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  1. Article ; Online: Survival strategies of

    Byun, Kye-Hwan / Kim, Hyun Jung

    Food science and biotechnology

    2023  Volume 32, Issue 12, Page(s) 1631–1651

    Abstract: ... Listeria ... ...

    Abstract Listeria monocytogenes
    Language English
    Publishing date 2023-09-14
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2000008-X
    ISSN 2092-6456 ; 1226-7708
    ISSN (online) 2092-6456
    ISSN 1226-7708
    DOI 10.1007/s10068-023-01427-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7438: Show issues

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  2. Article: COVID-19, Influenza, and RSV in Children and Adults: A Clinical Comparative Study of 12,000 Cases.

    Kwon, Jae-Hyun / Paek, So-Hyun / Park, Soo-Hyun / Kim, Min-Jung / Byun, Young-Hoon / Song, Ho-Young

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: 1) ...

    Abstract (1)
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exosomal LINC00853 promotes progression of gastric cancer via the MAP17/PDZK1/AKT signaling pathway.

    Yoon, Jung-Ho / Byun, Hyo Joo / Kim, Seo Yeon / Jung, Da Hyun / Lee, Sang Kil

    Non-coding RNA research

    2024  Volume 9, Issue 3, Page(s) 876–886

    Abstract: Although rare, there is ongoing research into biomarkers that predict the onset and recurrence of gastric cancer, particularly focusing on substances found in exosomes. Long non-coding RNAs (lncRNAs) have garnered attention for their potential in ... ...

    Abstract Although rare, there is ongoing research into biomarkers that predict the onset and recurrence of gastric cancer, particularly focusing on substances found in exosomes. Long non-coding RNAs (lncRNAs) have garnered attention for their potential in diagnosing gastric cancer. This study investigates the role of lncRNAs in gastric cancer, focusing on their presence in exosomes as potential biomarkers for the disease's onset and recurrence. We utilized the ArrayStar Human LncRNA array 2.0 to analyze lncRNA expression in tissues from early-stage gastric cancer patients. Our analysis highlighted LINC00853, which was significantly upregulated in cancer tissues and implicated in promoting epithelial-mesenchymal transition via the MAP17/PDZK1/AKT pathway. Functional studies on AGS and MKN74 gastric cancer cell lines demonstrated that LINC00853 facilitates cell proliferation, invasion, and migration. Additionally, RNA immunoprecipitation and electrophoretic mobility shift assays confirmed LINC00853 interaction with MAP17. Importantly, LINC00853 was also detected in exosomes from both patient samples and cell lines, and its downregulation led to decreased tumorigenicity in AGS cells. These findings suggest that both cellular and exosomal LINC00853 contribute to gastric cancer pathogenesis and may serve as valuable biomarkers for the disease.
    Language English
    Publishing date 2024-03-30
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-0540
    ISSN (online) 2468-0540
    DOI 10.1016/j.ncrna.2024.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Deep learning signature of brain [

    Ryoo, Hyun Gee / Byun, Jung-Ick / Choi, Hongyoon / Jung, Ki-Young

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 19259

    Abstract: An objective biomarker to predict the outcome of isolated rapid eye movement sleep behavior disorder (iRBD) is crucial for the management. This study aimed to investigate cognitive signature of brain [ ...

    Abstract An objective biomarker to predict the outcome of isolated rapid eye movement sleep behavior disorder (iRBD) is crucial for the management. This study aimed to investigate cognitive signature of brain [
    MeSH term(s) Humans ; REM Sleep Behavior Disorder/complications ; Fluorodeoxyglucose F18/metabolism ; Deep Learning ; Brain/metabolism ; Cognitive Dysfunction/metabolism ; Cognition
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2022-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-23347-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Evaluation of Anti-Cancer Activity of

    Lim, Hyun Jung / Byun, Eui-Hong

    Preventive nutrition and food science

    2020  Volume 26, Issue 4, Page(s) 453–458

    Abstract: ... Gryllus ... ...

    Abstract Gryllus bimaculatus
    Language English
    Publishing date 2020-03-11
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2668373-8
    ISSN 2287-8602 ; 2287-1098
    ISSN (online) 2287-8602
    ISSN 2287-1098
    DOI 10.3746/pnf.2021.26.4.453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7808: Show issues

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  6. Article: LKB1/STK11 Tumor Suppressor Reduces Angiogenesis by Directly Interacting with VEGFR2 in Tumorigenesis.

    Rho, Seung Bae / Byun, Hyun Jung / Kim, Boh-Ram / Lee, Chang Hoon

    Biomolecules & therapeutics

    2023  Volume 31, Issue 4, Page(s) 456–465

    Abstract: Cervical tumors represent a prevalent form of cancer affecting women worldwide; current treatment options involve surgery, radiotherapy, and chemotherapy. Angiogenesis, the process of new blood vessel formation, is a crucial factor in cervical tumor ... ...

    Abstract Cervical tumors represent a prevalent form of cancer affecting women worldwide; current treatment options involve surgery, radiotherapy, and chemotherapy. Angiogenesis, the process of new blood vessel formation, is a crucial factor in cervical tumor growth. The molecular mechanisms underlying the effects of the liver kinase B1 (LKB1/STK11) tumor suppressor protein on tumor angiogenesis have not been elucidated. Therefore, we investigated the role of LKB1 in cervical tumor angiogenesis both
    Language English
    Publishing date 2023-06-26
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2734146-X
    ISSN 2005-4483 ; 1976-9148
    ISSN (online) 2005-4483
    ISSN 1976-9148
    DOI 10.4062/biomolther.2023.106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Spatiotemporal characteristics of cortical activities of REM sleep behavior disorder revealed by explainable machine learning using 3D convolutional neural network.

    Kim, Hyun / Seo, Pukyeong / Byun, Jung-Ick / Jung, Ki-Young / Kim, Kyung Hwan

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 8221

    Abstract: Isolated rapid eye movement sleep behavior disorder (iRBD) is a sleep disorder characterized by dream enactment behavior without any neurological disease and is frequently accompanied by cognitive dysfunction. The purpose of this study was to reveal the ... ...

    Abstract Isolated rapid eye movement sleep behavior disorder (iRBD) is a sleep disorder characterized by dream enactment behavior without any neurological disease and is frequently accompanied by cognitive dysfunction. The purpose of this study was to reveal the spatiotemporal characteristics of abnormal cortical activities underlying cognitive dysfunction in patients with iRBD based on an explainable machine learning approach. A convolutional neural network (CNN) was trained to discriminate the cortical activities of patients with iRBD and normal controls based on three-dimensional input data representing spatiotemporal cortical activities during an attention task. The input nodes critical for classification were determined to reveal the spatiotemporal characteristics of the cortical activities that were most relevant to cognitive impairment in iRBD. The trained classifiers showed high classification accuracy, while the identified critical input nodes were in line with preliminary knowledge of cortical dysfunction associated with iRBD in terms of both spatial location and temporal epoch for relevant cortical information processing for visuospatial attention tasks.
    MeSH term(s) Humans ; REM Sleep Behavior Disorder ; Polysomnography/methods ; Cognitive Dysfunction ; Attention ; Cognition
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-35209-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Evaluation of the Immunological Activity of

    Lim, Hyun Jung / Han, Jeong Moo / Byun, Eui-Hong

    Preventive nutrition and food science

    2022  Volume 27, Issue 1, Page(s) 99–107

    Abstract: Edible insects are commonly consumed across the world because of their size, availability, and nutritional benefits. They have also been recommended as a potential solution to food shortage because of their high nutritional value. In this study, we ... ...

    Abstract Edible insects are commonly consumed across the world because of their size, availability, and nutritional benefits. They have also been recommended as a potential solution to food shortage because of their high nutritional value. In this study, we demonstrated the immunological effects of
    Language English
    Publishing date 2022-02-03
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2668373-8
    ISSN 2287-8602 ; 2287-1098
    ISSN (online) 2287-8602
    ISSN 2287-1098
    DOI 10.3746/pnf.2022.27.1.99
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7808: Show issues

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  9. Article ; Online: The First Case of Preauricular Fistular Abscess Caused by

    Kim, Mutbyul / Shin, Hyoshim / Lee, Dong-Hyun / Koh, Eun-Ha / Byun, Jung-Hyun

    Annals of laboratory medicine

    2022  Volume 42, Issue 4, Page(s) 488–490

    MeSH term(s) Abscess/diagnosis ; Craniofacial Abnormalities ; Firmicutes ; Humans
    Language English
    Publishing date 2022-02-17
    Publishing country Korea (South)
    Document type Case Reports ; Letter
    ZDB-ID 2677441-0
    ISSN 2234-3814 ; 2234-3814
    ISSN (online) 2234-3814
    ISSN 2234-3814
    DOI 10.3343/alm.2022.42.4.488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Liver Kinase B1 Mediates Its Anti-Tumor Function by Binding to the N-Terminus of Malic Enzyme 3.

    Rho, Seung Bae / Byun, Hyun Jung / Kim, Boh-Ram / Lee, Chang Hoon

    Biomolecules & therapeutics

    2023  Volume 31, Issue 3, Page(s) 330–339

    Abstract: Liver kinase B1 (LKB1) is a crucial tumor suppressor involved in various cellular processes, including embryonic development, tumor initiation and progression, cell adhesion, apoptosis, and metabolism. However, the precise mechanisms underlying its ... ...

    Abstract Liver kinase B1 (LKB1) is a crucial tumor suppressor involved in various cellular processes, including embryonic development, tumor initiation and progression, cell adhesion, apoptosis, and metabolism. However, the precise mechanisms underlying its functions remain elusive. In this study, we demonstrate that LKB1 interacts directly with malic enzyme 3 (ME3) through the N-terminus of the enzyme and identified the binding regions necessary for this interaction. The binding activity was confirmed to promote the expression of ME3 in an LKB1-dependent manner and was also shown to induce apoptosis activity. Furthermore, LKB1 and ME3 overexpression upregulated the expression of tumour suppressor proteins (p53 and p21) and downregulated the expression of antiapoptotic proteins (nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and B-cell lymphoma 2 (Bcl-2)). Additionally, LKB1 and ME3 enhanced the transcription of p21 and p53 and inhibited the transcription of NF-κB. Moreover, LKB1 and ME3 suppressed the phosphorylation of various components of the phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B signaling pathway. Overall, these results suggest that LKB1 promotes pro-apoptotic activities by inducing ME3 expression.
    Language English
    Publishing date 2023-03-17
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2734146-X
    ISSN 2005-4483 ; 1976-9148
    ISSN (online) 2005-4483
    ISSN 1976-9148
    DOI 10.4062/biomolther.2023.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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