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  1. Article ; Online: Multidisciplinary, multisite trauma team training during COVID-19: lessons from the first virtual E-S.T.A.R.T.T. course.

    Johnson, Garrett G R J / Beaumont, Jacqueline / Paton-Gay, John Damian / Widder, Sandy / Gillman, Lawrence M

    Canadian journal of surgery. Journal canadien de chirurgie

    2021  Volume 64, Issue 6, Page(s) E609–E612

    Abstract: ... simulation training in a virtual setting. The Simulated Trauma and Resuscitation Team Training (S.T.A.R.T.T ... satisfaction suggests that the new virtual E-S.T.A.R.T.T course is able to continue to help providers develop ...

    Abstract Trauma care delivery is a complex team-based task that requires deliberate practice. The COVID-19 pandemic has not diminished the importance of excellent trauma team dynamics. However, the pandemic hampers our ability to gather safely and train together. A mitigating solution is the provision of high-fidelity simulation training in a virtual setting. The Simulated Trauma and Resuscitation Team Training (S.T.A.R.T.T.) course has provided multidisciplinary trauma team members with skills in crisis resource management (CRM) for nearly 10 years. It has promoted collaborative learning from coast to coast, as the course typically runs at our national surgical and trauma meetings. In response to COVID-19 challenges, the course content has been modified to virtually connect 2 centres in different provinces simultaneously. High participant satisfaction suggests that the new virtual E-S.T.A.R.T.T course is able to continue to help providers develop important CRM skills in a multidisciplinary setting while remaining compliant with COVID-19 safety precautions.
    MeSH term(s) COVID-19 ; Canada ; Clinical Competence ; Crew Resource Management, Healthcare ; Curriculum ; Education, Distance ; High Fidelity Simulation Training/methods ; High Fidelity Simulation Training/standards ; Humans ; Pandemics ; Patient Care Team ; SARS-CoV-2 ; Traumatology/education ; Traumatology/standards ; Wounds and Injuries/therapy
    Language English
    Publishing date 2021-11-10
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 410651-9
    ISSN 1488-2310 ; 0008-428X
    ISSN (online) 1488-2310
    ISSN 0008-428X
    DOI 10.1503/cjs.009921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Fidelity in surgical simulation: further lessons from the S.T.A.R.T.T. course

    Johnson, Garrett G.R.J. / Brindley, Peter G. / Gillman, Lawrence M.

    Canadian journal of surgery. Journal canadien de chirurgie

    2020  Volume 63, Issue 2, Page(s) E161–E163

    Abstract: ... Training (S.T.A.R.T.T.) course suggests that higherfidelity simulation is viewed as highly valuable ...

    Abstract Summary: Simulation has become a popular and ubiquitous medical education tool. In response to learner demands, and because of technological advancement, there is a trend toward increasing the realism of simulation. However, there is a paucity of evidence regarding what degree of fidelity is needed to deliver optimal simulation-based medical education. Feedback from the Simulated Trauma And Resuscitation Team Training (S.T.A.R.T.T.) course suggests that higherfidelity simulation is viewed as highly valuable to learners. Research is needed in order to guide the growing demand for higher-fidelity simulation in our medical training curricula and in order to justify or mitigate the associated costs and logistical challenges.
    MeSH term(s) Attitude of Health Personnel ; Crew Resource Management, Healthcare ; Feedback ; Humans ; Patient Simulation ; Simulation Training ; Surveys and Questionnaires
    Language English
    Publishing date 2020-03-27
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 410651-9
    ISSN 1488-2310 ; 0008-428X
    ISSN (online) 1488-2310
    ISSN 0008-428X
    DOI 10.1503/cjs.017818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 221: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Search for heavy neutrinos and W(R) bosons with right-handed couplings in a left-right symmetric model in pp collisions at sqrt[s]=7  TeV.

    Chatrchyan, S / Khachatryan, V / Sirunyan, A M / Tumasyan, A / Adam, W / Aguilo, E / Bergauer, T / Dragicevic, M / Erö, J / Fabjan, C / Friedl, M / Frühwirth, R / Ghete, V M / Hammer, J / Hörmann, N / Hrubec, J / Jeitler, M / Kiesenhofer, W / Knünz, V /
    Krammer, M / Krätschmer, I / Liko, D / Mikulec, I / Pernicka, M / Rahbaran, B / Rohringer, C / Rohringer, H / Schöfbeck, R / Strauss, J / Taurok, A / Waltenberger, W / Wulz, C-E / Mossolov, V / Shumeiko, N / Suarez Gonzalez, J / Bansal, M / Bansal, S / Cornelis, T / De Wolf, E A / Janssen, X / Luyckx, S / Mucibello, L / Ochesanu, S / Roland, B / Rougny, R / Selvaggi, M / Van Haevermaet, H / Van Mechelen, P / Van Remortel, N / Van Spilbeeck, A / Blekman, F / Blyweert, S / D'Hondt, J / Gonzalez Suarez, R / Kalogeropoulos, A / Maes, M / Olbrechts, A / Van Doninck, W / Van Mulders, P / Van Onsem, G P / Villella, I / Clerbaux, B / De Lentdecker, G / Dero, V / Gay, A P R / Hreus, T / Léonard, A / Marage, P E / Mohammadi, A / Reis, T / Thomas, L / Vander Velde, C / Vanlaer, P / Wang, J / Adler, V / Beernaert, K / Cimmino, A / Costantini, S / Garcia, G / Grunewald, M / Klein, B / Lellouch, J / Marinov, A / Mccartin, J / Ocampo Rios, A A / Ryckbosch, D / Strobbe, N / Thyssen, F / Tytgat, M / Walsh, S / Yazgan, E / Zaganidis, N / Basegmez, S / Bruno, G / Castello, R / Ceard, L / Delaere, C / du Pree, T / Favart, D / Forthomme, L / Giammanco, A / Hollar, J / Lemaitre, V / Liao, J / Militaru, O / Nuttens, C / Pagano, D / Pin, A / Piotrzkowski, K / Vizan Garcia, J M / Beliy, N / Caebergs, T / Daubie, E / Hammad, G H / Alves, G A / Correa Martins Junior, M / Martins, T / Pol, M E / Souza, M H G / Aldá Júnior, W L / Carvalho, W / Custódio, A / Da Costa, E M / De Jesus Damiao, D / De Oliveira Martins, C / Fonseca De Souza, S / Malbouisson, H / Malek, M / Matos Figueiredo, D / Mundim, L / Nogima, H / Prado Da Silva, W L / Santoro, A / Soares Jorge, L / Sznajder, A / Vilela Pereira, A / Anjos, T S / Bernardes, C A / Dias, F A / Fernandez Perez Tomei, T R / Gregores, E M / Lagana, C / Marinho, F / Mercadante, P G / Novaes, S F / Padula, Sandra S / Genchev, V / Iaydjiev, P / Piperov, S / Rodozov, M / Stoykova, S / Sultanov, G / Tcholakov, V / Trayanov, R / Vutova, M / Dimitrov, A / Hadjiiska, R / Kozhuharov, V / Litov, L / Pavlov, B / Petkov, P / Bian, J G / Chen, G M / Chen, H S / Jiang, C H / Liang, D / Liang, S / Meng, X / Tao, J / Wang, X / Wang, Z / Xiao, H / Xu, M / Zang, J / Zhang, Z / Asawatangtrakuldee, C / Ban, Y / Guo, Y / Li, W / Liu, S / Mao, Y / Qian, S J / Teng, H / Wang, D / Zhang, L / Zou, W / Avila, C / Gomez, J P / Gomez Moreno, B / Osorio Oliveros, A F / Sanabria, J C / Godinovic, N / Lelas, D / Plestina, R / Polic, D / Puljak, I / Antunovic, Z / Kovac, M / Brigljevic, V / Duric, S / Kadija, K / Luetic, J / Mekterovic, D / Morovic, S / Attikis, A / Galanti, M / Mavromanolakis, G / Mousa, J / Nicolaou, C / Ptochos, F / Razis, P A / Finger, M / Assran, Y / Elgammal, S / Ellithi Kamel, A / Khalil, S / Mahmoud, M A / Radi, A / Kadastik, M / Müntel, M / Raidal, M / Rebane, L / Tiko, A / Eerola, P / Fedi, G / Voutilainen, M / Härkönen, J / Heikkinen, A / Karimäki, V / Kinnunen, R / Kortelainen, M J / Lampén, T / Lassila-Perini, K / Lehti, S / Lindén, T / Luukka, P / Mäenpää, T / Peltola, T / Tuominen, E / Tuominiemi, J / Tuovinen, E / Ungaro, D / Wendland, L / Banzuzi, K / Karjalainen, A / Korpela, A / Tuuva, T / Besancon, M / Choudhury, S / Dejardin, M / Denegri, D / Fabbro, B / Faure, J L / Ferri, F / Ganjour, S / Givernaud, A / Gras, P / Hamel de Monchenault, G / Jarry, P / Locci, E / Malcles, J / Millischer, L / Nayak, A / Rander, J / Rosowsky, A / Titov, M / Baffioni, S / Beaudette, F / Benhabib, L / Bianchini, L / Bluj, M / Broutin, C / Busson, P / Charlot, C / Daci, N / Dahms, T / Dalchenko, M / Dobrzynski, L / Florent, A / Granier de Cassagnac, R / Haguenauer, M / Miné, P / Mironov, C / Naranjo, I N / Nguyen, M / Ochando, C / Paganini, P / Sabes, D / Salerno, R / Sirois, Y / Veelken, C / Zabi, A / Agram, J-L / Andrea, J / Bloch, D / Bodin, D / Brom, J-M / Cardaci, M / Chabert, E C / Collard, C / Conte, E / Drouhin, F / Fontaine, J-C / Gelé, D / Goerlach, U / Juillot, P / Le Bihan, A-C / Van Hove, P / Fassi, F / Mercier, D / Beauceron, S / Beaupere, N / Bondu, O / Boudoul, G / Chasserat, J / Chierici, R / Contardo, D / Depasse, P / El Mamouni, H / Fay, J / Gascon, S / Gouzevitch, M / Ille, B / Kurca, T / Lethuillier, M / Mirabito, L / Perries, S / Sgandurra, L / Sordini, V / Tschudi, Y / Verdier, P / Viret, S / Tsamalaidze, Z / Autermann, C / Beranek, S / Calpas, B / Edelhoff, M / Feld, L / Heracleous, N / Hindrichs, O / Jussen, R / Klein, K / Merz, J / Ostapchuk, A / Perieanu, A / Raupach, F / Sammet, J / Schael, S / Sprenger, D / Weber, H / Wittmer, B / Zhukov, V / Ata, M / Caudron, J / Dietz-Laursonn, E / Duchardt, D / Erdmann, M / Fischer, R / Güth, A / Hebbeker, T / Heidemann, C / Hoepfner, K / Klingebiel, D / Kreuzer, P / Merschmeyer, M / Meyer, A / Olschewski, M / Papacz, P / Pieta, H / Reithler, H / Schmitz, S A / Sonnenschein, L / Steggemann, J / Teyssier, D / Thüer, S / Weber, M / Bontenackels, M / Cherepanov, V / Erdogan, Y / Flügge, G / Geenen, H / Geisler, M / Haj Ahmad, W / Hoehle, F / Kargoll, B / Kress, T / Kuessel, Y / Lingemann, J / Nowack, A / Perchalla, L / Pooth, O / Sauerland, P / Stahl, A / Aldaya Martin, M / Behr, J / Behrenhoff, W / Behrens, U / Bergholz, M / Bethani, A / Borras, K / Burgmeier, A / Cakir, A / Calligaris, L / Campbell, A / Castro, E / Costanza, F / Dammann, D / Diez Pardos, C / Eckerlin, G / Eckstein, D / Flucke, G / Geiser, A / Glushkov, I / Gunnellini, P / Habib, S / Hauk, J / Hellwig, G / Jung, H / Kasemann, M / Katsas, P / Kleinwort, C / Kluge, H / Knutsson, A / Krämer, M / Krücker, D / Kuznetsova, E / Lange, W / Leonard, J / Lohmann, W / Lutz, B / Mankel, R / Marfin, I / Marienfeld, M / Melzer-Pellmann, I-A / Meyer, A B / Mnich, J / Mussgiller, A / Naumann-Emme, S / Novgorodova, O / Olzem, J / Perrey, H / Petrukhin, A / Pitzl, D / Raspereza, A / Ribeiro Cipriano, P M / Riedl, C / Ron, E / Rosin, M / Salfeld-Nebgen, J / Schmidt, R / Schoerner-Sadenius, T / Sen, N / Spiridonov, A / Stein, M / Walsh, R / Wissing, C / Blobel, V / Enderle, H / Erfle, J / Gebbert, U / Görner, M / Gosselink, M / Haller, J / Hermanns, T / Höing, R S / Kaschube, K / Kaussen, G / Kirschenmann, H / Klanner, R / Lange, J / Nowak, F / Peiffer, T / Pietsch, N / Rathjens, D / Sander, C / Schettler, H / Schleper, P / Schlieckau, E / Schmidt, A / Schröder, M / Schum, T / Seidel, M / Sibille, J / Sola, V / Stadie, H / Steinbrück, G / Thomsen, J / Vanelderen, L / Barth, C / Berger, J / Böser, C / Chwalek, T / De Boer, W / Descroix, A / Dierlamm, A / Feindt, M / Guthoff, M / Hackstein, C / Hartmann, F / Hauth, T / Heinrich, M / Held, H / Hoffmann, K H / Husemann, U / Katkov, I / Komaragiri, J R / Lobelle Pardo, P / Martschei, D / Mueller, S / Müller, Th / Niegel, M / Nürnberg, A / Oberst, O / Oehler, A / Ott, J / Quast, G / Rabbertz, K / Ratnikov, F / Ratnikova, N / Röcker, S / Schilling, F-P / Schott, G / Simonis, H J / Stober, F M / Troendle, D / Ulrich, R / Wagner-Kuhr, J / Wayand, S / Weiler, T / Zeise, M / Anagnostou, G / Daskalakis, G / Geralis, T / Kesisoglou, S / Kyriakis, A / Loukas, D / Manolakos, I / Markou, A / Markou, C / Mavrommatis, C / Ntomari, E / Gouskos, L / Mertzimekis, T J / Panagiotou, A / Saoulidou, N / Evangelou, I / Foudas, C / Kokkas, P / Manthos, N / Papadopoulos, I / Patras, V / Bencze, G / Hajdu, C / Hidas, P / Horvath, D / Sikler, F / Veszpremi, V / Vesztergombi, G / Beni, N / Czellar, S / Molnar, J / Palinkas, J / Szillasi, Z / Karancsi, J / Raics, P / Trocsanyi, Z L / Ujvari, B / Beri, S B / Bhatnagar, V / Dhingra, N / Gupta, R / Kaur, M / Mehta, M Z / Nishu, N / Saini, L K / Sharma, A / Singh, J B / Kumar, Ashok / Kumar, Arun / Ahuja, S / Bhardwaj, A / Choudhary, B C / Malhotra, S / Naimuddin, M / Ranjan, K / Sharma, V / Shivpuri, R K / Banerjee, S / Bhattacharya, S / Dutta, S / Gomber, B / Jain, Sa / Jain, Sh / Khurana, R / Sarkar, S / Sharan, M / Abdulsalam, A / Dutta, D / Kailas, S / Kumar, V / Mohanty, A K / Pant, L M / Shukla, P / Aziz, T / Ganguly, S / Guchait, M / Gurtu, A / Maity, M / Majumder, G / Mazumdar, K / Mohanty, G B / Parida, B / Sudhakar, K / Wickramage, N / Dugad, S / Arfaei, H / Bakhshiansohi, H / Etesami, S M / Fahim, A / Hashemi, M / Hesari, H / Jafari, A / Khakzad, M / Mohammadi Najafabadi, M / Paktinat Mehdiabadi, S / Safarzadeh, B / Zeinali, M / Abbrescia, M / Barbone, L / Calabria, C / Chhibra, S S / Colaleo, A / Creanza, D / De Filippis, N / De Palma, M / Fiore, L / Iaselli, G / Maggi, G / Maggi, M / Marangelli, B / My, S / Nuzzo, S / Pacifico, N / Pompili, A / Pugliese, G / Selvaggi, G / Silvestris, L / Singh, G / Venditti, R / Verwilligen, P / Zito, G / Abbiendi, G / Benvenuti, A C / Bonacorsi, D / Braibant-Giacomelli, S / Brigliadori, L / Capiluppi, P / Castro, A / Cavallo, F R / Cuffiani, M / Dallavalle, G M / Fabbri, F / Fanfani, A / Fasanella, D / Giacomelli, P / Grandi, C / Guiducci, L / Marcellini, S / Masetti, G / Meneghelli, M / Montanari, A / Navarria, F L / Odorici, F / Perrotta, A / Primavera, F / Rossi, A M / Rovelli, T / Siroli, G P / Tosi, N / Travaglini, R / Albergo, S / Cappello, G / Chiorboli, M / Costa, S / Potenza, R / Tricomi, A / Tuve, C / Barbagli, G / Ciulli, V / Civinini, C / D'Alessandro, R / Focardi, E / Frosali, S / Gallo, E / Gonzi, S / Meschini, M / Paoletti, S / Sguazzoni, G / Tropiano, A / Benussi, L / Bianco, S / Colafranceschi, S / Piccolo, D / Fabbricatore, P / Musenich, R / Tosi, S / Benaglia, A / De Guio, F / Di Matteo, L / Fiorendi, S / Gennai, S / Ghezzi, A / Malvezzi, S / Manzoni, R A / Martelli, A / Massironi, A / Menasce, D / Moroni, L / Paganoni, M / Pedrini, D / Ragazzi, S / Redaelli, N / Sala, S / Tabarelli de Fatis, T / Buontempo, S / Carrillo Montoya, C A / Cavallo, N / De Cosa, A / Dogangun, O / Fabozzi, F / Iorio, A O M / Lista, L / Meola, S / Merola, M / Paolucci, P / Azzi, P / Bacchetta, N / Bellan, P / Bisello, D / Branca, A / Carlin, R / Checchia, P / Dorigo, T / Dosselli, U / Gasparini, F / Gasparini, U / Gozzelino, A / Kanishchev, K / Lacaprara, S / Lazzizzera, I / Margoni, M / Meneguzzo, A T / Nespolo, M / Pazzini, J / Ronchese, P / Simonetto, F / Torassa, E / Vanini, S / Zotto, P / Zumerle, G / Gabusi, M / Ratti, S P / Riccardi, C / Torre, P / Vitulo, P / Biasini, M / Bilei, G M / Fanò, L / Lariccia, P / Mantovani, G / Menichelli, M / Nappi, A / Romeo, F / Saha, A / Santocchia, A / Spiezia, A / Taroni, S / Azzurri, P / Bagliesi, G / Boccali, T / Broccolo, G / Castaldi, R / D'Agnolo, R T / Dell'Orso, R / Fiori, F / Foà, L / Giassi, A / Kraan, A / Ligabue, F / Lomtadze, T / Martini, L / Messineo, A / Palla, F / Rizzi, A / Serban, A T / Spagnolo, P / Squillacioti, P / Tenchini, R / Tonelli, G / Venturi, A / Verdini, P G / Barone, L / Cavallari, F / Del Re, D / Diemoz, M / Fanelli, C / Grassi, M / Longo, E / Meridiani, P / Micheli, F / Nourbakhsh, S / Organtini, G / Paramatti, R / Rahatlou, S / Sigamani, M / Soffi, L / Amapane, N / Arcidiacono, R / Argiro, S / Arneodo, M / Biino, C / Cartiglia, N / Casasso, S / Costa, M / Demaria, N / Mariotti, C / Maselli, S / Migliore, E / Monaco, V / Musich, M / Obertino, M M / Pastrone, N / Pelliccioni, M / Potenza, A / Romero, A / Ruspa, M / Sacchi, R / Solano, A / Staiano, A / Belforte, S / Candelise, V / Casarsa, M / Cossutti, F / Della Ricca, G / Gobbo, B / Marone, M / Montanino, D / Penzo, A / Schizzi, A / Kim, T Y / Nam, S K / Chang, S / Kim, D H / Kim, G N / Kong, D J / Park, H / Son, D C / Son, T / Kim, J Y / Kim, Zero J / Song, S / Choi, S / Gyun, D / Hong, B / Jo, M / Kim, H / Kim, T J / Lee, K S / Moon, D H / Park, S K / Choi, M / Kim, J H / Park, C / Park, I C / Park, S / Ryu, G / Choi, Y / Choi, Y K / Goh, J / Kim, M S / Kwon, E / Lee, B / Lee, J / Lee, S / Seo, H / Yu, I / Bilinskas, M J / Grigelionis, I / Janulis, M / Juodagalvis, A / Castilla-Valdez, H / De La Cruz-Burelo, E / Heredia-de La Cruz, I / Lopez-Fernandez, R / Martínez-Ortega, J / Sánchez-Hernández, A / Villasenor-Cendejas, L M / Carrillo Moreno, S / Vazquez Valencia, F / Salazar Ibarguen, H A / Casimiro Linares, E / Morelos Pineda, A / Reyes-Santos, M A / Krofcheck, D / Bell, A J / Butler, P H / Doesburg, R / Reucroft, S / Silverwood, H / Ahmad, M / Asghar, M I / Butt, J / Hoorani, H R / Khalid, S / Khan, W A / Khurshid, T / Qazi, S / Shah, M A / Shoaib, M / Bialkowska, H / Boimska, B / Frueboes, T / Górski, M / Kazana, M / Nawrocki, K / Romanowska-Rybinska, K / Szleper, M / Wrochna, G / Zalewski, P / Brona, G / Bunkowski, K / Cwiok, M / Dominik, W / Doroba, K / Kalinowski, A / Konecki, M / Krolikowski, J / Misiura, M / Almeida, N / Bargassa, P / David, A / Faccioli, P / Ferreira Parracho, P G / Gallinaro, M / Seixas, J / Varela, J / Vischia, P / Belotelov, I / Bunin, P / Gavrilenko, M / Golutvin, I / Gorbunov, I / Kamenev, A / Karjavin, V / Kozlov, G / Lanev, A / Malakhov, A / Moisenz, P / Palichik, V / Perelygin, V / Shmatov, S / Smirnov, V / Volodko, A / Zarubin, A / Evstyukhin, S / Golovtsov, V / Ivanov, Y / Kim, V / Levchenko, P / Murzin, V / Oreshkin, V / Smirnov, I / Sulimov, V / Uvarov, L / Vavilov, S / Vorobyev, A / Vorobyev, An / Andreev, Yu / Dermenev, A / Gninenko, S / Golubev, N / Kirsanov, M / Krasnikov, N / Matveev, V / Pashenkov, A / Tlisov, D / Toropin, A / Epshteyn, V / Erofeeva, M / Gavrilov, V / Kossov, M / Lychkovskaya, N / Popov, V / Safronov, G / Semenov, S / Shreyber, I / Stolin, V / Vlasov, E / Zhokin, A / Belyaev, A / Boos, E / Dubinin, M / Dudko, L / Ershov, A / Gribushin, A / Klyukhin, V / Kodolova, O / Lokhtin, I / Markina, A / Obraztsov, S / Perfilov, M / Petrushanko, S / Popov, A / Sarycheva, L / Savrin, V / Snigirev, A / Andreev, V / Azarkin, M / Dremin, I / Kirakosyan, M / Leonidov, A / Mesyats, G / Rusakov, S V / Vinogradov, A / Azhgirey, I / Bayshev, I / Bitioukov, S / Grishin, V / Kachanov, V / Konstantinov, D / Krychkine, V / Petrov, V / Ryutin, R / Sobol, A / Tourtchanovitch, L / Troshin, S / Tyurin, N / Uzunian, A / Volkov, A / Adzic, P / Djordjevic, M / Ekmedzic, M / Krpic, D / Milosevic, J / Aguilar-Benitez, M / Alcaraz Maestre, J / Arce, P / Battilana, C / Calvo, E / Cerrada, M / Chamizo Llatas, M / Colino, N / De La Cruz, B / Delgado Peris, A / Domínguez Vázquez, D / Fernandez Bedoya, C / Fernández Ramos, J P / Ferrando, A / Flix, J / Fouz, M C / Garcia-Abia, P / Gonzalez Lopez, O / Goy Lopez, S / Hernandez, J M / Josa, M I / Merino, G / Puerta Pelayo, J / Quintario Olmeda, A / Redondo, I / Romero, L / Santaolalla, J / Soares, M S / Willmott, C / Albajar, C / Codispoti, G / de Trocóniz, J F / Brun, H / Cuevas, J / Fernandez Menendez, J / Folgueras, S / Gonzalez Caballero, I / Lloret Iglesias, L / Piedra Gomez, J / Brochero Cifuentes, J A / Cabrillo, I J / Calderon, A / Chuang, S H / Duarte Campderros, J / Felcini, M / Fernandez, M / Gomez, G / Gonzalez Sanchez, J / Graziano, A / Jorda, C / Lopez Virto, A / Marco, J / Marco, R / Martinez Rivero, C / Matorras, F / Munoz Sanchez, F J / Rodrigo, T / Rodríguez-Marrero, A Y / Ruiz-Jimeno, A / Scodellaro, L / Vila, I / Vilar Cortabitarte, R / Abbaneo, D / Auffray, E / 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    Physical review letters

    2012  Volume 109, Issue 26, Page(s) 261802

    Abstract: ... W(R) bosons, which arise in the left-right symmetric extensions of the standard model. The analysis ... neutrinos are excluded at 95% confidence level for a range of neutrino masses below the W(R) mass, dependent ... on the value of M(W(R)). The excluded region in the two-dimensional (M(W(R)), M(N(μ)) mass plane extends to M(W ...

    Abstract Results are presented from a search for heavy, right-handed muon neutrinos, N(μ), and right-handed W(R) bosons, which arise in the left-right symmetric extensions of the standard model. The analysis is based on a 5.0  fb(-1) sample of proton-proton collisions at a center-of-mass energy of 7 TeV, collected by the CMS detector at the Large Hadron Collider. No evidence is observed for an excess of events over the standard model expectation. For models with exact left-right symmetry, heavy right-handed neutrinos are excluded at 95% confidence level for a range of neutrino masses below the W(R) mass, dependent on the value of M(W(R)). The excluded region in the two-dimensional (M(W(R)), M(N(μ)) mass plane extends to M(W(R))=2.5  TeV.
    Language English
    Publishing date 2012-12-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.109.261802
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  4. Book ; Online: R/V MARIA S. MERIAN Cruise Report MSM57, Gas Hydrate Dynamics at the Continental Margin of Svalbard, Reykjavik – Longyearbyen – Reykjavik, 29 July – 07 September 2016

    Bohrmann, Gerhard / Ahrlich, F. / Bergenthal, M. / Bünz, S. / Düßmann, R. / Ferreira, Ch. / Freudenthal, T. / Fröhlich, S. / Hamann, Kristin / Hong, W.-L. / Hsu, Ch.-W. / Johnson, J. / Kaszemeik, K. / Kausche, A. / Klein, T. / Lange, M. / Lepland, A. / Malnati, J. / Meckel, S. /
    Meyer-Schack, B. / Noorlander, K. / Panieri, G. / Pape, T. / Reuter, M. / Riedel, Michael / Rosiak, U. / Schmidt, Christopher / Schmidt, W. / Seiter, Ch. / Spagnoli, G. / Stachowski, A. / Stange, N. / Wallmann, Klaus / Wintersteller, P. / Wunsch, D. / Yao, H.

    2017  

    Language English
    Publishing country de
    Document type Book ; Online
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  5. Article ; Online: Crystal structures of S-HPCDH reveal determinants of stereospecificity for R- and S-hydroxypropyl-coenzyme M dehydrogenases.

    Bakelar, Jeremy W / Sliwa, Dariusz A / Johnson, Sean J

    Archives of biochemistry and biophysics

    2013  Volume 533, Issue 1-2, Page(s) 62–68

    Abstract: R)- and (S)-hydroxypropyl-coenzyme M dehydrogenases (R- and S-HPCDH) are stereospecific enzymes ... produces R- and S-HPCDH simultaneously to facilitate transformation of R- and S-enantiomers of epoxypropane ... to a common achiral product 2-ketopropyl-CoM (2-KPC). Both R- and S-HPCDH are highly specific ...

    Abstract (R)- and (S)-hydroxypropyl-coenzyme M dehydrogenases (R- and S-HPCDH) are stereospecific enzymes that are central to the metabolism of propylene and epoxide in Xanthobacter autotrophicus. The bacterium produces R- and S-HPCDH simultaneously to facilitate transformation of R- and S-enantiomers of epoxypropane to a common achiral product 2-ketopropyl-CoM (2-KPC). Both R- and S-HPCDH are highly specific for their respective substrates as each enzyme displays less than 0.5% activity with the opposite substrate isomer. In order to elucidate the structural basis for stereospecificity displayed by R- and S-HPCDH we have determined substrate bound crystal structures of S-HPCDH to 1.6Å resolution. Comparisons to the previously reported product-bound structure of R-HPCDH reveal that although the placement of catalytic residues within the active site of each enzyme is nearly identical, structural differences in the surrounding area provide each enzyme with a distinct substrate binding pocket. These structures demonstrate how chiral discrimination by R- and S-HPCDH results from alternative binding of the distal end of substrates within each substrate binding pocket.
    MeSH term(s) Amino Acid Sequence ; Catalytic Domain ; Crystallography, X-Ray ; Mesna/metabolism ; Models, Molecular ; Molecular Sequence Data ; Oxidoreductases/chemistry ; Oxidoreductases/metabolism ; Protein Multimerization ; Protein Structure, Quaternary ; Stereoisomerism ; Substrate Specificity ; Xanthobacter/enzymology
    Chemical Substances Oxidoreductases (EC 1.-) ; Mesna (NR7O1405Q9)
    Language English
    Publishing date 2013-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2013.02.017
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  6. Article ; Online: Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study.

    Keith, Dove J / Butler, Judy A / Bemer, Brett / Dixon, Brian / Johnson, Shawn / Garrard, Mary / Sudakin, Daniel L / Christensen, J Mark / Pereira, Cliff / Hagen, Tory M

    Pharmacological research

    2012  Volume 66, Issue 3, Page(s) 199–206

    Abstract: ... mixture of LA (R,S-LA) is equally as bioavailable as the naturally occurring R-enantiomer. To address ... years) each received 500 mg of either R- or R,S-LA. Blood samples were collected for 3h after ... In contrast, young males had a tendency for increased bioavailability of R,S-LA. Overall, bioavailability ...

    Abstract Lipoic acid (LA) shows promise as a beneficial micronutrient toward improving elder health. Studies using old rats show that (R)-α-LA (R-LA) significantly increases low molecular weight antioxidants that otherwise decline with age. Despite this rationale for benefiting human health, little is known about age-associated alterations in absorption characteristics of LA, or whether the commercially available racemic mixture of LA (R,S-LA) is equally as bioavailable as the naturally occurring R-enantiomer. To address these discrepancies, a pilot study was performed to establish which form of LA is most effectively absorbed in older subjects relative to young volunteers. Young adults (average age=32 years) and older adults (average age=79 years) each received 500 mg of either R- or R,S-LA. Blood samples were collected for 3h after supplementation. After a washout period they were given the other chiral form of LA not originally ingested. Results showed that 2 out of 6 elder males exhibited greater maximal plasma LA and area under the curve for the R-form of LA versus the racemic mixture. The elder subjects also demonstrated a reduced time to reach maximal plasma LA concentration following R-LA supplementation than for the racemic mixture. In contrast, young males had a tendency for increased bioavailability of R,S-LA. Overall, bioavailability for either LA isoform was much more variable between older subjects compared to young adults. Plasma glutathione levels were not altered during the sampling period. Thus subject age, and potential for varied response, should be considered when determining an LA supplementation regimen.
    MeSH term(s) Adult ; Age Factors ; Aged ; Antioxidants/metabolism ; Biological Availability ; Dietary Supplements ; Female ; Glutathione/metabolism ; Humans ; Male ; Pilot Projects ; Sex Factors ; Stereoisomerism ; Thioctic Acid/blood ; Thioctic Acid/chemistry ; Thioctic Acid/pharmacokinetics ; Thioctic Acid/pharmacology
    Chemical Substances Antioxidants ; Thioctic Acid (73Y7P0K73Y) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2012-05-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2012.05.002
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  7. Article ; Online: Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide).

    Johnson, Henry W B / Lowe, Eric / Anderl, Janet L / Fan, Andrea / Muchamuel, Tony / Bowers, Simeon / Moebius, David C / Kirk, Christopher / McMinn, Dustin L

    Journal of medicinal chemistry

    2018  Volume 61, Issue 24, Page(s) 11127–11143

    Abstract: Selective immunoproteasome inhibition is a promising approach for treating autoimmune disorders, but optimal proteolytic active site subunit inhibition profiles remain unknown. We reveal here our design of peptide epoxyketone-based selective low ... ...

    Abstract Selective immunoproteasome inhibition is a promising approach for treating autoimmune disorders, but optimal proteolytic active site subunit inhibition profiles remain unknown. We reveal here our design of peptide epoxyketone-based selective low molecular mass polypeptide-7 (LMP7) and multicatalytic endopeptidase complex subunit-1 (MECL-1) subunit inhibitors. Utilizing these and our previously disclosed low molecular mass polypeptide-2 (LMP2) inhibitor, we demonstrate a requirement of dual LMP7/LMP2 or LMP7/MECL-1 subunit inhibition profiles for potent cytokine expression inhibition and in vivo efficacy in an inflammatory disease model. These and additional findings toward optimized solubility led the design and selection of KZR-616 disclosed here and presently in clinical trials for treatment of rheumatic disease.
    MeSH term(s) Administration, Intravenous ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Arthritis, Experimental/drug therapy ; Arthritis, Rheumatoid/drug therapy ; Cell Line, Tumor ; Cysteine Endopeptidases/metabolism ; Cytokines/metabolism ; Drug Design ; Female ; Humans ; Mice, Inbred BALB C ; Morpholines/chemistry ; Morpholines/pharmacokinetics ; Morpholines/pharmacology ; Oligopeptides/pharmacology ; Proteasome Endopeptidase Complex/immunology ; Proteasome Endopeptidase Complex/metabolism ; Proteasome Inhibitors/chemistry ; Proteasome Inhibitors/pharmacokinetics ; Proteasome Inhibitors/pharmacology ; Structure-Activity Relationship
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Cytokines ; Morpholines ; Oligopeptides ; PR-957 ; Proteasome Inhibitors ; LMP-2 protein (144416-78-4) ; Cysteine Endopeptidases (EC 3.4.22.-) ; LMP7 protein (EC 3.4.25.1) ; PSMB10 protein, human (EC 3.4.25.1) ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; KZR-616 (O4BT6C02M2)
    Language English
    Publishing date 2018-12-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.8b01201
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  8. Article: Comparative distribution of binding of the muscarinic receptor ligands pirenzepine, AF-DX 384, (R,R)-I-QNB and (R,S)-I-QNB to human brain.

    Piggott, Margaret / Owens, Jonathan / O'Brien, John / Paling, Sean / Wyper, David / Fenwick, John / Johnson, Mary / Perry, Robert / Perry, Elaine

    Journal of chemical neuroanatomy

    2002  Volume 24, Issue 3, Page(s) 211–223

    Abstract: ... of [125I]-(R,R)-I-QNB and [125I]-(R,S)-I-QNB binding in vitro in human brain. We have compared the in vitro ... M2/M4 receptor subtypes, respectively, to the binding of [125I]-(R,R)-I-QNB and [125I]-(R,S)-I-QNB ... R,S)-I-QNB. Binding was investigated in striatum, globus pallidus, thalamus and cerebellum, and ...

    Abstract Quinuclidinyl benzilate (QNB) and its derivatives are being developed to investigate muscarinic receptor changes in vivo in Alzheimer's disease and dementia with Lewy bodies. This is the first study of [125I]-(R,R)-I-QNB and [125I]-(R,S)-I-QNB binding in vitro in human brain. We have compared the in vitro binding of the muscarinic ligands [3H]pirenzepine and [3H]AF-DX 384, which have selectivity for the M1 and M2/M4 receptor subtypes, respectively, to the binding of [125I]-(R,R)-I-QNB and [125I]-(R,S)-I-QNB. This will provide a guide to the interpretation of in vivo SPET images generated with [123I]-(R,R)-I-QNB and [123I]-(R,S)-I-QNB. Binding was investigated in striatum, globus pallidus, thalamus and cerebellum, and cingulate, insula, temporal and occipital cortical areas, which show different proportions of muscarinic receptor subtypes, in post-mortem brain from normal individuals. M1 receptors are of high density in cortex and striatum and are relatively low in the thalamus and cerebellum, while M4 receptors are mainly expressed in the striatum, and M2 receptors are most evident in the cerebellum and thalamus. [125I]-(R,R)-I-QNB and [125I]-(R,S)-I-QNB density distribution patterns were consistent with binding to both M1 and M4 receptors, with [125I]-(R,R)-I-QNB additionally binding to a non-cholinergic site not displaceable by atropine. This distribution can be exploited by in vivo imaging, developing ligands for both SPET and PET, to reveal muscarinic receptor changes in Alzheimer's disease and dementia with Lewy bodies during the disease process and following cholinergic therapy.
    MeSH term(s) Aged ; Aged, 80 and over ; Binding Sites/physiology ; Brain/metabolism ; Female ; Humans ; Ligands ; Male ; Pirenzepine/analogs & derivatives ; Pirenzepine/metabolism ; Quinuclidinyl Benzilate/metabolism ; Receptors, Muscarinic/metabolism ; Stereoisomerism
    Chemical Substances Ligands ; Receptors, Muscarinic ; AFDX 384 (118290-27-0) ; Pirenzepine (3G0285N20N) ; Quinuclidinyl Benzilate (6581-06-2)
    Language English
    Publishing date 2002-09-25
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ZDB-ID 639443-7
    ISSN 0891-0618
    ISSN 0891-0618
    DOI 10.1016/s0891-0618(02)00066-2
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  9. Article ; Online: Search for R-parity violating decays of sneutrinos to eμ, μτ, and eτ pairs in pp collisions at square root s = 1.96 TeV.

    Aaltonen, T / Adelman, J / Alvarez González, B / Amerio, S / Amidei, D / Anastassov, A / Annovi, A / Antos, J / Apollinari, G / Appel, J / Apresyan, A / Arisawa, T / Artikov, A / Asaadi, J / Ashmanskas, W / Attal, A / Aurisano, A / Azfar, F / Badgett, W /
    Barbaro-Galtieri, A / Barnes, V E / Barnett, B A / Barria, P / Bartos, P / Bauer, G / Beauchemin, P-H / Bedeschi, F / Beecher, D / Behari, S / Bellettini, G / Bellinger, J / Benjamin, D / Beretvas, A / Bhatti, A / Binkley, M / Bisello, D / Bizjak, I / Blair, R E / Blocker, C / Blumenfeld, B / Bocci, A / Bodek, A / Boisvert, V / Bortoletto, D / Boudreau, J / Boveia, A / Brau, B / Bridgeman, A / Brigliadori, L / Bromberg, C / Brubaker, E / Budagov, J / Budd, H S / Budd, S / Burkett, K / Busetto, G / Bussey, P / Buzatu, A / Byrum, K L / Cabrera, S / Calancha, C / Camarda, S / Campanelli, M / Campbell, M / Canelli, F / Canepa, A / Carls, B / Carlsmith, D / Carosi, R / Carrillo, S / Carron, S / Casal, B / Casarsa, M / Castro, A / Catastini, P / Cauz, D / Cavaliere, V / Cavalli-Sforza, M / Cerri, A / Cerrito, L / Chang, S H / Chen, Y C / Chertok, M / Chiarelli, G / Chlachidze, G / Chlebana, F / Cho, K / Chokheli, D / Chou, J P / Chung, K / Chung, W H / Chung, Y S / Chwalek, T / Ciobanu, C I / Ciocci, M A / Clark, A / Clark, D / Compostella, G / Convery, M E / Conway, J / Corbo, M / Cordelli, M / Cox, C A / Cox, D J / Crescioli, F / Cuenca Almenar, C / Cuevas, J / Culbertson, R / Cully, J C / Dagenhart, D / d'Ascenzo, N / Datta, M / Davies, T / de Barbaro, P / De Cecco, S / Deisher, A / De Lorenzo, G / Dell'Orso, M / Deluca, C / Demortier, L / Deng, J / Deninno, M / d'Errico, M / Di Canto, A / Di Ruzza, B / Dittmann, J R / D'Onofrio, M / Donati, S / Dong, P / Dorigo, T / Dube, S / Ebina, K / Elagin, A / Erbacher, R / Errede, D / Errede, S / Ershaidat, N / Eusebi, R / Fang, H C / Farrington, S / Fedorko, W T / Feild, R G / Feindt, M / Fernandez, J P / Ferrazza, C / Field, R / Flanagan, G / Forrest, R / Frank, M J / Franklin, M / Freeman, J C / Furic, I / Gallinaro, M / Galyardt, J / Garberson, F / Garcia, J E / Garfinkel, A F / Garosi, P / Gerberich, H / Gerdes, D / Gessler, A / Giagu, S / Giakoumopoulou, V / Giannetti, P / Gibson, K / Gimmell, J L / Ginsburg, C M / Giokaris, N / Giordani, M / Giromini, P / Giunta, M / Giurgiu, G / Glagolev, V / Glenzinski, D / Gold, M / Goldschmidt, N / Golossanov, A / Gomez, G / Gomez-Ceballos, G / Goncharov, M / González, O / Gorelov, I / Goshaw, A T / Goulianos, K / Gresele, A / Grinstein, S / Grosso-Pilcher, C / Group, R C / Grundler, U / Guimaraes da Costa, J / Gunay-Unalan, Z / Haber, C / Hahn, S R / Halkiadakis, E / Han, B-Y / Han, J Y / Happacher, F / Hara, K / Hare, D / Hare, M / Harr, R F / Hartz, M / Hatakeyama, K / Hays, C / Heck, M / Heinrich, J / Herndon, M / Heuser, J / Hewamanage, S / Hidas, D / Hill, C S / Hirschbuehl, D / Hocker, A / Hou, S / Houlden, M / Hsu, S-C / Hughes, R E / Hurwitz, M / Husemann, U / Hussein, M / Huston, J / Incandela, J / Introzzi, G / Iori, M / Ivanov, A / James, E / Jang, D / Jayatilaka, B / Jeon, E J / Jha, M K / Jindariani, S / Johnson, W / Jones, M / Joo, K K / Jun, S Y / Jung, J E / Junk, T R / Kamon, T / Kar, D / Karchin, P E / Kato, Y / Kephart, R / Ketchum, W / Keung, J / Khotilovich, V / Kilminster, B / Kim, D H / Kim, H S / Kim, H W / Kim, J E / Kim, M J / Kim, S B / Kim, S H / Kim, Y K / Kimura, N / Kirsch, L / Klimenko, S / Ko, B R / Kondo, K / Kong, D J / Konigsberg, J / Korytov, A / Kotwal, A V / Kreps, M / Kroll, J / Krop, D / Krumnack, N / Kruse, M / Krutelyov, V / Kuhr, T / Kulkarni, N P / Kurata, M / Kwang, S / Laasanen, A T / Lami, S / Lammel, S / Lancaster, M / Lander, R L / Lannon, K / Lath, A / Latino, G / Lazzizzera, I / LeCompte, T / Lee, E / Lee, H S / Lee, J S / Lee, S W / Leone, S / Lewis, J D / Lin, C-J / Linacre, J / Lindgren, M / Lipeles, E / Lister, A / Litvintsev, D O / Liu, C / Liu, T / Lockyer, N S / Loginov, A / Lovas, L / Lucchesi, D / Lueck, J / Lujan, P / Lukens, P / Lungu, G / Lys, J / Lysak, R / MacQueen, D / Madrak, R / Maeshima, K / Makhoul, K / Maksimovic, P / Malde, S / Malik, S / Manca, G / Manousakis-Katsikakis, A / Margaroli, F / Marino, C / Marino, C P / Martin, A / Martin, V / Martínez, M / 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    Physical review letters

    2010  Volume 105, Issue 19, Page(s) 191801

    Abstract: ... on the scenarios predicted by the R-parity violating (RPV) supersymmetric models in which sneutrinos decay to two ...

    Abstract We present a search for supersymmetric neutrino ν production using the Tevatron pp collision data collected with the CDF II detector and corresponding to an integrated luminosity of 1 fb-1. We focus on the scenarios predicted by the R-parity violating (RPV) supersymmetric models in which sneutrinos decay to two charged leptons of different flavor. With the data consistent with the standard model expectations, we set upper limits on σ(pp→ν)×BR(ν→eμ,μτ,eτ) and use these results to constrain the RPV couplings as a function of the sneutrino mass.
    Language English
    Publishing date 2010-11-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.105.191801
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  10. Article: Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: A pilot study

    Keith, Dove J / Butler, Judy A / Bemer, Brett / Dixon, Brian / Johnson, Shawn / Garrard, Mary / Sudakin, Daniel L / Christensen, J. Mark / Pereira, Cliff / Hagen, Tory M

    Pharmacological research. 2012 Sept., v. 66, no. 3

    2012  

    Abstract: ... mixture of LA (R,S-LA) is equally as bioavailable as the naturally occurring R-enantiomer. To address ... years) each received 500mg of either R- or R,S-LA. Blood samples were collected for 3h after ... In contrast, young males had a tendency for increased bioavailability of R,S-LA. Overall, bioavailability ...

    Abstract Lipoic acid (LA) shows promise as a beneficial micronutrient toward improving elder health. Studies using old rats show that (R)-α-LA (R-LA) significantly increases low molecular weight antioxidants that otherwise decline with age. Despite this rationale for benefiting human health, little is known about age-associated alterations in absorption characteristics of LA, or whether the commercially available racemic mixture of LA (R,S-LA) is equally as bioavailable as the naturally occurring R-enantiomer. To address these discrepancies, a pilot study was performed to establish which form of LA is most effectively absorbed in older subjects relative to young volunteers. Young adults (average age=32 years) and older adults (average age=79 years) each received 500mg of either R- or R,S-LA. Blood samples were collected for 3h after supplementation. After a washout period they were given the other chiral form of LA not originally ingested. Results showed that 2 out of 6 elder males exhibited greater maximal plasma LA and area under the curve for the R-form of LA versus the racemic mixture. The elder subjects also demonstrated a reduced time to reach maximal plasma LA concentration following R-LA supplementation than for the racemic mixture. In contrast, young males had a tendency for increased bioavailability of R,S-LA. Overall, bioavailability for either LA isoform was much more variable between older subjects compared to young adults. Plasma glutathione levels were not altered during the sampling period. Thus subject age, and potential for varied response, should be considered when determining an LA supplementation regimen.
    Keywords absorption ; antioxidants ; bioavailability ; blood ; elderly ; glutathione ; human health ; lipoic acid ; males ; molecular weight ; rats ; volunteers ; young adults
    Language English
    Dates of publication 2012-09
    Size p. 199-206.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 1043-6618
    DOI 10.1016/j.phrs.2012.05.002
    Database NAL-Catalogue (AGRICOLA)

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