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  1. Article ; Online: M. bovis

    Schwarz, Marcos Gustavo Araujo / Luzes, Bianca Gallart Cinelli / Correa, Paloma Rezende / da Silva-Gonçalves, Antônio José / Machado, Lucas de Almeida / Guimarães, Ana Carolina Ramos / Mendonça-Lima, Leila

    Frontiers in cellular and infection microbiology

    2021  Volume 11, Page(s) 658888

    Abstract: Tuberculosis still remains a concerning health problem worldwide. Its etiologic agent, ...

    Abstract Tuberculosis still remains a concerning health problem worldwide. Its etiologic agent,
    MeSH term(s) BCG Vaccine ; Brazil ; Flavins ; Mycobacterium bovis ; Mycobacterium tuberculosis
    Chemical Substances BCG Vaccine ; Flavins
    Language English
    Publishing date 2021-03-31
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.658888
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  2. Article ; Online: High nitrogen concentration causes G2/M arrest in Hanseniaspora vineae.

    Schwarz, Luisa Vivian / Sandri, Fernanda Knaach / Scariot, Fernando / Delamare, Ana Paula Longaray / Valera, Maria Jose / Carrau, Francisco / Echeverrigaray, Sergio

    Yeast (Chichester, England)

    2023  Volume 40, Issue 12, Page(s) 640–650

    Abstract: ... cell cycle progression and induces G2/M arrest in H. vineae after reaching the stationary phase. Additionally ...

    Abstract Yeasts have been widely used as a model to better understand cell cycle mechanisms and how nutritional and genetic factors can impact cell cycle progression. While nitrogen scarcity is well known to modulate cell cycle progression, the relevance of nitrogen excess for microorganisms has been overlooked. In our previous work, we observed an absence of proper entry into the quiescent state in Hanseniaspora vineae and identified a potential link between this behavior and nitrogen availability. Furthermore, the Hanseniaspora genus has gained attention due to a significant loss of genes associated with DNA repair and cell cycle. Thus, the aim of our study was to investigate the effects of varying nitrogen concentrations on H. vineae's cell cycle progression. Our findings demonstrated that nitrogen excess, regardless of the source, disrupts cell cycle progression and induces G2/M arrest in H. vineae after reaching the stationary phase. Additionally, we observed a viability decline in H. vineae cells in an ammonium-dependent manner, accompanied by increased production of reactive oxygen species, mitochondrial hyperpolarization, intracellular acidification, and DNA fragmentation. Overall, our study highlights the events of the cell cycle arrest in H. vineae induced by nitrogen excess and attempts to elucidate the possible mechanism triggering this absence of proper entry into the quiescent state.
    MeSH term(s) Hanseniaspora/metabolism ; Apoptosis ; G2 Phase Cell Cycle Checkpoints ; Cell Line, Tumor ; Nitrogen/metabolism
    Chemical Substances Nitrogen (N762921K75)
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 632636-5
    ISSN 1097-0061 ; 0749-503X
    ISSN (online) 1097-0061
    ISSN 0749-503X
    DOI 10.1002/yea.3911
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2820: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The effect of high altitude (2500 m) on incremental cycling exercise in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: a randomised controlled crossover trial.

    Müller, Julian / Titz, Anna / Schneider, Simon R / Bauer, Meret / Mayer, Laura / Lüönd, Lea / Ulrich, Tanja / Furian, Michael / Forrer, Aglaia / Schwarz, Esther I / Bloch, Konrad E / Lichtblau, Mona / Ulrich, Silvia

    The European respiratory journal

    2024  Volume 63, Issue 3

    Abstract: ... incremental exercise tests to exhaustion: one after 3-5 h at high altitude (2500 m) and one at low altitude ... 470 m).: Results: In 27 patients with PAH/CTEPH (44% females, mean±sd age 62±14 years), maximal ... work rate was 110±64 W at 2500 m and 123±64 W at 470 m (-11%, 95% CI -16- -11%; p<0.001 ...

    Abstract Background: Our objective was to investigate the effect of a day-long exposure to high altitude on peak exercise capacity and safety in stable patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH).
    Methods: In a randomised controlled crossover trial, stable patients with PAH or distal CTEPH without resting hypoxaemia at low altitude performed two incremental exercise tests to exhaustion: one after 3-5 h at high altitude (2500 m) and one at low altitude (470 m).
    Results: In 27 patients with PAH/CTEPH (44% females, mean±sd age 62±14 years), maximal work rate was 110±64 W at 2500 m and 123±64 W at 470 m (-11%, 95% CI -16- -11%; p<0.001). Oxygen saturation measured by pulse oximetry and arterial oxygen tension at end-exercise were 83±6%
    Conclusions: Among predominantly low-risk patients with stable PAH/CTEPH, cycling exercise during the first day at 2500 m was well tolerated, but peak exercise capacity, blood oxygenation and ventilatory efficiency were lower compared with 470 m.
    MeSH term(s) Female ; Humans ; Middle Aged ; Aged ; Male ; Hypertension, Pulmonary ; Pulmonary Arterial Hypertension ; Altitude ; Cross-Over Studies ; Familial Primary Pulmonary Hypertension ; Exercise Test ; Oxygen/therapeutic use
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01001-2023
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 292: Show issues

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  4. Article ; Online: Reaction of Winter Cover Crops to Meloidogyne enterolobii and Glasshouse Bioassay for Evaluating Utility in Managing M. enterolobii in Soybeans

    Saha Neel / Schwarz Tanner / Mowery Samantha / Gorny Adrienne M.

    Journal of Nematology, Vol 55, Iss 1, Pp 296-

    2023  Volume 298

    Abstract: ... the Southeastern United States. Winter cover cropping may be a cost-effective method for reducing populations of M. enterolobii ... in between summer cash crops, yet a gap in the knowledge remains about the response of these cover crops to M ... for their direct response to M. enterolobii infection, and to quantify their effect in reducing nematode ...

    Abstract Meloidogyne enterolobii is an invasive and highly aggressive root-knot nematode pathogen impacting the Southeastern United States. Winter cover cropping may be a cost-effective method for reducing populations of M. enterolobii in between summer cash crops, yet a gap in the knowledge remains about the response of these cover crops to M. enterolobii and their utility in suppressing nematode populations prior to a cash crop. A “two-step” glasshouse bioassay was performed to evaluate eight winter cover crops popular in North Carolina for their direct response to M. enterolobii infection, and to quantify their effect in reducing nematode populations for the following soybean plants. Data on cover crop root galling, soybean root galling, soybean shoot fresh weight, soybean root fresh weight, eggs per gram of soybean root, and a modified reproductive factor were collected. Cereal cover crops did not display root galling, and there was significantly less root galling in those soybean plants following cereal winter cover crops when compared to those following broadleaf winter cover crops. Broadleaf winter cover crops resulted in significantly higher eggs per gram of soybean root and modified reproductive factor in the soybean plants, compared to cereal cover crops and non-inoculated controls. Results from this study suggest that cereal winter cover crops may be poor-hosts to M. enterolobii and may significantly reduce M. enterolobii populations before a soybean crop, compared to broadleaf winter cover crops. This study lays the groundwork for management recommendations and future field trials to assess management of M. enterolobii through winter cover cropping.
    Keywords biomass ; guava root-knot nematode ; interaction ; management ; reproductive factor ; Biology (General) ; QH301-705.5
    Subject code 571 ; 580
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
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  5. Article: A Festschrift in Honor of Edward M. Messing, MD, FACS.

    Joseph, Jean V / Brasacchio, Ralph / Fung, Chunkit / Reeder, Jay / Bylund, Kevin / Sahasrabudhe, Deepak / Yeh, Shu Yuan / Ghazi, Ahmed / Fultz, Patrick / Rubens, Deborah / Wu, Guan / Singer, Eric / Schwarz, Edward / Mohile, Supriya / Mohler, James / Theodorescu, Dan / Lee, Yi Fen / Okunieff, Paul / McConkey, David /
    Rashid, Hani / Chang, Chawnshang / Fradet, Yves / Guru, Khurshid / Kukreja, Janet / Sufrin, Gerald / Lotan, Yair / Bailey, Howard / Noyes, Katia / Schwartz, Seymour / Rideout, Kathy / Bratslavsky, Gennady / Campbell, Steven C / Derweesh, Ithaar / Abrahamsson, Per-Anders / Soloway, Mark / Gomella, Leonard / Golijanin, Dragan / Svatek, Robert / Frye, Thomas / Lerner, Seth / Palapattu, Ganesh / Wilding, George / Droller, Michael / Trump, Donald

    Bladder cancer (Amsterdam, Netherlands)

    2018  Volume 4, Issue Suppl 1, Page(s) S1–S43

    Language English
    Publishing date 2018-10-03
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2352-3727
    ISSN 2352-3727
    DOI 10.3233/BLC-189037
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  6. Article: Effect of a day-trip to altitude (2500 m) on exercise performance in pulmonary hypertension: randomised crossover trial.

    Schneider, Simon R / Mayer, Laura C / Lichtblau, Mona / Berlier, Charlotte / Schwarz, Esther I / Saxer, Stéphanie / Tan, Lu / Furian, Michael / Bloch, Konrad E / Ulrich, Silvia

    ERJ open research

    2021  Volume 7, Issue 4

    Abstract: ... included. After >3 h at 2500 m : Conclusion: This randomised crossover study showed that the majority ... of PH patients tolerate a day-trip to 2500 m well. At high ...

    Abstract Question addressed by the study: To investigate exercise performance and hypoxia-related health effects in patients with pulmonary hypertension (PH) during a high-altitude sojourn.
    Patients and methods: In a randomised crossover trial in stable (same therapy for >4 weeks) patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) with resting arterial oxygen tension (
    Results: 28 PAH/CTEPH patients (n=15/n=13); 13 females; mean±sd age 63±15 years were included. After >3 h at 2500 m
    Conclusion: This randomised crossover study showed that the majority of PH patients tolerate a day-trip to 2500 m well. At high
    Language English
    Publishing date 2021-10-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00314-2021
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  7. Article ; Online: A peculiar cell cycle arrest at g2/m stage during the stationary phase of growth in the wine yeast

    Schwarz, Luisa Vivian / Valera, Maria Jose / Delamare, Ana Paula Longaray / Carrau, Francisco / Echeverrigaray, Sergio

    Current research in microbial sciences

    2022  Volume 3, Page(s) 100129

    Abstract: Yeasts of the ... ...

    Abstract Yeasts of the genus
    Language English
    Publishing date 2022-03-26
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-5174
    ISSN (online) 2666-5174
    DOI 10.1016/j.crmicr.2022.100129
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  8. Article ; Online: Metal-Dependent Strengthening and Weakening of M-H and M-C Bonds by an Oxo Ligand: Thermal Gas-Phase Activation of Methane by [OMH]

    Firouzbakht, Marjan / Zhou, Shaodong / González-Navarrete, Patricio / Schlangen, Maria / Kaupp, Martin / Schwarz, Helmut

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2017  Volume 23, Issue 50, Page(s) 12346–12352

    Abstract: The thermal gas-phase reactions of methane with [OMoH] ...

    Abstract The thermal gas-phase reactions of methane with [OMoH]
    Language English
    Publishing date 2017-09-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-x
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.201701615
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  9. Book ; Thesis: C-reaktives Protein (CRP) als Ligand an der I-Domäne des Leukozyten-Integrins Mac-1 (CD11b/CD18; alpha M beta 2) und seine Bedeutung bei der Arterioskleroseentstehung

    Schwarz, Sonja

    2011  

    Author's details von Sonja Schwarz, geb. Herzog
    Language German
    Size 115 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 2011
    HBZ-ID HT017007802
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 E 3598 order for loan Magazin

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  10. Article ; Online: Emergence of a tet(M) Variant Conferring Resistance to Tigecycline in Streptococcus suis

    Rui Yu / Yue Zhang / Yindi Xu / Stefan Schwarz / Xin-Sheng Li / Yan-Hong Shang / Xiang-Dang Du

    Frontiers in Veterinary Science, Vol

    2021  Volume 8

    Abstract: ... GI) GISsuSC128 was investigated by transformation. The roles of tet(L) or tet(M) in contributing ... to tigecycline resistance in S. suis were confirmed by transformation using different tet(L)- or tet(M)-carrying ... constructs. Only S. suis SC128 showed a tigecycline resistance phenotype. A tet(L)-tet(M) and catA8 co ...

    Abstract The aim of this study was to gain insight into the resistance determinants conferring resistance to tigecycline in Streptococcus (S.) suis and to investigate the genetic elements involved in their horizontal transfer. A total of 31 tetracycline-resistant S. suis isolates were screened for tigecycline resistance by broth microdilution. S. suis isolate SC128 was subjected to whole genome sequencing with particular reference to resistance determinants involved in tigecycline resistance. Transferability of genomic island (GI) GISsuSC128 was investigated by transformation. The roles of tet(L) or tet(M) in contributing to tigecycline resistance in S. suis were confirmed by transformation using different tet(L)- or tet(M)-carrying constructs. Only S. suis SC128 showed a tigecycline resistance phenotype. A tet(L)-tet(M) and catA8 co-carrying GISsuSC128 was identified in this isolate. After transfer of the novel GI into a susceptible recipient, this recipient showed the same tigecycline resistance phenotype. Further transfer experiments with specific tet(L)- or tet(M)-carrying constructs confirmed that only tet(M), but not tet(L), contributes to resistance to tigecycline. Protein sequence analysis identified a Tet(M) variant, which is responsible for tigecycline resistance in S. suis SC128. It displayed 94.8% amino acid identity with the reference Tet(M) of Enterococcus faecium DO plasmid 1. To the best of our knowledge, this is the first time that a tet(M) variant conferring resistance to tigecycline was identified in S. suis. Its location on a GI will accelerate its transmission among the S. suis population.
    Keywords Streptococcus suis ; genomic island ; tigecycline ; resistance ; tet(M) variant ; Veterinary medicine ; SF600-1100
    Subject code 900
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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