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Article: Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target.

Lai, Yen-Chung / Chao, Chiao-Hsuan / Yeh, Trai-Ming

2020 Volume 8, Issue 6

Abstract: Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection and can lead to severe dengue hemorrhagic fever (DHF) and even life-threatening dengue shock syndrome (DSS). Although the cytokine storm has been revealed as a critical ... ...

Abstract	Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection and can lead to severe dengue hemorrhagic fever (DHF) and even life-threatening dengue shock syndrome (DSS). Although the cytokine storm has been revealed as a critical factor in dengue disease, the limited understanding of dengue immunopathogenesis hinders the development of effective treatments. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that mediates diverse immune responses, and the serum level of MIF positively correlates with disease severity in patients with dengue. MIF is involved in DENV replication and many pathological changes, such as vascular leakage, during DENV infection. In this paper, the pathogenic roles of MIF and the regulation of MIF secretion during DENV infection are reviewed. Furthermore, whether MIF is a potential therapeutic target against DENV infection is also discussed.
Keywords	covid19
Language	English
Publishing date	2020-06-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms8060891
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis

Yen-Chung Lai / Chiao-Hsuan Chao / Trai-Ming Yeh

Microorganisms, Vol 8, Iss 891, p

From Pathogenic Factor to Therapeutic Target

2020 Volume 891

Abstract	Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection and can lead to severe dengue hemorrhagic fever (DHF) and even life-threatening dengue shock syndrome (DSS). Although the cytokine storm has been revealed as a critical factor in dengue disease, the limited understanding of dengue immunopathogenesis hinders the development of effective treatments. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that mediates diverse immune responses, and the serum level of MIF positively correlates with disease severity in patients with dengue. MIF is involved in DENV replication and many pathological changes, such as vascular leakage, during DENV infection. In this paper, the pathogenic roles of MIF and the regulation of MIF secretion during DENV infection are reviewed. Furthermore, whether MIF is a potential therapeutic target against DENV infection is also discussed.
Keywords	Dengue virus ; dengue pathogenesis ; macrophage migration inhibitory factor ; autophagy ; Biology (General) ; QH301-705.5
Subject code	306
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Enhancement of NETosis by ACE2-cross-reactive anti-SARS-CoV-2 RBD antibodies in patients with COVID-19.

Hsieh, Kun-Han / Chao, Chiao-Hsuan / Cheng, Yi-Ling / Lai, Yen-Chung / Chuang, Yung-Chun / Wang, Jen-Ren / Chang, Sui-Yuan / Hung, Yuan-Pin / Chen, Yi-Ming Arthur / Liu, Wei-Lun / Chuang, Woei-Jer / Yeh, Trai-Ming

Journal of biomedical science

2024 Volume 31, Issue 1, Page(s) 39

Abstract: Background: High levels of neutrophil extracellular trap (NET) formation or NETosis and autoantibodies are related to poor prognosis and disease severity of COVID-19 patients. Human angiotensin-converting enzyme 2 (ACE2) cross-reactive anti-severe acute ...

Abstract	Background: High levels of neutrophil extracellular trap (NET) formation or NETosis and autoantibodies are related to poor prognosis and disease severity of COVID-19 patients. Human angiotensin-converting enzyme 2 (ACE2) cross-reactive anti-severe acute respiratory syndrome coronavirus 2 spike protein receptor-binding domain (SARS-CoV-2 RBD) antibodies (CR Abs) have been reported as one of the sources of anti-ACE2 autoantibodies. However, the pathological implications of CR Abs in NET formation remain unknown. Methods: In this study, we first assessed the presence of CR Abs in the sera of COVID-19 patients with different severity by serological analysis. Sera and purified IgG from CR Abs positive COVID-19 patients as well as a mouse monoclonal Ab (mAb 127) that can recognize both ACE2 and the RBD were tested for their influence on NETosis and the possible mechanisms involved were studied. Results: An association between CR Abs levels and the severity of COVID-19 in 120 patients was found. The CR Abs-positive sera and IgG from severe COVID-19 patients and mAb 127 significantly activated human leukocytes and triggered NETosis, in the presence of RBD. This NETosis, triggered by the coexistence of CR Abs and RBD, activated thrombus-related cells but was abolished when the interaction between CR Abs and ACE2 or Fc receptors was disrupted. We also revealed that CR Abs-induced NETosis was suppressed in the presence of recombinant ACE2 or the Src family kinase inhibitor, dasatinib. Furthermore, we found that COVID-19 vaccination not only reduced COVID-19 severity but also prevented the production of CR Abs after SARS-CoV-2 infection. Conclusions: Our findings provide possible pathogenic effects of CR Abs in exacerbating COVID-19 by enhancing NETosis, highlighting ACE2 and dasatinib as potential treatments, and supporting the benefit of vaccination in reducing disease severity and CR Abs production in COVID-19 patients.
MeSH term(s)	Humans ; Animals ; Mice ; COVID-19 ; SARS-CoV-2 ; Angiotensin-Converting Enzyme 2 ; COVID-19 Vaccines ; Dasatinib ; Immunoglobulin G/metabolism ; Autoantibodies/metabolism ; Spike Glycoprotein, Coronavirus ; Protein Binding
Chemical Substances	Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; COVID-19 Vaccines ; Dasatinib (RBZ1571X5H) ; Immunoglobulin G ; Autoantibodies ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1193378-1
ISSN	1423-0127 ; 1021-7770
ISSN (online)	1423-0127
ISSN	1021-7770
DOI	10.1186/s12929-024-01026-5
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Article ; Online: Diverse cell-specific patterns of alternative polyadenylation in Drosophila.

Lee, Seungjae / Chen, Yen-Chung / Gillen, Austin E / Taliaferro, J Matthew / Deplancke, Bart / Li, Hongjie / Lai, Eric C

Nature communications

2022 Volume 13, Issue 1, Page(s) 5372

Abstract: Most genes in higher eukaryotes express isoforms with distinct 3' untranslated regions (3' UTRs), generated by alternative polyadenylation (APA). Since 3' UTRs are predominant locations of post-transcriptional regulation, APA can render such programs ... ...

Abstract	Most genes in higher eukaryotes express isoforms with distinct 3' untranslated regions (3' UTRs), generated by alternative polyadenylation (APA). Since 3' UTRs are predominant locations of post-transcriptional regulation, APA can render such programs conditional, and can also alter protein sequences via alternative last exon (ALE) isoforms. We previously used 3'-sequencing from diverse Drosophila samples to define multiple tissue-specific APA landscapes. Here, we exploit comprehensive single nucleus RNA-sequencing data (Fly Cell Atlas) to elucidate cell-type expression of 3' UTRs across >250 adult Drosophila cell types. We reveal the cellular bases of multiple tissue-specific APA/ALE programs, such as 3' UTR lengthening in differentiated neurons and 3' UTR shortening in spermatocytes and spermatids. We trace dynamic 3' UTR patterns across cell lineages, including in the male germline, and discover new APA patterns in the intestinal stem cell lineage. Finally, we correlate expression of RNA binding proteins (RBPs), miRNAs and global levels of cleavage and polyadenylation (CPA) factors in several cell types that exhibit characteristic APA landscapes, yielding candidate regulators of transcriptome complexity. These analyses provide a comprehensive foundation for future investigations of mechanisms and biological impacts of alternative 3' isoforms across the major cell types of this widely-studied model organism.
MeSH term(s)	3' Untranslated Regions/genetics ; Animals ; Drosophila/genetics ; Male ; Polyadenylation ; Protein Isoforms/genetics ; Sequence Analysis, RNA
Chemical Substances	3' Untranslated Regions ; Protein Isoforms
Language	English
Publishing date	2022-09-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-32305-0
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Article: Risk Factors and Outcomes of Community-Acquired Carbapenem-Resistant

Chen, Yen-Chou / Tsai, I-Ting / Lai, Chung-Hsu / Lin, Kuo-Hsuan / Hsu, Yin-Chou

Antibiotics (Basel, Switzerland)

2024 Volume 13, Issue 3

Abstract: The increasing prevalence of carbapenem- ... ...

Abstract	The increasing prevalence of carbapenem-resistant
Language	English
Publishing date	2024-03-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics13030282
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Article ; Online: Dengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidate.

Chen, Hong-Ru / Lai, Yen-Chung / Yeh, Trai-Ming

Journal of biomedical science

2018 Volume 25, Issue 1, Page(s) 58

Abstract: Dengue virus (DENV) infection is the most common mosquito-transmitted viral infection. DENV infection can cause mild dengue fever or severe dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Hemorrhage and vascular leakage are two characteristic ...

Abstract	Dengue virus (DENV) infection is the most common mosquito-transmitted viral infection. DENV infection can cause mild dengue fever or severe dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Hemorrhage and vascular leakage are two characteristic symptoms of DHF/DSS. However, due to the limited understanding of dengue pathogenesis, no satisfactory therapies to treat nor vaccine to prevent dengue infection are available, and the mortality of DHF/DSS is still high. DENV nonstructural protein 1 (NS1), which can be secreted in patients' sera, has been used as an early diagnostic marker for dengue infection for many years. However, the roles of NS1 in dengue-induced vascular leakage were described only recently. In this article, the pathogenic roles of DENV NS1 in hemorrhage and vascular leakage are reviewed, and the possibility of using NS1 as a therapeutic target and vaccine candidate is discussed.
MeSH term(s)	Antibodies, Viral/therapeutic use ; Dengue Virus/genetics ; Dengue Virus/immunology ; Dengue Virus/pathogenicity ; Humans ; Severe Dengue/immunology ; Severe Dengue/prevention & control ; Severe Dengue/virology ; Vaccines/immunology ; Vaccines/therapeutic use ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/immunology ; Viral Nonstructural Proteins/therapeutic use
Chemical Substances	Antibodies, Viral ; NS1 protein, dengue-1 virus ; Vaccines ; Viral Nonstructural Proteins
Language	English
Publishing date	2018-07-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1193378-1
ISSN	1423-0127 ; 1021-7770
ISSN (online)	1423-0127
ISSN	1021-7770
DOI	10.1186/s12929-018-0462-0
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Zs.A 4037: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target

Lai, Yen-Chung / Chao, Chiao-Hsuan / Yeh, Trai-Ming

Microorganisms. 2020 June 12, v. 8, no. 6

2020

Abstract	Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection and can lead to severe dengue hemorrhagic fever (DHF) and even life-threatening dengue shock syndrome (DSS). Although the cytokine storm has been revealed as a critical factor in dengue disease, the limited understanding of dengue immunopathogenesis hinders the development of effective treatments. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that mediates diverse immune responses, and the serum level of MIF positively correlates with disease severity in patients with dengue. MIF is involved in DENV replication and many pathological changes, such as vascular leakage, during DENV infection. In this paper, the pathogenic roles of MIF and the regulation of MIF secretion during DENV infection are reviewed. Furthermore, whether MIF is a potential therapeutic target against DENV infection is also discussed.
Keywords	Dengue virus ; blood serum ; dengue hemorrhagic fever ; disease severity ; macrophage migration inhibitory factors ; pathogenesis ; secretion ; therapeutics
Language	English
Dates of publication	2020-0612
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms8060891
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Compact and broadband silicon polarization splitter-rotator using adiabaticity engineering.

Hung, Yung-Jr / Chen, Chih-Hsien / Chung, Hung-Ching / Lai, Jun-Zhu / Tseng, Shuo-Yen

Optics letters

2024 Volume 49, Issue 7, Page(s) 1852–1855

Abstract: We propose and demonstrate a short and broadband silicon mode-conversion polarization splitter-rotator (PSR) consisting of a mode-conversion taper and an adiabatic coupler-based mode sorter both optimized by adiabaticity engineering (AE). AE is used to ... ...

Abstract	We propose and demonstrate a short and broadband silicon mode-conversion polarization splitter-rotator (PSR) consisting of a mode-conversion taper and an adiabatic coupler-based mode sorter both optimized by adiabaticity engineering (AE). AE is used to optimize the distribution of adiabaticity parameter over the length of the PSR, providing shortcut to adiabaticity at a shorter device length. The total length of the PSR is 85 µm. The design is compatible with standard silicon photonics platforms and requires only one patterning step. Fabricated PSR has a polarization cross talk of less than -20 dB over the entire O-band for the TE polarization and a polarization cross talk of less than -15 dB from 1267 to 1348 nm for the TM polarization. Overall, the PSR shows low polarization cross talk (-15 dB) over a bandwidth of 81 nm in the O-band. Cross-wafer measurements show that the PSR has good fabrication tolerance.
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.518607
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Article ; Online: Dengue virus non-structural protein 1

Hong-Ru Chen / Yen-Chung Lai / Trai-Ming Yeh

Journal of Biomedical Science, Vol 25, Iss 1, Pp 1-

a pathogenic factor, therapeutic target, and vaccine candidate

2018 Volume 11

Abstract: Abstract Dengue virus (DENV) infection is the most common mosquito-transmitted viral infection. DENV infection can cause mild dengue fever or severe dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Hemorrhage and vascular leakage are two ... ...

Abstract	Abstract Dengue virus (DENV) infection is the most common mosquito-transmitted viral infection. DENV infection can cause mild dengue fever or severe dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Hemorrhage and vascular leakage are two characteristic symptoms of DHF/DSS. However, due to the limited understanding of dengue pathogenesis, no satisfactory therapies to treat nor vaccine to prevent dengue infection are available, and the mortality of DHF/DSS is still high. DENV nonstructural protein 1 (NS1), which can be secreted in patients’ sera, has been used as an early diagnostic marker for dengue infection for many years. However, the roles of NS1 in dengue-induced vascular leakage were described only recently. In this article, the pathogenic roles of DENV NS1 in hemorrhage and vascular leakage are reviewed, and the possibility of using NS1 as a therapeutic target and vaccine candidate is discussed.
Keywords	Dengue virus (DENV) ; Nonstructural protein 1 (NS1) ; Hemorrhage ; Coagulopathy ; Vascular leakage ; Vaccine ; Medicine ; R
Subject code	570
Language	English
Publishing date	2018-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: DUSP5 and PHLDA1 mutations in mature cystic teratomas of the ovary identified on whole-exome sequencing may explain teratoma characteristics.

Wang, Wen-Chung / Lai, Yen-Chein

Human genomics

2022 Volume 16, Issue 1, Page(s) 50

Abstract: Background: Mature cystic teratomas of the ovary are the most common type of germ cell tumor, comprising 33% of ovarian tumors. Studying these tumors may result in a better understanding of their stepwise developmental processes and molecular bases and ... ...

Abstract	Background: Mature cystic teratomas of the ovary are the most common type of germ cell tumor, comprising 33% of ovarian tumors. Studying these tumors may result in a better understanding of their stepwise developmental processes and molecular bases and provide useful information for the development of tissue-engineering technologies. Methods: In the present study, 9 mature cystic teratomas of the ovary were analyzed by whole-exome sequencing and the results were compared with the Catalogue of Somatic Mutations in Cancer and dbSNP databases. Results: Mutations were validated in 15 genes with alterations in all 9 (100%) samples and changes in protein coding. The top 10 mutated genes were FLG, MUC17, MUC5B, RP1L1, NBPF1, GOLGA6L2, SLC29A3, SGK223, PTGFRN, and FAM186A. Moreover, 7 variants in exons with changes in protein coding are likely of importance in the development of mature cystic teratomas of the ovary, namely PTGFRN, DUSP5, MPP2, PHLDA1, PRR21, GOLGA6L2, and KRTAP4-2. Conclusions: These genetic alterations may play an important etiological role in teratoma formation. Moreover, novel mutations in DUSP5 and PHLDA1 genes found on whole-exome sequencing may help to explain the characteristics of teratomas.
MeSH term(s)	Female ; Humans ; Whole Exome Sequencing ; Teratoma/genetics ; Teratoma/metabolism ; Teratoma/pathology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Mutation ; Eye Proteins/genetics ; Eye Proteins/metabolism ; Dual-Specificity Phosphatases/genetics ; Dual-Specificity Phosphatases/metabolism ; Transcription Factors/genetics ; Nucleoside Transport Proteins/genetics
Chemical Substances	RP1L1 protein, human ; Eye Proteins ; DUSP5 protein, human (EC 3.1.3.48) ; Dual-Specificity Phosphatases (EC 3.1.3.48) ; PHLDA1 protein, human ; Transcription Factors ; SLC29A3 protein, human ; Nucleoside Transport Proteins
Language	English
Publishing date	2022-10-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2147618-4
ISSN	1479-7364 ; 1479-7364
ISSN (online)	1479-7364
ISSN	1479-7364
DOI	10.1186/s40246-022-00424-w
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