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  1. Article ; Online: A Twin Study of Inhibitory Control at Age Two and ADHD Behavior Problems at Age Three.

    Gagne, Jeffrey R / Asherson, Philip / Saudino, Kimberly J

    Behavior genetics

    2020  Volume 50, Issue 4, Page(s) 289–300

    Abstract: Low levels of childhood inhibitory control (IC) are phenotypically and genetically associated with externalizing behavior problems and attention deficit hyperactivity disorder (ADHD). Unfortunately, there is little research on this topic in early ... ...

    Abstract Low levels of childhood inhibitory control (IC) are phenotypically and genetically associated with externalizing behavior problems and attention deficit hyperactivity disorder (ADHD). Unfortunately, there is little research on this topic in early childhood, when IC first emerges. This investigation extends the previous findings of contemporaneous genetic covariance between parent-rated and laboratory-assessed IC and ADHD at age 2 by examining longitudinal links between IC at age two and ADHD behavior problems at age three in a sample of 314 same-sex twin pairs (145 monozygotic or MZ, 169 dizygotic or DZ). There were significant phenotypic associations between both parent and laboratory IC assessments at age two and later ADHD behavioral problems (correlations ranged from - .15 to - .44). In our model-fitting strategy, we included measures of ADHD and IC at age 2 as predictors of ADHD at age 3. Longitudinal genetic analyses showed that phenotypic covariance between age two IC and ADHD behavior problems one year later were explained by overlapping genetic variance (genetic correlations ranged from - .28 to - .60). However, these effects were not unique to IC and reflect variance shared with ADHD at age 2. Parent-rated IC at age two showed higher phenotypic and genetic covariance with ADHD at age three than lab ratings of IC at age two. This is the first investigation examining genetic covariance between parent and lab-based IC at age two and ADHD behavior problems at age three. Findings show that after accounting for co-occurring ADHD, early temperamental IC is not a unique genetic risk factor for later ADHD.
    MeSH term(s) Attention Deficit Disorder with Hyperactivity/genetics ; Child, Preschool ; Diseases in Twins/genetics ; Environment ; Female ; Gene-Environment Interaction ; Genome-Wide Association Study ; Genotype ; Humans ; Impulsive Behavior/physiology ; Inhibition, Psychological ; Male ; Parents ; Phenotype ; Problem Behavior ; Temperament/physiology ; Twins, Dizygotic/genetics ; Twins, Dizygotic/psychology ; Twins, Monozygotic/genetics ; Twins, Monozygotic/psychology
    Language English
    Publishing date 2020-03-11
    Publishing country United States
    Document type Journal Article ; Twin Study
    ZDB-ID 280238-7
    ISSN 1573-3297 ; 0005-7851 ; 0001-8244
    ISSN (online) 1573-3297
    ISSN 0005-7851 ; 0001-8244
    DOI 10.1007/s10519-020-09997-5
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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Mind-wandering in children with and without ADHD.

    Frick, Matilda A / Asherson, Philip / Brocki, Karin C

    The British journal of clinical psychology

    2019  Volume 59, Issue 2, Page(s) 208–223

    Abstract: ... of the MEWS were satisfactory. In addition, MW contributed independently to working memory (R: Conclusions ...

    Abstract Objectives: Mind-wandering (MW) is a commonly experienced phenomenon, characterized by focus of attention drifting away from the present situation to intrinsically originated thoughts. Studies in adults show that MW is related to ADHD symptoms, but this association is understudied in children. We set out to investigate the associations of MW in children with and without ADHD and to simultaneously validate the self-report Mind Excessively Wandering Scale (MEWS) in children.
    Design: We used a cross-sectional, correlational, design to examine the research questions.
    Methods: The sample consisted of 82 children (61 boys) aged 8-13 years (m = 10.46), of which 35 had a diagnosis of ADHD. Children rated MW; parents and teachers rated ADHD symptoms, emotion regulation and academic achievement. Working memory was assessed with Digit Span.
    Results: MW was positively related to ADHD symptoms, and the MEWS could differentiate between cases and controls with a sensitivity of 0.71 and specificity of 0.81. Psychometric properties of the MEWS were satisfactory. In addition, MW contributed independently to working memory (R
    Conclusions: MW is elevated in children with ADHD and contributes to functional domains. The MEWS is a valid tool for assessing MW in children, and the results are mostly comparable to that of adults (Mowlem et al., 2016, Journal of Attention Disorders, 23, 624), suggesting a similar relationship of MW to ADHD across the lifespan.
    Practitioner points: Spontaneous mind-wandering is elevated in children with ADHD compared to children without a diagnosis. Elevated spontaneous mind-wandering predicts lower working memory, emotion regulation and academic achievement beyond ADHD symptoms, IQ and socio-economic status. Clinicians should consider evaluating excessive spontaneous mind-wandering and targeting it as an important outcome when treating children with ADHD. The MEWS is a valid tool for assessing excessive mind-wandering in children.
    MeSH term(s) Adolescent ; Adult ; Attention/physiology ; Attention Deficit Disorder with Hyperactivity/psychology ; Child ; Cross-Sectional Studies ; Female ; Humans ; Male ; Psychometrics/methods ; Self Report ; Stress, Psychological/psychology
    Language English
    Publishing date 2019-12-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 625324-6
    ISSN 2044-8260 ; 0144-6657
    ISSN (online) 2044-8260
    ISSN 0144-6657
    DOI 10.1111/bjc.12241
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  3. Article: [Variants of antiphospholipid syndrome: some new conceptions?].

    Asherson, R A

    Terapevticheskii arkhiv

    2008  Volume 80, Issue 5, Page(s) 83–85

    MeSH term(s) Antibodies, Antiphospholipid/immunology ; Antiphospholipid Syndrome/classification ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/immunology ; Diagnosis, Differential ; Humans ; Prognosis ; Severity of Illness Index
    Chemical Substances Antibodies, Antiphospholipid
    Language Russian
    Publishing date 2008
    Publishing country Russia (Federation)
    Document type Lectures
    ZDB-ID 40718-5
    ISSN 2309-5342 ; 0040-3660
    ISSN (online) 2309-5342
    ISSN 0040-3660
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  4. Article ; Online: Remote Administration of ADHD-Sensitive Cognitive Tasks: A Pilot Study.

    Sun, Shaoxiong / Denyer, Hayley / Sankesara, Heet / Deng, Qigang / Ranjan, Yatharth / Conde, Pauline / Rashid, Zulqarnain / Bendayan, Rebecca / Asherson, Philip / Bilbow, Andrea / Groom, Madeleine / Hollis, Chris / Folarin, Amos A / Dobson, Richard J B / Kuntsi, Jonna

    Journal of attention disorders

    2023  Volume 27, Issue 9, Page(s) 1040–1050

    Abstract: Objective: We assessed the feasibility and validity of remote researcher-led administration and self-administration of modified versions of two cognitive tasks sensitive to ADHD, a four-choice reaction time task (Fast task) and a combined Continuous ... ...

    Abstract Objective: We assessed the feasibility and validity of remote researcher-led administration and self-administration of modified versions of two cognitive tasks sensitive to ADHD, a four-choice reaction time task (Fast task) and a combined Continuous Performance Test/Go No-Go task (CPT/GNG), through a new remote measurement technology system.
    Method: We compared the cognitive performance measures (mean and variability of reaction times (MRT, RTV), omission errors (OE) and commission errors (CE)) at a remote baseline researcher-led administration and three remote self-administration sessions between participants with and without ADHD (
    Results: The most consistent group differences were found for RTV, MRT and CE at the baseline researcher-led administration and the first self-administration, with 8 of the 10 comparisons statistically significant and all comparisons indicating medium to large effect sizes.
    Conclusion: Remote administration of cognitive tasks successfully captured the difficulties with response inhibition and regulation of attention, supporting the feasibility and validity of remote assessments.
    MeSH term(s) Humans ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/psychology ; Pilot Projects ; Reaction Time/physiology ; Attention/physiology ; Neuropsychological Tests ; Cognition/physiology
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2004350-8
    ISSN 1557-1246 ; 1087-0547
    ISSN (online) 1557-1246
    ISSN 1087-0547
    DOI 10.1177/10870547231172763
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  5. Article: Emotion dysregulation in attention-deficit/hyperactivity disorder and borderline personality disorder.

    Moukhtarian, Talar R / Mintah, Ruth S / Moran, Paul / Asherson, Philip

    Borderline personality disorder and emotion dysregulation

    2018  Volume 5, Page(s) 9

    Abstract: There is ongoing debate on the overlap between Attention-Deficit/Hyperactivity Disorder (ADHD) and Borderline Personality Disorder (BPD), particularly regarding emotion dysregulation (ED). In this paper, we present a narrative review of the available ... ...

    Abstract There is ongoing debate on the overlap between Attention-Deficit/Hyperactivity Disorder (ADHD) and Borderline Personality Disorder (BPD), particularly regarding emotion dysregulation (ED). In this paper, we present a narrative review of the available evidence on the association of these two disorders from several standpoints. First, we discuss the unique and shared diagnostic criteria for ADHD and BPD, focusing particularly on ED. We consider the methodology of ecological momentary assessment and discuss why this approach could be an alternative and more accurate way to qualitatively distinguish between ADHD and BPD. We summarise key findings on the genetic and environmental risk factors for ADHD and BPD and the extent to which there are shared or unique aetiological and neurobiological risk factors. Finally, we discuss the clinical relevance of considering both disorders in the assessment of patients presenting with trait-like behavioural syndromes, distinguishing the two conditions and implications for treatment.
    Language English
    Publishing date 2018-05-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2766243-3
    ISSN 2051-6673
    ISSN 2051-6673
    DOI 10.1186/s40479-018-0086-8
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  6. Article: Comparable emotional dynamics in women with ADHD and borderline personality disorder.

    Moukhtarian, Talar R / Reinhard, Iris / Moran, Paul / Ryckaert, Celine / Skirrow, Caroline / Ebner-Priemer, Ulrich / Asherson, Philip

    Borderline personality disorder and emotion dysregulation

    2021  Volume 8, Issue 1, Page(s) 6

    Abstract: Background: Emotional dysregulation (ED) is a core diagnostic symptom in borderline personality disorder (BPD) and an associated feature of attention-deficit/hyperactivity disorder (ADHD). We aimed to investigate differences in dynamical indices of ED ... ...

    Abstract Background: Emotional dysregulation (ED) is a core diagnostic symptom in borderline personality disorder (BPD) and an associated feature of attention-deficit/hyperactivity disorder (ADHD). We aimed to investigate differences in dynamical indices of ED in daily life in ADHD and BPD.
    Methods: We used experience sampling method (ESM) and multilevel modelling to assess momentary changes in reports of affective symptoms, and retrospective questionnaire measures of ED in a sample of 98 adult females with ADHD, BPD, comorbid ADHD+BPD and healthy controls.
    Results: We found marked differences between the clinical groups and healthy controls. However, the ESM assessments did not show differences in the intensity of feeling angry and irritable, and the instability of feeling sad, irritable and angry, findings paralleled by data from retrospective questionnaires. The heightened intensity in negative emotions in the clinical groups compared to controls was only partially explained by bad events at the time of reporting negative emotions, suggesting both reactive and endogenous influences on ED in both ADHD and BPD.
    Conclusions: This study supports the view that ED is a valuable trans-diagnostic aspect of psychopathology in both ADHD and BPD, with similar levels of intensity and instability. These findings suggest that the presence or severity of ED should not be used in clinical practice to distinguish between the two disorders.
    Language English
    Publishing date 2021-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2766243-3
    ISSN 2051-6673
    ISSN 2051-6673
    DOI 10.1186/s40479-021-00144-y
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  7. Article ; Online: Using e-diaries to investigate ADHD - State-of-the-art and the promising feature of just-in-time-adaptive interventions.

    Koch, Elena D / Moukhtarian, Talar R / Skirrow, Caroline / Bozhilova, Natali / Asherson, Philip / Ebner-Priemer, Ulrich W

    Neuroscience and biobehavioral reviews

    2021  Volume 127, Page(s) 884–898

    Abstract: Attention-deficit/hyperactive disorder (ADHD) is characterized by symptoms which are dynamic in nature: states of hyperactivity, inattention and impulsivity as core symptoms, and emotion dysregulation as associated feature. Although tremendous work has ... ...

    Abstract Attention-deficit/hyperactive disorder (ADHD) is characterized by symptoms which are dynamic in nature: states of hyperactivity, inattention and impulsivity as core symptoms, and emotion dysregulation as associated feature. Although tremendous work has been done to investigate between-subject differences (how patients with ADHD differ from healthy controls or patients with other disorders), little is known about the relationship between symptoms with triggers and contexts, that may allow us to better understand their causes and consequences. Understanding the temporal associations between symptoms and environmental triggers in an ecologically valid manner may be the basis to developing just-in-time adaptive interventions. Fortunately, recent years have seen advances in methodology, hardware and innovative statistical approaches to study dynamic processes in daily life. In this narrative review, we provide a description of the methodology (ambulatory assessment), summarize the existing literature in ADHD, and discuss future prospects for these methods, namely mobile sensing to assess contextual information, real-time analyses and just-in-time adaptive interventions.
    MeSH term(s) Attention Deficit Disorder with Hyperactivity ; Cognition ; Emotions ; Humans ; Impulsive Behavior
    Language English
    Publishing date 2021-06-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2021.06.002
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  8. Article ; Online: University students with attention deficit hyperactivity disorder (ADHD): a consensus statement from the UK Adult ADHD Network (UKAAN).

    Sedgwick-Müller, Jane A / Müller-Sedgwick, Ulrich / Adamou, Marios / Catani, Marco / Champ, Rebecca / Gudjónsson, Gísli / Hank, Dietmar / Pitts, Mark / Young, Susan / Asherson, Philip

    BMC psychiatry

    2022  Volume 22, Issue 1, Page(s) 292

    Abstract: Background: Attention deficit hyperactivity disorder (ADHD) is associated with poor educational outcomes that can have long-term negative effects on the mental health, wellbeing, and socio-economic outcomes of university students. Mental health ... ...

    Abstract Background: Attention deficit hyperactivity disorder (ADHD) is associated with poor educational outcomes that can have long-term negative effects on the mental health, wellbeing, and socio-economic outcomes of university students. Mental health provision for university students with ADHD is often inadequate due to long waiting times for access to diagnosis and treatment in specialist National Health Service (NHS) clinics. ADHD is a hidden and marginalised disability, and within higher education in the UK, the categorisation of ADHD as a specific learning difference (or difficulty) may be contributing to this.
    Aims: This consensus aims to provide an informed understanding of the impact of ADHD on the educational (or academic) outcomes of university students and highlight an urgent need for timely access to treatment and management.
    Methods: The UK Adult ADHD Network (UKAAN) convened a meeting of practitioners and experts from England, Wales, and Scotland, to discuss issues that university students with ADHD can experience or present with during their programme of studies and how best to address them. A report on the collective analysis, evaluation, and opinions of the expert panel and published literature about the impact of ADHD on the educational outcomes of university students is presented.
    Results: A consensus was reached that offers expert advice, practical guidance, and recommendations to support the medical, education, and disability practitioners working with university students with ADHD.
    Conclusions: Practical advice, guidance, and recommendations based on expert consensus can inform the identification of ADHD in university students, personalised interventions, and educational support, as well as contribute to existing research in this topic area. There is a need to move away from prevailing notions within higher education about ADHD being a specific learning difference (or difficulty) and attend to the urgent need for university students with ADHD to have timely access to treatment and support. A multimodal approach can be adapted to support university students with ADHD. This approach would view timely access to treatment, including reasonable adjustments and educational support, as having a positive impact on the academic performance and achievement of university students with ADHD.
    MeSH term(s) Adult ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/psychology ; Attention Deficit Disorder with Hyperactivity/therapy ; Humans ; State Medicine ; Students/psychology ; United Kingdom ; Universities
    Language English
    Publishing date 2022-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050438-X
    ISSN 1471-244X ; 1471-244X
    ISSN (online) 1471-244X
    ISSN 1471-244X
    DOI 10.1186/s12888-022-03898-z
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  9. Article ; Online: Genetic and environmental links between motor activity level and attention problems in early childhood.

    Saudino, Kimberly J / Wang, Manjie / Flom, Megan / Asherson, Philip

    Developmental science

    2017  Volume 21, Issue 5, Page(s) e12630

    Abstract: ... were moderate (r ...

    Abstract Cross-lagged biometric models were used to examine genetic and environmental links between actigraph-assessed motor activity level (AL) and parent-rated attention problems (AP) in 314 same-sex twin pairs (MZ = 145, DZ = 169) at ages 2 and 3 years. At both ages, genetic correlations between AL and AP were moderate (r
    MeSH term(s) Actigraphy ; Attention/physiology ; Attention Deficit Disorder with Hyperactivity/genetics ; Child ; Child, Preschool ; Female ; Humans ; Longitudinal Studies ; Male ; Motor Activity/genetics ; Motor Activity/physiology ; Parents ; Surveys and Questionnaires ; Twins, Dizygotic/genetics ; Twins, Monozygotic/genetics
    Language English
    Publishing date 2017-11-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2023952-X
    ISSN 1467-7687 ; 1363-755X
    ISSN (online) 1467-7687
    ISSN 1363-755X
    DOI 10.1111/desc.12630
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  10. Article: Antiphospholipid antibodies, malignancies and paraproteinemias.

    Asherson, R A

    Journal of autoimmunity

    2000  Volume 15, Issue 2, Page(s) 117–122

    MeSH term(s) Animals ; Antibodies, Antiphospholipid/analysis ; Humans ; Neoplasms/epidemiology ; Neoplasms/immunology ; Paraproteinemias/immunology
    Chemical Substances Antibodies, Antiphospholipid
    Language English
    Publishing date 2000-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639452-8
    ISSN 0896-8411
    ISSN 0896-8411
    DOI 10.1006/jaut.2000.0404
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