity known as antiviral RNA ... ...

    Abstract Immune recognition of viral genome-derived double-stranded RNA (dsRNA) molecules and their subsequent processing into small interfering RNAs (siRNAs) in plants, invertebrates, and mammals trigger specific antiviral immunity known as antiviral RNA interference (RNAi). Immune sensing of viral dsRNA is sequence-independent, and most regions of viral RNAs are targeted by virus-derived siRNAs which extensively overlap in sequence. Thus, the high mutation rates of viruses do not drive immune escape from antiviral RNAi, in contrast to other mechanisms involving specific virus recognition by host immune proteins such as antibodies and resistance (R) proteins in mammals and plants, respectively. Instead, viruses actively suppress antiviral RNAi at various key steps with a group of proteins known as viral suppressors of RNAi (VSRs). Some VSRs are so effective in virus counter-defense that potent inhibition of virus infection by antiviral RNAi is undetectable unless the cognate VSR is rendered nonexpressing or nonfunctional. Since viral proteins are often multifunctional, resistance phenotypes of antiviral RNAi are accurately defined by those infection defects of VSR-deletion mutant viruses that are efficiently rescued by host deficiency in antiviral RNAi. Here, we review and discuss
    MeSH term(s) Animals ; RNA Interference ; Antiviral Agents ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; RNA, Viral/genetics ; RNA, Viral/metabolism ; DNA Viruses/genetics ; DNA Viruses/metabolism ; RNA Viruses/genetics ; Mammals/genetics ; Mammals/metabolism
    Chemical Substances Antiviral Agents ; RNA, Small Interfering ; RNA, Viral
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1376131-6
    ISSN 1098-5557 ; 1070-6275 ; 1092-2172
    ISSN (online) 1098-5557 ; 1070-6275
    ISSN 1092-2172
    DOI 10.1128/mmbr.00035-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.96: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Sub-kHz high-order mode Brillouin random fiber laser based on long-period fiber grating and distributed Rayleigh scattering in a half-open linear cavity.

    Zhang, Liang / Wei, Zizhou / Li, Yichun / Shou, Haozhe / Wang, Han / Zhu, Mengshi / Zeng, Xianglong / Chen, Wei / Pang, Fufei / Wang, Tingyun

    Optics express

    2023  Volume 31, Issue 10, Page(s) 15484–15494

    Abstract: We demonstrate a narrow-linewidth high-order-mode (HOM) Brillouin random fiber laser (BRFL) based on a long-period fiber grating (LPFG) and distributed Rayleigh random feedback in a half-open linear cavity. The single-mode operation of the laser ... ...

    Abstract We demonstrate a narrow-linewidth high-order-mode (HOM) Brillouin random fiber laser (BRFL) based on a long-period fiber grating (LPFG) and distributed Rayleigh random feedback in a half-open linear cavity. The single-mode operation of the laser radiation with sub-kilohertz linewidth is achieved thanks to distributed Brillouin amplification and Rayleigh scattering along kilometer-long single mode fibers whilst a few mode fiber-based LPFGs enable the transverse mode conversion among a broadband wavelength range. Meanwhile, a dynamic fiber grating (DFG) is embedded and incorporated to manipulate and purify the random modes, which hence suppresses the frequency drift resulting from random mode hopping. Consequently, the random laser emission with either high-order scalar or vector modes can be generated with a high laser efficiency of 25.5% and an ultra-narrow 3-dB linewidth of 230 Hz. Furthermore, the dependence of the laser efficiency and frequency stability on the gain fiber length are also experimentally investigated. It is believed that our approach could provide a promising platform for a wide range of applications such as coherent optical communication, high-resolution imaging, highly sensitive sensing, etc.
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.488353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bioactive components and molecular mechanisms of Salvia miltiorrhiza Bunge in promoting blood circulation to remove blood stasis.

    Wei, Baoyu / Sun, Chengtao / Wan, Haitong / Shou, Qiyang / Han, Bing / Sheng, Miaomiao / Li, Liqing / Kai, Guoyin

    Journal of ethnopharmacology

    2023  Volume 317, Page(s) 116697

    Abstract: Ethnopharmacological relevance: Salvia miltiorrhiza Bunge (SM) is an outstanding herbal medicine with various traditional effects, especially promoting blood circulation to remove blood stasis. It has been widely used for centuries to treat blood stasis ...

    Abstract Ethnopharmacological relevance: Salvia miltiorrhiza Bunge (SM) is an outstanding herbal medicine with various traditional effects, especially promoting blood circulation to remove blood stasis. It has been widely used for centuries to treat blood stasis syndrome (BSS)-related diseases. BSS is one of the basic pathological syndromes of diseases such as cardiovascular and cerebrovascular diseases in traditional East Asian medicine, which is characterized by disturbance of blood circulation. However, the bioactive components and mechanisms of SM in the treatment of BSS have not been systematically reviewed. Therefore, this article outlines the anti-BSS effects of bioactive components of SM, concentrating on the molecular mechanisms.
    Aim of the review: To summarize the bioactive components of SM against BSS and highlight its potential targets and signaling pathways, hoping to provide a modern biomedical perspective to understand the efficacy of SM on enhancing blood circulation to remove blood stasis.
    Materials and methods: A comprehensive literature search was performed to retrieve articles published in the last two decades on bioactive components of SM used for BSS treatment from the online electronic medical literature database (PubMed).
    Results: Phenolic acids and tanshinones in SM are the main bioactive components in the treatment of BSS, including but not limited to salvianolic acid B, tanshinone IIA, salvianolic acid A, cryptotanshinone, Danshensu, dihydrotanshinone, rosmarinic acid, protocatechuic aldehyde, and caffeic acid. They protect vascular endothelial cells by alleviating oxidative stress and inflammatory damage and regulating of NO/ET-1 levels. They also enhance anticoagulant and fibrinolytic capacity, inhibit platelet activation and aggregation, and dilate blood vessels. Moreover, lowering blood lipids and improving blood rheological properties may be the underlying mechanisms of their anti-BSS. More notably, these compounds play an anti-BSS role by mediating multiple signaling pathways such as Nrf2/HO-1, TLR4/MyD88/NF-κB, PI3K/Akt/eNOS, MAPKs (p38, ERK, and JNK), and Ca
    Conclusions: Both phenolic acids and tanshinones in SM may act synergistically to target different signaling pathways to achieve the effect of promoting blood circulation.
    MeSH term(s) Salvia miltiorrhiza ; Phosphatidylinositol 3-Kinases/metabolism ; Endothelial Cells ; Abietanes
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; tanshinone (03UUH3J385) ; Abietanes ; phenolic acid (I3P9R8317T)
    Language English
    Publishing date 2023-06-08
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Spectrum-Effect Relationship Analysis of Bioactive Compounds in

    Rao, Si-Wei / Duan, Yuan-Yuan / Pang, Han-Qing / Xu, Shao-Hua / Hu, Shou-Qian / Cheng, Ke-Guang / Liang, Dong / Shi, Wei

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 794277

    Abstract: Zanthoxylum ... ...

    Abstract Zanthoxylum nitidum
    Language English
    Publishing date 2022-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.794277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Rubia cordifolia

    Qin, Wei / Luo, Han / Yang, Liu / Hu, Di / Jiang, Su-Ping / Peng, Dai-Yin / Hu, Jiang-Miao / Liu, Shou-Jin

    Heliyon

    2022  Volume 8, Issue 8, Page(s) e10314

    Abstract: The aerial part of ​ ...

    Abstract The aerial part of ​
    Language English
    Publishing date 2022-08-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e10314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Tuning capsid formation dynamics in recombinant adeno-associated virus producing synthetic cell lines to enhance full particle productivity.

    Lu, Min / Lin, Yu-Chieh / Kuo, Han-Jung / Cai, Wen / Ye, Qian / Zhao, Liang / Hu, Wei-Shou

    Biotechnology journal

    2024  Volume 19, Issue 3, Page(s) e2400051

    Abstract: Recombinant adeno-associated virus (rAAV) is widely used as an in vivo delivery vector for gene therapy. It is used in a very large dose, and the large quantities required for broad applications present manufacturing challenges. We have developed a ... ...

    Abstract Recombinant adeno-associated virus (rAAV) is widely used as an in vivo delivery vector for gene therapy. It is used in a very large dose, and the large quantities required for broad applications present manufacturing challenges. We have developed a synthetic biology platform of constructing cell lines integrated with essential viral genes which can be induced to produce rAAV without plasmid transfection or virus transduction. Through iterative design-construct-characterization cycles, we have showcased the potential of this synthetic cell production system. Systems characterization of the dynamics of viral transcripts and proteins as well as virus assembly and packaging revealed that the expression level and balance of viral genome and capsid protein are keys to not only the productivity but also the full particle content, an important product quality attribute. Boosting cap gene expression by sequential transfection and integration of multiple copies of the cap gene elevated the rAAV titer to levels on a par with traditional plasmid transfection and virus infection. However, overexpression of the cap gene shifted the balance and kinetics of the genome and capsid. We independently tuned the dynamics of genome amplification and capsid protein synthesis by modulating the induction concentration as well as the time profile, and significantly enhanced full particle content while maintaining a high productivity. This strategy of constructing an inducible stable producer cell line is readily adaptable to rAAV vectors of different serotypes and payloads. It can greatly facilitate scalable production of gene therapy vectors.
    MeSH term(s) Dependovirus/genetics ; Capsid Proteins/genetics ; Capsid Proteins/metabolism ; Genetic Vectors/genetics ; Capsid ; Artificial Cells ; Cell Line
    Chemical Substances Capsid Proteins
    Language English
    Publishing date 2024-03-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2221885-3
    ISSN 1860-7314 ; 1860-6768
    ISSN (online) 1860-7314
    ISSN 1860-6768
    DOI 10.1002/biot.202400051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6349: Show issues Location:
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  10. Article ; Online: Stable propagation of cylindrical-vector vortex solitons in strongly nonlocal media.

    Shou, Qian / Weng, Zhiwei / Guan, Siyin / Han, Hui / Huang, Hui / Guo, Qi / Hu, Wei

    Optics letters

    2021  Volume 46, Issue 12, Page(s) 2807–2810

    Abstract: We report the experimental observation of cylindrical-vector vortex solitons (CVVSs) in lead glass with strongly thermal nonlocal nonlinearity. The formations of radially and angularly polarized solitons with topological charge of $l = 1$ were observed. ... ...

    Abstract We report the experimental observation of cylindrical-vector vortex solitons (CVVSs) in lead glass with strongly thermal nonlocal nonlinearity. The formations of radially and angularly polarized solitons with topological charge of $l = 1$ were observed. We show that the ring profiles and the polarization distributions of the two first-order CVVSs can be preserved. We numerically prove that the first-order CVVS is stable, and the higher-order CVVSs with $l \ge 2$ are unstable based on the linear stability analysis method.
    Language English
    Publishing date 2021-06-15
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.424990
    Database MEDical Literature Analysis and Retrieval System OnLINE

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