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Article ; Online: Survival Impact of an Enhanced Multidisciplinary Thoracic Oncology Conference in a Regional Community Health Care System.

Ray, Meredith A / Faris, Nicholas R / Fehnel, Carrie / Derrick, Anna / Smeltzer, Matthew P / Meadows-Taylor, Meghan B / Ariganjoye, Folabi / Pacheco, Alicia / Optican, Robert / Tonkin, Keith / Wright, Jeffrey / Fox, Roy / Callahan, Thomas / Robbins, Edward T / Walsh, William / Lammers, Philip / Satpute, Shailesh / Osarogiagbon, Raymond U

JTO clinical and research reports

2021 Volume 2, Issue 8, Page(s) 100203

Abstract: Introduction: We compared NSCLC treatment and survival within and outside a multidisciplinary model of care from a large community health care system.: Methods: We implemented a rigorously benchmarked "enhanced" Multidisciplinary Thoracic Oncology ... ...

Abstract	Introduction: We compared NSCLC treatment and survival within and outside a multidisciplinary model of care from a large community health care system. Methods: We implemented a rigorously benchmarked "enhanced" Multidisciplinary Thoracic Oncology Conference (eMTOC) and used Tumor Registry data (2011-2017) to evaluate guideline-concordant care. Because eMTOC was located in metropolitan Memphis, we separated non-MTOC patient by metropolitan and regional location. We categorized National Comprehensive Cancer Network guideline-concordant treatment as "preferred," or "appropriate" (allowable under certain circumstances). We compared demographic and clinical characteristics across cohorts using chi-square tests and survival using Cox regression, adjusted for multiple testing. We also performed propensity-matched and adjusted survival analyses. Results: Of 6259 patients, 14% were in eMTOC, 55% metropolitan non-MTOC, and 31% regional non-MTOC cohorts. eMTOC had the highest rates of African Americans (34% versus 28% versus 22%), stages I to IIIB (63 versus 40 versus 50), urban residents (81 versus 78 versus 20), stage-preferred treatment (66 versus 57 versus 48), guideline-concordant treatment (78 versus 70 versus 63), and lowest percentage of nontreatment (6 versus 21 versus 28); all Conclusions: Multidisciplinary NSCLC care planning was associated with significantly higher rates of guideline-concordant care and survival, providing evidence for rigorous implementation of this model of care.
Language	English
Publishing date	2021-07-03
Publishing country	United States
Document type	Journal Article
ISSN	2666-3643
ISSN (online)	2666-3643
DOI	10.1016/j.jtocrr.2021.100203
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Article ; Online: Antigen-specific tolerogenic and immunomodulatory strategies for the treatment of autoimmune arthritis.

Satpute, Shailesh R / Durai, Malarvizhi / Moudgil, Kamal D

Seminars in arthritis and rheumatism

2008 Volume 38, Issue 3, Page(s) 195–207

Abstract: Objectives: To review various antigen-specific tolerogenic and immunomodulatory approaches for arthritis in animal models and patients in regard to their efficacy, mechanisms of action, and limitations.: Methods: We reviewed the published literature ... ...

Abstract	Objectives: To review various antigen-specific tolerogenic and immunomodulatory approaches for arthritis in animal models and patients in regard to their efficacy, mechanisms of action, and limitations. Methods: We reviewed the published literature in Medline (PubMed) on the induction of antigen-specific tolerance and its effect on autoimmune arthritis, as well as the recent work on B-cell-mediated tolerance from our laboratory. The prominent key words used in different combinations included arthritis, autoimmunity, immunotherapy, innate immunity, tolerance, treatment, and rheumatoid arthritis (RA). Although this search spanned the years 1975 to 2007, the majority of the short-listed articles belonged to the period 1990 to 2007. The relevant primary as well as cross-referenced articles were then collected from links within PubMed and reviewed. Results: Antigen-specific tolerance has been successful in the prevention and/or treatment of arthritis in animal models. The administration of soluble native antigen or an altered peptide ligand intravenously, orally, or nasally, and the delivery of the DNA encoding a particular antigen by gene therapy have been the mainstay of immunomodulation. Recently, the methods for in vitro expansion of CD4+CD25+ regulatory T-cells have been optimized. Furthermore, interleukin-17 has emerged as a promising new therapeutic target in arthritis. However, in RA patients, non-antigen-specific therapeutic approaches have been much more successful than antigen-specific tolerogenic regimens. Conclusion: An antigen-specific treatment against autoimmune arthritis is still elusive. However, insights into newly emerging mechanisms of disease pathogenesis provide hope for the development of effective and safe immunotherapeutic strategies in the near future.
MeSH term(s)	Animals ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/therapy ; Disease Models, Animal ; Humans ; Immune Tolerance ; Immunologic Factors/therapeutic use ; Immunotherapy/methods
Chemical Substances	Immunologic Factors
Language	English
Publishing date	2008-01-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	120247-9
ISSN	1532-866X ; 0049-0172
ISSN (online)	1532-866X
ISSN	0049-0172
DOI	10.1016/j.semarthrit.2007.10.002
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Article: Tolerization with Hsp65 induces protection against adjuvant-induced arthritis by modulating the antigen-directed interferon-gamma, interleukin-17, and antibody responses.

Satpute, Shailesh R / Rajaiah, Rajesh / Polumuri, Swamy K / Moudgil, Kamal D

Arthritis and rheumatism

2008 Volume 60, Issue 1, Page(s) 103–113

Abstract: Objective: Pretreatment of Lewis rats with soluble mycobacterial Hsp65 affords protection against subsequent adjuvant-induced arthritis (AIA). This study was aimed at unraveling the mechanisms underlying mycobacterial Hsp65-induced protection against ... ...

Abstract	Objective: Pretreatment of Lewis rats with soluble mycobacterial Hsp65 affords protection against subsequent adjuvant-induced arthritis (AIA). This study was aimed at unraveling the mechanisms underlying mycobacterial Hsp65-induced protection against arthritis, using contemporary parameters of immunity. Methods: Lewis rats were given 3 intraperitoneal injections of mycobacterial Hsp65 in solution prior to the initiation of AIA with heat-killed Mycobacterium tuberculosis. Thereafter, mycobacterial Hsp65-specific T cell proliferative, cytokine, and antibody responses were tested in tolerized rats. The roles of anergy and the indoleamine 2,3 dioxygenase (IDO)-tryptophan pathway in tolerance induction were assessed, and the frequency and suppressive function of CD4+FoxP3+ Treg cells were monitored. Also tested was the effect of mycobacterial Hsp65 tolerization on T cell responses to AIA-related mycobacterial Hsp70, mycobacterial Hsp10, and rat Hsp65. Results: The AIA-protective effect of mycobacterial Hsp65-induced tolerance was associated with a significantly reduced T cell proliferative response to mycobacterial Hsp65, which was reversed by interleukin-2 (IL-2), indicating anergy induction. The production of interferon-gamma (but not IL-4/IL-10) was increased, with concurrent down-regulation of IL-17 expression by mycobacterial Hsp65-primed T cells. Neither the frequency nor the suppressive activity of CD4+FoxP3+ T cells changed following tolerization, but the serum level of anti-mycobacterial Hsp65 antibodies was increased. However, no evidence was observed for a role of IDO or cross-tolerance to mycobacterial Hsp70, mycobacterial Hsp10, or rat Hsp65. Conclusion: Tolerization with soluble mycobacterial Hsp65 leads to suppression of IL-17, anergy induction, and enhanced production of anti-mycobacterial Hsp65 antibodies, which play a role in protection against AIA. These results are relevant to the development of effective immunotherapeutic approaches for autoimmune arthritis.
MeSH term(s)	Animals ; Arthritis, Experimental/immunology ; Arthritis, Experimental/prevention & control ; Autoantibodies/immunology ; Bacterial Proteins/immunology ; Bacterial Proteins/pharmacology ; CD4 Antigens/metabolism ; Chaperonin 10/immunology ; Chaperonin 10/pharmacology ; Chaperonin 60 ; Chaperonins/immunology ; Chaperonins/pharmacology ; Cross Reactions/immunology ; Down-Regulation/immunology ; Forkhead Transcription Factors/metabolism ; HSP70 Heat-Shock Proteins/immunology ; HSP70 Heat-Shock Proteins/pharmacology ; Immune Tolerance/drug effects ; Immune Tolerance/immunology ; Injections, Intraperitoneal ; Interferon-gamma/metabolism ; Interleukin-17/metabolism ; Interleukin-2/metabolism ; Male ; Rats ; Rats, Inbred Lew ; Solubility ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Up-Regulation/immunology
Chemical Substances	Autoantibodies ; Bacterial Proteins ; CD4 Antigens ; Chaperonin 10 ; Chaperonin 60 ; Forkhead Transcription Factors ; Foxp3 protein, rat ; HSP70 Heat-Shock Proteins ; Interleukin-17 ; Interleukin-2 ; heat-shock protein 65, Mycobacterium ; Interferon-gamma (82115-62-6) ; Chaperonins (EC 3.6.1.-)
Language	English
Publishing date	2008-12-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	127294-9
ISSN	1529-0131 ; 0004-3591 ; 2326-5191
ISSN (online)	1529-0131
ISSN	0004-3591 ; 2326-5191
DOI	10.1002/art.24139
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Zs.A 24: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: The dynamics of articular leukocyte trafficking and the immune response to self heat-shock protein 65 influence arthritis susceptibility.

Mia, Md Y / Kim, Eugene Y / Satpute, Shailesh R / Moudgil, Kamal D

Journal of clinical immunology

2008 Volume 28, Issue 5, Page(s) 420–431

Abstract: Introduction: Adjuvant arthritis (AA) shares several features with human rheumatoid arthritis, and it can be induced in the Lewis (LEW) rat but not the Wistar Kyoto (WKY) rat (both RT.1(l)) by immunization with heat-killed Mycobacterium tuberculosis ( ... ...

Abstract	Introduction: Adjuvant arthritis (AA) shares several features with human rheumatoid arthritis, and it can be induced in the Lewis (LEW) rat but not the Wistar Kyoto (WKY) rat (both RT.1(l)) by immunization with heat-killed Mycobacterium tuberculosis (Mtb). We set out to unravel the mechanisms underlying the differential susceptibility to AA of these MHC-compatible rat strains. Materials and methods: We compared the levels of T-cell proliferative and cytokine response to the immunoregulatory self (rat) hsp65 (Rhsp65) after an arthritogenic (Mtb) challenge and the kinetics of migration of adoptively transferred, (111)Indium-labeled, Mtb-primed leukocytes into the hind paw joints of recipient rats. Results and discussion: The WKY rats raised a significantly higher level of T-cell proliferative response coupled with a temporally opposite cytokine profile against the disease-regulating Rhsp65 compared to that of LEW rats. Moreover, the arthritogenic leukocytes accumulated into the joints of WKY rats at significantly lower numbers than that in LEW rats. Conclusions: These results offer novel insights into the immune events influencing the pathogenesis of autoimmune arthritis.
MeSH term(s)	Adoptive Transfer ; Animals ; Arthritis, Experimental/blood ; Arthritis, Experimental/genetics ; Arthritis, Experimental/immunology ; Autoantigens/administration & dosage ; Autoantigens/immunology ; Bacterial Proteins/administration & dosage ; Bacterial Proteins/genetics ; Bacterial Proteins/immunology ; Cartilage, Articular/pathology ; Cell Movement/immunology ; Cell Proliferation ; Chaperonin 60 ; Chaperonins/administration & dosage ; Chaperonins/genetics ; Chaperonins/immunology ; Cytokines/metabolism ; Genetic Predisposition to Disease ; Heat-Shock Proteins/administration & dosage ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/immunology ; Histocompatibility Antigens/immunology ; Immune Tolerance ; Immunization ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/pathology ; Male ; Mycobacterium tuberculosis/immunology ; Rats ; Rats, Inbred Lew ; Rats, Inbred WKY ; Species Specificity
Chemical Substances	Autoantigens ; Bacterial Proteins ; Chaperonin 60 ; Cytokines ; Heat-Shock Proteins ; Histocompatibility Antigens ; heat-shock protein 65, Mycobacterium ; histocompatibility antigens RT, rat ; Chaperonins (EC 3.6.1.-)
Language	English
Publishing date	2008-05-15
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-008-9205-4
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Zs.A 1640: Show issues

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Article ; Online: B cells limit repair after ischemic acute kidney injury.

Jang, Hye Ryoun / Gandolfo, Maria Teresa / Ko, Gang Jee / Satpute, Shailesh R / Racusen, Lorraine / Rabb, Hamid

Journal of the American Society of Nephrology : JASN

2010 Volume 21, Issue 4, Page(s) 654–665

Abstract: There is no established modality to repair kidney damage resulting from ischemia-reperfusion injury (IRI). Early responses to IRI involve lymphocytes, but the role of B cells in tissue repair after IRI is unknown. Here, we examined B cell trafficking ... ...

Abstract	There is no established modality to repair kidney damage resulting from ischemia-reperfusion injury (IRI). Early responses to IRI involve lymphocytes, but the role of B cells in tissue repair after IRI is unknown. Here, we examined B cell trafficking into postischemic mouse kidneys and compared the repair response between control (wild-type) and muMT (B cell-deficient) mice with and without adoptive transfer of B cells. B cells infiltrated postischemic kidneys and subsequently activated and differentiated to plasma cells during the repair phase. Plasma cells expressing CD126 increased and B-1 B cells trafficked into postischemic kidneys with distinct kinetics. An increase in B lymphocyte chemoattractant in the kidney preceded B cell trafficking. Postischemic kidneys of muMT mice expressed higher IL-10 and vascular endothelial growth factor and exhibited more tubular proliferation and less tubular atrophy. Adoptive transfer of B cells into muMT mice reduced tubular proliferation and increased tubular atrophy. Treatment with anti-CD126 antibody increased tubular proliferation and reduced tubular atrophy in the late repair phase. These results demonstrate that B cells may limit the repair process after kidney IRI. Targeting B cells could have therapeutic potential to improve repair after IRI.
MeSH term(s)	Acute Kidney Injury/etiology ; Acute Kidney Injury/immunology ; Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/physiology ; Cell Differentiation ; Cell Movement ; Interleukin-6 Receptor alpha Subunit/biosynthesis ; Mice ; Plasma Cells/cytology ; Plasma Cells/immunology ; Reperfusion Injury/complications
Chemical Substances	Interleukin-6 Receptor alpha Subunit
Language	English
Publishing date	2010-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.2009020182
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Article: Mycobacterial Hsp65-IgG-expressing tolerogenic B cells confer protection against adjuvant-induced arthritis in Lewis rats.

Satpute, Shailesh R / Soukhareva, Nadejda / Scott, David W / Moudgil, Kamal D

Arthritis and rheumatism

2007 Volume 56, Issue 5, Page(s) 1490–1496

Abstract: Objective: Tolerization of T cells directed against a target autoantigen is a desired goal of experimental approaches for the treatment of autoimmune diseases, and novel and improved methods of tolerance induction are continuously being sought. Because ... ...

Abstract	Objective: Tolerization of T cells directed against a target autoantigen is a desired goal of experimental approaches for the treatment of autoimmune diseases, and novel and improved methods of tolerance induction are continuously being sought. Because most traditional methods of tolerance induction using soluble antigen are effective in the prevention of autoimmunity but fail to control established disease, this study was carried out to explore an innovative tolerogenic approach for the treatment of ongoing disease, using the rat adjuvant-induced arthritis (AIA) model of human rheumatoid arthritis. Methods: Lewis (RT.1(l)) rats were injected subcutaneously with heat-killed Mycobacterium tuberculosis H37Ra to induce AIA. Before or after AIA induction, Lewis rats were treated intraperitoneally (IP) with tolerogenic B cells expressing a fusion construct of mycobacterial 65-kd heat-shock protein (Hsp65) and IgG heavy-chain. For comparison, control rats were treated IP with ovalbumin (OVA)-IgG-expressing B cells or soluble mycobacterial Hsp65, and the effects on AIA were observed. We also tested the immune response to mycobacterial Hsp65 in B cell-tolerized rats. Results: Administration of tolerogenic mycobacterial Hsp65-expressing B cells as well as soluble mycobacterial Hsp65, but not OVA-expressing B cells, resulted in a significant decrease in the severity of subsequent AIA. However, in rats with established disease, only the B cell regimen of mycobacterial Hsp65, but not the soluble antigen, suppressed ongoing AIA. Conclusion: Mycobacterial Hsp65-IgG-expressing B cells can successfully attenuate the progression of AIA. This study introduces a promising approach for the treatment of arthritis that should be further explored.
MeSH term(s)	Animals ; Arthritis, Experimental/immunology ; Arthritis, Experimental/pathology ; Arthritis, Experimental/prevention & control ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/pathology ; Arthritis, Rheumatoid/prevention & control ; Autoimmunity ; B-Lymphocytes/metabolism ; B-Lymphocytes/physiology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Chaperonin 60 ; Chaperonins/genetics ; Chaperonins/metabolism ; Disease Models, Animal ; Gene Expression Regulation, Bacterial ; Immunoglobulin G/genetics ; Immunoglobulin G/metabolism ; Injections, Intraperitoneal ; Male ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Inbred Lew ; Severity of Illness Index
Chemical Substances	Bacterial Proteins ; Chaperonin 60 ; Immunoglobulin G ; RNA, Messenger ; heat-shock protein 65, Mycobacterium ; Chaperonins (EC 3.6.1.-)
Language	English
Publishing date	2007-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	127294-9
ISSN	1529-0131 ; 0004-3591 ; 2326-5191
ISSN (online)	1529-0131
ISSN	0004-3591 ; 2326-5191
DOI	10.1002/art.22566
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Zs.A 24: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Green tea protects rats against autoimmune arthritis by modulating disease-related immune events.

Kim, Hong Ro / Rajaiah, Rajesh / Wu, Qing-Li / Satpute, Shailesh R / Tan, Ming T / Simon, James E / Berman, Brian M / Moudgil, Kamal D

The Journal of nutrition

2008 Volume 138, Issue 11, Page(s) 2111–2116

Abstract: Green tea, a product of the dried leaves of Camellia sinensis, is the most widely consumed beverage in the world. The polyphenolic compounds from green tea (PGT) possess antiinflammatory properties. We investigated whether PGT can afford protection ... ...

Abstract	Green tea, a product of the dried leaves of Camellia sinensis, is the most widely consumed beverage in the world. The polyphenolic compounds from green tea (PGT) possess antiinflammatory properties. We investigated whether PGT can afford protection against autoimmune arthritis and also examined the immunological basis of this effect using the rat adjuvant arthritis (AA) model of human rheumatoid arthritis (RA). AA can be induced in Lewis rats (RT.1(l)) by immunization with heat-killed Mycobacterium tuberculosis H37Ra (Mtb), and arthritic rats raise a T cell response to the mycobacterial heat-shock protein 65 (Bhsp65). Rats consumed green tea (2-12 g/L) in drinking water for 1-3 wk and then were injected with Mtb to induce disease. Thereafter, they were observed regularly and graded for signs of arthritis. Subgroups of these rats were killed at defined time points and their draining lymph node cells were harvested and tested for T cell proliferative and cytokine responses. Furthermore, the sera collected from these rats were tested for anti-Bhsp65 antibodies. Feeding 8 g/L PGT to Lewis rats for 9 d significantly reduced the severity of arthritis compared with the water-fed controls. Interestingly, PGT-fed rats had a lower concentration of the proinflammatory cytokine interleukin (IL)-17 but a greater concentration of the immunoregulatory cytokine IL-10 than controls. PGT feeding also suppressed the anti-Bhsp65 antibody response. Thus, green tea induced changes in arthritis-related immune responses. We suggest further systematic exploration of dietary supplementation with PGT as an adjunct nutritional strategy for the management of RA.
MeSH term(s)	Animals ; Antibodies, Bacterial ; Arthritis, Experimental/immunology ; Arthritis, Experimental/prevention & control ; Autoimmune Diseases/prevention & control ; Cytokines/immunology ; Cytokines/metabolism ; Heat-Shock Proteins/immunology ; Injections, Intra-Articular ; Male ; Mycobacterium tuberculosis ; Rats ; Rats, Inbred Lew ; T-Lymphocytes/metabolism ; Tea/metabolism
Chemical Substances	Antibodies, Bacterial ; Cytokines ; Heat-Shock Proteins ; Tea
Language	English
Publishing date	2008-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.3945/jn.108.089912
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Article ; Online: Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury.

Gandolfo, Maria Teresa / Jang, Hye Ryoun / Bagnasco, Serena M / Ko, Gang-Jee / Agreda, Patricia / Satpute, Shailesh R / Crow, Michael T / King, Landon S / Rabb, Hamid

Kidney international

2009 Volume 76, Issue 7, Page(s) 717–729

Abstract: T lymphocytes modulate early ischemia-reperfusion injury in the kidney; however, their role during repair is unknown. We studied the role of TCRbeta(+)CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs), known to blunt immune responses, in repair after ... ...

Abstract	T lymphocytes modulate early ischemia-reperfusion injury in the kidney; however, their role during repair is unknown. We studied the role of TCRbeta(+)CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs), known to blunt immune responses, in repair after ischemia-reperfusion injury to the kidney. Using a murine model of ischemic acute kidney injury we found that there was a significant trafficking of Tregs into the kidneys after 3 and 10 days. Post-ischemic kidneys had increased numbers of TCRbeta(+)CD4(+) and TCRbeta(+)CD8(+) T cells with enhanced pro-inflammatory cytokine production. Treg depletion starting 1 day after ischemic injury using anti-CD25 antibodies increased renal tubular damage, reduced tubular proliferation at both time points, enhanced infiltrating T lymphocyte cytokine production at 3 days and TNF-alpha generation by TCRbeta(+)CD4(+) T cells at 10 days. In separate mice, infusion of CD4(+)CD25(+) Tregs 1 day after initial injury reduced INF-gamma production by TCRbeta(+)CD4(+) T cells at 3 days, improved repair and reduced cytokine generation at 10 days. Treg manipulation had minimal effect on neutrophil and macrophage infiltration; Treg depletion worsened mortality and serum creatinine, while Treg infusion had a late beneficial effect on serum creatinine in bilateral ischemia. Our study demonstrates that Tregs infiltrate ischemic-reperfused kidneys during the healing process promoting repair, likely through modulation of pro-inflammatory cytokine production of other T cell subsets. Treg targeting could be a novel therapeutic approach to enhance recovery from ischemic acute kidney injury.
MeSH term(s)	Animals ; Cell Movement/immunology ; Cytokines/biosynthesis ; Cytokines/immunology ; Forkhead Transcription Factors ; Mice ; Regeneration/physiology ; Reperfusion Injury/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes, Regulatory/immunology ; Time Factors
Chemical Substances	Cytokines ; Forkhead Transcription Factors ; Foxp3 protein, mouse
Language	English
Publishing date	2009-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1038/ki.2009.259
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Article: Green Tea Protects Rats against Autoimmune Arthritis by Modulating Disease-Related Immune Events

Kim, Hong Ro / Rajaiah, Rajesh / Wu, Qing-Li / Satpute, Shailesh R / Tan, Ming T / Simon, James E / Berman, Brian M / Moudgil, Kamal D

Journal of nutrition. 2008 Nov., v. 138, no. 11

2008

Abstract	Green tea, a product of the dried leaves of Camellia sinensis, is the most widely consumed beverage in the world. The polyphenolic compounds from green tea (PGT) possess antiinflammatory properties. We investigated whether PGT can afford protection against autoimmune arthritis and also examined the immunological basis of this effect using the rat adjuvant arthritis (AA) model of human rheumatoid arthritis (RA). AA can be induced in Lewis rats (RT.1l) by immunization with heat-killed Mycobacterium tuberculosis H37Ra (Mtb), and arthritic rats raise a T cell response to the mycobacterial heat-shock protein 65 (Bhsp65). Rats consumed green tea (2-12 g/L) in drinking water for 1-3 wk and then were injected with Mtb to induce disease. Thereafter, they were observed regularly and graded for signs of arthritis. Subgroups of these rats were killed at defined time points and their draining lymph node cells were harvested and tested for T cell proliferative and cytokine responses. Furthermore, the sera collected from these rats were tested for anti-Bhsp65 antibodies. Feeding 8 g/L PGT to Lewis rats for 9 d significantly reduced the severity of arthritis compared with the water-fed controls. Interestingly, PGT-fed rats had a lower concentration of the proinflammatory cytokine interleukin (IL)-17 but a greater concentration of the immunoregulatory cytokine IL-10 than controls. PGT feeding also suppressed the anti-Bhsp65 antibody response. Thus, green tea induced changes in arthritis-related immune responses. We suggest further systematic exploration of dietary supplementation with PGT as an adjunct nutritional strategy for the management of RA.
Keywords	green tea ; rats ; animal models ; protective effect ; autoimmune diseases ; arthritis ; immunomodulators ; immune response ; Camellia sinensis ; polyphenols ; anti-inflammatory activity ; rheumatoid arthritis ; Mycobacterium tuberculosis ; T-lymphocytes ; cell proliferation ; cytokines ; functional foods
Language	English
Dates of publication	2008-11
Size	p. 2111-2116.
Publishing place	American Society for Nutrition
Document type	Article
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
Database	NAL-Catalogue (AGRICOLA)

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