LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 38

Search options

  1. Article ; Online: Antigenic imprinting in SARS-CoV-2.

    Reincke, S Momsen / Prüss, Harald / Wilson, Ian A / Kreye, Jakob

    Clinical and translational medicine

    2022  Volume 12, Issue 7, Page(s) e923

    MeSH term(s) Antibodies, Viral ; COVID-19 ; Humans ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus
    Chemical Substances Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.923
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Antigenic imprinting in SARS‐CoV‐2

    S. Momsen Reincke / Harald Prüss / Ian A. Wilson / Jakob Kreye

    Clinical and Translational Medicine, Vol 12, Iss 7, Pp n/a-n/a (2022)

    2022  

    Keywords antigenic imprinting ; SARS‐CoV‐2 ; vaccination strategies ; variants of concern ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Do cross-reactive antibodies cause neuropathology in COVID-19?

    Kreye, Jakob / Reincke, S Momsen / Prüss, Harald

    Nature reviews. Immunology

    2020  Volume 20, Issue 11, Page(s) 645–646

    MeSH term(s) Antibodies, Monoclonal/biosynthesis ; Antibodies, Neutralizing/biosynthesis ; Antibodies, Viral/biosynthesis ; Autoimmunity ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; Brain Diseases/complications ; Brain Diseases/diagnosis ; Brain Diseases/immunology ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/immunology ; Cross Reactions ; Headache/complications ; Headache/diagnosis ; Headache/immunology ; Humans ; Pandemics ; Parkinsonian Disorders/complications ; Parkinsonian Disorders/diagnosis ; Parkinsonian Disorders/immunology ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/immunology ; SARS-CoV-2 ; Seizures/complications ; Seizures/diagnosis ; Seizures/immunology ; Tremor/complications ; Tremor/diagnosis ; Tremor/immunology
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral
    Keywords covid19
    Language English
    Publishing date 2020-10-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-020-00458-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 34: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Brain antibody sequence evaluation (BASE): an easy-to-use software for complete data analysis in single cell immunoglobulin cloning.

    Reincke, S Momsen / Prüss, Harald / Kreye, Jakob

    BMC bioinformatics

    2020  Volume 21, Issue 1, Page(s) 446

    Abstract: Background: Repertoire analysis of patient-derived recombinant monoclonal antibodies is an important tool to study the role of B cells in autoimmune diseases of the human brain and beyond. Current protocols for generation of patient-derived recombinant ... ...

    Abstract Background: Repertoire analysis of patient-derived recombinant monoclonal antibodies is an important tool to study the role of B cells in autoimmune diseases of the human brain and beyond. Current protocols for generation of patient-derived recombinant monoclonal antibody libraries are time-consuming and contain repetitive steps, some of which can be assisted with the help of software automation.
    Results: We developed BASE, an easy-to-use software for complete data analysis in single cell immunoglobulin cloning. BASE consists of two modules: aBASE for immunological annotations and cloning primer lookup, and cBASE for plasmid sequence identity confirmation before expression. Comparing automated BASE analysis with manual analysis we confirmed the validity of BASE output: identity between manual and automated aBASE analysis was 100% for all outputs, except for immunoglobulin isotype determination. In this case, aBASE yielded correct results in 96% of cases, whereas 4% of cases required manual confirmation. cBASE automatically concluded expression recommendations in 89.8% of cases, 91.8% of which were identical to manually derived results and none of them were false-positive.
    Conclusions: BASE offers an easy-to-use software solution suitable for complete Ig sequence data analysis and tracking during recombinant mAb cloning from single cells. Plasmid sequence identity confirmation by cBASE offers functionality not provided by existing software solutions in the field and will help to reduce time-consuming steps of the monoclonal antibody generation workflow. BASE can be installed locally or accessed online at Code Ocean.
    MeSH term(s) Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/immunology ; Brain/immunology ; Cloning, Molecular ; Data Analysis ; Humans ; Plasmids/genetics ; Sequence Analysis/methods ; Software
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2020-10-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041484-5
    ISSN 1471-2105 ; 1471-2105
    ISSN (online) 1471-2105
    ISSN 1471-2105
    DOI 10.1186/s12859-020-03741-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Brain antibody sequence evaluation (BASE)

    S. Momsen Reincke / Harald Prüss / Jakob Kreye

    BMC Bioinformatics, Vol 21, Iss 1, Pp 1-

    an easy-to-use software for complete data analysis in single cell immunoglobulin cloning

    2020  Volume 10

    Abstract: Abstract Background Repertoire analysis of patient-derived recombinant monoclonal antibodies is an important tool to study the role of B cells in autoimmune diseases of the human brain and beyond. Current protocols for generation of patient-derived ... ...

    Abstract Abstract Background Repertoire analysis of patient-derived recombinant monoclonal antibodies is an important tool to study the role of B cells in autoimmune diseases of the human brain and beyond. Current protocols for generation of patient-derived recombinant monoclonal antibody libraries are time-consuming and contain repetitive steps, some of which can be assisted with the help of software automation. Results We developed BASE, an easy-to-use software for complete data analysis in single cell immunoglobulin cloning. BASE consists of two modules: aBASE for immunological annotations and cloning primer lookup, and cBASE for plasmid sequence identity confirmation before expression. Comparing automated BASE analysis with manual analysis we confirmed the validity of BASE output: identity between manual and automated aBASE analysis was 100% for all outputs, except for immunoglobulin isotype determination. In this case, aBASE yielded correct results in 96% of cases, whereas 4% of cases required manual confirmation. cBASE automatically concluded expression recommendations in 89.8% of cases, 91.8% of which were identical to manually derived results and none of them were false-positive. Conclusions BASE offers an easy-to-use software solution suitable for complete Ig sequence data analysis and tracking during recombinant mAb cloning from single cells. Plasmid sequence identity confirmation by cBASE offers functionality not provided by existing software solutions in the field and will help to reduce time-consuming steps of the monoclonal antibody generation workflow. BASE can be installed locally or accessed online at Code Ocean.
    Keywords Single cell ; B cell ; Antibody ; Immunoglobulin ; Sequence analysis ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Biology (General) ; QH301-705.5
    Subject code 005 ; 004
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: Brain blood vessel autoantibodies in patients with NMDA and GABA

    Li, Lucie Y / Kreye, Jakob / Burek, Malgorzata / Cordero-Gomez, César / Barthel, Paula C / Sánchez-Sendín, Elisa / Kornau, Hans-Christian / Schmitz, Dietmar / Scharf, Madeleine / Meybohm, Patrick / Reincke, S Momsen / Prüss, Harald / Höltje, Markus

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1077204

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1077204
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Intravenous immunoglobulins for treatment of severe COVID-19-related acute encephalopathy.

    Huo, Shufan / Ferse, Caroline / Bösl, Fabian / Reincke, S Momsen / Enghard, Philipp / Hinrichs, Carl / Treskatsch, Sascha / Angermair, Stefan / Eckardt, Kai-Uwe / Audebert, Heinrich J / Ploner, Christoph J / Endres, Matthias / Prüss, Harald / Franke, Christiana / Scheibe, Franziska

    Journal of neurology

    2022  Volume 269, Issue 8, Page(s) 4013–4020

    MeSH term(s) Brain Diseases/drug therapy ; Brain Diseases/etiology ; COVID-19/complications ; Humans ; Immunoglobulins, Intravenous/therapeutic use
    Chemical Substances Immunoglobulins, Intravenous
    Language English
    Publishing date 2022-05-10
    Publishing country Germany
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-022-11152-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells.

    Reincke, S Momsen / von Wardenburg, Niels / Homeyer, Marie A / Kornau, Hans-Christian / Spagni, Gregorio / Li, Lucie Y / Kreye, Jakob / Sánchez-Sendín, Elisa / Blumenau, Sonja / Stappert, Dominik / Radbruch, Helena / Hauser, Anja E / Künkele, Annette / Edes, Inan / Schmitz, Dietmar / Prüss, Harald

    Cell

    2023  Volume 186, Issue 23, Page(s) 5084–5097.e18

    Abstract: Anti-NMDA receptor (NMDAR) autoantibodies cause NMDAR encephalitis, the most common autoimmune encephalitis, leading to psychosis, seizures, and autonomic dysfunction. Current treatments comprise broad immunosuppression or non-selective antibody removal. ...

    Abstract Anti-NMDA receptor (NMDAR) autoantibodies cause NMDAR encephalitis, the most common autoimmune encephalitis, leading to psychosis, seizures, and autonomic dysfunction. Current treatments comprise broad immunosuppression or non-selective antibody removal. We developed NMDAR-specific chimeric autoantibody receptor (NMDAR-CAAR) T cells to selectively eliminate anti-NMDAR B cells and disease-causing autoantibodies. NMDAR-CAARs consist of an extracellular multi-subunit NMDAR autoantigen fused to intracellular 4-1BB/CD3ζ domains. NMDAR-CAAR T cells recognize a large panel of human patient-derived autoantibodies, release effector molecules, proliferate, and selectively kill antigen-specific target cell lines even in the presence of high autoantibody concentrations. In a passive transfer mouse model, NMDAR-CAAR T cells led to depletion of an anti-NMDAR B cell line and sustained reduction of autoantibody levels without notable off-target toxicity. Treatment of patients may reduce side effects, prevent relapses, and improve long-term prognosis. Our preclinical work paves the way for CAAR T cell phase I/II trials in NMDAR encephalitis and further autoantibody-mediated diseases.
    MeSH term(s) Animals ; Humans ; Mice ; Autoantibodies/metabolism ; Encephalitis/metabolism ; Encephalitis/therapy ; Receptors, N-Methyl-D-Aspartate ; T-Lymphocytes ; Autoimmune Diseases ; Disease Models, Animal
    Chemical Substances Autoantibodies ; Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2023.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 58: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Preclinical safety and efficacy of a therapeutic antibody that targets SARS-CoV-2 at the sotrovimab face but is escaped by Omicron.

    Kreye, Jakob / Reincke, S Momsen / Edelburg, Stefan / Jeworowski, Lara M / Kornau, Hans-Christian / Trimpert, Jakob / Hombach, Peter / Halbe, Sophia / Nölle, Volker / Meyer, Martin / Kattenbach, Stefanie / Sánchez-Sendin, Elisa / Schmidt, Marie L / Schwarz, Tatjana / Rose, Ruben / Krumbholz, Andi / Merz, Sophie / Adler, Julia M / Eschke, Kathrin /
    Abdelgawad, Azza / Schmitz, Dietmar / Sander, Leif E / Janssen, Uwe / Corman, Victor M / Prüss, Harald

    iScience

    2023  Volume 26, Issue 4, Page(s) 106323

    Abstract: The recurrent emerging of novel viral variants of concern (VOCs) with evasion of preexisting antibody immunity upholds severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) case numbers and maintains a persistent demand for updated therapies. We ... ...

    Abstract The recurrent emerging of novel viral variants of concern (VOCs) with evasion of preexisting antibody immunity upholds severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) case numbers and maintains a persistent demand for updated therapies. We selected the patient-derived antibody CV38-142 based on its potency and breadth against the VOCs Alpha, Beta, Gamma, and Delta for preclinical development into a therapeutic. CV38-142 showed
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.106323
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Daratumumab treatment for therapy-refractory anti-CASPR2 encephalitis.

    Scheibe, Franziska / Ostendorf, Lennard / Reincke, S Momsen / Prüss, Harald / von Brünneck, Ann-Christin / Köhnlein, Martin / Alexander, Tobias / Meisel, Christian / Meisel, Andreas

    Journal of neurology

    2019  Volume 267, Issue 2, Page(s) 317–323

    Abstract: The anti-CD38 antibody daratumumab is approved for treatment of refractory multiple myeloma and acts by depletion of plasma cells and modification of various T-cell functions. Its safety, immunological effects and therapeutic potential was evaluated in a ...

    Abstract The anti-CD38 antibody daratumumab is approved for treatment of refractory multiple myeloma and acts by depletion of plasma cells and modification of various T-cell functions. Its safety, immunological effects and therapeutic potential was evaluated in a 60-year old patient with life-threatening and treatment-refractory anti-CASPR2 encephalitis requiring medical care and artificial ventilation in an intensive care unit. His autoimmune dysfunction was driven by exceptional high anti-CASPR2 autoantibody titers combined with an abnormally increased T-cell activation. As he remained unresponsive to standard and escalation immunotherapies (methylprednisolone, plasma exchange, immunoadsorption, immunoglobulins, rituximab and bortezomib), therapy was escalated to 13 cycles of 16 mg/kg daratumumab. During the treatment period, clinical, radiological, histological and laboratory findings, including quantification of autoreactive and protective antibody levels and FACS-based immune phenotyping, were analyzed. Daratumumab treatment was associated with significant clinical improvement, substantial reduction of anti-CASPR2 antibody titers, especially in CSF, decrease of immunoglobulin levels and protective vaccine titers, as well as normalization of initially increased T-cell activation markers. However, the patient died of Gram-negative septicemia in a neurorehabilitation center. In conclusion, our findings suggest that daratumumab induces not only depletion of autoreactive long-lived plasma cells associated with improvements of neurological sequelae, but also severe side effects requiring clinical studies investigating efficacy and safety of anti-CD38 therapy in antibody-driven autoimmune encephalitis.
    MeSH term(s) Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/pharmacology ; Autoimmune Diseases of the Nervous System/drug therapy ; Autoimmune Diseases of the Nervous System/immunology ; Encephalitis/drug therapy ; Encephalitis/immunology ; Humans ; Immunologic Factors/administration & dosage ; Immunologic Factors/pharmacology ; Male ; Membrane Proteins/immunology ; Middle Aged ; Nerve Tissue Proteins/immunology
    Chemical Substances Antibodies, Monoclonal ; CNTNAP2 protein, human ; Immunologic Factors ; Membrane Proteins ; Nerve Tissue Proteins ; daratumumab (4Z63YK6E0E)
    Language English
    Publishing date 2019-10-19
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-019-09585-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top