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  1. Article: Fu Fang Zhen Zhu Tiao Zhi Capsules Protect against Myocardial Ischemia by Inhibiting Cardiomyocyte Pyroptosis.

    Shao, Xiaoqi / Huang, Bingying / Tan, Huiling / Wang, Ruonan / Huang, Xueying / Diao, Hongtao / Cheng, Jiawen / Sun, Mengxian / Wang, Dongwei / Wu, Kaili / Yan, Meiling / Rong, Xianglu / Zhang, Yue / Guo, Jiao

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 4752360

    Abstract: Background: Fu Fang Zhen Zhu Tiao Zhi (FTZ) is a traditional Chinese herbal prescription widely ...

    Abstract Background: Fu Fang Zhen Zhu Tiao Zhi (FTZ) is a traditional Chinese herbal prescription widely used to treat dyslipidemia, metabolic diseases, and diabetic coronary disorders. Cardiomyocyte death and loss of regenerative ability cause cardiac dysfunction and heart failure. FTZ can effectively treat diabetic cardiomyopathy and macrovascular diseases; however, the mechanism behind the phenomenon is still unclear. Here, we determined the mechanism of action of FTZ in treating myocardial infarction.
    Methods: Male C57BL/6 mice were treated with 2.4 or 1.2 g/kg FTZ, or administered saline by oral gavage daily for four weeks, and a 24-hour ligation was administered to the artery. Echocardiography was used to evaluate cardiac function. Hematoxylin and eosin and Evans blue/triphenyltetrazolium chloride staining were carried out by staining the cardiac tissue, used to evaluate cardiac function and infarct size. Using western blotting and reverse transcriptase-polymerase chain reaction, we determined the relative levels of NOD-like receptor protein (NLRP) 3, ASC, cleaved caspase-l (C-Caspase-1), GSDMD, and GSDMD-N. TUNEL, immunohistochemical, and immunofluorescence staining were used to determine cell death and NLRP3 expression. An enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of interleukin (IL)-1
    Results: FTZ reduced ischemia-induced cardiomyocyte cell death
    Conclusion: FTZ could preserve cardiac function resulting from ischemic insult by inhibiting pyroptosis, which was partially reversed by NLRP3 overexpression, indicating that NLRP3 could be a potential target of FTZ in treating myocardial infarction.
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/4752360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Fu Fang Zhen Zhu Tiao Zhi Capsules Protect against Myocardial Ischemia by Inhibiting Cardiomyocyte Pyroptosis

    Xiaoqi Shao / Bingying Huang / Huiling Tan / Ruonan Wang / Xueying Huang / Hongtao Diao / Jiawen Cheng / Mengxian Sun / Dongwei Wang / Kaili Wu / Meiling Yan / Xianglu Rong / Yue Zhang / Jiao Guo

    Evidence-Based Complementary and Alternative Medicine, Vol

    2022  Volume 2022

    Abstract: Background. Fu Fang Zhen Zhu Tiao Zhi (FTZ) is a traditional Chinese herbal prescription widely ...

    Abstract Background. Fu Fang Zhen Zhu Tiao Zhi (FTZ) is a traditional Chinese herbal prescription widely used to treat dyslipidemia, metabolic diseases, and diabetic coronary disorders. Cardiomyocyte death and loss of regenerative ability cause cardiac dysfunction and heart failure. FTZ can effectively treat diabetic cardiomyopathy and macrovascular diseases; however, the mechanism behind the phenomenon is still unclear. Here, we determined the mechanism of action of FTZ in treating myocardial infarction. Methods. Male C57BL/6 mice were treated with 2.4 or 1.2 g/kg FTZ, or administered saline by oral gavage daily for four weeks, and a 24-hour ligation was administered to the artery. Echocardiography was used to evaluate cardiac function. Hematoxylin and eosin and Evans blue/triphenyltetrazolium chloride staining were carried out by staining the cardiac tissue, used to evaluate cardiac function and infarct size. Using western blotting and reverse transcriptase-polymerase chain reaction, we determined the relative levels of NOD-like receptor protein (NLRP) 3, ASC, cleaved caspase-l (C-Caspase-1), GSDMD, and GSDMD-N. TUNEL, immunohistochemical, and immunofluorescence staining were used to determine cell death and NLRP3 expression. An enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of interleukin (IL)-1β and IL-18. Results. FTZ reduced ischemia-induced cardiomyocyte cell death in vivo and H2O2-induced cell death in vitro by maintaining cardiac architecture and restoring cardiac function. FTZ decreased the NLRP3 expression and inhibited pyroptosis-correlated genes, including NLRP3, ASC, GSDMD, C-Caspase-1, and GSDMD-N. NLRP3 overexpression impaired the efficacy of FTZ by inducing pyroptosis. Conclusion. FTZ could preserve cardiac function resulting from ischemic insult by inhibiting pyroptosis, which was partially reversed by NLRP3 overexpression, indicating that NLRP3 could be a potential target of FTZ in treating myocardial infarction.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: [Tapping along meridians on back combined with acupuncture of "Qi Shen Zhen" (Seven acupoints for regulating mind) improves symptoms of post-stroke anxiety disorder patients].

    Yao, Li-Jun / Feng, Yu-Xing / Jiang, Guo-Yan / Liu, Zhao-Qing / He, Xue-Wen / Zhou, Jin

    Zhen ci yan jiu = Acupuncture research

    2021  Volume 45, Issue 12, Page(s) 990–994

    Abstract: ... acupuncture at "Qi Shen Zhen"（including Shenting ［GV24］, Benshen ［GB13］, Sishenchong ［EX-HN1］）, and Baihui ... Qi Shen Zhen" needling has a significant therapeutic effect in improving PSAD patients' anxiety state ...

    Abstract Objective: To observe the effect of round magnetic needle tapping along meridians on the back plus acupuncture at "Qi Shen Zhen"（including Shenting ［GV24］, Benshen ［GB13］, Sishenchong ［EX-HN1］）, and Baihui （GV20）, Shenmen （HT7） on gastrointestinal function, daily living activities and anxiety status in post-stroke anxiety disorder (PSAD) patients.
    Methods: Fifty-seven PSAD patients were randomly divided into acupuncture group (28 cases) and medication group (29 cases). On the basis of routine treatment and physical therapy, patients of the acupuncture group were treated by applying round magnetic needle to mildly tapping the second line→the first line of the Bladder Meridian→Jiaji acupoints→Governor Meridian on the back from outside to the inside in sequence for 20 min, followed by needling GV24, GV20, GB13, EX-HN1 and HT7, respectively, with the needles retained for 30 min after one minute's twisting. The treatment was conducted once daily, 5 times a week, for 6 weeks. Patients of the medication group were asked to take Escitalopram Oxalate tablets (5-20 mg/d) for 6 weeks. The Hamilton Anxiety Rating Scale (HAMA) was used to assess the patient's severity of anxiety, cognition, somatic sensation, symptoms of cardiovascular, respiratory, gastrointestinal, urogenital, automatic and muscular systems, the Barthel Index (BI) used to evaluated the activities of daily living (ADL), and the gastrointestinal function （Spleen-stomach Symptom Score ［SSS］） assessed according to the "Standards for Diagnosis and Curative Effect Evaluation of Syndromes of Traditional Chinese Medicine". The adverse reactions were observed at the end of treatment.
    Results: After the treatment, the HAMA scores at the 2nd, 4th and 6th week and the SSS scores at the 4th and 6th week were significantly decreased (
    Conclusion: The round magnetic needle tapping plus "Qi Shen Zhen" needling has a significant therapeutic effect in improving PSAD patients' anxiety state, being similar to Escitalopram Oxalate tablets in reducing anxiety state and being superior to Escitalopram in improving gastrointestinal function and daily living activities.
    MeSH term(s) Activities of Daily Living ; Acupuncture Points ; Acupuncture Therapy ; Anxiety Disorders ; Humans ; Meridians ; Qi ; Stroke/complications ; Stroke/therapy ; Treatment Outcome
    Language Chinese
    Publishing date 2021-01-08
    Publishing country China
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1283179-7
    ISSN 1000-0607
    ISSN 1000-0607
    DOI 10.13702/j.1000-0607.200294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4364: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book: Zhen jiu zu he xue quan zhen tu jie

    Guo, Changqing

    Zhong Ying wen dui zhao ban = Illustration of combination points : Chinese-English

    2013  

    Title variant Illustration of combination points
    Author's details zhu bian Guo Changqing, Liu Naigang, Fu Weitao, Guo Yan
    MeSH term(s) Acupuncture Points ; Acupuncture Therapy/methods
    Language Chinese ; English
    Size 2, 9, 211 pages :, illustrations
    Edition Di 1 ban.
    Document type Book
    Note Chinese and English.
    ISBN 9787506760454 ; 7506760452
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Book: Zhen jiu te xiao xue quan zhen tu jie

    Guo, Changqing

    Zhong Ying wen dui zhao ban = Illustration of specific accupuncture points : Chinese-English

    2013  

    Title variant Illustration of specific accupuncture points
    Author's details zhu bian Guo Changqing, Guo Yan, Liu Naigang
    MeSH term(s) Acupuncture Points ; Acupuncture Therapy/methods
    Language Chinese ; English
    Size 2, 145 pages :, illustrations
    Edition Di 1 ban.
    Document type Book
    Note Chinese and English.
    ISBN 9787506760447 ; 7506760444
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Article ; Online: Tibetan medicine Ru-yi-Zhen-bao Pills exhibits anti-migraine effect through mediating PAG anti-nociceptive channel.

    Luo, Ya Min / Ren, Xiao Qiao / Yang, Xue Qin / Song, Hui Rong / Li, Ran / Gao, Ming Hui / Li, Yi Ran / Zhou, Ran Ran / Ma, Lei / Zhang, Shu Jing / Dong, Ruan Juan / Ge, Dong Yu / Wang, Chun Guo / Ren, Qing Jia / Tao, Xiao Hua

    Journal of ethnopharmacology

    2019  Volume 249, Page(s) 112437

    Abstract: ... As one of the marketed Tibetan drugs, Ru-yi-Zhen-bao Pills (RYZBP) have been clinically used to treat ... medium/low-dose groups (Ru-yi-Zhen-bao Pills; TH 1.00 g/kg, TM 0.50 g/kg and TL 0.25 g/kg). All rats were ...

    Abstract Ethnopharmacological relevance: Migraine is a disabling neurovascular disorder, which increases risk of cardiovascular events and is a social burden worldwide. The present first-line anti-migraine medications can cause overwhelming side-effects, of which one includes the onset of cardiovascular disease. As one of the marketed Tibetan drugs, Ru-yi-Zhen-bao Pills (RYZBP) have been clinically used to treat cardiovascular disorders and as anti-migraine medication. However, there is currently no research exploring the anti-migraine actions of RYZBP.
    Aim of the study: The current research was designed to assess the anti-migraine roles of RYZBP and explore the underlying mechanisms in a nitroglycerin (NTG)-induced migraine rat model trial.
    Materials and methods: 120 rats were randomly divided into the following six groups of 20 rats each: normal control group, model control group, positive control group, and RYZBP high/medium/low-dose groups (Ru-yi-Zhen-bao Pills; TH 1.00 g/kg, TM 0.50 g/kg and TL 0.25 g/kg). All rats were administered intragastrically for 7 consecutive days, which were subcutaneously injected with the NTG (10 mg/kg) after the last gavage (except in the normal control group). 3min after NTG treatment, 30 rats (5 rats from each group) were anesthetized and devoted to electroencephalogram(EEG) testing, which was used to evaluate the analgesic effect of RYZBP. One hour after NTG treatment, the rest of the 90 rats (15 rats from each group) were anesthetized and midbrain tissue sample was dissected. The dissection was then washed with physiological saline and collected. The histopathological changes in the periaqueductal gray(PAG) of 5 tissue samples were determined by aematoxylin-eosin (H&E) staining, as well as an estimation of substance P (SP) and neurokinin 1 receptor (NK1R) expression through immunohistochemically staining(IHC). Another 5 midbrain preparations were carried out to evaluate calcitonin gene-related peptide (CGRP), proenkephalin (PENK), SP, and cholecystokinin (CCK) expressions by real-time quantitative polymerase chain reaction (RT-qPCR). The rest of the 5 brainstem tissues were then used to measure CCK, CGRP, and opioid peptide receptor (DORR) levels by western blotting(WB).
    Results: In the EEG test, RYZBP (TM 0.50 g / kg) treatment transformed the EEG pain-wave of the NTG-induced migraine model rats in different time period. In the mechanism assay, compared with the model control group, RYZBP pretreatment reduced inflammatory cell infiltration, fibrosis and vacuolation of neuronal cells of PAG tissue seen by HE staining. IHC experiments further showed that RYZBPTM up-regulated SP expression levels and enhanced NK1R levels in the NTG-induced migraine rats (P < 0.05). Therapeutic administration of RYZBP also increased PENK mRNA expression and DORR protein level. Both RT-qPCR and western blotting trials indicated that RYZBP treatment significantly decreased CCK and CGRP expression levels (P < 0.01 or P < 0.05) in the NTG-induced migraine rats.
    Conclusions: RYZBP has the potential to be an effective anti-migraine treatment through suppressing the EEG pain-wave, increasing the levels of SP, PENK, DORR and reducing expression of CCK and CGRP. Mediating the PAG anti-nociceptive channel and inhibiting central sensitization were the two potential mechanisms, which offers further evidence for clinical therapy.
    MeSH term(s) Animals ; Calcitonin Gene-Related Peptide/metabolism ; Cholecystokinin/metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Electroencephalography ; Enkephalins/metabolism ; Humans ; Male ; Medicine, Tibetan Traditional/methods ; Migraine Disorders/chemically induced ; Migraine Disorders/diagnosis ; Migraine Disorders/drug therapy ; Migraine Disorders/pathology ; Nitroglycerin/toxicity ; Nociception/drug effects ; Periaqueductal Gray/drug effects ; Periaqueductal Gray/pathology ; Protein Precursors/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid/metabolism
    Chemical Substances Drugs, Chinese Herbal ; Enkephalins ; Protein Precursors ; Receptors, Opioid ; proenkephalin ; Cholecystokinin (9011-97-6) ; Nitroglycerin (G59M7S0WS3) ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
    Language English
    Publishing date 2019-11-30
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2019.112437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: Zhen jiu tui na lin chuang yu jie pou

    Yan, Zhen'guo

    2012  

    Author's details zhu bian Yan Zhenguo
    MeSH term(s) Acupuncture Therapy/methods ; Massage/methods ; Diagnosis, Differential
    Language Chinese
    Size 4, 457 pages :, illustratons, portrait
    Edition Di 1 ban.
    Document type Book
    ISBN 9787810609586 ; 7810609580
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Book: Zhen jiu xue wei tu jie

    Guo, Changqing

    2013  

    Title variant Anatomical illustration of acupuncture points
    Author's details zhu bian Guo Changqing, Liu Naigang, Hu Bo
    MeSH term(s) Acupuncture Points
    Language Chinese
    Size 22, 407 pages :, illustrations, portraits.
    Edition Di 2 ban.
    Document type Book
    ISBN 9787117172615 ; 7117172614
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Book: Jing luo xue wei quan zhen cai se tu ce

    Guo, Changqing

    2015  

    Author's details Guo Changqing, Liu Naigang, Du Ningyu zhu bian
    MeSH term(s) Meridians ; Acupuncture Points
    Language Chinese
    Size 89 p. :, ill.
    Edition Di 1 ban.
    Publisher Zhongguo Zhong yi yao chu ban she
    Publishing place Beijing
    Document type Book
    ISBN 9787513226448 ; 751322644X
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article: Tibetan medicine Ru-yi-Zhen-bao Pills exhibits anti-migraine effect through mediating PAG anti-nociceptive channel

    Luo, Ya min / Dong, Ruan juan / Gao, Ming hui / Ge, Dong yu / Li, Ran / Li, Yi ran / Ma, Lei / Ren, Qing jia / Ren, Xiao qiao / Song, Hui rong / Tao, Xiao hua / Wang, Chun guo / Yang, Xue qin / Zhang, Shu jing / Zhou, Ran ran

    Journal of ethnopharmacology. 2020 Mar. 01, v. 249

    2020  

    Abstract: ... Ru-yi-Zhen-bao Pills (RYZBP) have been clinically used to treat cardiovascular disorders and as anti ... RYZBP high/medium/low-dose groups (Ru-yi-Zhen-bao Pills; TH 1.00 g/kg, TM 0.50 g/kg and TL 0.25 g/kg ...

    Abstract Migraine is a disabling neurovascular disorder, which increases risk of cardiovascular events and is a social burden worldwide. The present first-line anti-migraine medications can cause overwhelming side-effects, of which one includes the onset of cardiovascular disease. As one of the marketed Tibetan drugs, Ru-yi-Zhen-bao Pills (RYZBP) have been clinically used to treat cardiovascular disorders and as anti-migraine medication. However, there is currently no research exploring the anti-migraine actions of RYZBP.The current research was designed to assess the anti-migraine roles of RYZBP and explore the underlying mechanisms in a nitroglycerin (NTG)-induced migraine rat model trial.120 rats were randomly divided into the following six groups of 20 rats each: normal control group, model control group, positive control group, and RYZBP high/medium/low-dose groups (Ru-yi-Zhen-bao Pills; TH 1.00 g/kg, TM 0.50 g/kg and TL 0.25 g/kg). All rats were administered intragastrically for 7 consecutive days, which were subcutaneously injected with the NTG (10 mg/kg) after the last gavage (except in the normal control group). 3min after NTG treatment, 30 rats (5 rats from each group) were anesthetized and devoted to electroencephalogram(EEG) testing, which was used to evaluate the analgesic effect of RYZBP. One hour after NTG treatment, the rest of the 90 rats (15 rats from each group) were anesthetized and midbrain tissue sample was dissected. The dissection was then washed with physiological saline and collected. The histopathological changes in the periaqueductal gray(PAG) of 5 tissue samples were determined by aematoxylin-eosin (H&E) staining, as well as an estimation of substance P (SP) and neurokinin 1 receptor (NK1R) expression through immunohistochemically staining(IHC). Another 5 midbrain preparations were carried out to evaluate calcitonin gene-related peptide (CGRP), proenkephalin (PENK), SP, and cholecystokinin (CCK) expressions by real-time quantitative polymerase chain reaction (RT-qPCR). The rest of the 5 brainstem tissues were then used to measure CCK, CGRP, and opioid peptide receptor (DORR) levels by western blotting(WB).In the EEG test, RYZBP (TM 0.50 g / kg) treatment transformed the EEG pain-wave of the NTG-induced migraine model rats in different time period. In the mechanism assay, compared with the model control group, RYZBP pretreatment reduced inflammatory cell infiltration, fibrosis and vacuolation of neuronal cells of PAG tissue seen by HE staining. IHC experiments further showed that RYZBPTM up-regulated SP expression levels and enhanced NK1R levels in the NTG-induced migraine rats (P < 0.05). Therapeutic administration of RYZBP also increased PENK mRNA expression and DORR protein level. Both RT-qPCR and western blotting trials indicated that RYZBP treatment significantly decreased CCK and CGRP expression levels (P < 0.01 or P < 0.05) in the NTG-induced migraine rats.RYZBP has the potential to be an effective anti-migraine treatment through suppressing the EEG pain-wave, increasing the levels of SP, PENK, DORR and reducing expression of CCK and CGRP. Mediating the PAG anti-nociceptive channel and inhibiting central sensitization were the two potential mechanisms, which offers further evidence for clinical therapy.
    Keywords adverse effects ; analgesic effect ; animal models ; brain stem ; calcitonin gene-related peptide ; cholecystokinin ; electroencephalography ; fibrosis ; gene expression ; histopathology ; immunohistochemistry ; messenger RNA ; migraine ; neurons ; nitroglycerin ; Oriental traditional medicine ; peptide receptors ; protein content ; quantitative polymerase chain reaction ; rats ; reverse transcriptase polymerase chain reaction ; risk ; staining ; substance P ; Western blotting
    Language English
    Dates of publication 2020-0301
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2019.112437
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 90/710: Show issues

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