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Article: Improved Oral Health Is Associated with a Lower Risk of Late Onset Ankylosing Spondylitis: A Nationwide Cohort Study.

Chung, Min Kyung / Chang, Yoonkyung / Park, Jung-Hyun / Leem, Gwang Hyun / Song, Tae-Jin

2024 Volume 13, Issue 6

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13061606
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exploring the Therapeutic Potential of Scorpion-Derived Css54 Peptide Against Candida albicans.

Park, Jonggwan / Kim, Hyeongsun / Kang, Da Dam / Park, Yoonkyung

Journal of microbiology (Seoul, Korea)

2024 Volume 62, Issue 2, Page(s) 101–112

Abstract: Candida albicans (C. albicans) is one of the most common opportunistic fungi worldwide, which is associated with a high mortality rate. Despite treatment, C. albicans remains the leading cause of life-threatening invasive infections. Consequently, ... ...

Abstract	Candida albicans (C. albicans) is one of the most common opportunistic fungi worldwide, which is associated with a high mortality rate. Despite treatment, C. albicans remains the leading cause of life-threatening invasive infections. Consequently, antimicrobial peptides (AMPs) are potential alternatives as antifungal agents with excellent antifungal activity. We previously reported that Css54, found in the venom of Centrurodies suffusus suffusus (C. s. suffusus) showed antibacterial activity against zoonotic bacteria. However, the antifungal activity of Css54 has not yet been elucidated. The objective of this study was to identify the antifungal activity of Css54 against C. albicans and analyze its mechanism. Css54 showed high antifungal activity against C. albicans. Css54 also inhibited biofilm formation in fluconazole-resistant fungi. The antifungal mechanism of action of Css54 was investigated using membrane-related assays, including the membrane depolarization assay and analysis of the membrane integrity of C. albicans after treatment with Css54. Css54 induced reactive oxygen species (ROS) production in C. albicans, which affected its antifungal activity. Our results indicate that Css54 causes membrane damage in C. albicans, highlighting its value as a potential therapeutic agent against C. albicans infection.
MeSH term(s)	Animals ; Antifungal Agents/pharmacology ; Candida albicans ; Scorpions ; Peptides/pharmacology ; Fluconazole/pharmacology ; Microbial Sensitivity Tests ; Biofilms
Chemical Substances	Antifungal Agents ; Peptides ; Fluconazole (8VZV102JFY)
Language	English
Publishing date	2024-04-08
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2012399-1
ISSN	1976-3794 ; 1225-8873
ISSN (online)	1976-3794
ISSN	1225-8873
DOI	10.1007/s12275-024-00113-4
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Article ; Online: Serum folate levels and hypertension

Yoonkyung Lee / Sangshin Park

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 5

Abstract: Abstract We aimed to examine the association between serum folate levels and hypertension in Korean adults. Our study population was 6343 Korean adults whose blood pressure and folate levels were measured in the Korea National Health and Nutrition ... ...

Abstract	Abstract We aimed to examine the association between serum folate levels and hypertension in Korean adults. Our study population was 6343 Korean adults whose blood pressure and folate levels were measured in the Korea National Health and Nutrition Examination Survey 2016–2018. We aggregated the study populations into quintiles according to serum folate levels (1.5–4.3, 4.4–5.7, 5.8–7.5, 7.6–10.3, and 10.4–35.9 ng/mL). Multivariable logistic and linear regression models were used to analyze the relationships between serum folate levels, blood pressure, and hypertension. The weighted average of serum folate levels was 7.4 ng/mL, and the weighted prevalence of hypertension was 30.4% in the study populations. After adjusting for all potential confounders, compared to those in the lowest quintile of serum folate levels, systolic and diastolic blood pressure of the people in the other quintiles were not significantly different. The linear relationship between serum folate levels and blood pressure was not statistically significant. The odds for hypertension were not significantly different across the quintiles of serum folate levels. This study showed high serum folate levels was not significantly associated with lowering hypertension in Korean adults.
Keywords	Medicine ; R ; Science ; Q
Subject code	630
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Serum folate levels and hypertension.

Lee, Yoonkyung / Park, Sangshin

Scientific reports

2022 Volume 12, Issue 1, Page(s) 10071

Abstract: We aimed to examine the association between serum folate levels and hypertension in Korean adults. Our study population was 6343 Korean adults whose blood pressure and folate levels were measured in the Korea National Health and Nutrition Examination ... ...

Abstract	We aimed to examine the association between serum folate levels and hypertension in Korean adults. Our study population was 6343 Korean adults whose blood pressure and folate levels were measured in the Korea National Health and Nutrition Examination Survey 2016-2018. We aggregated the study populations into quintiles according to serum folate levels (1.5-4.3, 4.4-5.7, 5.8-7.5, 7.6-10.3, and 10.4-35.9 ng/mL). Multivariable logistic and linear regression models were used to analyze the relationships between serum folate levels, blood pressure, and hypertension. The weighted average of serum folate levels was 7.4 ng/mL, and the weighted prevalence of hypertension was 30.4% in the study populations. After adjusting for all potential confounders, compared to those in the lowest quintile of serum folate levels, systolic and diastolic blood pressure of the people in the other quintiles were not significantly different. The linear relationship between serum folate levels and blood pressure was not statistically significant. The odds for hypertension were not significantly different across the quintiles of serum folate levels. This study showed high serum folate levels was not significantly associated with lowering hypertension in Korean adults.
MeSH term(s)	Adult ; Blood Pressure/physiology ; Cross-Sectional Studies ; Folic Acid ; Humans ; Hypertension ; Nutrition Surveys ; Republic of Korea/epidemiology ; Risk Factors
Chemical Substances	Folic Acid (935E97BOY8)
Language	English
Publishing date	2022-06-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-13978-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficacy of the bee-venom antimicrobial peptide Osmin against sensitive and carbapenem-resistant Klebsiella pneumoniae strains.

Jeon, Eunyeong / Kim, Min Kyung / Park, Yoonkyung

International journal of antimicrobial agents

2023 Volume 63, Issue 2, Page(s) 107054

Abstract: The emergence of multidrug-resistant (MDR) Klebsiella pneumoniae strains causes severe problems in the treatment of bacterial infections owing to limited treatment options. Especially, carbapenem-resistant Klebsiella pneumoniae (CRKP) is rapidly ... ...

Abstract	The emergence of multidrug-resistant (MDR) Klebsiella pneumoniae strains causes severe problems in the treatment of bacterial infections owing to limited treatment options. Especially, carbapenem-resistant Klebsiella pneumoniae (CRKP) is rapidly spreading worldwide and is emerging as a new cause of drug-resistant healthcare-associated infections. CRKP also has been announced by the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) as one of the most pressing antibiotic resistance threats. Antimicrobial peptides (AMPs) are drawing considerable attention as ideal antibiotic alternative candidates to combat MDR bacterial infections. In a previous study, Osmin is composed of 17 amino acids and is isolated from solitary bee (Osmia rufa) venom. Herein, we evaluated the potential of Osmin to be used against drug-resistant K. pneumoniae as an alternative to conventional antibiotics. Osmin exhibited significant antimicrobial and anti-biofilm activity and lower toxicity than melittin, a well-known bee venom peptide. Additionally, we confirmed that it possesses a bactericidal mechanism that rapidly destroys bacterial membranes. Osmin was relatively more stable than melittin under the influence of various environmental factors and unlike conventional antibiotics, it exhibited a low bacterial resistance risk. During in vivo tests, Osmin reduced bacterial growth and the expression of pro-inflammatory cytokines and fibrosis-related genes in mice with CRKP-induced sepsis. Overall, our results indicate a high potential for Osmin to be used as a valuable therapeutic agent against drug-resistant K. pneumoniae infections.
MeSH term(s)	Bees ; Mice ; Animals ; Klebsiella pneumoniae ; Antimicrobial Peptides ; Bee Venoms/pharmacology ; Bee Venoms/therapeutic use ; Melitten/pharmacology ; Melitten/therapeutic use ; Klebsiella Infections/drug therapy ; Klebsiella Infections/microbiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/therapeutic use ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Microbial Sensitivity Tests
Chemical Substances	Antimicrobial Peptides ; Bee Venoms ; Melitten (20449-79-0) ; Anti-Bacterial Agents ; Anti-Infective Agents ; Carbapenems
Language	English
Publishing date	2023-12-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2023.107054
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Article ; Online: Correction: Considerable slowdown of short DNA fragment translocation across a protein nanopore using pH-induced generation of enthalpic traps inside the permeation pathway.

Mereuta, Loredana / Asandei, Alina / Andricioaei, Ioan / Park, Jonggwan / Park, Yoonkyung / Luchian, Tudor

Nanoscale

2023 Volume 15, Issue 47, Page(s) 19389

Abstract: Correction for 'Considerable slowdown of short DNA fragment translocation across a protein nanopore using pH-induced generation of enthalpic traps inside the permeation pathway' by Loredana ... ...

Abstract	Correction for 'Considerable slowdown of short DNA fragment translocation across a protein nanopore using pH-induced generation of enthalpic traps inside the permeation pathway' by Loredana Mereuta
Language	English
Publishing date	2023-12-07
Publishing country	England
Document type	Published Erratum
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d3nr90226a
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Article ; Online: Evaluation of the lead and chromium removal capabilities of Bacillus subtilis-induced food waste compost-based biomedia.

Ahn, Chang Hyuk / Jung, Woosik / Park, Yoonkyung / Joo, Jin Chul / Nam, Kyoungphile

Chemosphere

2023 Volume 343, Page(s) 140186

Abstract: Food waste compost (FWC) is a sustainable recycling approach employed in soil media, offering extensive advantages to urban areas by promoting resource circulation and effectively managing water pollution. To improve value, Bacillus subtilis (B. subtilis) ...

Abstract	Food waste compost (FWC) is a sustainable recycling approach employed in soil media, offering extensive advantages to urban areas by promoting resource circulation and effectively managing water pollution. To improve value, Bacillus subtilis (B. subtilis)-induced FWC-based biomedia (BIBM
Language	English
Publishing date	2023-09-17
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.140186
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Article: Association of Oral Health with Risk of Rheumatoid Arthritis: A Nationwide Cohort Study.

Chang, Yoonkyung / Chung, Min Kyung / Park, Jung-Hyun / Song, Tae-Jin

Journal of personalized medicine

2023 Volume 13, Issue 2

Abstract: Periodontitis and rheumatoid arthritis (RA) are inflammatory diseases that share many similarities. We aimed to investigate the associations of periodontitis and oral hygiene status and behaviors with RA in a nationwide general population cohort. ... ...

Abstract	Periodontitis and rheumatoid arthritis (RA) are inflammatory diseases that share many similarities. We aimed to investigate the associations of periodontitis and oral hygiene status and behaviors with RA in a nationwide general population cohort. Participants from the National Health Screening cohort database of Korea who underwent oral health screening by dentists between 2003 and 2004 were included. The occurrence of RA was analyzed according to the presence of periodontitis, oral health examination findings, and behaviors. Overall, 2,239,586 participants were included. During a median of 16.7 years, RA occurred in 27,029 (1.2%) participants. The risk for incident RA was higher when participants had periodontitis (hazard ratio (HR) 1.2, 95% confidence interval (CI), 1.08-1.24) and an increased number of missing teeth (HR 1.5, 95% CI, 1.38-1.69). In contrast, better oral hygiene behaviors, such as a higher frequency of daily tooth brushing (HR 0.76, 95% CI 0.73-0.79,
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13020340
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Article ; Online: Assessment of Rainwater Harvesting Facilities Tank Size Based on a Daily Water Balance Model

Amjad Khan / Yoonkyung Park / Jongpyo Park / Reeho Kim

Sustainability, Vol 14, Iss 15556, p

The Case of Korea

2022 Volume 15556

Abstract: Factors affecting rainwater resource management for the present and future include population growth, urbanization, and climate change. Rainwater harvesting (RWH) allows multiple urban water-related issues to be mitigated. In this study, a spreadsheet- ... ...

Abstract	Factors affecting rainwater resource management for the present and future include population growth, urbanization, and climate change. Rainwater harvesting (RWH) allows multiple urban water-related issues to be mitigated. In this study, a spreadsheet-based daily water balance model was developed to analyze the existing laws and regulations regarding the storage tank size of RWH facilities. Six buildings at different locations were selected for this study. Two are office buildings, two are school buildings, and two are sports buildings. The term “RWH facility evaluation criteria” is collectively used for rainwater supply satisfaction rate, rainwater guarantee rate, and rainwater utilization rate. A green roof can hold the rainwater for some time, reducing the peak flow and runoff volume. The results provide evidence that, among the selected studied buildings, buildings having a combination of a green roof and RWH facility score the highest in terms of RWH facility evaluation criteria, even though the actual tank size is much smaller than the standard tank size. This is the case with the Yesan County Office, in which a green roof connected to a small (66 m 3 ) rainwater storage tank is installed. As a green roof can decrease the runoff volume, the rainwater can be managed efficiently with less pumping energy and only a small storage tank.
Keywords	rainwater harvesting ; daily water balance ; rainfall ; storage tank size ; RWH facility evaluation criteria ; South Korea ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	720
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assessing the impacts of dam/weir operation on streamflow predictions using LSTM across South Korea

Yongsung Kwon / YoonKyung Cha / Yeonjeong Park / Sangchul Lee

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 15

Abstract: Abstract Recently, weather data have been applied to one of deep learning techniques known as “long short-term memory (LSTM)” to predict streamflow in rainfall-runoff relationships. However, this approach may not be suitable for regions with artificial ... ...

Abstract	Abstract Recently, weather data have been applied to one of deep learning techniques known as “long short-term memory (LSTM)” to predict streamflow in rainfall-runoff relationships. However, this approach may not be suitable for regions with artificial water management structures such as dams and weirs. Therefore, this study aims to evaluate the prediction accuracy of LSTM for streamflow depending on the availability of dam/weir operational data across South Korea. Four scenarios were prepared for 25 streamflow stations. Scenarios #1 and #2 used weather data and weather and dam/weir operational data, respectively, with the same LSTM model conditions for all stations. Scenarios #3 and #4 used weather data and weather and dam/weir operational data, respectively, with the different LSTM models for individual stations. The Nash–Sutcliffe efficiency (NSE) and the root mean squared error (RMSE) were adopted to assess the LSTM’s performance. The results indicated that the mean values of NSE and RMSE were 0.277 and 292.6 (Scenario #1), 0.482 and 214.3 (Scenario #2), 0.410 and 260.7 (Scenario #3), and 0.592 and 181.1 (Scenario #4), respectively. Overall, the model performance was improved by the addition of dam/weir operational data, with an increase in NSE values of 0.182–0.206 and a decrease in RMSE values of 78.2–79.6. Surprisingly, the degree of performance improvement varied according to the operational characteristics of the dam/weir, and the performance tended to increase when the dam/weir with high frequency and great amount of water discharge was included. Our findings showed that the overall LSTM prediction of streamflow was improved by the inclusion of dam/weir operational data. When using dam/weir operational data to predict streamflow using LSTM, understanding of their operational characteristics is important to obtain reliable streamflow predictions.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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