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Article ; Online: Evaluation of Benzaldehyde as an Antibiotic Modulator and Its Toxic Effect against

Neto, Luiz Jardelino de Lacerda / Ramos, Andreza Guedes Barbosa / Freitas, Thiago Sampaio de / Barbosa, Cristina Rodrigues Dos Santos / de Sousa Júnior, Dárcio Luiz / Siyadatpanah, Abolghasem / Nejat, Morteza / Wilairatana, Polrat / Coutinho, Henrique Douglas Melo / da Cunha, Francisco Assis Bezerra

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 18

Abstract: Products of natural origin remain important in the discovery of new bioactive molecules and are less damaging to the environment. Benzaldehyde is a product of the metabolism of plants, and similarly to oxygenated terpenes, it can have antibacterial ... ...

Abstract	Products of natural origin remain important in the discovery of new bioactive molecules and are less damaging to the environment. Benzaldehyde is a product of the metabolism of plants, and similarly to oxygenated terpenes, it can have antibacterial activity against
MeSH term(s)	Animals ; Anti-Bacterial Agents ; Benzaldehydes ; Drosophila melanogaster ; Microbial Sensitivity Tests ; Staphylococcus aureus/drug effects
Chemical Substances	Anti-Bacterial Agents ; Benzaldehydes ; benzaldehyde (TA269SD04T)
Language	English
Publishing date	2021-09-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26185570
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Article ; Online: Terpinolene inhibits acute responses triggered by different inflammatory agents in vivo models of mouse

Menezes, Isis Oliveira / da Silva, Lucas Yure Santos / Pessoa, Renata Torres / Ramos, Andreza Guedes Barbosa / da Cunha, Francisco Assis Bezerra / Ribeiro-Filho, Jaime / Martins, Anita Oliveira Brito Pereira Bezerra / Coutinho, Henrique Douglas Melo / de Menezes, Irwin Rose Alencar

Food Bioscience. 2023 June, v. 53 p.102621-

2023

Abstract: The aim of this work was evaluate the effects of terpinolene on acute inflammatory responses in mice. In vivo preclinical research using different inflammatory agents to induce acute responses and evaluate the effects of terpinolene in orally treated ... ...

Abstract	The aim of this work was evaluate the effects of terpinolene on acute inflammatory responses in mice. In vivo preclinical research using different inflammatory agents to induce acute responses and evaluate the effects of terpinolene in orally treated mice. The acute inflammatory responses were induced by injecting phlogistic agents in the mice paw to observe the development of pain responses (formalin test) or edema (carrageenan, dextran, histamine, arachidonic acid, and prostaglandin). The antiedematogenic activity was also evaluated using a croton oil-induced ear edema model. Finally, cotton pellet-induced granuloma was used to carry out a preliminary evaluation of terpinolene in a chronic inflammatory model. Topically administered terpinolene (5, 10, and 20 mg/mL) significantly inhibited ear edema development (by 33.82%, 29.63%, and 33,30%, respectively). Following an oral administration, only the highest dose of the monoterpene (200 mg/kg) reduced the licking time of the formalin test in both phases 1 (73.55%) and 2 (96.61%). The carrageenan-induced edema significantly inhibited over time following the oral administration of terpinolene at 50 mg/kg (T1: 47.74%, T2: 54.67%, T3: 48.63%, and T4: 62.99%), 100 mg/kg (T1: 72.86%, T2: 71.03%, T3: 48.63%, and T4: 57.83%), and 200 mg/kg (T1: 43.22%, T2: 34.11%, T3: 36.47%, and T4: 45.20%). On the other hand, only the dose of 200 mg/kg) caused a significant reduction of the dextran-induced paw edema (T1: 51.18%, T2: 60%, T3: 50.92%, and T4: 65.15%). Regarding the participation of inflammatory pathways, the monoterpene (200 mg/kg, p.o.) had little impact on histamine-induced edema, while the edema induced by arachidonic acid was significantly reduced at all time-points (T1: 37.04%, T2: 24.32%, and T3: 35.13%, and T4: 35.53%), which was corroborated by the observation that the compound inhibited the response triggered by prostaglandin E₂ (PGE₂), suggesting interference with downstream signaling cascades. Finally, terpinolene (200 mg/kg, p.o.) reduced both the weight (21.43%) and total protein content (36.21%) of the cotton pellet-induced granuloma, indicating an anti-inflammatory activity in this chronic model. Terpinolene inhibited acute inflammatory responses and reduced granuloma development in vivo, possibly by interfering with the tissue changes orchestrated by inflammatory mediators such as histamine and PGE₂. However, the molecular mechanisms underlying this pharmacological observation need to be confirmed by further research.
Keywords	anti-inflammatory activity ; arachidonic acid ; carrageenan ; cotton ; dextran ; ears ; edema ; formalin test ; granuloma ; histamine ; mice ; models ; monoterpenoids ; oral administration ; pain ; prostaglandins ; protein content ; terpinolene ; Antiedematogenic ; Inflammation ; In vivo study ; Inflammatory pathways
Language	English
Dates of publication	2023-06
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ISSN	2212-4292
DOI	10.1016/j.fbio.2023.102621
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Article ; Online: Evaluation of the antiedematogenic and anti-inflammatory properties of Ximenia americana L. (Olacaceae) bark extract in experimental models of inflammation.

da Silva, Bruno Anderson Fernandes / Pessoa, Renata Torres / da Costa, Roger Henrique Sousa / de Oliveira, Maria Rayane Correia / Ramos, Andreza Guedes Barbosa / de Lima Silva, Maria Gabriely / da Silva, Lucas Yure Santos / Medeiros, Cassio Rocha / Florencio, Sloana Giesta Lemos / Ribeiro-Filho, Jaime / Coutinho, Henrique Douglas Melo / Raposo, António / Yoo, Sunghoon / Han, Heesup / de Menezes, Irwin Rose Alencar / Quintans Júnior, Lucindo José

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 166, Page(s) 115249

Abstract: Edema is one of the obvious indicators of inflammation and a crucial factor to take into account when assessing a substance's capacity to reduce inflammation. We aimed to evaluate the antiedematogenic and anti-inflammatory profile of the hydroethanolic ... ...

Abstract	Edema is one of the obvious indicators of inflammation and a crucial factor to take into account when assessing a substance's capacity to reduce inflammation. We aimed to evaluate the antiedematogenic and anti-inflammatory profile of the hydroethanolic barks extract of Ximenia americana (HEXA). The possible antiedematogenic and anti-inflammatory effect of EHXA (50, 100 mg/kg and 250 mg/kg v.o) was evaluated using the paw edema induced by carrageenan, zymosan, dextran, CFA and by different agents inflammatory (serotonin, histamine, arachidonic acid and PGE
MeSH term(s)	Olacaceae ; Arachidonic Acid ; Carrageenan ; Dextrans ; Histamine ; Plant Bark ; Serotonin ; Tumor Necrosis Factor-alpha ; Zymosan ; Inflammation/chemically induced ; Inflammation/drug therapy ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Pleurisy/chemically induced ; Pleurisy/drug therapy ; Dinoprostone ; Models, Theoretical ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use
Chemical Substances	Arachidonic Acid (27YG812J1I) ; Carrageenan (9000-07-1) ; Dextrans ; Histamine (820484N8I3) ; Serotonin (333DO1RDJY) ; Tumor Necrosis Factor-alpha ; Zymosan (9010-72-4) ; Anti-Inflammatory Agents ; Dinoprostone (K7Q1JQR04M) ; Plant Extracts
Language	English
Publishing date	2023-08-17
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115249
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Article ; Online: Evaluation of Benzaldehyde as an Antibiotic Modulator and Its Toxic Effect against Drosophila melanogaster

Luiz Jardelino de Lacerda Neto / Andreza Guedes Barbosa Ramos / Thiago Sampaio de Freitas / Cristina Rodrigues dos Santos Barbosa / Dárcio Luiz de Sousa Júnior / Abolghasem Siyadatpanah / Morteza Nejat / Polrat Wilairatana / Henrique Douglas Melo Coutinho / Francisco Assis Bezerra da Cunha

Molecules, Vol 26, Iss 5570, p

2021 Volume 5570

Abstract	Products of natural origin remain important in the discovery of new bioactive molecules and are less damaging to the environment. Benzaldehyde is a product of the metabolism of plants, and similarly to oxygenated terpenes, it can have antibacterial activity against Staphylococcus aureus and toxic action against Drosophila melanogaster we aimed to verify these activities. The broth microdilution tests determined the minimum inhibitory concentration (MIC) of benzaldehyde alone and in association with antibiotics and ethidium bromide (EtBr). Toxicity against Drosophila melanogaster was determined by fumigation tests that measured lethality and damage to the locomotor system. The results indicated that there was an association of norfloxacin and ciprofloxacin with benzaldehyde, from 64 μg/mL to 32 μg/mL of ciprofloxacin in the strain K6028 and from 256 μg/mL to 128 μg/mL of norfloxacin in the strain 1199B; however, the associations were not able to interfere with the functioning of the tested efflux pumps. In addition, benzaldehyde had a toxic effect on flies. Thus, the results proved the ability of benzaldehyde to modulate quinolone antibiotics and its toxic effects on fruit flies, thus enabling further studies in this area.
Keywords	antibacterial ; toxicity ; benzaldehyde ; resistance ; insecticide ; Organic chemistry ; QD241-441
Subject code	590
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Biological properties of terpinolene evidenced by in silico, in vitro and in vivo studies: A systematic review.

Menezes, Isis Oliveira / Scherf, Jackelyne Roberta / Martins, Anita Oliveira Brito Pereira Bezerra / Ramos, Andreza Guedes Barbosa / Quintans, Jullyana de Souza Siqueira / Coutinho, Henrique Douglas Melo / Ribeiro-Filho, Jaime / de Menezes, Irwin Rose Alencar

Phytomedicine : international journal of phytotherapy and phytopharmacology

2021 Volume 93, Page(s) 153768

Abstract: Background: Terpinolene, a monoterpene that is naturally found in a variety of herbs, is widely used as a flavoring agent in the industry. Although it's well established in the literature that terpinolene is an important component of plant extracts, the ...

Abstract	Background: Terpinolene, a monoterpene that is naturally found in a variety of herbs, is widely used as a flavoring agent in the industry. Although it's well established in the literature that terpinolene is an important component of plant extracts, the biological properties and the potential therapeutic use of this compound remain poorly explored. Purpose: This work aimed to answer the following guiding question: "What are the biological activities of terpinolene demonstrated through in silico, in vitro, and in vivo assays?". Study design and methodology: A systematic review was carried out in four electronic databases (Embase, Web of Science, Scopus, and PubMed) according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, using the following search terms: terpinolene "AND" activity "OR" properties "OR" therapeutic "OR" treatment. This search included manuscripts published between 1960 and June 2020. Study selection was conducted by two independent reviewers according to predefined criteria. Results: The initial search found a total of 2449 articles. However, only 57 of them were selected as they met the inclusion criteria and answered the guiding question. The analysis of these studies indicated that terpinolene presents a series of biological effects, from which the antioxidant, larvicide, and insecticide activities stand out. Despite the evidence demonstrating that terpinolene has the potential to be used in a broad pharmacological context, the mechanisms underlying its cellular and molecular effects remain to be better elucidated. In addition, the in vivo efficacy and safety of the administration of this compound have been poorly evaluated through either preclinical and clinical trials. Therefore, this study highlights the importance of characterizing the biological aspects and mechanisms of action of this natural compound. Conclusion: The data summarized in the present systematic review demonstrates the pharmacological potential of terpinolene. Nevertheless, most studies included in this review provide a superficial characterization of terpinolene biological effects and therefore, further research elucidating its mechanism of action and potential therapeutic benefits through preclinical and clinical trials are required. Nevertheless, due to its wide range of different biological activities, terpinolene will certainly attract the interest of scientific research, which could significantly contribute to the development of new products with both therapeutic and environmental applications.
MeSH term(s)	Computer Simulation ; Cyclohexane Monoterpenes ; Publications
Chemical Substances	Cyclohexane Monoterpenes ; terpinolene (N9830X5KSL)
Language	English
Publishing date	2021-09-26
Publishing country	Germany
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2021.153768
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Article ; Online: Myorelaxant Effect of the

de Lacerda Neto, Luiz Jardelino / Ramos, Andreza Guedes Barbosa / da Silva, Renata Evaristo Rodrigues / Pereira-de-Morais, Luís / Silva, Fernanda Maria / da Costa, Roger Henrique Sousa / Rodrigues Dantas, Lindaiane Bezerra / da Costa, José Galberto Martins / Coutinho, Henrique Douglas Melo / Kowalska, Grażyna / Hawlena, Joanna / Kowalski, Radosław / Barbosa, Roseli / da Cunha, Francisco Assis Bezerra

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 7

Abstract: Purpose: Alternative methods for the use of animals in research have gained increasing importance, due to assessments evaluating the real need for their use and the development of legislation that regulates the subject. The principle of the 3R's ( ... ...

Abstract	Purpose: Alternative methods for the use of animals in research have gained increasing importance, due to assessments evaluating the real need for their use and the development of legislation that regulates the subject. The principle of the 3R's (replacement, reduction and refinement) has been an important reference, such that in vitro, ex vivo and cord replacement methods have achieved a prominent place in research. Methods: Therefore, due to successful results from studies developed with these methods, the present study aimed to evaluate the myorelaxant effect of the Results: The EODa relaxed the smooth muscle of swine coronary arteries precontracted with K Conclusions: Moreover, the results reveal the possibility of using the EODa in vascular disease studies since it promoted the relaxation of the Sus scrofa domesticus coronary smooth muscle.
MeSH term(s)	Animals ; Chenopodiaceae/chemistry ; Coronary Vessels/drug effects ; Coronary Vessels/physiology ; Cyclohexane Monoterpenes/pharmacology ; Disease Models, Animal ; Drosophila melanogaster/drug effects ; Drosophila melanogaster/physiology ; Motor Activity/drug effects ; Muscle Contraction/drug effects ; Muscle Relaxation/drug effects ; Oils, Volatile/pharmacology ; Oils, Volatile/toxicity ; Phytochemicals/analysis ; Serotonin/pharmacology ; Swine ; Toxicity Tests
Chemical Substances	Cyclohexane Monoterpenes ; Oils, Volatile ; Phytochemicals ; Serotonin (333DO1RDJY) ; gamma-terpinene (4YGF4PQP49)
Language	English
Publishing date	2021-04-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26072041
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Article: Mechanisms of Actions Involved in The Antinociceptive Effect of Estragole and its

da Costa, Roger Henrique Sousa / Martins, Anita Oliveira Brito Pereira Bezerra / Pessoa, Renata Torres / Alshehri, Saad Ali / Wahab, Shadma / Ahmad, Md Faruque / Suliman, Muath / da Silva, Lucas Yure Santos / Alcântara, Isabel Sousa / Ramos, Andreza Guedes Barbosa / Oliveira, Maria Rayane Correia de / Batista, Francisco Lucas Alves / Delmondes, Gyllyandeson de Araújo / de Farias, Pablo Antonio Maia / Rocha, Janaína Esmeraldo / Coutinho, Henrique Douglas Melo / Raposo, António / Carrascosa, Conrado / Jaber, José Raduan /

de Menezes, Irwin Rose Alencar

Plants (Basel, Switzerland)

2022 Volume 11, Issue 21

Abstract: 1) Background: estragole is a monoterpene found in the essential oils of several aromatic plants, which can be used for several pharmacological activities. The aim of this study was to evaluate the antinociceptive effect of estragole (Es) and ... ...

Abstract	(1) Background: estragole is a monoterpene found in the essential oils of several aromatic plants, which can be used for several pharmacological activities. The aim of this study was to evaluate the antinociceptive effect of estragole (Es) and its
Language	English
Publishing date	2022-10-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants11212854
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Article ; Online: Ximenia americana L.

Renata Torres Pessoa / Isabel Sousa Alcântara / Lucas Yure Santos da Silva / Roger Henrique Souza da Costa / Tarcísio Mendes Silva / Cícera Datiane de Morais Oliveira-Tintino / Andreza Guedes Barbosa Ramos / Maria Rayane Correia de Oliveira / Anita Oliveira Brito Pereira Bezerra Martins / Bruna Caroline Gonçalves Vasconcelos de Lacerda / Edlane Martins de Andrade / Jaime Ribeiro-Filho / Clara Mariana Gonçalves Lima / Henrique Douglas Melo Coutinho / Irwin Rose Alencar de Menezes

Analytica, Vol 4, Iss 12, Pp 141-

Chemical Characterization and Gastroprotective Effect

2023 Volume 158

Abstract: Ximenia americana L., popularly known in Brazil as “ameixa do-mato, ameixa-brava, and ameixa-do-sertão,” is widely used in folk medicine to treat several intestinal disorders. The present study assessed the potential mechanisms of action underlying the ... ...

Abstract	Ximenia americana L., popularly known in Brazil as “ameixa do-mato, ameixa-brava, and ameixa-do-sertão,” is widely used in folk medicine to treat several intestinal disorders. The present study assessed the potential mechanisms of action underlying the gastroprotective activity of the hydroethanolic extract of Ximenia americana L. (EHXA) stem bark. The acute toxicity of EHXA was estimated, and later, the gastroprotective effect in mice was assessed through acute models of gastric lesions induced by acidified or absolute ethanol and indomethacin, where the following mechanisms were pharmacologically analyzed: the involvement of prostaglandins (PG), histamine (H 2 ) receptors, ATP-dependent potassium channels, sulfhydryl groups (SH), α 2 adrenergic receptors, nitric oxide (NO), myeloperoxidase (MPO), gastric mucus production, and acetylcholine-mediated intestinal motility. Regarding toxicity, EHXA did not cause deaths or signs of toxicity (LD 50 greater than or equal to 2000 mg/kg/p.o.). When the gastroprotective effect was assessed, EHXA (50, 100, and 200 mg/kg/p.o.) reduced the rate of lesions induced by acidified ethanol by 65.63; 53.66, and 58.02% in absolute ethanol at 88.91, 78.82, and 74.68%, respectively, when compared to the negative control group. In the indomethacin-induced gastric injury model, the reductions were 84.69, 55.99, 55.99, and 42.50%, respectively. The study revealed that EHXA might stimulate mucus production and reduce intestinal motility through SH groups, NO production, and activation of α 2 adrenergic receptors. The results indicated that EHXA had significant gastroprotective activity in the evaluated models. However, further investigation is required to elucidate the cellular and molecular events underlying the action of EHXA components and to correlate them with the modulation of the signaling pathways, as demonstrated by the current pharmacological approach. Therefore, the results demonstrated in the present study, as well as previously reported findings, support the recommendation ...
Keywords	Ximenia americana L ; EHXA ; gastroprotective activity ; preclinical research ; Analytical chemistry ; QD71-142
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Myorelaxant Effect of the Dysphania ambrosioides Essential Oil on Sus scrofa domesticus Coronary Artery and Its Toxicity in the Drosophila melanogaster Model

Luiz Jardelino de Lacerda Neto / Andreza Guedes Barbosa Ramos / Renata Evaristo Rodrigues da Silva / Luís Pereira-de-Morais / Fernanda Maria Silva / Roger Henrique Sousa da Costa / Lindaiane Bezerra Rodrigues Dantas / José Galberto Martins da Costa / Henrique Douglas Melo Coutinho / Grażyna Kowalska / Joanna Hawlena / Radosław Kowalski / Roseli Barbosa / Francisco Assis Bezerra da Cunha

Molecules, Vol 26, Iss 2041, p

2021 Volume 2041

Abstract	Purpose: Alternative methods for the use of animals in research have gained increasing importance, due to assessments evaluating the real need for their use and the development of legislation that regulates the subject. The principle of the 3R’s (replacement, reduction and refinement) has been an important reference, such that in vitro, ex vivo and cord replacement methods have achieved a prominent place in research. Methods: Therefore, due to successful results from studies developed with these methods, the present study aimed to evaluate the myorelaxant effect of the Dysphania ambrosioides essential oil (EODa) using a Sus scrofa domesticus coronary artery model, and the toxicity of both the Dysphania ambrosioides essential oil and its major constituent, α-terpinene, against Drosophila melanogaster in toxicity and negative geotaxis assays. Results: The EODa relaxed the smooth muscle of swine coronary arteries precontracted with K + and 5-HT in assays using Sus scrofa domesticus coronary arteries. The toxicity results presented LC 50 values of 1.546 mg/mL and 2.282 mg/mL for the EODa and α-terpinene, respectively, thus showing the EODa and α-terpinene presented toxicity to these dipterans, with the EODa being more toxic. Conclusions: Moreover, the results reveal the possibility of using the EODa in vascular disease studies since it promoted the relaxation of the Sus scrofa domesticus coronary smooth muscle.
Keywords	essential oil ; natural product ; myorelaxative activity ; toxicity ; Organic chemistry ; QD241-441
Subject code	590
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Biological properties of terpinolene evidenced by in silico, in vitro and in vivo studies: A systematic review

Phytomedicine. 2021 Dec., v. 93

2021

Abstract: Terpinolene, a monoterpene that is naturally found in a variety of herbs, is widely used as a flavoring agent in the industry. Although it's well established in the literature that terpinolene is an important component of plant extracts, the biological ... ...

Abstract	Terpinolene, a monoterpene that is naturally found in a variety of herbs, is widely used as a flavoring agent in the industry. Although it's well established in the literature that terpinolene is an important component of plant extracts, the biological properties and the potential therapeutic use of this compound remain poorly explored.This work aimed to answer the following guiding question: "What are the biological activities of terpinolene demonstrated through in silico, in vitro, and in vivo assays?".A systematic review was carried out in four electronic databases (Embase, Web of Science, Scopus, and PubMed) according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, using the following search terms: terpinolene “AND” activity “OR” properties “OR” therapeutic “OR” treatment. This search included manuscripts published between 1960 and June 2020. Study selection was conducted by two independent reviewers according to predefined criteria.The initial search found a total of 2449 articles. However, only 57 of them were selected as they met the inclusion criteria and answered the guiding question. The analysis of these studies indicated that terpinolene presents a series of biological effects, from which the antioxidant, larvicide, and insecticide activities stand out. Despite the evidence demonstrating that terpinolene has the potential to be used in a broad pharmacological context, the mechanisms underlying its cellular and molecular effects remain to be better elucidated. In addition, the in vivo efficacy and safety of the administration of this compound have been poorly evaluated through either preclinical and clinical trials. Therefore, this study highlights the importance of characterizing the biological aspects and mechanisms of action of this natural compound.The data summarized in the present systematic review demonstrates the pharmacological potential of terpinolene. Nevertheless, most studies included in this review provide a superficial characterization of terpinolene biological effects and therefore, further research elucidating its mechanism of action and potential therapeutic benefits through preclinical and clinical trials are required. Nevertheless, due to its wide range of different biological activities, terpinolene will certainly attract the interest of scientific research, which could significantly contribute to the development of new products with both therapeutic and environmental applications.
Keywords	antioxidants ; computer simulation ; industry ; insecticides ; larvicides ; mechanism of action ; meta-analysis ; monoterpenoids ; systematic review ; terpinolene ; therapeutics
Language	English
Dates of publication	2021-12
Publishing place	Elsevier GmbH
Document type	Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2021.153768
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