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  1. Article ; Online: Impact of Vaccination During Pregnancy on Infant Pertussis Disease.

    Edwards, Kathryn M

    Pediatrics

    2023  Volume 152, Issue 5

    MeSH term(s) Pregnancy ; Female ; Infant ; Humans ; Whooping Cough/epidemiology ; Whooping Cough/prevention & control ; Vaccination ; Immunization ; Family
    Language English
    Publishing date 2023-09-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2023-063067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Therapy of SARS-CoV-2 Infection in Children.

    Edwards, Kathryn M

    Journal of clinical medicine

    2023  Volume 13, Issue 1

    Abstract: The impact of SARS-CoV-2 infections in children has fortunately been lower than what has been seen in adults. However, even previously healthy children have developed severe disease, sometimes with subsequent mortality, and those who are infants or ... ...

    Abstract The impact of SARS-CoV-2 infections in children has fortunately been lower than what has been seen in adults. However, even previously healthy children have developed severe disease, sometimes with subsequent mortality, and those who are infants or adolescents, are from racial and ethnic minority groups, or have certain chronic conditions are at higher risk of these outcomes. During the pandemic, extensive studies of therapeutic agents, including antivirals and immunomodulators, were conducted in adults. Few trials included children, and most were in older children and adolescents. Thus, the potential benefits of therapies in children must be extrapolated from adult evidence. Despite these limitations, advisory committees of the National Institute of Health (NIH), the Infectious Disease Society of America (IDSA), and the Pediatric Infectious Diseases Society (PIDS) were constituted, and expert consensus guidelines were developed. This review provides a synthesis of those comprehensive recommendations for therapy in children. These address treatment during the early infectious period with antiviral agents, including remdesivir and nirmatrelvir/ritonavir, as well as treatment in the later period of immune dysregulation with corticosteroids and immunomodulators. In addition, the therapeutic approach for multisystem inflammatory syndrome in children (MIS-C), also referred to as Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 (PIMS-TS), is also provided.
    Language English
    Publishing date 2023-12-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13010120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Postmarketing Vaccine Safety Assessments: Important Work in Progress.

    Edwards, Kathryn M / Griffin, Marie R

    JAMA

    2024  Volume 331, Issue 11, Page(s) 915–917

    MeSH term(s) Vaccines/adverse effects ; Vaccines/therapeutic use ; Product Surveillance, Postmarketing ; Vaccine Development/standards ; Outcome Assessment, Health Care/standards
    Chemical Substances Vaccines
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.26630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Sparing of Severe Covid-19 in Vaccinated Adolescents.

    Edwards, Kathryn M

    The New England journal of medicine

    2022  Volume 386, Issue 8, Page(s) 789–790

    MeSH term(s) Adolescent ; COVID-19 ; Hospitalization ; Humans ; SARS-CoV-2 ; Vaccination
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2118471
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  5. Article ; Online: Ensuring the Safety of Maternal Immunization.

    Edwards, Kathryn M

    Pediatrics

    2021  Volume 147, Issue 5

    MeSH term(s) Humans ; Immunization ; Vaccination
    Language English
    Publishing date 2021-04-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Comment
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2020-047456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: An alternative route to pertussis protection?

    Edwards, Kathryn M / Decker, Michael D

    Lancet (London, England)

    2023  Volume 401, Issue 10379, Page(s) 800–801

    MeSH term(s) Humans ; Whooping Cough/prevention & control ; Administration, Intranasal ; Pertussis Vaccine
    Chemical Substances Pertussis Vaccine
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)00225-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 94: Show issues

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  7. Article ; Online: The Therapy of SARS-CoV-2 Infection in Children

    Kathryn M. Edwards

    Journal of Clinical Medicine, Vol 13, Iss 1, p

    2023  Volume 120

    Abstract: The impact of SARS-CoV-2 infections in children has fortunately been lower than what has been seen in adults. However, even previously healthy children have developed severe disease, sometimes with subsequent mortality, and those who are infants or ... ...

    Abstract The impact of SARS-CoV-2 infections in children has fortunately been lower than what has been seen in adults. However, even previously healthy children have developed severe disease, sometimes with subsequent mortality, and those who are infants or adolescents, are from racial and ethnic minority groups, or have certain chronic conditions are at higher risk of these outcomes. During the pandemic, extensive studies of therapeutic agents, including antivirals and immunomodulators, were conducted in adults. Few trials included children, and most were in older children and adolescents. Thus, the potential benefits of therapies in children must be extrapolated from adult evidence. Despite these limitations, advisory committees of the National Institute of Health (NIH), the Infectious Disease Society of America (IDSA), and the Pediatric Infectious Diseases Society (PIDS) were constituted, and expert consensus guidelines were developed. This review provides a synthesis of those comprehensive recommendations for therapy in children. These address treatment during the early infectious period with antiviral agents, including remdesivir and nirmatrelvir/ritonavir, as well as treatment in the later period of immune dysregulation with corticosteroids and immunomodulators. In addition, the therapeutic approach for multisystem inflammatory syndrome in children (MIS-C), also referred to as Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 (PIMS-TS), is also provided.
    Keywords COVID-19 ; COVID-19 drug treatment ; pediatrics ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The Impact of Social Distancing for Severe Acute Respiratory Syndrome Coronavirus 2 on Respiratory Syncytial Virus and Influenza Burden.

    Edwards, Kathryn M

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 72, Issue 12, Page(s) 2076–2078

    MeSH term(s) Alaska ; COVID-19 ; Child ; Child, Preschool ; Hospitals ; Humans ; Influenza, Human/epidemiology ; Physical Distancing ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2021-04-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1543
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    Zs.MO 480: Show issues

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  9. Article ; Online: Understanding COVID-19 through human challenge models.

    Edwards, Kathryn M / Neuzil, Kathleen M

    Nature medicine

    2022  Volume 28, Issue 5, Page(s) 903–904

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-022-01778-3
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  10. Article ; Online: Developing Mucosal Vaccines for Severe Acute Respiratory Syndrome Coronavirus 2: What Will It Take?

    Edwards, Kathryn M / Neuzil, Kathleen M

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 76, Issue 8, Page(s) 1400–1402

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/prevention & control ; Vaccination ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2022-12-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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