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  1. Article: Fortbildung. Topische Therapie des perianalen Ekzems

    Schauber, Jürgen

    Dermatologie-Praxis

    2011  Volume -, Issue 6, Page(s) 4

    Language German
    Document type Article
    ZDB-ID 2231659-0
    ISSN 1661-6200
    Database Current Contents Medicine

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  2. Article ; Online: Facial Erythema of Rosacea - Aetiology, Different Pathophysiologies and Treatment Options.

    Steinhoff, Martin / Schmelz, Martin / Schauber, Jürgen

    Acta dermato-venereologica

    2016  Volume 96, Issue 5, Page(s) 579–586

    Abstract: Rosacea is a common chronic skin condition that displays a broad diversity of clinical manifestations. Although the pathophysiological mechanisms of the four subtypes are not completely elucidated, the key elements often present are augmented immune ... ...

    Abstract Rosacea is a common chronic skin condition that displays a broad diversity of clinical manifestations. Although the pathophysiological mechanisms of the four subtypes are not completely elucidated, the key elements often present are augmented immune responses of the innate and adaptive immune system, and neurovascular dysregulation. The most common primary feature of all cutaneous subtypes of rosacea is transient or persistent facial erythema. Perilesional erythema of papules or pustules is based on the sustained vasodilation and plasma extravasation induced by the inflammatory infiltrates. In contrast, transient erythema has rapid kinetics induced by trigger factors independent of papules or pustules. Amongst the current treatments for facial erythema of rosacea, only the selective α2-adrenergic receptor agonist brimonidine 0.33% topical gel (Mirvaso®) is approved. This review aims to discuss the potential causes, different pathophysiologies and current treatment options to address the unmet medical needs of patients with facial erythema of rosacea.
    MeSH term(s) Administration, Topical ; Adrenergic alpha-2 Receptor Agonists/therapeutic use ; Antihypertensive Agents/therapeutic use ; Brimonidine Tartrate/therapeutic use ; Erythema/drug therapy ; Erythema/etiology ; Erythema/physiopathology ; Humans ; Rosacea/drug therapy ; Rosacea/etiology ; Rosacea/physiopathology
    Chemical Substances Adrenergic alpha-2 Receptor Agonists ; Antihypertensive Agents ; Brimonidine Tartrate (4S9CL2DY2H)
    Language English
    Publishing date 2016-06-15
    Publishing country Sweden
    Document type Journal Article ; Review
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-2335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cathelicidin LL-37: a defense molecule with a potential role in psoriasis pathogenesis.

    Dombrowski, Yvonne / Schauber, Jürgen

    Experimental dermatology

    2012  Volume 21, Issue 5, Page(s) 327–330

    Abstract: Epidermal keratinocytes produce and secrete antimicrobial peptides (AMPs) that subsequently form a chemical shield on the skin surface. Cathelicidins are one family of AMPs in skin with various further immune functions. Consequently, dysfunction of these ...

    Abstract Epidermal keratinocytes produce and secrete antimicrobial peptides (AMPs) that subsequently form a chemical shield on the skin surface. Cathelicidins are one family of AMPs in skin with various further immune functions. Consequently, dysfunction of these peptides has been implicated in the pathogenesis of inflammatory skin disease. In particular, the cathelicidin LL-37 is overexpressed in inflamed skin in psoriasis, binds to extracellular self-DNA released from dying cells and converts self-DNA in a potent stimulus for plasmacytoid dendritic cells (pDCs). Subsequently, pDCs secrete type I interferons and trigger an auto-inflammatory cascade. Paradoxically, therapies targeting the vitamin D pathway such as vitamin D analogues or UVB phototherapy ameliorate cutaneous inflammation in psoriasis but strongly induce cathelicidin expression in skin at the same time. Current evidence now suggests that self-DNA present in the cytosol of keratinocytes is also pro-inflammatory active and triggers IL-1β secretion in psoriatic lesions through the AIM2 inflammasome. This time, however, binding of LL-37 to self-DNA neutralizes DNA-mediated inflammation. Hence, cathelicidin LL-37 shows contrasting roles in skin inflammation in psoriasis and might serve as a target for novel therapies for this chronic skin disease.
    MeSH term(s) Antimicrobial Cationic Peptides/physiology ; DNA/physiology ; Humans ; Immunity, Innate/physiology ; Inflammasomes/physiology ; Keratinocytes/pathology ; Keratinocytes/physiology ; Psoriasis/etiology ; Psoriasis/pathology ; Psoriasis/physiopathology ; Signal Transduction/physiology ; Vitamin D/physiology
    Chemical Substances Antimicrobial Cationic Peptides ; Inflammasomes ; Vitamin D (1406-16-2) ; ropocamptide (3DD771JO2H) ; DNA (9007-49-2)
    Language English
    Publishing date 2012-04-11
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/j.1600-0625.2012.01459.x
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  4. Book ; Online ; Thesis: Aktivierung angeborener Immunmechanismen in der Haut durch Amyloid β

    Blatner, Carolin [Verfasser] / Schauber, Jürgen [Akademischer Betreuer]

    2015  

    Author's details Carolin Blatner. Betreuer: Jürgen Schauber
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article: Condylomata acuminata: A retrospective analysis on clinical characteristics and treatment options.

    Clanner-Engelshofen, Benjamin M / Marsela, Enklajd / Engelsberger, Nicole / Guertler, Anne / Schauber, Jürgen / French, Lars E / Reinholz, Markus

    Heliyon

    2020  Volume 6, Issue 3, Page(s) e03547

    Abstract: Background: Anogenital HPV is the most frequent sexually transmitted disease (STD) worldwide. There is no obligation to officially register HPV infections in Germany and thus the epidemiology of condylomata acuminata (CA) is not well characterized.: ... ...

    Abstract Background: Anogenital HPV is the most frequent sexually transmitted disease (STD) worldwide. There is no obligation to officially register HPV infections in Germany and thus the epidemiology of condylomata acuminata (CA) is not well characterized.
    Objectives: To provide a better understanding of the epidemiology of CA and outline the treatment options that are available to patients with this disease.
    Methods: Data of 1124 patients with a confirmed diagnosis of CA, presenting in our university hospital outpatient consultation between 2011 and 2015 were retrospectively evaluated and the efficacy of various types of treatments was addressed.
    Results: A large patient cohort of 1124 predominately young (mean age 36.5 years old), male (83.9 %), single (50.2 %), heterosexual (92.8 %) Germans (62.5 %) received consults in our outpatient clinic for STDs. Nearly 60 % of the diagnosed patients presented with first-time CA, indicating a considerable proportion of roughly 40 % recurrent infections as well. Only 13.7 % of patients were previously immunized against HPV.
    Conclusions: The evaluation of a large patient cohort provided a better understanding of the present epidemiology of CA in an outpatient hospital setting in Germany. An effective three-scale therapeutic regime and preventive measures were outlined.
    Language English
    Publishing date 2020-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2020.e03547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Aktivierung des AIM2-Inflammasoms durch mitochondriale DNA in humanen epidermalen Keratinozyten nach Stimulation mit dem Bienengiftbestandteil Melittin

    Schmezer, Vanessa [Verfasser] / Schauber, Jürgen [Akademischer Betreuer]

    2014  

    Author's details Vanessa Schmezer. Betreuer: Jürgen Schauber
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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  7. Article ; Online: Face-to-face with anti-inflammatory therapy for rosacea.

    Salzer, Suzanna / Ruzicka, Thomas / Schauber, Jürgen

    Experimental dermatology

    2014  Volume 23, Issue 6, Page(s) 379–381

    Abstract: In the past, our understanding of rosacea has been inadequate and limited to descriptions of factors that exacerbate and improve the disease. While the pathophysiology of rosacea is complex and multifactorial, cathelicidin peptides have emerged as key ... ...

    Abstract In the past, our understanding of rosacea has been inadequate and limited to descriptions of factors that exacerbate and improve the disease. While the pathophysiology of rosacea is complex and multifactorial, cathelicidin peptides have emerged as key players in the pathogenesis of this common dermatological disorder. This article correlates recent findings in abnormal cathelicidin production and proteolytic processing in rosacea with therapeutic actions of current treatment options and, in this way, highlights potential points of intervention for the development of efficient therapeutic alternatives.
    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Antimicrobial Cationic Peptides/physiology ; Humans ; Immunity, Innate/physiology ; Rosacea/drug therapy ; Rosacea/physiopathology
    Chemical Substances Anti-Inflammatory Agents ; Antimicrobial Cationic Peptides ; ropocamptide (3DD771JO2H)
    Language English
    Publishing date 2014-03-29
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.12401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online ; Thesis: Zytosolische DNA aktiviert das AIM2-Inflammasom in Keratinozyten bei Psoriasis

    Göß, Christine [Verfasser] / Schauber, Jürgen [Akademischer Betreuer]

    2013  

    Author's details Christine Göß. Betreuer: Jürgen Schauber
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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  9. Article: Vitamin d, the cutaneous barrier, antimicrobial peptides and allergies: is there a link?

    Roider, Elisabeth / Ruzicka, Thomas / Schauber, Jürgen

    Allergy, asthma & immunology research

    2013  Volume 5, Issue 3, Page(s) 119–128

    Abstract: Atopic diseases such as atopic dermatitis (AD) are very common in industrialized countries. Up to 15%-30% of all children and 2%-10% of all adults suffer from AD. Already in early disease stages, a defective epidermal barrier is known to contribute to ... ...

    Abstract Atopic diseases such as atopic dermatitis (AD) are very common in industrialized countries. Up to 15%-30% of all children and 2%-10% of all adults suffer from AD. Already in early disease stages, a defective epidermal barrier is known to contribute to the pathogenesis of AD. Central elements in the epidermal barrier are antimicrobial peptides (AMPs), which are secreted by keratinocytes, sweat gland cells but also infiltrating immune cells. AMPs function as endogenous antibiotics and are able to kill bacteria, viruses, and fungi. Furthermore AMPs act as immune modulators with effects on the innate and adaptive immune system. The probably best studied AMPs in human skin are the defensins and cathelicidin. In atopic diseases the functions of AMPs such as cathelicidin might be impaired and microbial superinfections could serve as cofactors for allergic sensitization. Hence, induction of AMPs could be beneficial in these patients. Cathelicidin which is often referred to its peptide form hCAP18 or LL-37 can be induced by ultraviolet light B (UVB) irradiation and is upregulated in infected and injured skin. The cathelicidin gene carries a vitamin D response element and the vitamin D pathway could therefore be targeted for cathelicidin regulation. As the development and course of atopic diseases might be influenced by vitamin D signaling these pathomechanisms could explain the growing evidence connecting vitamin D to allergic diseases, including AD, allergic rhinitis, food allergies and asthma. In this review the role of vitamin D and the AMP cathelicidin in the pathogenesis of atopic diseases with impaired barrier function will be discussed.
    Language English
    Publishing date 2013-02-04
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2545725-1
    ISSN 2092-7363 ; 2092-7355
    ISSN (online) 2092-7363
    ISSN 2092-7355
    DOI 10.4168/aair.2013.5.3.119
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  10. Article ; Online: Antimicrobial peptides and the skin immune defense system.

    Schauber, Jürgen / Gallo, Richard L

    The Journal of allergy and clinical immunology

    2009  Volume 124, Issue 3 Suppl 2, Page(s) R13–8

    Abstract: Our skin is constantly challenged by microbes but is rarely infected. Cutaneous production of antimicrobial peptides (AMPs) is a primary system for protection, and expression of some AMPs further increases in response to microbial invasion. Cathelicidins ...

    Abstract Our skin is constantly challenged by microbes but is rarely infected. Cutaneous production of antimicrobial peptides (AMPs) is a primary system for protection, and expression of some AMPs further increases in response to microbial invasion. Cathelicidins are unique AMPs that protect the skin through 2 distinct pathways: (1) direct antimicrobial activity and (2) initiation of a host response resulting in cytokine release, inflammation, angiogenesis, and reepithelialization. Cathelicidin dysfunction emerges as a central factor in the pathogenesis of several cutaneous diseases, including atopic dermatitis, in which cathelicidin is suppressed; rosacea, in which cathelicidin peptides are abnormally processed to forms that induce inflammation; and psoriasis, in which cathelicidin peptide converts self-DNA to a potent stimulus in an autoinflammatory cascade. Recent work identified vitamin D3 as a major factor involved in the regulation of cathelicidin. Therapies targeting control of cathelicidin and other AMPs might provide new approaches in the management of infectious and inflammatory skin diseases.
    Language English
    Publishing date 2009-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2009.07.014
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