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Article ; Online: A Preliminary Investigation into the Frequency Dose Effects of High-Intensity Functional Training on Cardiometabolic Health.

Smith, Leslie E / Van Guilder, Gary P / Dalleck, Lance C / Lewis, Nicole R / Dages, Allison G / Harris, Nigel K

2023 Volume 22, Issue 4, Page(s) 688–699

Abstract: The objective of this study was to explore the effects of three weekly frequency doses of high-intensity functional training (HIFT) on an array of cardiometabolic markers in adults with metabolic syndrome (MetS). Twenty-one men and women, randomized into ...

Abstract	The objective of this study was to explore the effects of three weekly frequency doses of high-intensity functional training (HIFT) on an array of cardiometabolic markers in adults with metabolic syndrome (MetS). Twenty-one men and women, randomized into one (HIFT1), two (HIFT2), or three (HIFT3) days per week of HIFT, completed 3-weeks of familiarization plus a 12-week progressive training program. Pre- and post-intervention, several cardiometabolic, body composition, oxygen consumption, metabolic syndrome severity, and perceptions of fitness measurements were assessed. Additionally, an exercise enjoyment survey was administered post-intervention. A Cohen's
MeSH term(s)	Adult ; Male ; Humans ; Female ; High-Intensity Interval Training ; Metabolic Syndrome/prevention & control ; Pleasure ; Analysis of Variance ; Cardiovascular Diseases
Language	English
Publishing date	2023-12-01
Publishing country	Turkey
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2075564-8
ISSN	1303-2968 ; 1303-2968
ISSN (online)	1303-2968
ISSN	1303-2968
DOI	10.52082/jssm.2023.688
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Effects of a Single Session of High Intensity Functional Training on Energy Expenditure, VO

Smith, Leslie E / Van Guilder, Gary P / Dalleck, Lance C / Harris, Nigel K

Journal of sports science & medicine

2022 Volume 21, Issue 4, Page(s) 545–554

Abstract: High intensity functional training (HIFT) provides a potential option to meet public exercise recommendations for both cardiorespiratory and strength outcomes in a time efficient manner. To better understand the potential for HIFT as an exercise approach, ...

Abstract	High intensity functional training (HIFT) provides a potential option to meet public exercise recommendations for both cardiorespiratory and strength outcomes in a time efficient manner. To better understand the potential for HIFT as an exercise approach, energy expenditure (EE) and relative intensity need quantifying. In thirteen sedentary men and women with metabolic syndrome (MetS), we used both indirect calorimetry and blood lactate levels to calculate EE of a single session of HIFT. The HIFT session included four, 6-minute sets of consecutive functional exercises. Examples of the exercises involved were squats, deadlifts, suspension rows, suspension chest press, and planks. Intensity is described relative to individual ventilatory thresholds. The total group EE was 270.3 ± 77.3 kcal with approximately 5% attributed anaerobic energy production. VO
Language	English
Publishing date	2022-12-01
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2075564-8
ISSN	1303-2968 ; 1303-2968
ISSN (online)	1303-2968
ISSN	1303-2968
DOI	10.52082/jssm.2022.547
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Article ; Online: Solid Phase Immunoassay for the Detection of Anti-β

Willis, Rohan / Papalardo, Elizabeth / Nigel Harris, E

Methods in molecular biology (Clifton, N.J.)

2017 Volume 1646, Page(s) 201–215

Abstract: The discovery in the 1990s that the protein beta-2-glycoprotein I ( ... ...

Abstract	The discovery in the 1990s that the protein beta-2-glycoprotein I (β
MeSH term(s)	Antiphospholipid Syndrome/blood ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/immunology ; Enzyme-Linked Immunosorbent Assay/methods ; Humans ; Immunoglobulin A/blood ; Immunoglobulin A/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Immunoglobulin M/blood ; Immunoglobulin M/immunology ; beta 2-Glycoprotein I/immunology
Chemical Substances	Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; beta 2-Glycoprotein I
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-7196-1_17
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Article ; Online: Return to work and employment retention after uni-compartmental and total knee replacement: findings from the Clinical Outcomes in Arthroplasty study.

Zaballa, Elena / Ntani, Georgia / Harris, E Clare / Arden, Nigel K / Cooper, Cyrus / Walker-Bone, Karen

The Knee

2022 Volume 40, Page(s) 245–255

Abstract: Background: Little is known about ability to work after unicompartmental knee replacement (UKR) and total knee replacement (TKR), especially in physically-demanding occupations. This study described rates of return-to-work (RTW) and ability to sustain ... ...

Abstract	Background: Little is known about ability to work after unicompartmental knee replacement (UKR) and total knee replacement (TKR), especially in physically-demanding occupations. This study described rates of return-to-work (RTW) and ability to sustain work by job after arthroplasty. Method: Participants from The Clinical Outcomes in Arthroplasty Study (COASt) aged 18-65 were eligible if they underwent UKR or TKR and had at least 5 years' follow-up post-operation. We posted a survey asking about pre-operative occupation, post-operative occupations and associated physical demands, and whether they had quit a job post-surgery due to difficulties with the operated knee (knee-related job loss (KRJL)). We fitted Cox Proportional Hazard Models to investigate the role of demanding physical activities on KRJL. Results: 251 people (143 UKR, 108 TKR) returned a questionnaire, of whom 101 UKR and 57 TKR worked post-operatively. Rates of RTW were highest amongst those in managerial and professional or technical roles, whichever operation they received. RTW was poorest amongst those in elementary occupations. In associate professional/technical occupations, RTW rates were better amongst UKR recipients. Amongst participants who returned to work, 17 reported KRJL (8.5% UKR and 16.7% TKR). Respondents were more likely to have KRJL if their job involved carrying/lifting ≥10 kg (HR:4.81, 95%CI 1.55-14.93) or climbing >30 flights of stairs (HR:4.03, 95%CI 1.36-11.98). Conclusions: Knee arthroplasty recipients working pre-operatively mostly RTW. RTW may be more difficult after TKR than UKR. Jobs which involve lifting and climbing stairs may be particularly challenging. Surgeons offering knee arthroplasty should counsel patients about workability as well as risk of revision.
MeSH term(s)	Humans ; Arthroplasty, Replacement, Knee/adverse effects ; Return to Work ; Knee Joint/surgery ; Employment ; Reoperation ; Osteoarthritis, Knee/surgery ; Osteoarthritis, Knee/etiology
Language	English
Publishing date	2022-12-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1200476-5
ISSN	1873-5800 ; 0968-0160
ISSN (online)	1873-5800
ISSN	0968-0160
DOI	10.1016/j.knee.2022.11.022
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Article ; Online: Solid Phase Immunoassay for the Detection of Anticardiolipin Antibodies.

Willis, Rohan / Papalardo, Elizabeth / Nigel Harris, E

Methods in molecular biology (Clifton, N.J.)

2017 Volume 1646, Page(s) 185–199

Abstract: The anticardiolipin (aCL) test was first developed in the 1980s and proved to be a valuable addition to the lupus anticoagulant assay for identifying patients with a disorder that came to be later known as the antiphospholipid syndrome (APS). Although ... ...

Abstract	The anticardiolipin (aCL) test was first developed in the 1980s and proved to be a valuable addition to the lupus anticoagulant assay for identifying patients with a disorder that came to be later known as the antiphospholipid syndrome (APS). Although the test has relatively poor specificity for APS diagnosis, particularly at low positive levels, it has continued to play a major role in the identification and management of these patients because of its high sensitivity and ability to be measured in both serum and plasma, and despite concomitant presence of anticoagulants normally given to APS patients. In this chapter we outline the procedure for producing essential assay components and for performing the aCL ELISA, which can be used to determine the presence of IgG, IgM and IgA aCL antibodies in human samples. We also provide general guidelines that will facilitate optimal performance of the aCL ELISA assay.
MeSH term(s)	Antibodies, Anticardiolipin/analysis ; Antibodies, Anticardiolipin/blood ; Antiphospholipid Syndrome/blood ; Antiphospholipid Syndrome/diagnosis ; Enzyme-Linked Immunosorbent Assay/methods ; Humans ; Immunoglobulin A/analysis ; Immunoglobulin A/blood ; Immunoglobulin G/analysis ; Immunoglobulin G/blood ; Immunoglobulin M/analysis ; Immunoglobulin M/blood ; Quality Control
Chemical Substances	Antibodies, Anticardiolipin ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-7196-1_16
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Article ; Online: Time Course Changes in Confirmed 'True' VO

Weatherwax, Ryan / Harris, Nigel / Kilding, Andrew E / Dalleck, Lance

Sports medicine international open

2019 Volume 3, Issue 2, Page(s) E32–E39

Abstract: This study sought to examine time course changes in maximal oxygen consumption ( ... ...

Abstract	This study sought to examine time course changes in maximal oxygen consumption (VO
Language	English
Publishing date	2019-06-11
Publishing country	United States
Document type	Journal Article
ISSN	2367-1890
ISSN (online)	2367-1890
DOI	10.1055/a-0867-9415
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Article ; Online: Feasibility and sustainability of working in different types of jobs after total hip arthroplasty: analysis of longitudinal data from two cohorts.

Zaballa, Elena / Ntani, Georgia / Harris, E Clare / Lübbeke, Anne / Arden, Nigel K / Hannouche, Didier / Cooper, Cyrus / Walker-Bone, Karen

Occupational and environmental medicine

2022 Volume 79, Issue 7, Page(s) 486–493

Abstract: Objectives: To investigate the rates of return to work and workability among working-age people following total hip arthroplasty (THA).: Methods: Participants from the Geneva Arthroplasty Registry and the Clinical Outcomes for Arthroplasty Study aged ...

Abstract	Objectives: To investigate the rates of return to work and workability among working-age people following total hip arthroplasty (THA). Methods: Participants from the Geneva Arthroplasty Registry and the Clinical Outcomes for Arthroplasty Study aged 18-64 years when they had primary THA and with at least 5 years' follow-up were mailed a questionnaire 2017-2019. Information was collected about preoperative and post-THA employment along with exposure to physically demanding activities at work or in leisure. Patterns of change of job were explored. Survival analyses using Cox proportional hazard models were created to explore risk factors for having to stop work because of difficulties with the replaced hip. Results: In total, 825 returned a questionnaire (response 58%), 392 (48%) men, mean age 58 years, median follow-up 7.5 years post-THA. The majority (93%) of those who worked preoperatively returned to work, mostly in the same sector but higher rates of non-return (36%-41%) were seen among process, plant and machine operatives and workers in elementary occupations. 7% reported subsequently leaving work because of their replaced hip and the risk of this was strongly associated with: standing >4 hours/day (HR 3.81, 95% CI 1.62 to 8.96); kneeling/squatting (HR 3.32, 95% CI 1.46 to 7.55) and/or carrying/lifting ≥10 kg (HR 5.43, 95% CI 2.29 to 12.88). Conclusions: It may be more difficult to return to some (particularly physically demanding) jobs post-THA than others. Rehabilitation may need to be targeted to these types of workers or it may be that redeployment or job change counselling are required.
MeSH term(s)	Arthroplasty, Replacement, Hip/rehabilitation ; Arthroplasty, Replacement, Knee/rehabilitation ; Employment ; Feasibility Studies ; Female ; Humans ; Male ; Middle Aged ; Occupations
Language	English
Publishing date	2022-01-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1180733-7
ISSN	1470-7926 ; 1351-0711
ISSN (online)	1470-7926
ISSN	1351-0711
DOI	10.1136/oemed-2021-107970
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Article ; Online: The Effects of a Single Session of High Intensity Functional Training on Energy Expenditure, VO2, and Blood Lactate

Leslie E. Smith, Gary P. Van Guilder, Lance C. Dalleck, Nigel K. Harris

Journal of Sports Science and Medicine, Vol 21, Iss 4, Pp 545-

2022 Volume 554

Abstract	High intensity functional training (HIFT) provides a potential option to meet public exercise recommendations for both cardiorespiratory and strength outcomes in a time efficient manner. To better understand the potential for HIFT as an exercise approach, energy expenditure (EE) and relative intensity need quantifying. In thirteen sedentary men and women with metabolic syndrome (MetS), we used both indirect calorimetry and blood lactate levels to calculate EE of a single session of HIFT. The HIFT session included four, 6-minute sets of consecutive functional exercises. Examples of the exercises involved were squats, deadlifts, suspension rows, suspension chest press, and planks. Intensity is described relative to individual ventilatory thresholds. The total group EE was 270.3 ± 77.3 kcal with approximately 5% attributed anaerobic energy production. VO2 ranged between 88.8 ± 12.3% and 99 ± 12% of the second ventilatory threshold (VT2), indicating a vigorous effort. After each work interval, peak blood lactate ranged between 7.9 ± 1.9 and 9.3 ± 2.9 mmol, and rate of perceived exertion between 6.9 ± 1.0 and 8.7 ± 0.8 arbitrary units from 1-10. These were achieved in approximately 46 minutes of exercise per participant. In conclusion, HIFT elicits the energy expenditure and effort requisite to result in the adaptive responses to produce the known suite of benefits of exercise for individuals with MetS.
Keywords	acute exercise ; ventilatory threshold ; metabolic syndrome ; Sports ; GV557-1198.995 ; Sports medicine ; RC1200-1245
Subject code	796
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	University of Uludag
Document type	Article ; Online
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Article ; Online: Predicting Norovirus in England Using Existing and Emerging Syndromic Data: Infodemiology Study.

Ondrikova, Nikola / Harris, John P / Douglas, Amy / Hughes, Helen E / Iturriza-Gomara, Miren / Vivancos, Roberto / Elliot, Alex J / Cunliffe, Nigel A / Clough, Helen E

Journal of medical Internet research

2023 Volume 25, Page(s) e37540

Abstract: Background: Norovirus is associated with approximately 18% of the global burden of gastroenteritis and affects all age groups. There is currently no licensed vaccine or available antiviral treatment. However, well-designed early warning systems and ... ...

Abstract	Background: Norovirus is associated with approximately 18% of the global burden of gastroenteritis and affects all age groups. There is currently no licensed vaccine or available antiviral treatment. However, well-designed early warning systems and forecasting can guide nonpharmaceutical approaches to norovirus infection prevention and control. Objective: This study evaluates the predictive power of existing syndromic surveillance data and emerging data sources, such as internet searches and Wikipedia page views, to predict norovirus activity across a range of age groups across England. Methods: We used existing syndromic surveillance and emerging syndromic data to predict laboratory data indicating norovirus activity. Two methods are used to evaluate the predictive potential of syndromic variables. First, the Granger causality framework was used to assess whether individual variables precede changes in norovirus laboratory reports in a given region or an age group. Then, we used random forest modeling to estimate the importance of each variable in the context of others with two methods: (1) change in the mean square error and (2) node purity. Finally, these results were combined into a visualization indicating the most influential predictors for norovirus laboratory reports in a specific age group and region. Results: Our results suggest that syndromic surveillance data include valuable predictors for norovirus laboratory reports in England. However, Wikipedia page views are less likely to provide prediction improvements on top of Google Trends and Existing Syndromic Data. Predictors displayed varying relevance across age groups and regions. For example, the random forest modeling based on selected existing and emerging syndromic variables explained 60% variance in the ≥65 years age group, 42% in the East of England, but only 13% in the South West region. Emerging data sets highlighted relative search volumes, including "flu symptoms," "norovirus in pregnancy," and norovirus activity in specific years, such as "norovirus 2016." Symptoms of vomiting and gastroenteritis in multiple age groups were identified as important predictors within existing data sources. Conclusions: Existing and emerging data sources can help predict norovirus activity in England in some age groups and geographic regions, particularly, predictors concerning vomiting, gastroenteritis, and norovirus in the vulnerable populations and historical terms such as stomach flu. However, syndromic predictors were less relevant in some age groups and regions likely due to contrasting public health practices between regions and health information-seeking behavior between age groups. Additionally, predictors relevant to one norovirus season may not contribute to other seasons. Data biases, such as low spatial granularity in Google Trends and especially in Wikipedia data, also play a role in the results. Moreover, internet searches can provide insight into mental models, that is, an individual's conceptual understanding of norovirus infection and transmission, which could be used in public health communication strategies.
MeSH term(s)	Humans ; Infodemiology ; Norovirus ; England/epidemiology ; Gastroenteritis/epidemiology ; Caliciviridae Infections/epidemiology
Language	English
Publishing date	2023-05-08
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1438-8871
ISSN (online)	1438-8871
ISSN	1438-8871
DOI	10.2196/37540
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Article ; Online: Raising offspring increases ageing: Differences in senescence among three populations of a long-lived seabird, the Atlantic puffin.

Landsem, Terje L / Yoccoz, Nigel G / Layton-Matthews, Kate / Hilde, Christoffer H / Harris, Michael P / Wanless, Sarah / Daunt, Francis / Reiertsen, Tone K / Erikstad, Kjell E / Anker-Nilssen, Tycho

The Journal of animal ecology

2023 Volume 92, Issue 3, Page(s) 774–785

Abstract: ... Røst (Norwegian Sea) and Hornøya (Barents Sea), showing contrasting productivities (i.e. annual ...

Abstract	Actuarial senescence, the decline of survival with age, is well documented in the wild. Rates of senescence vary widely between taxa, to some extent also between sexes, with the fastest life histories showing the highest rates of senescence. Few studies have investigated differences in senescence among populations of the same species, although such variation is expected from population-level differences in environmental conditions, leading to differences in vital rates and thus life histories. We predict that, within species, populations differing in productivity (suggesting different paces of life) should experience different rates of senescence, but with little or no sexual difference in senescence within populations of monogamous, monomorphic species where the sexes share breeding duties. We compared rates of actuarial senescence among three contrasting populations of the Atlantic puffin Fratercula arctica. The dataset comprised 31 years (1990-2020) of parallel capture-mark-recapture data from three breeding colonies, Isle of May (North Sea), Røst (Norwegian Sea) and Hornøya (Barents Sea), showing contrasting productivities (i.e. annual breeding success) and population trends. We used time elapsed since first capture as a proxy for bird age, and productivity and the winter North Atlantic Oscillation Index (wNAO) as proxies for the environmental conditions experienced by the populations within and outside the breeding season, respectively. In accordance with our predictions, we found that senescence rates differed among the study populations, with no evidence for sexual differences. There was no evidence for an effect of wNAO, but the population with the lowest productivity, Røst, showed the lowest rate of senescence. As a consequence, the negative effect of senescence on the population growth rate (λ) was up to 3-5 times smaller on Røst (Δλ = -0.009) than on the two other colonies. Our findings suggest that environmentally induced differences in senescence rates among populations of a species should be accounted for when predicting effects of climate variation and change on species persistence. There is thus a need for more detailed information on how both actuarial and reproductive senescence influence vital rates of populations of the same species, calling for large-scale comparative studies.
MeSH term(s)	Animals ; Charadriiformes ; Aging ; Birds ; Climate ; Seasons
Language	English
Publishing date	2023-02-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3024-7
ISSN	1365-2656 ; 0021-8790
ISSN (online)	1365-2656
ISSN	0021-8790
DOI	10.1111/1365-2656.13884
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