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Article ; Online: Ruling out Color Transparency in Quasielastic ^{12}C(e,e^{'}p) up to Q^{2} of 14.2 (GeV/c)^{2}.

Bhetuwal, D / Matter, J / Szumila-Vance, H / Kabir, M L / Dutta, D / Ent, R / Abrams, D / Ahmed, Z / Aljawrneh, B / Alsalmi, S / Ambrose, R / Androic, D / Armstrong, W / Asaturyan, A / Assumin-Gyimah, K / Ayerbe Gayoso, C / Bandari, A / Basnet, S / Berdnikov, V /

Bhatt, H / Biswas, D / Boeglin, W U / Bosted, P / Brash, E / Bukhari, M H S / Chen, H / Chen, J P / Chen, M / Christy, E M / Covrig, S / Craycraft, K / Danagoulian, S / Day, D / Diefenthaler, M / Dlamini, M / Dunne, J / Duran, B / Evans, R / Fenker, H / Fomin, N / Fuchey, E / Gaskell, D / Gautam, T N / Gonzalez, F A / Hansen, J O / Hauenstein, F / Hernandez, A V / Horn, T / Huber, G M / Jones, M K / Joosten, S / Karki, A / Keppel, C / Khanal, A / King, P M / Kinney, E / Ko, H S / Kohl, M / Lashley-Colthirst, N / Li, S / Li, W B / Liyanage, A H / Mack, D / Malace, S / Markowitz, P / Meekins, D / Michaels, R / Mkrtchyan, A / Mkrtchyan, H / Nazeer, S J / Nanda, S / Niculescu, G / Niculescu, I / Nguyen, D / Nuruzzaman / Pandey, B / Park, S / Pooser, E / Puckett, A / Rehfuss, M / Reinhold, J / Santiesteban, N / Sawatzky, B / Smith, G R / Sun, A / Tadevosyan, V / Trotta, R / Wood, S A / Yero, C / Zhang, J

Physical review letters

2021 Volume 126, Issue 8, Page(s) 82301

Abstract: Quasielastic ^{12}C(e,e^{'}p) scattering was measured at spacelike 4-momentum transfer squared Q^{2 ... 8, 9.4, 11.4, and 14.2 (GeV/c)^{2}, the highest ever achieved to date. Nuclear transparency ... Q^{2} dependence, up to proton momenta of 8.5 GeV/c, ruling out the quantum chromodynamics effect ...

Abstract	Quasielastic ^{12}C(e,e^{'}p) scattering was measured at spacelike 4-momentum transfer squared Q^{2}=8, 9.4, 11.4, and 14.2 (GeV/c)^{2}, the highest ever achieved to date. Nuclear transparency for this reaction was extracted by comparing the measured yield to that expected from a plane-wave impulse approximation calculation without any final state interactions. The measured transparency was consistent with no Q^{2} dependence, up to proton momenta of 8.5 GeV/c, ruling out the quantum chromodynamics effect of color transparency at the measured Q^{2} scales in exclusive (e,e^{'}p) reactions. These results impose strict constraints on models of color transparency for protons.
Language	English
Publishing date	2021-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.126.082301
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Article ; Online: Hand hygiene practices for prevention of health care-associated infections associated with admitted infectious patients in the emergency department: a systematic review.

Issa, M / Dunne, S S / Dunne, C P

Irish journal of medical science

2022 Volume 192, Issue 2, Page(s) 871–899

Abstract: Background: In most high-income countries, emergency departments (ED) represent the principal point of access forcer by critically ill or injured patients. Unlike inpatient units, ED healthcare workers (ED HCWs) have demonstrated relative lack of ... ...

Abstract	Background: In most high-income countries, emergency departments (ED) represent the principal point of access forcer by critically ill or injured patients. Unlike inpatient units, ED healthcare workers (ED HCWs) have demonstrated relative lack of adherence to hand hygiene (HH) guidelines, commonly citing frequency of intervention and high rates of admission, which reflect severity of cases encountered. Aim: Assessment of studies on hand hygiene compliance (HHC) by ED HCWs conducted between 2010 and 2020, seeking to estimate HHC rates and intervention strategies utilised to improve HHC in EDs. Methods: Searches conducted in Web of Science, EBSCO HOST (CINHAL & Medline), PubMed, Embase, and Cochrane for full studies published between 2010 and 2020 on the topic of HHC in the ED. Results: One hundred twenty-nine eligible articles were identified of which 79 were excluded. Fifty-one underwent full-text screening before 20 studies were deemed relevant. Of the eligible studies, fifteen (75%) had, as the primary outcome, HHC according to the WHO-recommended 5-moments. Twelve studies (60%) implemented multimodal or single intervention strategies. Eight studies were ambiguous regarding the nature of the approach adopted. In the nine observational studies where HHC was documented, an overall post-intervention median HHC rate of 45% (range 8-89.7%). Conclusion: Multimodal approaches appear to have enhanced HHC moderately among ED HCWs. Elevated complexity associated with critically ill patients, and ED overcrowding, are contributing factors to relatively low compliance rates observed. Strategies to improve HHC rates may need to acknowledge, and cater for, the context of an unpredictable environment.
MeSH term(s)	Humans ; Hand Hygiene ; Critical Illness ; Guideline Adherence ; Cross Infection/prevention & control ; Health Personnel ; Emergency Service, Hospital ; Inpatients ; Delivery of Health Care
Language	English
Publishing date	2022-04-18
Publishing country	Ireland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-022-03004-y
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Article: Health literacy, eHealth literacy and their association with burden, distress, and self-efficacy among cancer caregivers.

Moore, Chloe / Gallagher, Pamela / Dunne, Simon

Frontiers in psychology

2024 Volume 15, Page(s) 1283227

Abstract: Purpose: Health literacy skills are vital for cancer caregivers in helping cancer survivors to navigate their diagnosis, treatment, and recovery but little is known. This study explored health literacy and eHealth literacy among cancer caregivers and ... ...

Abstract	Purpose: Health literacy skills are vital for cancer caregivers in helping cancer survivors to navigate their diagnosis, treatment, and recovery but little is known. This study explored health literacy and eHealth literacy among cancer caregivers and the relationship between health literacy/eHealth literacy and potential associated factors. Methods: Informal caregivers who had cared for an individual with cancer completed a survey which collected demographic data and measured caregiver health literacy, eHealth literacy, self-efficacy, burden, and distress. Results: Seven percent of caregivers had inadequate health literacy. Caregivers scored lowest on health literacy domains related to caregiver social support, information seeking and understanding care recipient preferences. eHealth literacy was associated with self-efficacy and burden while, different health literacy domains were associated with burden (' Conclusion: Findings highlight key areas of need regarding cancer caregiver health literacy which future research can target. Given the observed relationship between aspects of health literacy and burden, distress and self-efficacy future work could be carried out on how to alleviate high levels of burden and distress and how to enhance self-efficacy among cancer caregivers by addressing health literacy skills. Implications for cancer survivors: Findings from this study will inform the development of health literacy interventions to support caregivers to build their health literacy skills and enable this group to better support cancer survivors as a result.
Language	English
Publishing date	2024-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2024.1283227
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Article: Glycaemic control and novel technology management strategies in pregestational diabetes mellitus.

Newman, Christine / Ero, Adesuwa / Dunne, Fidelma P

Frontiers in endocrinology

2023 Volume 13, Page(s) 1109825

Abstract: Introduction: Pregestational diabetes (PGDM) is an increasingly common and complex condition that infers risk to both mother and infant. To prevent serious morbidity, strict glycaemic control is essential. The aim of this review is to review the glucose ...

Abstract	Introduction: Pregestational diabetes (PGDM) is an increasingly common and complex condition that infers risk to both mother and infant. To prevent serious morbidity, strict glycaemic control is essential. The aim of this review is to review the glucose sensing and insulin delivering technologies currently available for women with PGDM. Methods: We reviewed online databases for articles relating to technology use in pregnancy using a combination of keywords and MeSH headings. Relevant articles are included below. Results: A number of technological advancements have improved care and outcomes for women with PGDM. Real time continuous glucose monitoring (rtCGM) offers clear advantages in terms of infants size and neonatal intensive care unit admissions; and further benefits are seen when combined with continuous subcutaneous insulin delivery (insulin pump) and algorithms which continuously adjust insulin levels to glucose targets (hybrid closed loop). Other advancements including flash or intermittent scanning CGM (isCGM) and stand-alone insulin pumps do not confer as many advantages for women and their infants, however they are increasingly used outside of pregnancy and many women enter pregnancy already using these devices. Discussion: This article offers a discussion of the most commonly used technologies in pregnancy and evaluates their current and future roles.
MeSH term(s)	Pregnancy ; Infant, Newborn ; Female ; Humans ; Hypoglycemic Agents/therapeutic use ; Diabetes Mellitus, Type 1/drug therapy ; Blood Glucose Self-Monitoring ; Glycemic Control ; Blood Glucose ; Insulin/therapeutic use ; Pregnancy in Diabetics/therapy
Chemical Substances	Hypoglycemic Agents ; Blood Glucose ; Insulin
Language	English
Publishing date	2023-01-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1109825
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Article ; Online: Corrigendum to "Hand hygiene-related clinical trials reported between 2014 and 2020: a comprehensive systematic review" [J Hosp Infect 111 (2021) 6-26].

Clancy, C / Delungahawatta, T / Dunne, C P

The Journal of hospital infection

2021 Volume 117, Page(s) 194–196

Language	English
Publishing date	2021-08-06
Publishing country	England
Document type	Published Erratum
ZDB-ID	779366-2
ISSN	1532-2939 ; 0195-6701
ISSN (online)	1532-2939
ISSN	0195-6701
DOI	10.1016/j.jhin.2021.06.010
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Article ; Online: A hypothesis for association between electrical surgical incision techniques and surgical site infection.

Clancy, C / Dunne, S S / Baban, C / Tormey, S / Merrigan, A / O'Connell, N H / Coffey, J C / Dunne, C P

The Journal of hospital infection

2022 Volume 128, Page(s) 36–38

MeSH term(s)	Humans ; Negative-Pressure Wound Therapy/methods ; Surgical Wound ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/prevention & control
Language	English
Publishing date	2022-07-16
Publishing country	England
Document type	Journal Article
ZDB-ID	779366-2
ISSN	1532-2939 ; 0195-6701
ISSN (online)	1532-2939
ISSN	0195-6701
DOI	10.1016/j.jhin.2022.07.012
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Article ; Online: Metformin for pregnancy and beyond: the pros and cons.

Newman, Christine / Dunne, Fidelma P

Diabetic medicine : a journal of the British Diabetic Association

2021 Volume 39, Issue 3, Page(s) e14700

Abstract: Context and aim: Metformin has been used in pregnancy since the 1970s. It is cheap, widely available and is acceptable to women. Despite its increasing use, controversy remains surrounding its benefits and risks. Metformin effectively reduces ... ...

Abstract	Context and aim: Metformin has been used in pregnancy since the 1970s. It is cheap, widely available and is acceptable to women. Despite its increasing use, controversy remains surrounding its benefits and risks. Metformin effectively reduces hyperglycaemia for the mother during pregnancy and it reduces rates of macrosomia and neonatal hypoglycaemia. However, concern exists surrounding an increase in the rate of SGA births and obesity in childhood. We aim to review the evidence and expert opinion behind metformin in pregnancy through to the post-partum period. Methods: We performed a literature review of relevant studies from online databases using a combination of keywords. We also searched the references of retrieved articles for pertinent studies. Results: There is strong evidence that metformin is safe in early pregnancy with no risk of congenital malformations. If used throughout pregnancy, it is likely to lead to reduced maternal weight gain and reduced insulin dose in women with type 2 diabetes. In infants, metformin reduces hypoglycaemia and macrosomia but may increase the rate of infants born SGA. There is some evidence of an increased risk of obesity and altered fat distribution in offspring. Metformin appears well tolerated in pregnancy and is more acceptable to women than insulin therapy. Conclusion: Due to increasing rates of maternal obesity, GDM and type 2 diabetes, metformin use in pregnancy is increasing. Overall, it appears safe and effective but further research is needed to examine mechanisms linking metformin to obesity reported during childhood in some follow-up studies.
MeSH term(s)	Administration, Oral ; Child ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes, Gestational/drug therapy ; Diabetes, Gestational/prevention & control ; Female ; Gestational Weight Gain/drug effects ; Humans ; Hyperglycemia/drug therapy ; Hyperglycemia/prevention & control ; Hypoglycemia/chemically induced ; Hypoglycemia/prevention & control ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/adverse effects ; Infant, Newborn ; Infant, Small for Gestational Age ; Insulin/administration & dosage ; Metformin/administration & dosage ; Metformin/adverse effects ; Pediatric Obesity/chemically induced ; Pregnancy ; Pregnancy Outcome ; Randomized Controlled Trials as Topic
Chemical Substances	Hypoglycemic Agents ; Insulin ; Metformin (9100L32L2N)
Language	English
Publishing date	2021-10-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	605769-x
ISSN	1464-5491 ; 0742-3071 ; 1466-5468
ISSN (online)	1464-5491
ISSN	0742-3071 ; 1466-5468
DOI	10.1111/dme.14700
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Article ; Online: Hand-hygiene-related clinical trials reported between 2014 and 2020: a comprehensive systematic review.

Clancy, C / Delungahawatta, T / Dunne, C P

The Journal of hospital infection

2021 Volume 111, Page(s) 6–26

Abstract: Background: There is general consensus that hand hygiene is the most effective way to prevent healthcare-associated infections. However, low rates of compliance amongst healthcare workers have been reported globally. The coronavirus disease 2019 ... ...

Abstract	Background: There is general consensus that hand hygiene is the most effective way to prevent healthcare-associated infections. However, low rates of compliance amongst healthcare workers have been reported globally. The coronavirus disease 2019 pandemic has further emphasized the need for global improvement in hand hygiene compliance by healthcare workers. Aim: This comprehensive systematic review provides an up-to-date compilation of clinical trials, reported between 2014 and 2020, assessing hand hygiene interventions in order to inform healthcare leaders and practitioners regarding approaches to reduce healthcare-associated infections using hand hygiene. Methods: CINAHL, Cochrane, EMbase, Medline, PubMed and Web of Science databases were searched for clinical trials published between March 2014 and December 2020 on the topic of hand hygiene compliance among healthcare workers. In total, 332 papers were identified from these searches, of which 57 studies met the inclusion criteria. Findings: Forty-five of the 57 studies (79%) included in this review were conducted in Asia, Europe and the USA. The large majority of these clinical trials were conducted in acute care facilities, including hospital wards and intensive care facilities. Nurses represented the largest group of healthcare workers studied (44 studies, 77%), followed by physicians (41 studies, 72%). Thirty-six studies (63%) adopted the World Health Organization's multi-modal framework or a variation of this framework, and many of them recorded hand hygiene opportunities at each of the 'Five Moments'. However, recording of hand hygiene technique was not common. Conclusion: Both single intervention and multi-modal hand hygiene strategies can achieve modest-to-moderate improvements in hand hygiene compliance among healthcare workers.
MeSH term(s)	Adult ; COVID-19/prevention & control ; Cross Infection/prevention & control ; Female ; Forecasting ; Guideline Adherence/statistics & numerical data ; Guideline Adherence/trends ; Hand Hygiene/standards ; Hand Hygiene/statistics & numerical data ; Hand Hygiene/trends ; Health Personnel/psychology ; Health Personnel/statistics & numerical data ; Humans ; Infectious Disease Transmission, Professional-to-Patient/prevention & control ; Male ; Middle Aged ; SARS-CoV-2
Language	English
Publishing date	2021-03-17
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	779366-2
ISSN	1532-2939 ; 0195-6701
ISSN (online)	1532-2939
ISSN	0195-6701
DOI	10.1016/j.jhin.2021.03.007
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Article: Effects of pneumococcal conjugate vaccines on reducing the risk of respiratory disease associated with coronavirus infection.

Dunne, Eileen M / Nunes, Marta C / Slack, Mary P E / Theilacker, Christian / Gessner, Bradford D

Pneumonia (Nathan Qld.)

2023 Volume 15, Issue 1, Page(s) 10

Abstract: Pneumococcal conjugate vaccines (PCVs) provide protection against vaccine-type pneumococcal disease in both children and adults. Growing evidence suggests that PCVs also reduce pneumonia and lower respiratory tract infections (LRTIs) more broadly, ... ...

Abstract	Pneumococcal conjugate vaccines (PCVs) provide protection against vaccine-type pneumococcal disease in both children and adults. Growing evidence suggests that PCVs also reduce pneumonia and lower respiratory tract infections (LRTIs) more broadly, including protecting against viral-associated respiratory diseases. In this short narrative review, we highlight clinical studies investigating whether PCVs might have a role in reducing coronavirus disease, both those caused by endemic human coronaviruses (HCoVs) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). These studies include two randomized controlled trials assessing HCoV-associated pneumonia, one each in children and older adults, and two observational studies of PCV13 effectiveness against HCoV-associated LRTI and COVID-19 in adults. We discuss possible mechanisms for PCV protection including preventing viral pneumococcal co-infections and the possibility that pneumococci in the upper respiratory tract might modify the host immune response to SARS-CoV-2. Lastly, we identify knowledge gaps and further questions on the potential role of PCVs during the COVID-19 pandemic.
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2803296-2
ISSN	2200-6133
ISSN	2200-6133
DOI	10.1186/s41479-023-00112-w
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Article ; Online: Vascular access device type for systemic anti-cancer therapies in cancer patients: A scoping review.

Duggan, C / Hernon, O / Dunne, R / McInerney, V / Walsh, S R / Lowery, A / McCarthy, M / Carr, P J

Critical reviews in oncology/hematology

2024 Volume 196, Page(s) 104277

Abstract: Background: Patients with cancer can expect to receive numerous invasive vascular access procedures for intravenous therapy and clinical diagnostics. Due to the increased incidence and prevalence of cancer globally there will be significantly more ... ...

Abstract	Background: Patients with cancer can expect to receive numerous invasive vascular access procedures for intravenous therapy and clinical diagnostics. Due to the increased incidence and prevalence of cancer globally there will be significantly more people who require first-line intravenous chemotherapy over the next ten years. Methods: Our objective was to determine the types of evidence that exist for the vascular access device (VAD) type for the delivery of systemic anti-cancer therapy (SACT) in cancer patients. We used JBI scoping review methodology to identify the types of VADs used for SACT and with a specific search strategy included articles from 2012-2022 published in the English language. We identify (i) type of VADs used for SACT delivery (ii) the type of insertion and post-insertion complications (iii) the geographical location and clinical environment (iv) and whether VAD choice impacts on quality of life (QOL). Findings were presented using the PAGER framework. Main findings: Our search strategy identified 10,390 titles, of these, 5318 duplicates were removed. The remaining 5072 sources were screened for eligibility, 240 articles met the inclusion criteria. The most common design include retrospective study designs (n = 91) followed by prospective study designs (n = 31). We found 28 interventional studies with 21 registered in a clinical trial registry and identified no core outcome sets papers specific to VAD for SACT. The most prevalent publications were those that featured two or more VAD types (n = 70), followed by tunnelled intravenous VADs (n = 67). Of 38 unique complications identified, the most frequent catheter related complication was catheter related thrombosis (n = 178, 74%), followed by infection (n = 170, 71%). The county where the most publications originated from was China (n = 62) with one randomized controlled multicenter study from a comprehensive cancer centre. Of the thirty three studies that included QOL we found 4 which reported on body image. No QOL measurement tools specific to the process of SACT administration via VAD are available INTERPRETATION: Our findings suggest a systematic review and meta-analysis of VAD use for intravenous SACT can be considered. However, the development of a core outcome set for SACT should be prioritised. Funding for high quality programs of research for VAD in cancer are needed. Comprehensive cancer centres should lead this research agenda.
MeSH term(s)	Humans ; Quality of Life ; Prospective Studies ; Retrospective Studies ; Neoplasms/drug therapy ; Vascular Access Devices/adverse effects ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
Language	English
Publishing date	2024-03-14
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	605680-5
ISSN	1879-0461 ; 0737-9587 ; 1040-8428
ISSN (online)	1879-0461
ISSN	0737-9587 ; 1040-8428
DOI	10.1016/j.critrevonc.2024.104277
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