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  1. Book ; Online: Dysregulation of Autonomic Cardiac Control by Traumatic Stress and Anxiety

    Ginsberg, J. P.

    2016  

    Abstract: Current understanding of the interplay between sympathetic and parasympathetic influences on cardiac response to environmental stimuli and subsequent response selection (e.g. maintenance of resting homeostasis, mobilization of defensive response, task ... ...

    Abstract Current understanding of the interplay between sympathetic and parasympathetic influences on cardiac response to environmental stimuli and subsequent response selection (e.g. maintenance of resting homeostasis, mobilization of defensive response, task performance, tonic immobilization, and/or affiliation) will be explored. Reference will be made to how these processes conjoin with proposed polyvagal theory. Cardiac adjustments to environmental stimuli affect the internal physiological state of the organism as well as the quality of information processing that the individual can perform during the stimulus appraisal stage of the orienting response. Bradyrdia is adaptive in early stages of orientation to novel or potential threat, while greater HRV power serves to facilitate self-regulation, stimulus information processing and appraisal, and appropriate response selection.-

    This issue is devoted to current research findings on how normal patterns of cardiac autonomic regulation of HRV are disrupted in PTSD, impairing sustained attention to the environment and increasing the rate of inappropriate responding to stimuli. Origins of our current state of understanding in the 'intake-rejection' hypothesis will be considered, and how the intake-rejection hypothesis has morphed into present-day Optimal Performance practice. Additionally, empirical data where available will be presented on how dysregulation of the normal pattern of cardiac autonomic regulation by PTSD impairs sustained attention to the environment, and increases the rate of inappropriate responding to stimuli through disinhibition, poor impulse control, emotional withdrawal, over-arousal, and attentional bias.-

    Current research findings are sought that address in controlled, experimental and clinical trials the restorative effects of HRV biofeedback on HRV power, and how increases in HRV power relate to improved attention / immediate memory and self-regulation of affect using outcome measures of cognition, symptoms of PTSD and depression, stress perception, and level of adaptive function
    Keywords Science (General) ; Psychology
    Size 1 electronic resource (118 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020090635
    ISBN 9782889199150 ; 2889199150
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Clinical experiences with a new spasmolytic drug, J. B. 305.

    WEINBERG, B / GINSBERG, R / SORTER, H

    The American journal of digestive diseases

    2003  Volume 20, Issue 8, Page(s) 230–231

    MeSH term(s) Cardiovascular Agents ; Muscle Relaxants, Central/therapeutic use ; Parasympatholytics
    Chemical Substances Cardiovascular Agents ; Muscle Relaxants, Central ; Parasympatholytics
    Language English
    Publishing date 2003-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80027-2
    ISSN 0002-9211 ; 0092-5640
    ISSN 0002-9211 ; 0092-5640
    DOI 10.1007/bf02893215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity.

    Aplan, P D / Lombardi, D P / Ginsberg, A M / Cossman, J / Bertness, V L / Kirsch, I R

    Science (New York, N.Y.)

    1990  Volume 250, Issue 4986, Page(s) 1426–1429

    Abstract: ... This event is probably mediated by V-(D)-J recombinase activity, although neither locus is an immunoglobulin ...

    Abstract A fusion complementary DNA in the T cell line HSB-2 elucidates a provocative mechanism for the disruption of the putative hematopoietic transcription factor SCL. The fusion cDNA results from an interstitial deletion between a previously unknown locus, SIL (SCL interrupting locus), and the 5' untranslated region of SCL. Similar to 1;14 translocations, this deletion disrupts the SCL 5' regulatory region. This event is probably mediated by V-(D)-J recombinase activity, although neither locus is an immunoglobulin or a T cell receptor. Two other T cell lines, CEM and RPMI 8402, have essentially identical deletions. Thus, in lymphocytes, growth-affecting genes other than immune receptors risk rearrangements.
    MeSH term(s) Base Sequence ; Basic Helix-Loop-Helix Transcription Factors ; Cell Line ; Chromosome Deletion ; DNA Nucleotidyltransferases/metabolism ; DNA-Binding Proteins/genetics ; Exons ; Gene Rearrangement ; Humans ; Molecular Sequence Data ; Oligonucleotide Probes ; Plasmids ; Proto-Oncogene Proteins/genetics ; Restriction Mapping ; Sequence Homology, Nucleic Acid ; T-Cell Acute Lymphocytic Leukemia Protein 1 ; T-Lymphocytes ; Transcription Factors/genetics ; VDJ Recombinases
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; DNA-Binding Proteins ; Oligonucleotide Probes ; Proto-Oncogene Proteins ; T-Cell Acute Lymphocytic Leukemia Protein 1 ; Transcription Factors ; TAL1 protein, human (135471-20-4) ; DNA Nucleotidyltransferases (EC 2.7.7.-) ; VDJ Recombinases (EC 2.7.7.-)
    Language English
    Publishing date 1990-12-07
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.2255914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Disappearing discs after posterior cervical fusion.

    Schär, Ralph T / Ginsberg, Howard J

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2023  Volume 120, Page(s) 3–4

    MeSH term(s) Humans ; Spinal Diseases ; Spinal Fusion ; Neck ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery ; Spinal Cord Diseases
    Language English
    Publishing date 2023-12-30
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2023.12.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Microisolation of Spatially Characterized Single Populations of Neurons for RNA Sequencing from Mouse and Postmortem Human Brain Tissues.

    Alldred, Melissa J / Ginsberg, Stephen D

    Journal of clinical medicine

    2023  Volume 12, Issue 9

    Abstract: Single-cell and single-population RNA sequencing (RNA-seq) is a rapidly evolving new field of intense investigation. Recent studies indicate unique transcriptomic profiles are derived based on the spatial localization of neurons within circuits and ... ...

    Abstract Single-cell and single-population RNA sequencing (RNA-seq) is a rapidly evolving new field of intense investigation. Recent studies indicate unique transcriptomic profiles are derived based on the spatial localization of neurons within circuits and regions. Individual neuronal subtypes can have vastly different transcriptomic fingerprints, well beyond the basic excitatory neuron and inhibitory neuron designations. To study single-population gene expression profiles of spatially characterized neurons, we have developed a methodology combining laser capture microdissection (LCM), RNA purification of single populations of neurons, and subsequent library preparation for downstream applications, including RNA-seq. LCM provides the benefit of isolating single neurons characterized by morphology or via transmitter-identified and/or receptor immunoreactivity and enables spatial localization within the sample. We utilize unfixed human postmortem and mouse brain tissue that is frozen to preserve RNA quality in order to isolate the desired neurons of interest. Microisolated neurons are then pooled for RNA purification utilizing as few as 250 individual neurons from a tissue section, precluding extraneous nonspecific tissue contaminants. Library preparation is performed from picogram RNA quantities extracted from LCM-captured neurons. Single-population RNA-seq analysis demonstrates that microisolated neurons from both postmortem human and mouse brain tissues are viable for transcriptomic profiling, including differential gene expression assessment and bioinformatic pathway inquiry.
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12093304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Heart Rate Variability, Health and Well-being: A Systems Perspective

    Drury, Robert / Ginsberg, J. P. / Porges, Stephen W. / Thayer, Julian F.

    2020  

    Keywords Medicine ; Public health & preventive medicine ; heart rate variability (HRV) ; integrative health ; autonomic nerve activity ; cardiac control ; coherence
    Size 1 electronic resource (164 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229885
    ISBN 9782889632978 ; 2889632970
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article ; Online: Editorial.

    Ginsberg, David A / Clemens, J Quentin / Cameron, Anne P / Vasavada, Sandip P / Wein, Alan J

    Neurourology and urodynamics

    2024  Volume 43 Suppl 1, Page(s) S5

    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Editorial
    ZDB-ID 604904-7
    ISSN 1520-6777 ; 0733-2467
    ISSN (online) 1520-6777
    ISSN 0733-2467
    DOI 10.1002/nau.25403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Broadening the Scope of Dyslipidemia Therapy by Targeting APOC3 (Apolipoprotein C3) and ANGPTL3 (Angiopoietin-Like Protein 3).

    Ginsberg, Henry N / Goldberg, Ira J

    Arteriosclerosis, thrombosis, and vascular biology

    2022  Volume 43, Issue 3, Page(s) 388–398

    Abstract: The positive relationship between increased levels of circulating triglycerides and cardiovascular events has been observed for decades. Driven by genetic cohort studies, inhibitors of APOC3 (apolipoprotein C3) and ANGPTL (angiopoietin-like protein) 3 ... ...

    Abstract The positive relationship between increased levels of circulating triglycerides and cardiovascular events has been observed for decades. Driven by genetic cohort studies, inhibitors of APOC3 (apolipoprotein C3) and ANGPTL (angiopoietin-like protein) 3 that reduce circulating triglycerides are poised to enter clinical practice. We will review the biology of how inhibition of these 2 proteins affects circulating lipoproteins as well as the current state of clinical development of monoclonal antibodies, antisense oligonucleotides, and silencing RNAs targeting APOC3 and ANGPTL3.
    MeSH term(s) Humans ; Angiopoietin-Like Protein 3 ; Angiopoietin-like Proteins/genetics ; Apolipoprotein C-III ; Triglycerides/metabolism ; Dyslipidemias/drug therapy
    Chemical Substances Angiopoietin-Like Protein 3 ; Angiopoietin-like Proteins ; Apolipoprotein C-III ; Triglycerides ; ANGPTL3 protein, human
    Language English
    Publishing date 2022-12-29
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.122.317966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A digital Acceptance and Commitment Therapy and education intervention targeting stress of parents and caregivers with preterm babies in the neonatal intensive care unit: A randomised controlled cluster trial protocol.

    Ginsberg, Kristin H / Alsweiler, Jane / Rogers, Jen / Cavadino, Alana / Douglas, Meihana / Serlachius, Anna

    Contemporary clinical trials

    2024  Volume 140, Page(s) 107519

    Abstract: Background: Parents with babies in the neonatal intensive care unit (NICU) experience high levels of stress, anxiety, and depression. The NICU experience may also lead to impaired parenting and early childhood socio-emotional problems. Psychosocial ... ...

    Abstract Background: Parents with babies in the neonatal intensive care unit (NICU) experience high levels of stress, anxiety, and depression. The NICU experience may also lead to impaired parenting and early childhood socio-emotional problems. Psychosocial interventions can reduce NICU parent distress. Yet many are time-intensive and costly to deliver. Acceptance and Commitment Therapy (ACT), an evidence-based psychological therapy, may address these needs. ACT has been shown to be effective in reducing distress of parents of children with chronic illnesses, particularly when combined with parent education. Therefore, the primary aim of this study is to determine if a digital intervention that uses a brief form of ACT plus parent education will reduce the stress of primary caregivers with preterm babies in the NICU more than a digital education-only intervention or standard care control group.
    Methods: In a randomised controlled cluster trial design, participants will be randomly assigned to one of three groups: ACT plus education; education-only; or standard care control. The primary outcome will be parental/caregiver stress levels, measured on the Parental Stress Scale: Neonatal Intensive Care Unit. Secondary outcomes include overall stress, anxiety, and depression. Outcome measures will be evaluated at baseline, two weeks after enrolment, discharge to home, and 3-months post-discharge.
    Conclusion: This study will explore the efficacy of a digital ACT plus education intervention on parental stress levels. While position papers have advocated for the use of ACT with NICU parents, this study will be the first to test ACT as a stand-alone intervention with this population.
    Trial registration: This trial was prospectively registered with the Australian New Zealand Clinical Trials Registry on 14 June 2023 (ACTRN12623000641695p).
    MeSH term(s) Humans ; Intensive Care Units, Neonatal ; Parents/psychology ; Parents/education ; Stress, Psychological/therapy ; Acceptance and Commitment Therapy/methods ; Infant, Premature ; Infant, Newborn ; Caregivers/psychology ; Caregivers/education ; Depression/therapy ; Anxiety/therapy ; Female ; Male
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article ; Clinical Trial Protocol ; Research Support, Non-U.S. Gov't ; Randomized Controlled Trial
    ZDB-ID 2182176-8
    ISSN 1559-2030 ; 1551-7144
    ISSN (online) 1559-2030
    ISSN 1551-7144
    DOI 10.1016/j.cct.2024.107519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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