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Article ; Online: The impact of the COVID-19 pandemic on the European Union’s public health policy

Virág Attila / Túri Gergő

Politics in Central Europe, Vol 17, Iss 4, Pp 651-

2021 Volume 674

Abstract: ... as well as the organisations responsible for shaping and implementing the European Union’s ... our findings, we may find answers about the impact of the COVID-19 pandemic on the European Union’s ...

Abstract	In the spring of 2020 the COVID-19 pandemic emerged as one of the most complex and most serious challenges of the European Union, threatening the lives and quality of life of European citizens and the economy and healthcare systems of EU Member States. The fight against the pandemic required the collaboration of many different disciplines and sectors, and over time it had become clear that co-operation between EU Member States and EU organisations is essential for successful crisis management. This cross-border healthcare emergency has seriously tested the mechanisms set by EU treaties and legislations, as well as the organisations responsible for shaping and implementing the European Union’s public health policy. Over the past year we have gained valuable data on how the system of rules and task sharing mechanisms have supported the fight against the pandemic and its effects. By reviewing and examining our findings, we may find answers about the impact of the COVID-19 pandemic on the European Union’s public health policy and how it can be further developed.
Keywords	covid-19 ; public health ; european union ; health policy ; healthcare ; Political science ; J
Subject code	320
Language	Czech
Publishing date	2021-12-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article ; Online: Impact of low-dose chronic exposure to bisphenol A and its analogue bisphenol B, bisphenol F and bisphenol S on hypothalamo-pituitary-testicular activities in adult rats: A focus on the possible hormonal mode of action.

Ullah, Asad / Pirzada, Madeeha / Jahan, Sarwat / Ullah, Hizb / Turi, Naheed / Ullah, Waheed / Siddiqui, Mariyam Fatima / Zakria, Muhammad / Lodhi, Kinza Zafar / Khan, Muhammad Munir

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2018 Volume 121, Page(s) 24–36

Abstract: Bisphenol A an estrogen-mimic endocrine disrupting chemical, used to manufacture polycarbonate plastics and epoxy resins with toxic effects for male reproduction. Due to its toxicity, industries have started to replace it with other bisphenols. In this ... ...

Abstract	Bisphenol A an estrogen-mimic endocrine disrupting chemical, used to manufacture polycarbonate plastics and epoxy resins with toxic effects for male reproduction. Due to its toxicity, industries have started to replace it with other bisphenols. In this study, the toxicity of BPA analogues (BPB, BPF and BPS) was evaluated in a chronic study. We investigated whether the chronic exposure to low bisphenols doses affects spermatogenesis with outcomes on oxidative stress and male reproductive system. Male rats (22 day old) were exposed to water containing 0.1% ethanol for control or different concentrations of BPA and its analogues BPB, BPF and BPS (5, 25 and 50 μg/L) in drinking water for 48 weeks. Results of the present study showed a significant alteration in the gonadosomatic index (GSI) and relative reproductive organs weights. Oxidative stress in the testis was significantly elevated while sperm motility, Daily sperm production (DSP) and number of sperm in epididymis were reduced. Plasma testosterone, LH and FSH concentrations were reduced and estradiol levels were high in 50 μg/L exposed group. These results suggest that exposure to BPA and its analogues for chronic duration can induce structural changes in testicular tissue and endocrine alterations in the male reproductive system.
MeSH term(s)	Animals ; Benzhydryl Compounds/administration & dosage ; Benzhydryl Compounds/toxicity ; Body Weight/drug effects ; Catalase/metabolism ; Dose-Response Relationship, Drug ; Endocrine Disruptors/administration & dosage ; Endocrine Disruptors/toxicity ; Estradiol/blood ; Follicle Stimulating Hormone/blood ; Hypothalamo-Hypophyseal System/drug effects ; Lipid Peroxidation/drug effects ; Luteinizing Hormone/blood ; Male ; Organ Size/drug effects ; Oxidative Stress/drug effects ; Phenols/administration & dosage ; Phenols/toxicity ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Spermatogenesis/drug effects ; Sulfones/administration & dosage ; Sulfones/toxicity ; Superoxide Dismutase/metabolism ; Testis/drug effects ; Testis/enzymology ; Testis/metabolism ; Testosterone/blood
Chemical Substances	Benzhydryl Compounds ; Endocrine Disruptors ; Phenols ; Reactive Oxygen Species ; Sulfones ; bisphenol F ; bisphenol B (1RC731TJJA) ; Testosterone (3XMK78S47O) ; Estradiol (4TI98Z838E) ; bis(4-hydroxyphenyl)sulfone (80-09-1) ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0) ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1) ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2018-08-16
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2018.08.024
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Article ; Online: Dangers of misinterpreting intraoperative hypotension. Response to Br J Anaesth 2024; 132: 802-3.

D'Amico, Filippo / Turi, Stefano / Landoni, Giovanni

British journal of anaesthesia

2024

Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Letter
ZDB-ID	80074-0
ISSN	1471-6771 ; 0007-0912
ISSN (online)	1471-6771
ISSN	0007-0912
DOI	10.1016/j.bja.2024.03.029
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Article: Impact of low-dose chronic exposure to bisphenol A and its analogue bisphenol B, bisphenol F and bisphenol S on hypothalamo-pituitary-testicular activities in adult rats: A focus on the possible hormonal mode of action

Ullah, Asad / Hizb Ullah / Kinza Zafar Lodhi / Madeeha Pirzada / Mariyam Fatima Siddiqui / Muhammad Munir Khan / Muhammad Zakria / Naheed Turi / Sarwat Jahan / Waheed Ullah

Food and chemical toxicology. 2018 Nov., v. 121

2018

Abstract	Bisphenol A an estrogen-mimic endocrine disrupting chemical, used to manufacture polycarbonate plastics and epoxy resins with toxic effects for male reproduction. Due to its toxicity, industries have started to replace it with other bisphenols. In this study, the toxicity of BPA analogues (BPB, BPF and BPS) was evaluated in a chronic study. We investigated whether the chronic exposure to low bisphenols doses affects spermatogenesis with outcomes on oxidative stress and male reproductive system. Male rats (22 day old) were exposed to water containing 0.1% ethanol for control or different concentrations of BPA and its analogues BPB, BPF and BPS (5, 25 and 50 μg/L) in drinking water for 48 weeks. Results of the present study showed a significant alteration in the gonadosomatic index (GSI) and relative reproductive organs weights. Oxidative stress in the testis was significantly elevated while sperm motility, Daily sperm production (DSP) and number of sperm in epididymis were reduced. Plasma testosterone, LH and FSH concentrations were reduced and estradiol levels were high in 50 μg/L exposed group. These results suggest that exposure to BPA and its analogues for chronic duration can induce structural changes in testicular tissue and endocrine alterations in the male reproductive system.
Keywords	adults ; bisphenol A ; bisphenol F ; bisphenol S ; chronic exposure ; drinking water ; endocrine-disrupting chemicals ; epididymis ; epoxides ; estradiol ; ethanol ; follicle-stimulating hormone ; gonadosomatic index ; luteinizing hormone ; males ; manufacturing ; mechanism of action ; oxidative stress ; plastics ; rats ; resins ; sperm motility ; spermatogenesis ; spermatozoa ; testes ; testosterone ; toxicity ; toxicology
Language	English
Dates of publication	2018-11
Size	p. 24-36.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2018.08.024
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Article ; Online: Changes in the Patterns of Population Distribution and Built-Up Areas of the Rural–Urban Fringe in Post-Socialist Context—A Central European Case Study

János Pénzes / László Dávid Hegedűs / Kanat Makhanov / Zoltán Túri

Land, Vol 12, Iss 1682, p

2023 Volume 1682

Abstract: The rapid and significant expansion of urban areas is observed worldwide; however, considerable differences are detected within the characteristics of the process. The rural–urban fringe is changing most dynamically from the aspect of land use and this ... ...

Abstract	The rapid and significant expansion of urban areas is observed worldwide; however, considerable differences are detected within the characteristics of the process. The rural–urban fringe is changing most dynamically from the aspect of land use and this tends to be relevant in the case of post-socialist cities in Central Europe even with a stagnating or decreasing population. Debrecen (Hungary) and its hinterland adequately represent the migration trends of Hungarian cities and the great administrative area provided wide intra-urban suburbanization processes. The current study put the emphasis on the analysis of the spatial pattern of built-up areas and the distribution of residents. In order to discover the processes of the post-socialist transition period, detailed point layers were created to illustrate every built-up parcel in the rural–urban fringe of Debrecen (for the years 1980, 2000, and 2020). The most important characteristics were discovered with the help of GIS methods—Kernel-density, grid pattern analysis of the object density, and analysis of land cover/land use changes using Corine Land Cover Change (CLCC) databases. The dynamic and extended expansion of built-up areas was seen until 2000, in which the outskirts (including hobby gardens) densified spectacularly. The urban sprawl has been less intensive since the millennium and the increase in built-up areas has become more concentrated. As a consequence of the transition period, extended territories—primarily the least dense parts of the rural–urban fringe—are faced with the disappearance of buildings due to agricultural cultivation reasons.
Keywords	grid pattern analysis ; intra-urban suburbanization ; Kernel density estimation ; post-socialist countries ; rural–urban fringe ; urban sprawl ; Agriculture ; S
Subject code	910
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Dry or wet? Fluid therapy in upper gastrointestinal surgery patients.

Turi, S / Marmiere, M / Beretta, L

Updates in surgery

2022 Volume 75, Issue 2, Page(s) 325–328

Abstract: A correct perioperative fluid administration represents one of the most important items proposed by the Enhanced Recovery After Surgery Society. Upper gastrointestinal (UGI) surgery patients undergoing major oncological procedures are often elderly and ... ...

Abstract	A correct perioperative fluid administration represents one of the most important items proposed by the Enhanced Recovery After Surgery Society. Upper gastrointestinal (UGI) surgery patients undergoing major oncological procedures are often elderly and frail. Should we prefer a wet or a dry patient? Both conditions should probably be avoided in this surgical setting. We present a narrative review on perioperative fluid administration in UGI patients undergoing major surgery, also analyzing the role of Goal Directed therapy.
MeSH term(s)	Humans ; Aged ; Digestive System Surgical Procedures ; Fluid Therapy/methods ; Specialties, Surgical ; Length of Stay ; Postoperative Complications/prevention & control
Language	English
Publishing date	2022-08-09
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-022-01352-z
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Article: Spatial assessment of the inland excess water presence on subsurface drained areas in the Körös Interfluve (Hungary)

Túri, Norbert / Körösparti, János / Kajári, Balázs / Kerezsi, György / Zain, Mohammed / Rakonczai, János / Bozán, Csaba

Agrokémia és talajtan. 2022 June 22, v. 71, no. 1

2022

Abstract: ... been used as a best practice in several countries. SD interventions took place between 1960’s and 1990 ...

Abstract	Due to extreme meteorological and soil hydrological situations the agricultural production security is highly unpredictable. To release the extent and duration of inland excess water (IEW) inundations or two-phase soil conditions during the period intended for cultivation, subsurface drainage (SD) has been used as a best practice in several countries. SD interventions took place between 1960’s and 1990 in Hungary. After 1989, land ownership conditions changed, thus professional operation and the necessary maintenance of the SD networks designed as a complex system became insignificant. In this paper, our aim was to present the IEW hazard in one of the most equipped areas by SD in Hungary. The occurrence frequency of IEW inundations in drained and non-drained (control) areas in different time intervals were compared. According to our results, we could state that the frequency of IEW on the subsurface drained areas was moderately lower in only a few periods compared to the control areas. IEW hazard of the arable areas at the Körös Interfluve was classified as nonhazarded in 52.7% of the area. Another 38.2% were moderately hazarded, 8.26% of the lands were meanly hazarded and less than 1% were highly hazarded area by IEW.
Keywords	land ownership ; soil ; subsurface drainage ; Hungary
Language	English
Dates of publication	2022-0622
Size	p. 23-42.
Publishing place	Akadémiai Kiadó
Document type	Article
ISSN	1588-2713
DOI	10.1556/0088.2022.00126
Database	NAL-Catalogue (AGRICOLA)

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Article: The Effects of Intensive Rehabilitation Combined with Thiamine Treatment on Cognitive Recovery in a Case of Non-Alcoholic Wernicke-Korsakoff Syndrome.

Palmirotta, Cinzia / Turi, Gilda / Tagliente, Serena / Pansini, Michele / De Trane, Stefania / Lagravinese, Gianvito

Neurology international

2024 Volume 16, Issue 1, Page(s) 263–273

Abstract: Wernicke-Korsakoff Syndrome (WKS) is a severe neurological disorder resulting from thiamine deficiency, commonly associated with alcohol consumption but also stemming from dietary imbalances or other clinical conditions. Cognitive deficits, affecting ... ...

Abstract	Wernicke-Korsakoff Syndrome (WKS) is a severe neurological disorder resulting from thiamine deficiency, commonly associated with alcohol consumption but also stemming from dietary imbalances or other clinical conditions. Cognitive deficits, affecting memory and executive functions, pose a serious concern, with partial recovery often not complete. A 28-year-old woman underwent surgery for acute necrotizing hemorrhagic pancreatitis, leading to admission for post-acute intensive treatment due to prolonged bed rest syndrome. Clinical examinations revealed sensory-motor neuropathy, denervation in the active phase, mammillary body hyperintensity, and cognitive impairment. The patient exhibited poor orientation, lacked awareness of her clinical condition, and experienced impaired nonverbal memory, practical constructive issues, and planning difficulties-consistent with WKS. The patient received high-dose thiamine (300 mg TDS), coupled with daily physiokinesitherapy and occupational therapy. A final neuropsychological evaluation three months later showed substantial remission of executive and memory difficulties, improved spatial-temporal orientation, and enhanced awareness. The complex case required timely multidisciplinary intervention for accurate diagnosis and effective rehabilitation. The patient experienced rapid clinical improvement and cognitive recovery with high-dose thiamine and physiotherapy.
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2514727-4
ISSN	2035-8377 ; 2035-8385
ISSN (online)	2035-8377
ISSN	2035-8385
DOI	10.3390/neurolint16010018
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Article ; Online: Expression of GCaMP6s in the dentate gyrus induces tonic-clonic seizures.

Teng, Sasa / Wang, Wanqi / Wen, Jia Jun Joel / Wang, Jingxuan / Turi, Gergely F / Peng, Yueqing

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8104

Abstract: GCaMP is a genetically encoded calcium indicator (GECI) widely used in neuroscience research. It measures intracellular ... ...

Abstract	GCaMP is a genetically encoded calcium indicator (GECI) widely used in neuroscience research. It measures intracellular Ca
MeSH term(s)	Humans ; Calcium/metabolism ; Neurons/metabolism ; Seizures/genetics ; Seizures/metabolism ; Calcium Signaling ; Calcium, Dietary/metabolism ; Dentate Gyrus/metabolism
Chemical Substances	Calcium (SY7Q814VUP) ; Calcium, Dietary
Language	English
Publishing date	2024-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58819-9
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Article: Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors.

Ward, Yancey D / Thomson, David S / Frye, Leah L / Cywin, Charles L / Morwick, Tina / Emmanuel, Michel J / Zindell, Renée / McNeil, Daniel / Bekkali, Younes / Girardot, Marc / Hrapchak, Matt / DeTuri, Molly / Crane, Kathy / White, Della / Pav, Susan / Wang, Yong / Hao, Ming-Hong / Grygon, Christine A / Labadia, Mark E /

Freeman, Dorothy M / Davidson, Walter / Hopkins, Jerry L / Brown, Maryanne L / Spero, Denice M / Giradot, Marc

Journal of medicinal chemistry

2002 Volume 45, Issue 25, Page(s) 5471–5482

Abstract: ... of T-cells, should, in theory, modulate the immune response. The cysteine protease Cathepsin S performs ... we report a series of potent and reversible Cathepsin S inhibitors based on dipeptide nitriles ... The first X-ray crystal structure of a reversible inhibitor cocrystallized with Cathepsin S is also reported. ...

Abstract	The specificity of the immune response relies on processing of foreign proteins and presentation of antigenic peptides at the cell surface. Inhibition of antigen presentation, and the subsequent activation of T-cells, should, in theory, modulate the immune response. The cysteine protease Cathepsin S performs a fundamental step in antigen presentation and therefore represents an attractive target for inhibition. Herein, we report a series of potent and reversible Cathepsin S inhibitors based on dipeptide nitriles. These inhibitors show nanomolar inhibition of the target enzyme as well as cellular potency in a human B cell line. The first X-ray crystal structure of a reversible inhibitor cocrystallized with Cathepsin S is also reported.
MeSH term(s)	B-Lymphocytes/drug effects ; Binding, Competitive ; Cathepsins/chemical synthesis ; Cathepsins/chemistry ; Cathepsins/pharmacology ; Cell Line ; Crystallography, X-Ray ; Dipeptides/chemical synthesis ; Dipeptides/chemistry ; Dipeptides/pharmacology ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Humans ; Kinetics ; Models, Molecular ; Nitriles/chemical synthesis ; Nitriles/chemistry ; Nitriles/pharmacology ; Stereoisomerism ; Structure-Activity Relationship
Chemical Substances	Dipeptides ; Enzyme Inhibitors ; Nitriles ; Cathepsins (EC 3.4.-) ; cathepsin S (EC 3.4.22.27)
Language	English
Publishing date	2002-10-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/jm020209i
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