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  1. Article ; Online: H

    Shirakawa, Kohsuke / Kobayashi, Eiji / Ichihara, Genki / Kitakata, Hiroki / Katsumata, Yoshinori / Sugai, Kazuhisa / Hakamata, Yoji / Sano, Motoaki

    JACC. Basic to translational science

    2022  Volume 7, Issue 2, Page(s) 146–161

    Abstract: ... therapeutic targets. H ...

    Abstract Neutrophil extracellular traps (NETs) contribute to inflammatory pathogenesis in numerous conditions, including infectious and cardiovascular diseases, and have attracted attention as potential therapeutic targets. H
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Journal Article
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2021.11.005
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  2. Article ; Online: Performance of the H

    Tada, Atsushi / Nagai, Toshiyuki / Omote, Kazunori / Iwano, Hiroyuki / Tsujinaga, Shingo / Kamiya, Kiwamu / Konishi, Takao / Sato, Takuma / Komoriyama, Hirokazu / Kobayashi, Yuta / Takenaka, Sakae / Mizuguchi, Yoshifumi / Sato, Tomoya / Yamamoto, Kazuhiro / Yoshikawa, Tsutomu / Saito, Yoshihiko / Anzai, Toshihisa

    International journal of cardiology

    2021  Volume 342, Page(s) 43–48

    Abstract: ... Although the H: Methods: We examined patients with HFpEF recently hospitalized with acute decompensated HF ... population included 372 patients (194 HFpEF group and 178 Non-HFpEF group; HFpEF prevalence, 52%). A high H ... Conclusions: The H ...

    Abstract Background: Diagnosing heart failure with preserved ejection fraction (HFpEF) is challenging. Although the H
    Methods: We examined patients with HFpEF recently hospitalized with acute decompensated HF from a nationwide HFpEF-specific multicenter registry (HFpEF group) and control patients who underwent echocardiography to investigate the cause of dyspnea in our hospital (Non-HFpEF group).
    Results: The studied population included 372 patients (194 HFpEF group and 178 Non-HFpEF group; HFpEF prevalence, 52%). A high H
    Conclusions: The H
    MeSH term(s) Echocardiography ; Heart Failure/diagnostic imaging ; Heart Failure/epidemiology ; Humans ; Japan/epidemiology ; Registries ; Stroke Volume
    Language English
    Publishing date 2021-08-05
    Publishing country Netherlands
    Document type Journal Article ; Multicenter Study
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2021.08.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1673: Show issues Location:
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  3. Article ; Online: A Simple, Fast, Sensitive LC-MS/MS Method to Quantify NAD(H) in Biological Samples: Plasma NAD(H) Measurement to Monitor Brain Pathophysiology.

    Ishima, Tamaki / Kimura, Natsuka / Kobayashi, Mizuki / Nagai, Ryozo / Osaka, Hitoshi / Aizawa, Kenichi

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: Nicotinamide adenine dinucleotide (NAD) is a cofactor in redox reactions and an essential mediator of energy metabolism. The redox balance between ... ...

    Abstract Nicotinamide adenine dinucleotide (NAD) is a cofactor in redox reactions and an essential mediator of energy metabolism. The redox balance between NAD
    MeSH term(s) Mice ; Animals ; NAD/metabolism ; Chromatography, Liquid ; Liquid Chromatography-Mass Spectrometry ; Tandem Mass Spectrometry ; Brain Diseases ; Brain/metabolism ; Oxidation-Reduction
    Chemical Substances NAD (0U46U6E8UK)
    Language English
    Publishing date 2024-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042325
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  4. Article ; Online: Synthesis and H

    Nawaz, Haq / Takeiri, Fumitaka / Kuwabara, Akihide / Yonemura, Masao / Kobayashi, Genki

    Chemical communications (Cambridge, England)

    2020  Volume 56, Issue 71, Page(s) 10373–10376

    Abstract: A new layered perovskite oxyhydride ... ...

    Abstract A new layered perovskite oxyhydride Ba
    Language English
    Publishing date 2020-08-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d0cc03638b
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  5. Article ; Online: Anion ordering enables fast H

    Ubukata, Hiroki / Takeiri, Fumitaka / Shitara, Kazuki / Tassel, Cédric / Saito, Takashi / Kamiyama, Takashi / Broux, Thibault / Kuwabara, Akihide / Kobayashi, Genki / Kageyama, Hiroshi

    Science advances

    2021  Volume 7, Issue 23

    Abstract: The introduction of chemical disorder by substitutional chemistry into ionic conductors is the most commonly used strategy to stabilize high-symmetric phases while maintaining ionic conductivity at lower temperatures. In recent years, hydride materials ... ...

    Abstract The introduction of chemical disorder by substitutional chemistry into ionic conductors is the most commonly used strategy to stabilize high-symmetric phases while maintaining ionic conductivity at lower temperatures. In recent years, hydride materials have received much attention owing to their potential for new energy applications, but there remains room for development in ionic conductivity below 300°C. Here, we show that layered anion-ordered Ba
    Language English
    Publishing date 2021-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abf7883
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  6. Article ; Online: Visible-Light-Driven C-H Imidation of Arenes and Heteroarenes by a Phosphonium Ylide Organophotoredox Catalyst: Application to C-H Functionalization of Alkenes.

    Toda, Yasunori / Kobayashi, Toya / Hirai, Fumiya / Yano, Takamichi / Oikawa, Makoto / Sukegawa, Kimiya / Shimizu, Masahiro / Ito, Fuyuki / Suga, Hiroyuki

    The Journal of organic chemistry

    2023  Volume 88, Issue 13, Page(s) 9574–9578

    Abstract: ... for visible-light-driven C-H imidation of arenes and heteroarenes. The present protocol could be applied not only ...

    Abstract Phosphonium ylide catalysis through an oxidative quenching cycle has been developed for visible-light-driven C-H imidation of arenes and heteroarenes. The present protocol could be applied not only to trihalomethylative lactonization reactions involving trifluoromethyl, trichloromethyl, and tribromomethyl radicals but also to the first example of an organophotoredox-catalyzed imidative lactonization reaction involving a nitrogen-centered electrophilic radical species.
    MeSH term(s) Alkenes ; Catalysis ; Light ; Oxidation-Reduction
    Chemical Substances Alkenes
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c00988
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
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  7. Article ; Online: Histamine H

    Takei, Hiroki / Yamamoto, Kiyofumi / Bae, Yong-Chul / Shirakawa, Tetsuo / Kobayashi, Masayuki

    Frontiers in neural circuits

    2017  Volume 11, Page(s) 85

    Abstract: Histamine H ...

    Abstract Histamine H
    MeSH term(s) Animals ; Axons/drug effects ; Axons/metabolism ; Axons/ultrastructure ; Cerebral Cortex/cytology ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; Excitatory Postsynaptic Potentials/drug effects ; Excitatory Postsynaptic Potentials/physiology ; Glutamic Acid/metabolism ; Histamine Agonists/pharmacology ; Histamine Antagonists/pharmacology ; Inhibitory Postsynaptic Potentials/drug effects ; Inhibitory Postsynaptic Potentials/physiology ; Interneurons/cytology ; Interneurons/drug effects ; Interneurons/metabolism ; Male ; Miniature Postsynaptic Potentials/drug effects ; Miniature Postsynaptic Potentials/physiology ; Pyramidal Cells/cytology ; Pyramidal Cells/drug effects ; Pyramidal Cells/metabolism ; Rats, Sprague-Dawley ; Rats, Transgenic ; Receptors, Histamine H3/metabolism ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology ; Tissue Culture Techniques ; gamma-Aminobutyric Acid/metabolism
    Chemical Substances Histamine Agonists ; Histamine Antagonists ; Receptors, Histamine H3 ; Glutamic Acid (3KX376GY7L) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452968-0
    ISSN 1662-5110 ; 1662-5110
    ISSN (online) 1662-5110
    ISSN 1662-5110
    DOI 10.3389/fncir.2017.00085
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  8. Article ; Online: High plasma aldosterone concentration is associated with worse 24-h ambulatory blood pressure profile in patients with primary aldosteronism.

    Morita, Ryutaro / Azushima, Kengo / Sunohara, Sumire / Haze, Tatsuya / Kobayashi, Ryu / Kinguchi, Sho / Kanaoka, Tomohiko / Kobayashi, Kazuo / Toya, Yoshiyuki / Wakui, Hiromichi / Tamura, Kouichi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 8, Page(s) 1995–2004

    Abstract: ... blood samples were collected from the inferior vena cava before and 1 h after adrenocorticotropic hormone (ACTH ...

    Abstract Patients with primary aldosteronism (PA) have a higher risk of cardiovascular disease (CVD) than essential hypertension due to underlying hyperaldosteronism. However, the association between high plasma aldosterone concentrations (PACs) and diurnal blood pressure (BP) variation has not been fully elucidated. Because abnormal ambulatory blood pressure monitoring (ABPM) profiles are associated with increased CVD risk, we investigated the association between PACs and the ABPM profile in 36 patients with PA diagnosed by confirmatory tests who underwent adrenal venous sampling (AVS). The clinical parameters were measured during hospitalization for AVS. The dietary salt intake of hospitalized patients was controlled at 6 g/day. During AVS, blood samples were collected from the inferior vena cava before and 1 h after adrenocorticotropic hormone (ACTH) stimulation to measure the PACs. The post-stimulation PAC had a significant negative correlation with nocturnal BP dipping rates (R = -0.387, p = 0.020), whereas pre-stimulation PAC did not (R = -0.217, p = 0.204). The nocturnal BP dipping rates were significantly lower in the high PAC group (PAC higher than the median) than low PAC group (PAC lower than the median) (p = 0.009). Multiple regression analysis revealed that high PAC was an independent factor contributing to low nocturnal BP dipping rates (β = -0.316, p = 0.038). In conclusion, in patients with PA, hyperaldosteronism is associated with nocturnal hypertension, which is an important risk factor for CVD. Additionally, ACTH stimulation may improve the sensitivity of PACs as a clinical indicator of nocturnal hypertension.
    MeSH term(s) Humans ; Aldosterone ; Blood Pressure Monitoring, Ambulatory ; Blood Pressure ; Hyperaldosteronism/complications ; Hyperaldosteronism/diagnosis ; Hypertension ; Adrenocorticotropic Hormone ; Cardiovascular Diseases
    Chemical Substances Aldosterone (4964P6T9RB) ; Adrenocorticotropic Hormone (9002-60-2)
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01325-8
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    Zs.A 3898: Show issues Location:
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  9. Article ; Online: Development of multiple AI pipelines that predict neoadjuvant chemotherapy response of breast cancer using H&E-stained tissues.

    Shen, Bin / Saito, Akira / Ueda, Ai / Fujita, Koji / Nagamatsu, Yui / Hashimoto, Mikihiro / Kobayashi, Masaharu / Mirza, Aashiq H / Graf, Hans Peter / Cosatto, Eric / Hazama, Shoichi / Nagano, Hiroaki / Sato, Eiichi / Matsubayashi, Jun / Nagao, Toshitaka / Cheng, Esther / Hoda, Syed Af / Ishikawa, Takashi / Kuroda, Masahiko

    The journal of pathology. Clinical research

    2023  Volume 9, Issue 3, Page(s) 182–194

    Abstract: In recent years, the treatment of breast cancer has advanced dramatically and neoadjuvant chemotherapy (NAC) has become a common treatment method, especially for locally advanced breast cancer. However, other than the subtype of breast cancer, no clear ... ...

    Abstract In recent years, the treatment of breast cancer has advanced dramatically and neoadjuvant chemotherapy (NAC) has become a common treatment method, especially for locally advanced breast cancer. However, other than the subtype of breast cancer, no clear factor indicating sensitivity to NAC has been identified. In this study, we attempted to use artificial intelligence (AI) to predict the effect of preoperative chemotherapy from hematoxylin and eosin images of pathological tissue obtained from needle biopsies prior to chemotherapy. Application of AI to pathological images typically uses a single machine-learning model such as support vector machines (SVMs) or deep convolutional neural networks (CNNs). However, cancer tissues are extremely diverse and learning with a realistic number of cases limits the prediction accuracy of a single model. In this study, we propose a novel pipeline system that uses three independent models each focusing on different characteristics of cancer atypia. Our system uses a CNN model to learn structural atypia from image patches and SVM and random forest models to learn nuclear atypia from fine-grained nuclear features extracted by image analysis methods. It was able to predict the NAC response with 95.15% accuracy on a test set of 103 unseen cases. We believe that this AI pipeline system will contribute to the adoption of personalized medicine in NAC therapy for breast cancer.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Artificial Intelligence ; Neoadjuvant Therapy/methods ; Machine Learning ; Chemotherapy, Adjuvant
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2814357-7
    ISSN 2056-4538 ; 2056-4538
    ISSN (online) 2056-4538
    ISSN 2056-4538
    DOI 10.1002/cjp2.314
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  10. Article ; Online: Design and synthesis of histamine H

    Watanabe, Mizuki / Kobayashi, Takaaki / Ito, Yoshihiko / Fukuda, Hayato / Yamada, Shizuo / Arisawa, Mitsuhiro / Shuto, Satoshi

    Bioorganic & medicinal chemistry letters

    2018  Volume 28, Issue 23-24, Page(s) 3630–3633

    Abstract: ... with an imidazolylcyclopropane scaffold and identified potent non-selective antagonists for histamine H ...

    Abstract We previously designed and synthesized a series of histamine analogues with an imidazolylcyclopropane scaffold and identified potent non-selective antagonists for histamine H
    MeSH term(s) Benzimidazoles/chemistry ; Benzimidazoles/metabolism ; Cyclopropanes/chemistry ; Cyclopropanes/metabolism ; Drug Design ; Histamine Antagonists/chemical synthesis ; Histamine Antagonists/chemistry ; Histamine Antagonists/metabolism ; Humans ; Imidazoles/chemistry ; Imidazoles/metabolism ; Indoles/chemistry ; Indoles/metabolism ; Ligands ; Protein Binding ; Receptors, Histamine H3/chemistry ; Receptors, Histamine H3/metabolism ; Receptors, Histamine H4/chemistry ; Receptors, Histamine H4/metabolism ; Structure-Activity Relationship
    Chemical Substances Benzimidazoles ; Cyclopropanes ; Histamine Antagonists ; Imidazoles ; Indoles ; Ligands ; Receptors, Histamine H3 ; Receptors, Histamine H4 ; indole (8724FJW4M5) ; benzimidazole (E24GX49LD8)
    Language English
    Publishing date 2018-10-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2018.10.041
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