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Article ; Online: Guiding Principles for Adolescent Web-Based Portal Access Policies: Interviews With Informatics Administrators.

Sisk, Bryan / Antes, Alison L / Bereitschaft, Christine / Enloe, Madi / Bourgeois, Fabienne / DuBois, James

JMIR pediatrics and parenting

2024 Volume 7, Page(s) e49177

Abstract: Background: Web-based patient portals are tools that could support adolescents in managing their health and developing autonomy. However, informatics administrators must navigate competing interests when developing portal access policies for adolescents ...

Abstract	Background: Web-based patient portals are tools that could support adolescents in managing their health and developing autonomy. However, informatics administrators must navigate competing interests when developing portal access policies for adolescents and their parents. Objective: We aimed to assess the perspectives of informatics administrators on guiding principles for the development of web-based health care portal access policies in adolescent health care. Methods: We interviewed informatics administrators from US hospitals with ≥50 dedicated pediatric beds. We performed a thematic analysis of guiding principles for developing and implementing adolescent portal access policies. Results: We interviewed 65 informatics leaders who represented 63 pediatric hospitals, 58 health care systems, 29 states, and 14,379 pediatric hospital beds. Participants described 9 guiding principles related to three overarching themes: (1) balancing confidentiality and other care needs, (2) balancing simplicity and granularity, and (3) collaborating and advocating. Participants described the central importance of prioritizing the health and safety of the adolescent while also complying with state and federal laws. However, there were differing beliefs about how to prioritize health and safety and what role parents should play in supporting the adolescent's health care. Participants also identified areas where clinicians and institutions can advocate for adolescents, especially with electronic health record vendors and legislators. Conclusions: Informatics administrators provided guiding principles for adolescent portal access policies that aimed to balance the competing needs of adolescent confidentiality and the usefulness of the portal. Portal access policies must prioritize the adolescent's health and safety while complying with state and federal laws. However, institutions must determine how to best enact these principles. Institutions and clinicians should strive for consensus on principles to strengthen advocacy efforts with institutional leadership, electronic health record vendors, and lawmakers.
Language	English
Publishing date	2024-03-11
Publishing country	Canada
Document type	Journal Article
ISSN	2561-6722
ISSN (online)	2561-6722
DOI	10.2196/49177
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Article ; Online: Hydrology Predominates Over Harvest History and Landscape Variation to Control Water Quality and Disinfection Byproduct Formation Potentials in Forested Pacific Coast Watersheds.

Bourgeois, Alyssa K / Tank, Suzanne E / Floyd, William C / Emelko, Monica B / Amiri, Fariba

ACS ES&T water

2024 Volume 4, Issue 4, Page(s) 1335–1345

Abstract: Despite the global importance of forested watersheds as sources of drinking water, few studies have examined the effects of forestry on drinking water treatability. Relatively little is known about how the interaction between landscape variation and flow ...

Abstract	Despite the global importance of forested watersheds as sources of drinking water, few studies have examined the effects of forestry on drinking water treatability. Relatively little is known about how the interaction between landscape variation and flow impacts source water quality and what this interaction means for drinking water treatability. To address this knowledge gap, we examined variability in sediments, dissolved organic matter, and disinfection byproduct formation potentials (DBP-FPs) across a range of flow conditions in four small watersheds with contrasting forest harvest histories and soil characteristics on Vancouver Island. Storm event-driven change in streamflow was the primary driver of water quality and DBP-FPs at our sites, with greater changes during stormflow (e.g., a 3-fold increase in dissolved organic carbon concentrations) than those across contrasting watersheds. Flow-driven changes in water quality and DBP-FPs were not significantly different across watersheds with different harvest histories; muted responses may be attributed to widespread second growth forests (i.e., recent harvesting effects may be confounded by historical harvest), forestry practices (e.g., slash burning), or soils with low organic carbon storage. This study suggests that variation in hydrology predominates over harvest history and soil characteristics to drive water quality and DBP-FPs on the east coast of Vancouver Island.
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ISSN	2690-0637
ISSN (online)	2690-0637
DOI	10.1021/acsestwater.3c00471
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Article ; Online: Advancing Plasmon-Induced Selectivity in Chemical Transformations with Optically Coupled Transmission Electron Microscopy.

Swearer, Dayne F / Bourgeois, Briley B / Angell, Daniel K / Dionne, Jennifer A

Accounts of chemical research

2021 Volume 54, Issue 19, Page(s) 3632–3642

Abstract: Nanoparticle photocatalysts are essential to processes ranging from chemical production and water purification to air filtration and surgical instrument sterilization. Photochemical reactions are generally mediated by the illumination of metallic and/or ... ...

Abstract	Nanoparticle photocatalysts are essential to processes ranging from chemical production and water purification to air filtration and surgical instrument sterilization. Photochemical reactions are generally mediated by the illumination of metallic and/or semiconducting nanomaterials, which provide the necessary optical absorption, electronic band structure, and surface faceting to drive molecular reactions. However, with reaction efficiency and selectivity dictated by atomic and molecular interactions, imaging and controlling photochemistry at the atomic scale are necessary to both understand reaction mechanisms and to improve nanomaterials for next-generation catalysts. Here, we describe how advances in plasmonics, combined with advances in electron microscopy, particularly optically coupled transmission electron microscopy (OTEM), can be used to image and control light-induced chemical transformations at the nanoscale. We focus on our group's research investigating the interaction between hydrogen gas and Pd nanoparticles, which presents an important model system for understanding both hydrogenation catalysis and hydrogen storage. The studies described in this Account primarily rely on an environmental transmission electron microscope, a tool capable of circumventing traditional TEM's high-vacuum requirements, outfitted with optical sources and detectors to couple light into and out of the microscope. First, we describe the H
Language	English
Publishing date	2021-09-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1483291-4
ISSN	1520-4898 ; 0001-4842
ISSN (online)	1520-4898
ISSN	0001-4842
DOI	10.1021/acs.accounts.1c00309
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Article ; Online: The Link between Deployment-Related Injuries and Suicidal Thinking in the Army National Guard: Examining the Role of Perceived Burdensomeness and Hopelessness.

Pardue-Bourgeois, Sarah / Goldberg, Simon B / Wyman, Mary F / Abbas, Maleeha / Flynn, Anthony W P / Domínguez, Sergio / Tucker, Raymond P

Archives of suicide research : official journal of the International Academy for Suicide Research

2023 , Page(s) 1–12

Abstract: Objective: In 2020, Army National Guard members demonstrated greater risk of suicide than their military and civilian counterparts. Though literature on deployment-related experiences and suicidal ideation (SI) is mixed, investigations of specific ... ...

Abstract	Objective: In 2020, Army National Guard members demonstrated greater risk of suicide than their military and civilian counterparts. Though literature on deployment-related experiences and suicidal ideation (SI) is mixed, investigations of specific deployment-related experiences (e.g., injuries) may further elucidate the relationship between deployment and suicide risk. Deployment-related injuries, including pain severity and functional impairment, have been linked to increased risk of SI, and correlates like perceived burdensomeness (PB) and hopelessness. The current study sought to examine the cross-sectional relationship between deployment-related injuries, including pain severity and functional impairment, and severity of SI through PB and hopelessness. Method: Immediately post-deployment, Army National Guard members ( Results: Indirect effect analyses revealed that experience of deployment-related injury was related to SI through PB and hopelessness ( Conclusions: Army National Guard members who develop a sense of PB related to their injury and functional impairment of that injury may be at increased risk for suicidal ideation. Military suicide-prevention efforts may be potentiated through targeting distorted cognitions such as PB and hopelessness, especially in service members who have been injured.
Language	English
Publishing date	2023-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1283671-0
ISSN	1543-6136 ; 1381-1118
ISSN (online)	1543-6136
ISSN	1381-1118
DOI	10.1080/13811118.2023.2270667
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Article ; Online: Master Protocols and Adaptive Trial Designs to Develop Tumor-Agnostic Drugs for Children: Essential Tools in the Era of the Research to Accelerate Cures and Equity Act.

Arfè, Andrea / Silverman, Lewis B / Bourgeois, Florence

JAMA oncology

2021 Volume 7, Issue 9, Page(s) 1281–1282

MeSH term(s)	Child ; Humans ; Neoplasms/drug therapy ; Research Design
Language	English
Publishing date	2021-06-10
Publishing country	United States
Document type	Journal Article
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2021.1508
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Article ; Online: Survey on infectious disease telephone hotlines in primary care: General practitioners' satisfaction and compliance with advice.

Sette, A-L / Pavese, P / Lesprit, P / Maillet, M / Bourgeois, G / Lutz, M-F / Baldeyrou, M / Mondain, V / Suy, F / Contejean, A / Diamantis, S / Poitrenaud, D / Touati, S / Boussat, B / François, P

Infectious diseases now

2023 Volume 53, Issue 8, Page(s) 104775

Abstract: Objectives: Infectious disease (ID) advice is a major part of antimicrobial stewardship programs. The objective of this study was to assess general practitioners' (GPs)' opinions and compliance with advice given by ID hotlines.: Patients and methods: ...

Abstract	Objectives: Infectious disease (ID) advice is a major part of antimicrobial stewardship programs. The objective of this study was to assess general practitioners' (GPs)' opinions and compliance with advice given by ID hotlines. Patients and methods: This multicenter survey was based on the 7-day assessment of initial advice requested by GPs to a hotline set up by volunteer hospital ID teams to record advice for 3 years. The primary endpoint was the GPs' satisfaction with the advice given by ID specialists. Results: Ten ID teams participated in the study and recorded 4138 requests for advice, of which 1325 requests included a proposal for antibiotic therapy and justified a follow-up call at seven days. Only 398 follow-up calls (30%) were carried out because many GPs were not reachable. GPs were very satisfied with ID hotlines: 58% considered them indispensable and 38% very useful. The recommendations provided by ID specialists were followed by GPs in more than 80% of cases. The two main motivations for GPs to call the hotline were to get quick advice (86%) and to receive help in managing a patient (76%). Conclusions: The ID telephone consultations and advice systems for GPs are highly appreciated and are effective in terms of following the recommendations.
MeSH term(s)	Humans ; General Practitioners ; Hotlines ; Communicable Diseases/drug therapy ; Surveys and Questionnaires ; Primary Health Care
Language	English
Publishing date	2023-08-25
Publishing country	France
Document type	Multicenter Study ; Journal Article
ISSN	2666-9919
ISSN (online)	2666-9919
DOI	10.1016/j.idnow.2023.104775
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Article ; Online: Identification of macaque dendritic cell precursors in blood and tissue reveals their dysregulation in early SIV infection.

Gardet, Margaux / Haigh, Oscar / Meurisse, Florian / Coindre, Sixtine / Dimant, Nastasia / Desjardins, Delphine / Bourgeois, Christine / Goujard, Cecile / Vaslin, Bruno / Relouzat, Francis / Le Grand, Roger / Lambotte, Olivier / Favier, Benoit

Cell reports

2024 Volume 43, Issue 4, Page(s) 113994

Abstract: Distinct dendritic cell (DC) subsets play important roles in shaping immune responses. Circulating DC precursors (pre-DCs) are more susceptible to HIV infection in vitro, which may explain the inefficiency of immune responses against HIV. However, the ... ...

Abstract	Distinct dendritic cell (DC) subsets play important roles in shaping immune responses. Circulating DC precursors (pre-DCs) are more susceptible to HIV infection in vitro, which may explain the inefficiency of immune responses against HIV. However, the interplay between HIV and pre-DC is not defined in vivo. We identify human pre-DC equivalents in the cynomolgus macaque and then analyze their dynamics during simian immunodeficiency virus (SIV) infection to illustrate a sharp decrease of blood pre-DCs in early SIV infection and accumulation in lymph nodes (LNs), where they neglect to upregulate CD83/CD86 or MHC-II. Additionally, SIV infection attenuates the capacity of stimulated LN pre-DCs to produce IL-12p40. Analysis of HIV cohorts provides correlation between costimulatory molecule expression on pre-DCs and T cell activation in spontaneous HIV controllers. These findings pinpoint certain dynamics and functional changes of pre-DCs during SIV infection, providing a deeper understanding of immune dysregulation mechanisms elicited in people living with HIV.
MeSH term(s)	Animals ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Acquired Immunodeficiency Syndrome/blood ; Simian Acquired Immunodeficiency Syndrome/pathology ; Dendritic Cells/immunology ; Simian Immunodeficiency Virus/immunology ; Humans ; Lymph Nodes/immunology ; Lymph Nodes/pathology ; HIV Infections/immunology ; HIV Infections/virology ; HIV Infections/blood ; HIV Infections/pathology ; Macaca fascicularis ; Lymphocyte Activation/immunology
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2024.113994
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Article: Factors associated with adverse outcome among children with sickle cell disease admitted to the pediatric intensive care unit: an observational cohort.

Levy, Michaël / Naudin, Jérôme / Geslain, Guillaume / Maroni, Arielle / Koehl, Bérengère / Le Bourgeois, Fleur / Poncelet, Géraldine / Chomton, Maryline / Deho, Anna / Julliand, Sébastien / Dauger, Stéphane / Sommet, Julie

Annals of intensive care

2024 Volume 14, Issue 1, Page(s) 55

Abstract: Background: Sickle cell disease (SCD) is one of the most frequent inherited diseases in the world. Over the last decades, in high-income countries, an important decrease in mortality have been observed due to the improvement of care. However, children ... ...

Abstract	Background: Sickle cell disease (SCD) is one of the most frequent inherited diseases in the world. Over the last decades, in high-income countries, an important decrease in mortality have been observed due to the improvement of care. However, children with SCD can become critically ill and require admission in Pediatric Intensive Care Units (PICU). The purpose of this study was to describe the epidemiology of children with SCD admitted to PICU for acute crisis and to identify factors associated with adverse outcome (AO). Methods: We conducted a retrospective study in a Tertiary Hospital in France including all consecutive children with SCD admitted to PICU between January 1st, 2009 and December 31, 2019. We collected baseline patient's characteristics, clinical and biological data as well as treatments and life sustaining therapies used in the PICU. Patients were defined as experiencing AO in case of death during stay and/or need for invasive mechanical ventilation (MV) and/or for non-invasive ventilation (NIV) for more than 3 days and/or need for vasopressors and/or need for renal replacement therapy. Results: We included 579 admissions in 395 patients, mainly of SS genotype (90%) with a median age of 9.2 years [5.5-13.4] and a median baseline hemoglobin of 8.0 g/dl (7.5-8.8). The two main reasons for admission were acute chest syndrome (ACS) (n = 331, 57%) and vaso-occlusive crisis refractory to first line therapy (n = 99, 17%). Half of patients required NIV and 47 (8%) required MV. The overall length of stay was 3 days [1-4] and seven (1%) patients died during PICU stay.There was a total of 113 (20%) admissions with AO and on multivariable analysis, baseline hemoglobin < 8 g/dL, history of bronchial obstruction and admission for ACS were associated with AO. There was no difference in the proportion of hydroxyurea treatment or exchange transfusion program between patients with AO and the other patients. Conclusions: Baseline hemoglobin < 8 g/dL, history of bronchial obstruction and admission for ACS were the strongest risk factors for severe evolution in SCD children admitted to PICU. These factors could be taken into consideration when choosing the adequate therapeutic options.
Language	English
Publishing date	2024-04-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2617094-2
ISSN	2110-5820
ISSN	2110-5820
DOI	10.1186/s13613-024-01283-5
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Article ; Online: Development and Initial Validation of the Functional External Memory Aid Tool.

Lanzi, Alyssa / Bourgeois, Michelle S / Dedrick, Robert F

American journal of speech-language pathology

2020 Volume 29, Issue 2, Page(s) 611–624

Abstract: ... a) Medical Tasks, (b) Instrumental Daily Tasks, and (c) Retrieval-Based Tasks. Internal consistency (Phase 2 ...

Abstract	Purpose The purpose of this study was to develop the item pool and investigate the structure and measurement properties of the Functional External Memory Aid Tool (FEMAT), a performance-based measure of everyday strategy use for persons with mild memory impairments. The FEMAT examines one's use of strategies to compensate for cognitive communication impairments that interfere with the completion of complex daily tasks. Method During Phase 1, six expert panel members reviewed the initial item pool and scoring rubric to assess item verification. Each item was developed to elicit strategy use and represent a complex daily task. During Phase 2, 99 participants with possible mild neurocognitive disorder (as determined by screening procedures) responded to 11 items. The factor structure of the data was analyzed using confirmatory factor analysis. Reliability and relationships between the FEMAT and additional factors were also examined. Results The process of development (Phase 1) resulted in 11 items distributed among three factors: (a) Medical Tasks, (b) Instrumental Daily Tasks, and (c) Retrieval-Based Tasks. Internal consistency (Phase 2), assessed with confirmatory factor analysis, confirmed the proposed three-factor model. Reliability analyses revealed at least 62%-84% of within-test score variance was due to true score variance. Correlation analyses indicated weak and strong relationships between the FEMAT and participant demographic variables and additional assessment measures. Conclusions The FEMAT provides reliable measurement of everyday external memory aid use in persons with possible mild neurocognitive disorder. The FEMAT was designed to be used in clinical settings and to provide better guidance to clinicians to design person-centered interventions than currently available cognitive communication measures.
MeSH term(s)	Cognitive Dysfunction ; Factor Analysis, Statistical ; Humans ; Memory ; Memory Disorders/diagnosis ; Psychometrics ; Reproducibility of Results ; Surveys and Questionnaires
Language	English
Publishing date	2020-02-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1154406-5
ISSN	1558-9110 ; 1058-0360
ISSN (online)	1558-9110
ISSN	1058-0360
DOI	10.1044/2019_AJSLP-19-00075
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Article ; Online: The effects of microstructure, Nb content and secondary Ruddlesden-Popper phase on thermoelectric properties in perovskite CaMn

Ekström, E / le Febvrier, A / Bourgeois, F / Lundqvist, B / Palisaitis, J / Persson, P O Å / Caballero-Calero, O / Martín-González, M S / Klarbring, J / Simak, S I / Eriksson, F / Paul, B / Eklund, P

RSC advances

2020 Volume 10, Issue 13, Page(s) 7918–7926

Abstract: ... ...

Abstract	CaMn
Language	English
Publishing date	2020-02-24
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c9ra10007e
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