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Article ; Online: C Norman Coleman.

Watts, Geoff

2024 Volume 403, Issue 10435, Page(s) 1442

Language	English
Publishing date	2024-04-14
Publishing country	England
Document type	Journal Article
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(24)00692-5
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Article ; Online: RNA Interference Therapy Targeting Apolipoprotein C-III in Hypertriglyceridemia.

Gaudet, Daniel / Clifton, Peter / Sullivan, David / Baker, John / Schwabe, Christian / Thackwray, Susan / Scott, Russell / Hamilton, James / Given, Bruce / Melquist, Stacey / Zhou, Rong / Chang, Ting / San Martin, Javier / Watts, Gerald F / Goldberg, Ira J / Knowles, Joshua W / Hegele, Robert A / Ballantyne, Christie M

NEJM evidence

2023 Volume 2, Issue 12, Page(s) EVIDoa2200325

Abstract: APOC3-Targeting RNAi for HypertriglyceridemiaThis randomized controlled trial examined the safety and side effects of the small interfering RNA ARO-APOC3 in healthy volunteers and patients with hypertriglyceridemia and chylomicronemia. ARO-APOC3 was ... ...

Abstract	APOC3-Targeting RNAi for HypertriglyceridemiaThis randomized controlled trial examined the safety and side effects of the small interfering RNA ARO-APOC3 in healthy volunteers and patients with hypertriglyceridemia and chylomicronemia. ARO-APOC3 was associated with few adverse events and no dose-limiting toxicities.
MeSH term(s)	Humans ; Apolipoprotein C-III/genetics ; RNA Interference ; Hypertriglyceridemia/complications
Chemical Substances	Apolipoprotein C-III
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Journal Article
ISSN	2766-5526
ISSN (online)	2766-5526
DOI	10.1056/EVIDoa2200325
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Article ; Online: Application and limitations of configuration factor (C-factor) in stress analysis of dental restorations.

Zhou, Zixuan / Guo, Di / Watts, David C / Fischer, Nicholas G / Fu, Jing

Dental materials : official publication of the Academy of Dental Materials

2023 Volume 39, Issue 12, Page(s) 1137–1149

Abstract: Objective: The configuration factor (C-factor) is an index used to evaluate the relationship ... Although C-factor has been widely researched, its correlation with stress analysis in dental restorations ... remains controversial. This review aims to discuss the application and limitations of C-factor and define ...

Abstract	Objective: The configuration factor (C-factor) is an index used to evaluate the relationship between cavity configuration and the development of polymerization shrinkage stress in dental restorations. Although C-factor has been widely researched, its correlation with stress analysis in dental restorations remains controversial. This review aims to discuss the application and limitations of C-factor and define the restricted conditions under which the C-factor "rule of thumb" is applicable. Methods: A thorough literature review was conducted on the application and limitations of C-factor in stress analysis of dental restorations. This was principally based on MEDLINE/PubMed and Web of Science databases and a review of the relevant studies and publications in scientific papers in international peer-reviewed journals for the specific topic of C-factor and polymerization shrinkage. Results: The C-factor alone cannot provide an accurate prediction of the shrinkage stress of restorations and the mechanical behavior of material-tooth interfaces. C-factor is only applicable under one condition not typically seen in clinical practice: low, near-rigid compliance. Significance: Conditions for the application of C-factor have been explicitly defined. A more accurate and precise understanding and utilization of the C-factor is of benefit as it contributes to better understanding of polymerization shrinkage behavior of restorations.
MeSH term(s)	Humans ; Composite Resins ; Dental Restoration, Permanent ; Polymerization ; Molar ; Dental Caries ; Stress, Mechanical ; Materials Testing ; Dental Stress Analysis
Chemical Substances	Composite Resins
Language	English
Publishing date	2023-10-12
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	605995-8
ISSN	1879-0097 ; 0109-5641
ISSN (online)	1879-0097
ISSN	0109-5641
DOI	10.1016/j.dental.2023.10.014
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Article ; Online: Response to: Correspondence on '2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for granulomatosis with polyangiitis' by Joanna C Robson

Grayson, Peter C / Robson, Joanna C / Suppiah, Ravi / Ponte, Cristina / Watts, Richard A / Luqmani, Raashid A / Merkel, Peter A

Annals of the rheumatic diseases

2022 Volume 82, Issue 8, Page(s) e198

MeSH term(s)	Humans ; United States ; Granulomatosis with Polyangiitis ; Microscopic Polyangiitis ; Rheumatology ; Polyarteritis Nodosa
Language	English
Publishing date	2022-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2022-222362
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Article ; Online: Safety of Glecaprevir/Pibrentasvir for hepatitis C in patients with posttraumatic stress disorder: A post-marketing surveillance study.

Shiner, Brian / Park, Jenna A / Rozema, Luke / Hoyt, Jessica E / Watts, Bradley V / Gradus, Jaimie L

General hospital psychiatry

2023 Volume 84, Page(s) 268–270

MeSH term(s)	Humans ; Stress Disorders, Post-Traumatic/drug therapy ; Hepatitis C/drug therapy ; Hepacivirus ; Quinoxalines/adverse effects ; Pyrrolidines/therapeutic use ; Product Surveillance, Postmarketing ; Antiviral Agents/adverse effects ; Hepatitis C, Chronic/drug therapy ; Proline/adverse effects ; Genotype
Chemical Substances	glecaprevir (K6BUU8J72P) ; pibrentasvir (2WU922TK3L) ; Quinoxalines ; Pyrrolidines ; Antiviral Agents ; Proline (9DLQ4CIU6V)
Language	English
Publishing date	2023-06-22
Publishing country	United States
Document type	Letter ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	392299-6
ISSN	1873-7714 ; 0163-8343
ISSN (online)	1873-7714
ISSN	0163-8343
DOI	10.1016/j.genhosppsych.2023.06.012
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Article ; Online: Risks for acquiring hepatitis C virus among women in the United States.

Watts, Theresa / Lauver, Diane / Snedden, Traci / Zahner, Susan

Public health nursing (Boston, Mass.)

2021 Volume 38, Issue 2, Page(s) 309–320

Abstract: ... hepatitis C virus (HCV) among women who are living in the United States.: Design: A mixed research synthesis ...

Abstract	Objective: To conduct a literature review about the breadth of risks for acquiring hepatitis C virus (HCV) among women who are living in the United States. Design: A mixed research synthesis of qualitative, quantitative, and mixed-methods studies guided by the Socioecological Model and Theory of Gender and Power. Sample and analytic strategy: The sample consisted of 29 studies: 10 qualitative, 18 quantitative, and one mixed-methods studies. Data were analyzed using a segregated approach and integrated into a narrative synthesis of themes by components of the Socioecological Model. Results: Individual risks themes were drug use as a coping strategy, transition to injection drug use, and lack of awareness about HCV. Interpersonal risks themes were social norms of drug use and drug use and sexual activities. Community risks themes were community re-entry, housing instability, and community HCV resources. Societal risks themes are policies affecting drug markets and social construct of "worthlessness." Conclusions: Findings highlight the need for comprehensive gender-specific HCV prevention strategies built around harm reduction. In partnership with women with lived experience, public health nurses can apply findings to build harm reduction collaborations aimed at implementing HCV risk-reduction or risk-elimination strategies.
MeSH term(s)	Female ; Harm Reduction ; Hepacivirus ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Hepatitis C/prevention & control ; Humans ; Sexual Behavior ; Substance-Related Disorders ; United States/epidemiology
Language	English
Publishing date	2021-03-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	632563-4
ISSN	1525-1446 ; 0737-1209
ISSN (online)	1525-1446
ISSN	0737-1209
DOI	10.1111/phn.12892
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Article ; Online: Improved Λp Elastic Scattering Cross Sections between 0.9 and 2.0 GeV/c as a Main Ingredient of the Neutron Star Equation of State.

Rowley, J / Compton, N / Djalali, C / Hicks, K / Price, J / Zachariou, N / Adhikari, K P / Armstrong, W R / Atac, H / Baashen, L / Barion, L / Bashkanov, M / Battaglieri, M / Bedlinskiy, I / Benmokhtar, F / Bianconi, A / Biondo, L / Biselli, A S / Bondi, M /

Bossù, F / Boiarinov, S / Briscoe, W J / Brooks, W K / Bulumulla, D / Burkert, V D / Carman, D S / Carvajal, J C / Celentano, A / Chatagnon, P / Chesnokov, V / Chetry, T / Ciullo, G / Clark, L / Cole, P L / Contalbrigo, M / Costantini, G / Crede, V / D'Angelo, A / Dashyan, N / De Vita, R / Defurne, M / Deur, A / Diehl, S / Dupré, R / Egiyan, H / Ehrhart, M / El Alaoui, A / El Fassi, L / Eugenio, P / Fedotov, G / Fegan, S / Fersch, R / Filippi, A / Fradi, A / Gavalian, G / Girod, F X / Glazier, D I / Golubenko, A / Gothe, R W / Griffioen, K / Guo, L / Hafidi, K / Hakobyan, H / Hattawy, M / Hayward, T B / Heddle, D / Hobart, A / Holtrop, M / Ilieva, Y / Ireland, D G / Isupov, E L / Jenkins, D / Jo, H S / Joo, K / Keller, D / Khanal, A / Khandaker, M / Kim, A / Korover, I / Kripko, A / Kubarovsky, V / Kuhn, S E / Lanza, L / Leali, M / Lenisa, P / Livingston, K / MacGregor, I J D / Marchand, D / Markov, N / Marsicano, L / Mascagna, V / McCracken, M E / McKinnon, B / McLauchlin, C / Meziani, Z E / Migliorati, S / Mineeva, T / Mirazita, M / Mokeev, V / Munevar, E / Munoz Camacho, C / Nadel-Turonski, P / Neupane, K / Niccolai, S / Niculescu, G / O'Connell, T R / Osipenko, M / Ostrovidov, A I / Pandey, P / Paolone, M / Pappalardo, L L / Pasyuk, E / Pogorelko, O / Prok, Y / Reed, T / Ripani, M / Ritman, J / Rizzo, A / Rosner, G / Sabatie, F / Salgado, C / Schmidt, A / Schumacher, R A / Sharabian, Y G / Shrestha, U / Sokhan, D / Soto, O / Sparveris, N / Strakovsky, I I / Strauch, S / Tyson, R / Ungaro, M / Venturelli, L / Voskanyan, H / Vossen, A / Voutier, E / Watts, D P / Wei, K / Wei, X / Wishart, R / Wood, M H / Yale, B / Yurov, M / Zhang, J / Zhao, Z W

Physical review letters

2022 Volume 127, Issue 27, Page(s) 272303

Abstract: ... scattering cross section in the incident Λ momentum range 0.9-2.0 GeV/c. These are the first data ...

Abstract	Strange matter is believed to exist in the cores of neutron stars based on simple kinematics. If this is true, then hyperon-nucleon interactions will play a significant part in the neutron star equation of state. Yet, compared to other elastic scattering processes, there is very little data on Λ-N scattering. This experiment utilized the CEBAF Large Acceptance Spectrometer (CLAS) detector to study the Λp→Λp elastic scattering cross section in the incident Λ momentum range 0.9-2.0 GeV/c. These are the first data on this reaction since the 1970s. The new cross sections have significantly better accuracy and precision than the existing world data, and the techniques developed here can also be used in future experiments.
Language	English
Publishing date	2022-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.272303
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Book: Yoga and Somatics for Immune and Respiratory Health

Watts, Charlotte

2022

Author's details	Charlotte has been teaching yoga since 2009, and runs courses for yoga teachers on somatics, as well as specialised trauma-informed courses for various health aspects. She also teaches on the Yoga Therapy courses run by both Yogacampus and The Minded Institute. Charlotte is also an award-winning nutritional therapist, practising since 2000. Her other books include Yoga Therapy for Digestive Health, Good Mood Food and The De-Stress Effect
Size	400 p.
Publisher	Jessica Kingsley Publishers
Document type	Book
Note	PDA Manuell_18
Format	171 x 249 x 22
ISBN	9781839970870 ; 1839970871
Database	PDA

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Article: The effects of cryogenically preserved sperm on the fertilization, embryonic development and hatching success of lumpfish C. lumpus

Imsland, Albert Kjartan Dagbjartarson / Purvis, Emily / Reinardy, Helena C. / Kapari, Lauri / Watts, Ellie Jane / Hangstad, Thor Arne

Aquaculture. 2022 Jan. 30, v. 547

2022

Abstract: Lumpfish (C. lumpus) are used as cleaner fish in the Atlantic salmon (Salmo salar) farming industry ...

Abstract	Lumpfish (C. lumpus) are used as cleaner fish in the Atlantic salmon (Salmo salar) farming industry to remove parasitic sea lice. At present, wild lumpfish broodstock are used which puts strain on wild populations. By successfully cryopreserving lumpfish sperm, the number of wild males required will be reduced and it enables the long-term storage of sperm for use in breeding programmes. The present study compared the use of fresh sperm and sperm which was cryogenically frozen for 24 h to test whether it is a viable method of preservation. The fresh and frozen sperm from 5 males was used (in equal volumes) to fertilize eggs pooled from 5 females and the difference between fertilization success, percentage of eggs which reached the eyed stage, and the hatching success was measured. A group of 100 hatched larvae were on-grown for two weeks to test whether there was a difference weight between treatment groups. The results of the trial showed that fresh sperm produced a significantly higher percentage of fertilized eggs (fresh 92.6 ± 0.8%, frozen 77.9 ± 1.8%, mean ± SEM), a higher percentage of eggs surviving to the eyed stage (fresh 93.9 ± 0.5% and frozen 80.8 ± 1.4%) and had a more successful hatch rate (fresh 72.3 ± 6.6% and frozen 63.6 ± 5.0%). There was no difference in mean weight (± SEM) of the two-week old larvae between treatments (fresh 0.63 g ± 0.024, frozen 0.59 g ± 0.028). In conclusion, this study showed that the same volume of cryogenically preserved lumpfish sperm produced fewer viable lumpfish larvae than fresh sperm. Despite this difference, the use of cryopreserved sperm did produce relatively high results at each stage of testing.
Keywords	Cylopterus lumpus ; Salmo salar ; aquaculture ; breeding stock ; cryopreservation ; embryogenesis ; fish ; industry ; spermatozoa ; storage time
Language	English
Dates of publication	2022-0130
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	185380-6
ISSN	0044-8486 ; 0044-8516
ISSN	0044-8486 ; 0044-8516
DOI	10.1016/j.aquaculture.2021.737466
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Homeostatic control of stearoyl desaturase expression via patched-like receptor PTR-23 ensures the survival of C. elegans during heat stress.

Venkatesh, Siddharth R / Siddiqui, Ritika / Sandhu, Anjali / Ramani, Malvika / Houston, Isabel R / Watts, Jennifer L / Singh, Varsha

PLoS genetics

2023 Volume 19, Issue 12, Page(s) e1011067

Abstract: ... cytosolic chaperone machinery as well as adaptive alterations in lipid constituents of cellular membranes. Using C ... This study provides evidence for the negative regulation of fatty acid desaturase expression in the soma of C ...

Abstract	Organismal responses to temperature fluctuations include an evolutionarily conserved cytosolic chaperone machinery as well as adaptive alterations in lipid constituents of cellular membranes. Using C. elegans as a model system, we asked whether adaptable lipid homeostasis is required for survival during physiologically relevant heat stress. By systematic analyses of lipid composition in worms during and before heat stress, we found that unsaturated fatty acids are reduced in heat-stressed animals. This is accompanied by the transcriptional downregulation of fatty acid desaturase enzymes encoded by fat-1, fat-3, fat-4, fat-5, fat-6, and fat-7 genes. Conversely, overexpression of the Δ9 desaturase FAT-7, responsible for the synthesis of PUFA precursor oleic acid, and supplementation of oleic acid causes accelerated death of worms during heat stress. Interestingly, heat stress causes permeability defects in the worm's cuticle. We show that fat-7 expression is reduced in the permeability defective collagen (PDC) mutant, dpy-10, known to have enhanced heat stress resistance (HSR). Further, we show that the HSR of dpy-10 animals is dependent on the upregulation of PTR-23, a patched-like receptor in the epidermis, and that PTR-23 downregulates the expression of fat-7. Consequently, abrogation of ptr-23 in wild type animals affects its survival during heat stress. This study provides evidence for the negative regulation of fatty acid desaturase expression in the soma of C. elegans via the non-canonical role of a patched receptor signaling component. Taken together, this constitutes a skin-gut axis for the regulation of lipid desaturation to promote the survival of worms during heat stress.
MeSH term(s)	Animals ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins/metabolism ; Fatty Acid Desaturases/genetics ; Fatty Acid Desaturases/metabolism ; Fatty Acids, Unsaturated/genetics ; Fatty Acids, Unsaturated/metabolism ; Stearoyl-CoA Desaturase/genetics ; Homeostasis ; Heat-Shock Response/genetics ; Oleic Acids
Chemical Substances	Caenorhabditis elegans Proteins ; Fatty Acid Desaturases (EC 1.14.19.-) ; Fatty Acids, Unsaturated ; Stearoyl-CoA Desaturase (EC 1.14.19.1) ; Oleic Acids
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1011067
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