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  1. Article ; Online: Trial of Intravenous Alteplase before Endovascular Treatment for Stroke. Reply.

    LeCouffe, Natalie E / Kappelhof, Manon / Roos, Yvo B W E M

    The New England journal of medicine

    2022  Volume 386, Issue 5, Page(s) 496–497

    MeSH term(s) Administration, Intravenous ; Fibrinolytic Agents/therapeutic use ; Humans ; Stroke/drug therapy ; Tissue Plasminogen Activator/therapeutic use
    Chemical Substances Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2119227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Advancements in diagnostic and interventional radiology for stroke treatment: the path from trial to bedside through the pre-MR CLEAN, MR CLEAN, and MR CLEAN II eras.

    Samuels, Noor / van de Graaf, Rob A / Roos, Yvo B W M / Dippel, Diederik / van der Lugt, Aad

    Insights into imaging

    2024  Volume 15, Issue 1, Page(s) 30

    Abstract: The stroke field is inevitably connected with imaging in which radiologists fulfill a central role. Our landmark MR CLEAN trial led to the implementation of baseline computed tomography angiography or magnetic resonance angiography in the acute stroke ... ...

    Abstract The stroke field is inevitably connected with imaging in which radiologists fulfill a central role. Our landmark MR CLEAN trial led to the implementation of baseline computed tomography angiography or magnetic resonance angiography in the acute stroke workup and subsequent endovascular treatment (EVT) for ischemic stroke patients with a large vessel occlusion in the anterior circulation, resulting in numerous patients worldwide currently being treated often successfully. A reversal of the pathophysiologic process behind an acute cerebrovascular event was made possible. Subsequently, in the MR CLEAN II trials, the clinical impact of both diagnostic and interventional radiologists remained a cornerstone of our research, which means value-based radiology. Within these MR CLEAN II trials, we proved that aspirin and heparin during EVT should be avoided due to increased symptomatic intracranial hemorrhage risk (MR CLEAN-MED). We concluded there is additional benefit of EVT in the 6-to-24-h window after stroke in the presence of good collaterals on baseline CTA (MR CLEAN-LATE). The impactful success of our stroke trials that changed many guidelines was mainly attributable to (1) the societal burden of the disease, with two thirds of patients dying or being independent at 3 months; (2) the fact that stroke is a common disease, (3) the relatively simple and pragmatic approach of the trials resembling real-world setting; (4) the acceleration of implementation in clinical practice facilitated by a structured approach to guideline development and conditional funding; and foremost (5) the excellent collaboration on a professional level between-disciplines, i.e., diagnostic radiologists, interventionalists, and neurologists.Critical relevance statement The MR CLEAN and MR CLEAN II trials have had tremendous impact on clinical practice, directly by more patients being treated with an effective intervention and indirectly through adoption of evidence-based guidelines. It is in this setting of stroke treatment that diagnostic and interventional radiologists have played a crucial role and created clinical impact.
    Language English
    Publishing date 2024-01-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2543323-4
    ISSN 1869-4101
    ISSN 1869-4101
    DOI 10.1186/s13244-023-01597-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Clinical Outcome in Patients With Intracerebral Hemorrhage Stratified by Type of Antithrombotic Therapy.

    Baharoglu, Merih Irem / Coutinho, Jonathan M / Marquering, Henk A / Majoie, Charles B / Roos, Yvo B

    Frontiers in neurology

    2021  Volume 12, Page(s) 684476

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-06-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.684476
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  4. Article ; Online: Blood pressure reduction and intravenous thrombolysis.

    Kruyt, Nyika D / Roos, Yvo B / Nederkoorn, Paul J

    Lancet (London, England)

    2019  Volume 394, Issue 10199, Page(s) e24

    MeSH term(s) Blood Pressure ; Brain Ischemia ; Humans ; Stroke ; Thrombolytic Therapy ; Tissue Plasminogen Activator
    Chemical Substances Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2019-09-11
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)31624-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
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    Zs.MG 94: Show issues

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  5. Article: Leukocyte Count Predicts Carotid Artery Stenosis in Men with Ischemic Stroke: Sub Study of the Preventive Antibiotics in Stroke Study (PASS).

    van Velzen, Twan J / Stolp, Jeffrey / Westendorp, Willeke F / Roos, Yvo B W E M / van de Beek, Diederik / Nederkoorn, Paul J

    Journal of clinical medicine

    2022  Volume 11, Issue 24

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2022-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11247286
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  6. Article ; Online: Impact of time to start of tranexamic acid treatment on rebleed risk and outcome in aneurysmal subarachnoid hemorrhage.

    Germans, Menno R / Tjerkstra, Maud A / Post, René / Brenner, Amy / Vergouwen, Mervyn DI / Rinkel, Gabriël Je / Roos, Yvo Bwem / van den Berg, René / Coert, Bert A / Vandertop, W Peter / Verbaan, Dagmar

    European stroke journal

    2024  , Page(s) 23969873241246591

    Abstract: Introduction: The ULTRA-trial investigated effectiveness of ultra-early administration of tranexamic acid (TXA) in subarachnoid hemorrhage (SAH) and showed that TXA reduces the risk of rebleeding without concurrent improvement in clinical outcome. ... ...

    Abstract Introduction: The ULTRA-trial investigated effectiveness of ultra-early administration of tranexamic acid (TXA) in subarachnoid hemorrhage (SAH) and showed that TXA reduces the risk of rebleeding without concurrent improvement in clinical outcome. Previous trials in bleeding conditions, distinct from SAH, have shown that time to start of antifibrinolytic treatment influences outcome. This post-hoc analysis of the ULTRA-trial investigates whether the interval between hemorrhage and start of TXA impacts the effect of TXA on rebleeding and functional outcome following aneurysmal SAH.
    Patients and methods: A post-hoc comparative analysis was conducted between aneurysmal SAH patients of the ULTRA-trial, receiving TXA and usual care to those receiving usual care only. We assessed confounders, hazard ratio (HR) of rebleeding and odds ratio (OR) of good outcome (modified Rankin Scale 0-3) at 6 months, and investigated the impact of time between hemorrhage and start of TXA on the treatment effect, stratified into time categories (0-3, 3-6 and >6 h).
    Results: Sixty-four of 394 patients (16.2%) in the TXA group experienced a rebleeding, compared to 83 of 413 patients (19.9%) with usual care only (HR 0.86, 95% confidence interval (CI): 0.62-1.19). Time to start of TXA modifies the effect of TXA on rebleeding rate (
    Discussion and conclusions: This study suggests that the effect of TXA on rebleeding is modified by time to treatment, providing a protective, albeit clinically non-relevant, effect only when started after 6 h. No difference in functional outcome was seen. Routine TXA treatment in the aneurysmal SAH population, even within a specified time frame, is not recommended to improve functional outcome.
    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2851287-X
    ISSN 2396-9881 ; 2396-9873
    ISSN (online) 2396-9881
    ISSN 2396-9873
    DOI 10.1177/23969873241246591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cost-effectiveness of tenecteplase versus alteplase for acute ischemic stroke.

    Nguyen, Chi Phuong / Lahr, Maarten Mh / van der Zee, Durk-Jouke / van Voorst, Henk / Roos, Yvo Bwem / Uyttenboogaart, Maarten / Buskens, Erik

    European stroke journal

    2023  Volume 8, Issue 3, Page(s) 638–646

    Abstract: Introduction: Alteplase is widely used as an intravenous thrombolytic drug in acute ischemic stroke (AIS). Recently however, tenecteplase, a modified form of tissue plasminogen activator, has been shown to increase early recanalization rate and has ... ...

    Abstract Introduction: Alteplase is widely used as an intravenous thrombolytic drug in acute ischemic stroke (AIS). Recently however, tenecteplase, a modified form of tissue plasminogen activator, has been shown to increase early recanalization rate and has proven to be non-inferior with a similar safety profile compared to alteplase. This study aims to evaluate the cost-effectiveness of 0.25 mg/kg tenecteplase versus 0.9 mg/kg alteplase for intravenous thrombolysis in AIS patients from the Dutch healthcare payer perspective.
    Methods: A Markov decision-analytic model was constructed to assess total costs, total quality-adjusted life year (QALY), an incremental cost-effectiveness ratio, and incremental net monetary benefit (INMB) of two treatments at willingness-to-pay (WTP) thresholds of €50,000/QALY and €80,000/QALY over a 10-year time horizon. One-way sensitivity analysis, probabilistic sensitivity analysis, and scenario analysis were conducted to test the robustness of results. Clinical data were obtained from large randomized controlled trials and real-world data.
    Results: Treatment with tenecteplase saved €21 per patient while gaining 0.05 QALYs, resulting in INMB of €2381, clearly rendering tenecteplase cost-effective compared to alteplase. Importantly, tenecteplase remained the cost-effective alternative in all scenarios, including AIS patients due to large vessel occlusion (LVO). Probabilistic sensitivity analysis proved tenecteplase to be cost-effective with a 71.0% probability at a WTP threshold of €50,000/QALY.
    Conclusions: Tenecteplase treatment was cost-effective for all AIS patients (including AIS patients with LVO) compared to alteplase. The finding supports the broader use of tenecteplase in acute stroke care, as health outcomes improve at acceptable costs while having practical advantages, and a similar safety profile.
    MeSH term(s) Humans ; Tissue Plasminogen Activator/therapeutic use ; Tenecteplase/therapeutic use ; Cost-Benefit Analysis ; Ischemic Stroke ; Stroke/drug therapy
    Chemical Substances Tissue Plasminogen Activator (EC 3.4.21.68) ; Tenecteplase (WGD229O42W)
    Language English
    Publishing date 2023-05-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2851287-X
    ISSN 2396-9881 ; 2396-9873
    ISSN (online) 2396-9881
    ISSN 2396-9873
    DOI 10.1177/23969873231174943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Two-Year Outcome after Endovascular Treatment for Stroke.

    van den Berg, Lucie A / Roos, Yvo B

    The New England journal of medicine

    2017  Volume 376, Issue 26, Page(s) 2597

    MeSH term(s) Brain Ischemia ; Endovascular Procedures ; Humans ; Stroke ; Treatment Outcome
    Language English
    Publishing date 2017--29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1705673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  9. Article: From Three-Months to Five-Years: Sustaining Long-Term Benefits of Endovascular Therapy for Ischemic Stroke.

    Ganesh, Aravind / Ospel, Johanna Maria / Marko, Martha / van Zwam, Wim H / Roos, Yvo B W E M / Majoie, Charles B L M / Goyal, Mayank

    Frontiers in neurology

    2021  Volume 12, Page(s) 713738

    Abstract: Background and Purpose: ...

    Abstract Background and Purpose:
    Language English
    Publishing date 2021-07-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.713738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Value of Automatically Derived Full Thrombus Characteristics: An Explorative Study of Their Associations with Outcomes in Ischemic Stroke Patients.

    Mojtahedi, Mahsa / Bruggeman, Agnetha E / van Voorst, Henk / Ponomareva, Elena / Kappelhof, Manon / van der Lugt, Aad / Hoving, Jan W / Dutra, Bruna G / Dippel, Diederik / Cavalcante, Fabiano / Yo, Lonneke / Coutinho, Jonathan / Brouwer, Josje / Treurniet, Kilian / Tolhuisen, Manon L / LeCouffe, Natalie / Arrarte Terreros, Nerea / Konduri, Praneeta R / van Zwam, Wim /
    Roos, Yvo / Majoie, Charles B L M / Emmer, Bart J / Marquering, Henk A

    Journal of clinical medicine

    2024  Volume 13, Issue 5

    Abstract: 1) ...

    Abstract (1)
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13051388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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