LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 39

Search options

  1. Article ; Online: Can existing unrelated vaccines boost a COVID-19 vaccine prime?

    Hupert, Nathaniel / Marín-Hernández, Daniela / Nixon, Douglas F

    EClinicalMedicine

    2021  Volume 32, Page(s) 100758

    Language English
    Publishing date 2021-02-11
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2021.100758
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Extreme immunotherapy: emergency immunology to defeat pandemics.

    Nixon, Douglas F / Marín-Hernández, Daniela / Hupert, Nathaniel

    Molecular medicine (Cambridge, Mass.)

    2021  Volume 27, Issue 1, Page(s) 112

    Abstract: The ongoing global COVID-19 pandemic has thrown into sharp relief the gap between modern biology's ability to investigate and respond to a novel pathogen and modern medicine's ability to marshal effective front-line interventions to limit its immediate ... ...

    Abstract The ongoing global COVID-19 pandemic has thrown into sharp relief the gap between modern biology's ability to investigate and respond to a novel pathogen and modern medicine's ability to marshal effective front-line interventions to limit its immediate health impact. While we have witnessed the rapid development of innovative vaccines against SARS-CoV-2 using novel molecular platforms, these have yet to alter the pandemic's long-term trajectory in all but a handful of high-income countries. Health workers at the clinical front lines have little more in their clinical armamentarium than was available a century ago-chiefly oxygen and steroids-and yet advances in modern immunology and immunotherapeutics suggest an underuse of extant and effective, if unorthodox, therapies, which we now call "Extreme Immunotherapies for Pandemics (EIPs)."
    MeSH term(s) COVID-19/immunology ; COVID-19 Vaccines/immunology ; Humans ; Immunotherapy/methods ; Pandemics/prevention & control ; SARS-CoV-2/immunology
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-09-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1283676-x
    ISSN 1528-3658 ; 1076-1551
    ISSN (online) 1528-3658
    ISSN 1076-1551
    DOI 10.1186/s10020-021-00366-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4456: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Heterologous vaccine interventions: boosting immunity against future pandemics.

    Marín-Hernández, Daniela / Nixon, Douglas F / Hupert, Nathaniel

    Molecular medicine (Cambridge, Mass.)

    2021  Volume 27, Issue 1, Page(s) 54

    Abstract: While vaccines traditionally have been designed and used for protection against infection or disease caused by one specific pathogen, there are known off-target effects from vaccines that can impact infection from unrelated pathogens. The best-known non- ... ...

    Abstract While vaccines traditionally have been designed and used for protection against infection or disease caused by one specific pathogen, there are known off-target effects from vaccines that can impact infection from unrelated pathogens. The best-known non-specific effects from an unrelated or heterologous vaccine are from the use of the Bacillus Calmette-Guérin (BCG) vaccine, mediated partly through trained immunity. Other vaccines have similar heterologous effects. This review covers molecular mechanisms behind the heterologous effects, and the potential use of heterologous vaccination in the current COVID-19 pandemic. We then discuss novel pandemic response strategies based on rapidly deployed, widespread heterologous vaccination to boost population-level immunity for initial, partial protection against infection and/or clinical disease, while specific vaccines are developed.
    MeSH term(s) BCG Vaccine/immunology ; BCG Vaccine/therapeutic use ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; Humans ; Immunity, Heterologous/immunology ; Pandemics ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Vaccines/immunology ; Vaccines/therapeutic use
    Chemical Substances BCG Vaccine ; Vaccines
    Language English
    Publishing date 2021-05-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1283676-x
    ISSN 1528-3658 ; 1076-1551
    ISSN (online) 1528-3658
    ISSN 1076-1551
    DOI 10.1186/s10020-021-00317-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4456: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Anticipated reduction in COVID-19 mortality due to population-wide BCG vaccination: evidence from Germany.

    Marín-Hernández, Daniela / Nixon, Douglas F / Hupert, Nathaniel

    Human vaccines & immunotherapeutics

    2021  Volume 17, Issue 8, Page(s) 2451–2453

    Abstract: Bacillus Calmette-Guérin (BCG) vaccine is known to have "bystander benefits" in protecting against heterologous infections; interim analysis of the "ACTIVATE" trial shows protection against respiratory infections in the elderly population. Epidemiologic ... ...

    Abstract Bacillus Calmette-Guérin (BCG) vaccine is known to have "bystander benefits" in protecting against heterologous infections; interim analysis of the "ACTIVATE" trial shows protection against respiratory infections in the elderly population. Epidemiologic studies suggest a potential benefit of BCG vaccination on COVID-19 outcomes. Differential past BCG vaccination policies between the former East and West German states provides a unique natural experiment to assess the potential effect of prior BCG vaccination on COVID-19. We estimated a 5% heterologous vaccine efficacy in the highly vaccinated former East Germany using the COVID-19 International Modeling (CoMo) Consortium model. A comparable BCG vaccination campaign undertaken prior to the pandemic in former West Germany, instituted along with known country-wide transmission reduction measures, is associated with a 37% decrease in projected mortality by mid-summer, 2020. These findings support a combined heterologous vaccine and non-pharmaceutical interventions (HVI+NPI) approach to mitigate the SARS-CoV-2 pandemic until SARS-CoV-2 specific vaccines are widely distributed.
    MeSH term(s) Aged ; BCG Vaccine ; COVID-19 ; Germany/epidemiology ; Humans ; SARS-CoV-2 ; Vaccination
    Chemical Substances BCG Vaccine
    Language English
    Publishing date 2021-02-05
    Publishing country United States
    Document type Letter
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2021.1872344
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6967: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Epidemiological evidence for association between higher influenza vaccine uptake in the elderly and lower COVID-19 deaths in Italy.

    Marín-Hernández, Daniela / Schwartz, Robert E / Nixon, Douglas F

    Journal of medical virology

    2020  Volume 93, Issue 1, Page(s) 64–65

    MeSH term(s) Aged ; COVID-19/epidemiology ; COVID-19/mortality ; Humans ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/immunology ; Influenza, Human/prevention & control ; Italy/epidemiology ; SARS-CoV-2 ; Vaccination/statistics & numerical data
    Chemical Substances Influenza Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-06-09
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26120
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: The Immunologists' Guide to Pandemic Preparedness.

    Marín-Hernández, Daniela / Hupert, Nathaniel / Nixon, Douglas F

    Trends in immunology

    2020  Volume 42, Issue 2, Page(s) 91–93

    Abstract: Immunologists are central to fighting any pandemic. From pathogenesis to disease modeling, pharmaceuticals to vaccines, immunologists play a crucial role in translating basic science into effective response strategies. This article describes our view on ... ...

    Abstract Immunologists are central to fighting any pandemic. From pathogenesis to disease modeling, pharmaceuticals to vaccines, immunologists play a crucial role in translating basic science into effective response strategies. This article describes our view on how lessons from the coronavirus disease 2019 (COVID-19) pandemic can be developed into an immunologists' guide for preparedness for future pandemics.
    MeSH term(s) Allergy and Immunology/trends ; Animals ; Arthritis, Infectious/immunology ; COVID-19/immunology ; COVID-19 Vaccines/immunology ; Humans ; Immunity ; Pandemics ; Practice Guidelines as Topic ; Public Health ; SARS-CoV-2/physiology ; Translational Medical Research ; Vaccination ; Vaccines ; World Health Organization
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2020-12-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2020.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1601: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 2: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Heterologous vaccination interventions to reduce pandemic morbidity and mortality: Modeling the US winter 2020 COVID-19 wave.

    Hupert, Nathaniel / Marín-Hernández, Daniela / Gao, Bo / Águas, Ricardo / Nixon, Douglas F

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 3

    Abstract: COVID-19 remains a stark health threat worldwide, in part because of minimal levels of targeted vaccination outside high-income countries and highly transmissible variants causing infection in vaccinated individuals. Decades of theoretical and ... ...

    Abstract COVID-19 remains a stark health threat worldwide, in part because of minimal levels of targeted vaccination outside high-income countries and highly transmissible variants causing infection in vaccinated individuals. Decades of theoretical and experimental data suggest that nonspecific effects of non-COVID-19 vaccines may help bolster population immunological resilience to new pathogens. These routine vaccinations can stimulate heterologous cross-protective effects, which modulate nontargeted infections. For example, immunization with
    MeSH term(s) Algorithms ; BCG Vaccine/administration & dosage ; BCG Vaccine/immunology ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/virology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Hospital Mortality ; Hospitalization/statistics & numerical data ; Humans ; Intensive Care Units/statistics & numerical data ; Models, Theoretical ; Pandemics/prevention & control ; Patient Admission/statistics & numerical data ; SARS-CoV-2/immunology ; SARS-CoV-2/physiology ; Seasons ; Survival Rate ; United States/epidemiology ; Vaccination/methods ; Vaccination/statistics & numerical data
    Chemical Substances BCG Vaccine ; COVID-19 Vaccines
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2025448119
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Can existing unrelated vaccines boost a COVID-19 vaccine prime?

    Nathaniel Hupert / Daniela Marín-Hernández / Douglas F. Nixon

    EClinicalMedicine, Vol 32, Iss , Pp 100758- (2021)

    2021  

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Addressing the HIV crisis in the Philippines.

    Marston, Jez Lim / Marín-Hernández, Daniela / Nixon, Douglas F

    The Lancet. Public health

    2019  Volume 4, Issue 3, Page(s) e126

    MeSH term(s) HIV Infections ; Humans ; Philippines
    Language English
    Publishing date 2019-03-08
    Publishing country England
    Document type Letter ; Comment
    ISSN 2468-2667
    ISSN (online) 2468-2667
    DOI 10.1016/S2468-2667(19)30024-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Immune Escape of AML Cells after Transplantation.

    Marín-Hernández, Daniela / Iñiguez, Luis P / Nixon, Douglas F

    The New England journal of medicine

    2019  Volume 380, Issue 13, Page(s) 1289

    MeSH term(s) Humans ; Leukemia, Myeloid, Acute ; Transplantation, Homologous
    Language English
    Publishing date 2019-01-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1900424
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top