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Article ; Online: HIV-1 subtype F integrase polymorphisms external to the catalytic core domain contribute to severe loss of replication capacity in context of the integrase inhibitor resistance mutation Q148H.

Aulicino, Paula C / Momin, Zoha / Rozenszajn, Mijael / Monzon, Arturo / Arazi-Caillaud, Solange / Bologna, Rosa / Mangano, Andrea / Kimata, Jason T

The Journal of antimicrobial chemotherapy

2022 Volume 77, Issue 10, Page(s) 2793–2802

Abstract: Background: In prior studies, HIV-1 BF recombinants with subtype F integrases failed to develop ... of Q148H in the context of subtype F integrases from BF recombinants explains the lack of selection ...

Abstract	Background: In prior studies, HIV-1 BF recombinants with subtype F integrases failed to develop resistance to raltegravir through the Q148H mutational pathway. We aimed to determine the role of subtype-specific polymorphisms in integrase on drug susceptibility, viral replication and integration. Methods: Integrase sequences were retrieved from the Los Alamos Database or obtained from the Garrahan HIV cohort. HIV-1 infectious molecular clones with or without Q148H (+ G140S) resistance mutations were constructed using integrases of subtype B (NL4-3) or F1(BF) ARMA159 and URTR23. Integrase chimeras were generated by reciprocal exchanges of a 200 bp fragment spanning amino acids 85-150 of the catalytic core domain (CCD) of NL4-3-Q148H and either ARMA159-Q148H or URTR23-Q148H. Viral infections were quantified by p24 ELISA and Alu-gag integration PCR assay. Results: At least 18 different polymorphisms distinguish subtype B from F1(BF) recombinant integrases. In phenotypic experiments, p24 at Day 15 post-infection was high (105-106 pg/mL) for WT and NL4-3-Q148H; by contrast, it was low (102-104 pg/mL) for both F1(BF)-Q148H + G140S viruses, and undetectable for the Q148H mutants. Compared with WT viruses, integrated DNA was reduced by 5-fold for NL4-3-Q148H (P = 0.05), 9-fold for URTR23-Q148H (P = 0.01) and 16000-fold for ARMA159-Q148H (P = 0.01). Reciprocal exchange between B and F1(BF) of an integrase CCD region failed to rescue the replicative defect of F1(BF) integrase mutants. Conclusions: The functional impairment of Q148H in the context of subtype F integrases from BF recombinants explains the lack of selection of this pathway in vivo. Non-B polymorphisms external to the integrase CCD may influence the pathway to integrase strand transfer inhibitor resistance.
MeSH term(s)	Amino Acids/therapeutic use ; Catalytic Domain ; Drug Resistance, Viral/genetics ; HIV Infections/drug therapy ; HIV Integrase/metabolism ; HIV Integrase Inhibitors/pharmacology ; HIV Integrase Inhibitors/therapeutic use ; HIV-1/genetics ; Humans ; Mutation ; Pyrrolidinones/pharmacology ; Raltegravir Potassium/pharmacology ; Raltegravir Potassium/therapeutic use
Chemical Substances	Amino Acids ; HIV Integrase Inhibitors ; Pyrrolidinones ; Raltegravir Potassium (43Y000U234) ; HIV Integrase (EC 2.7.7.-)
Language	English
Publishing date	2022-07-20
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkac238
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Article: Performance of gerbera (Gerbera jamesonii Bolus ex Hooker F) cultivars for growth, flowering and yield characters under naturally ventilated polyhouse

Sangma, Sierra M / Kumar, Sunil / Collis, J.P / Momin, Baggio CH

Journal of Ornamental Horticulture. 2017 July, v. 20, no. 3and4

2017

Abstract: An experiment was conducted during the year 2013–14 to asses the performance of gerbera varieties namely, Lanceolot, Rich, Shania, Stanza, Kento, Intezz, Daphne and Cherany. Gerbera suckers were planted on raised bed comprised with recommended nutrient ... ...

Abstract	An experiment was conducted during the year 2013–14 to asses the performance of gerbera varieties namely, Lanceolot, Rich, Shania, Stanza, Kento, Intezz, Daphne and Cherany. Gerbera suckers were planted on raised bed comprised with recommended nutrient mixtures and adequate watering was supplied to the plants as per need during entire investigation. Significant response in vegetative and flowering characters was observed among the cultivars. Cultivar Daphne showed maximum number of leaves (38.73), plant height (40.20 cm) and minimum number of days taken to flower bud emergence (64.27). Whereas, increased plant spread (38.57 cm) and stalk length (56.97 cm) was associated with cultivar Kento. However, highest flower diameter (11.83 cm), fresh weight (42.33 g) and vase life (14.33 days) was recorded in cultivar Stanza, while, maximum flower per plant (7.67) was obtained with cultivar Shania.
Keywords	Daphne ; Gerbera jamesonii ; asses ; cultivars ; diameter ; flower buds ; flowering ; leaves ; length ; mixtures ; ornamental horticulture ; plant height ; raised beds ; vase life ; weight
Language	English
Dates of publication	2017-07
Size	p. 108-112.
Publishing place	Indian Society of Ornamental Horticulture
Document type	Article
Note	NAL-light
ISSN	2249-880X
DOI	10.5958/2249-880X.2017.00003.2
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Degradation of Procion brilliant yellow H-E6G using ultrasonic and hydrodynamic cavitation combined with oxidants with demonstration at pilot scale.

Momin, Rahat F / Gogate, Parag R

Water environment research : a research publication of the Water Environment Federation

2024 Volume 96, Issue 3, Page(s) e11011

Abstract: The current study focuses on the degradation of Procion brilliant yellow H-E6G, an azo dye, using ultrasonic and hydrodynamic cavitation (HC), evaluating the impact of various parameters on the extent of degradation. The use of only ultrasound showed ... ...

Abstract	The current study focuses on the degradation of Procion brilliant yellow H-E6G, an azo dye, using ultrasonic and hydrodynamic cavitation (HC), evaluating the impact of various parameters on the extent of degradation. The use of only ultrasound showed less oxidation capacity as indicated by only 19.1% degradation at an optimized power of 140 W, pH of 2.5, temperature of 40°C, and initial dye concentration of 15 ppm. The effectiveness of hybrid approaches involving US + H
MeSH term(s)	Oxidants ; Hydrogen Peroxide ; Hydrodynamics ; Ultrasonics ; Azo Compounds ; Benzenesulfonates
Chemical Substances	Oxidants ; Direct Yellow 4 dye (91-34-9) ; Hydrogen Peroxide (BBX060AN9V) ; Azo Compounds ; Benzenesulfonates
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1098976-6
ISSN	1554-7531 ; 1047-7624 ; 1061-4303
ISSN (online)	1554-7531
ISSN	1047-7624 ; 1061-4303
DOI	10.1002/wer.11011
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Article ; Online: Degradation of Procion Brilliant Purple H-3R using ultrasound coupled with advanced oxidation processes.

Momin, Rahat F / Gogate, Parag R

Journal of environmental management

2023 Volume 350, Page(s) 119642

Abstract: The complexity of wastewater matrix poses a challenge for conventional processes especially due to the presence of refractory compounds such as dyes. The present work focuses on utilizing ultrasound-induced cavitation in conjunction with different ... ...

Abstract	The complexity of wastewater matrix poses a challenge for conventional processes especially due to the presence of refractory compounds such as dyes. The present work focuses on utilizing ultrasound-induced cavitation in conjunction with different oxidants such as hydrogen peroxide, Fenton's reagent and potassium persulfate to treat Procion Brilliant Purple H-3R dye containing wastewater. The impact of various operating parameters as pH, frequency, and power on degradation levels has been studied with the aim of optimizing degradation. The optimal conditions for the degradation of Procion Brilliant Purple H-3R were determined as pH of 12, frequency of 22 kHz, and power of 250 W, resulting in a maximum degradation of 70.25%. Combination of a cavitation reactor with hydrogen peroxide, Fenton reagent, and KPS was then applied at optimized conditions, which confirmed a notable enhancement in degradation compared to the only ultrasound based process. Specifically, the degradation extent was 95.99% for combination with H
MeSH term(s)	Hydrogen Peroxide/chemistry ; Wastewater ; Oxidation-Reduction ; Oxidants ; Coloring Agents
Chemical Substances	Fenton's reagent ; Hydrogen Peroxide (BBX060AN9V) ; Wastewater ; Oxidants ; Coloring Agents
Language	English
Publishing date	2023-11-27
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.119642
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Article ; Online: Linear IgA bullous dermatosis associated with immunotherapy.

Momin, Bahar / Nguyen, Tue F / Glade, Daniel / Messer, Alison

Dermatology online journal

2023 Volume 29, Issue 6

Abstract: Linear IgA bullous dermatosis (LABD) is a rare mucocutaneus blistering autoimmune disease caused by IgA autoantibodies. Its clinical manifestation can be indistinguishable from bullous pemphigoid (BP), a similar autoimmune bullous disease caused by IgG ... ...

Abstract	Linear IgA bullous dermatosis (LABD) is a rare mucocutaneus blistering autoimmune disease caused by IgA autoantibodies. Its clinical manifestation can be indistinguishable from bullous pemphigoid (BP), a similar autoimmune bullous disease caused by IgG and IgE autoantibodies. Although BP has been reported as an adverse cutaneous effect of immunotherapy, LABD has rarely been associated with immunotherapy in the literature. We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone therapy. We favor that our patient's LABD is secondary to her immunotherapy. Our case highlights the importance of both H&E histology and direct immunofluorescence in diagnosis of blistering disorders in patients on immunotherapy to help in choosing the most effective treatment option in an attempt to avoid discontinuation of immunotherapy.
MeSH term(s)	Humans ; Female ; Aged ; Linear IgA Bullous Dermatosis/pathology ; Skin/pathology ; Pemphigoid, Bullous/diagnosis ; Autoimmune Diseases/pathology ; Autoantibodies ; Blister/pathology ; Immunotherapy/adverse effects ; Immunoglobulin A
Chemical Substances	Autoantibodies ; Immunoglobulin A
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2026239-5
ISSN	1087-2108 ; 1087-2108
ISSN (online)	1087-2108
ISSN	1087-2108
DOI	10.5070/D329662995
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Article: The impact of 180° return bend inclination on pressure drop characteristics and phase distribution during oil-water flow.

Momin, Mushtaque / Rahmani, Faisal / Makki, Emad / Sharma, Mukesh / Giri, Jayant / Sathish, T

Heliyon

2024 Volume 10, Issue 2, Page(s) e24251

Abstract: The present work aims to capture the influence of the inclination of the return bend on flow patterns and pressure drop during oil-water flow. The experiments were carried out for different inclinations (0°, 15°, 30°, and 45°) of return bend for various ... ...

Abstract	The present work aims to capture the influence of the inclination of the return bend on flow patterns and pressure drop during oil-water flow. The experiments were carried out for different inclinations (0°, 15°, 30°, and 45°) of return bend for various superficial velocity combinations of oil (kerosene) and water ranging from 0.07 to 0.66 m/s. The experiments showed that pressure drop increases with the increase in inclination. However, the pressure drop at a fixed inclination (say 15°) decreases with the increase in the superficial velocity of the water. Distinct flow patterns observed in the return bend were droplet flow, film inversion, slug flow, plug flow and large slug flow. Droplet flow dominates at the lower range of kerosene (i.e.,
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24251
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Article: Hyperkeratotic, pruritic plaques in an incarcerated patient.

Momin, Fareen / Armenta, Andrew M / Wilson, Janice M / Winsett, Frank T / Goodwin, Brandon P

JAAD case reports

2023 Volume 37, Page(s) 137–139

Language	English
Publishing date	2023-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2834220-3
ISSN	2352-5126
ISSN	2352-5126
DOI	10.1016/j.jdcr.2023.06.013
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Article ; Online: Additive effect between homocysteine and low-density-lipoprotein cholesterol upon incidence of novel carotid plaque formation: data from a Chinese community-based cohort.

Momin, Mohetaboer / Fan, Fangfang / Yang, Ying / Li, Jianping / Jia, Jia / Zhang, Yan

BMC cardiovascular disorders

2023 Volume 23, Issue 1, Page(s) 332

Abstract: Objective: Homocysteine (HCY) has been associated with carotid plaque in cross-sectional studies, but the prospective relationship between HCY and incident carotid plaque has not been well established. The purpose of this study was to investigate the ... ...

Abstract	Objective: Homocysteine (HCY) has been associated with carotid plaque in cross-sectional studies, but the prospective relationship between HCY and incident carotid plaque has not been well established. The purpose of this study was to investigate the association between HCY and incidence of novel carotid plaque in a Chinese community-based population without pre-existing carotid atherosclerosis and to assess the additive effect of HCY and low-density lipoprotein cholesterol (LDL-C) on the incidence of novel plaque. Methods: At baseline, we measured HCY and other risk factors in subjects aged ≥ 40 years. All participants underwent carotid ultrasound examinations at baseline and after an average of 6.8 years of follow-up. Incidence of plaque was identified if plaque was absent at baseline, but plaque was detected at the end of follow-up. A total of 474 subjects were included in the analysis. Results: The incidence of novel carotid plaque was 24.47%. Multivariate regression analyses showed that HCY was independently associated with a 1.05-fold-higher likelihood for incident novel plaque (adjusted odds ratio [OR] = 1.05, 95% confidence interval [CI]: 1.01-1.09, P = 0.008). Using tertile 1 and tertile 2 for reference, the top HCY tertile (T3) showed a 2.28-fold-higher likelihood for incident plaque (adjusted OR = 2.28, 95%CI: 1.33-3.93, P = 0.002). The combination of HCY T3 and LDL-C ≥ 3.4 mmol/L had the highest risk for novel plaque formation (adjusted OR = 3.63, 95%CI: 1.67-7.85, P = 0.001) compared to those without either condition. In the LDL-C ≥ 3.4 mmol/L subgroup, HCY was significantly associated with incidence of plaque (adjusted OR = 1.16, 95%CI: 1.04-1.28, P = 0.005, P-interaction = 0.023). Conclusion: In the Chinese community-based population, HCY was independently associated with the incidence of novel carotid plaque. There were additive effect between HCY and LDL-C on the incidence of plaque, the highest risk was observed in individuals with both high HCY levels and LDL-C ≥ 3.4 mmol/L. Our findings suggest that HCY may be a potential target for preventing the incidence of carotid plaque, particularly in individuals with elevated LDL-C levels.
MeSH term(s)	Humans ; Cholesterol, LDL/blood ; Cross-Sectional Studies ; East Asian People ; Homocysteine/blood ; Incidence ; Prospective Studies ; Carotid Artery Diseases/blood ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/epidemiology ; Plaque, Atherosclerotic/blood ; Plaque, Atherosclerotic/diagnostic imaging ; Plaque, Atherosclerotic/epidemiology ; Adult ; Middle Aged
Chemical Substances	Cholesterol, LDL ; Homocysteine (0LVT1QZ0BA)
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-023-03282-z
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Article ; Online: Therapeutic benefits of natural oils along with permeation enhancing activity.

Amra, Kesrin / Momin, Munira / Desai, Neha / Khan, Fateh

International journal of dermatology

2021 Volume 61, Issue 4, Page(s) 484–507

Abstract: The skin is the largest organ of the integumentary system with a multifunctional purpose to protect the body from heat and microbes, regulate body temperature, and act as a sensory organ. A topical dosage form applied on the skin will have to cross the ... ...

Abstract	The skin is the largest organ of the integumentary system with a multifunctional purpose to protect the body from heat and microbes, regulate body temperature, and act as a sensory organ. A topical dosage form applied on the skin will have to cross the stratum corneum, which would then allow the dosage form to traverse the subsequent layers of the skin. The drug with poor solubility and short half-life would serve as an ideal candidate for its delivery via the transdermal route. This review reports the role of natural oils in enhancing the permeation of drugs through skin as they possess different features like natural origin, favorable penetration enhancement, and partitioning action in the skin. Chemical penetration enhancers have been used widely but are associated with toxicities. Thus, more research should be channelized in the area of extraction of oils from natural sources, along with their active constituents, which can serve as therapeutic alternatives to various disorders and diseases. Natural oils are obtained from leaves, fruits, flowers, seeds, bark, and roots, which have a therapeutic potential as well as penetration enhancing activity. The demerits of oral drug delivery include degradation of drugs in the gastrointestinal tract, addition of taste masking, and coating of tablets, which can be overcome by delivering the drug via the transdermal route. Natural oil contains lipids, flavonoids, and terpenes, which play a significant role in anti-inflammatory and penetration enhancing activity.
MeSH term(s)	Administration, Cutaneous ; Drug Delivery Systems ; Humans ; Oils ; Pharmaceutical Preparations ; Skin Absorption
Chemical Substances	Oils ; Pharmaceutical Preparations
Language	English
Publishing date	2021-07-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.15733
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Article ; Online: Pharmacokinetics and Safety Evaluation of Single-Dose Saroglitazar Magnesium in Subjects with Hepatic Impairment.

Lawitz, Eric / Parmar, Deven / Momin, Taufik / Shaikh, Farheen / Patel, Harilal / Hayes, Helen / Swint, Kimberly

Clinical pharmacology in drug development

2023 Volume 12, Issue 12, Page(s) 1142–1155

Abstract: Saroglitazar magnesium, a dual peroxisome proliferator-activated receptor agonist, is under evaluation for treating various liver conditions. While the pharmacokinetics (PK) of saroglitazar have been extensively studied in diverse preclinical models and ... ...

Abstract	Saroglitazar magnesium, a dual peroxisome proliferator-activated receptor agonist, is under evaluation for treating various liver conditions. While the pharmacokinetics (PK) of saroglitazar have been extensively studied in diverse preclinical models and healthy subjects, a comprehensive assessment of its PK behavior under conditions of hepatic impairment is lacking. In this Phase 1, open-label, parallel-group study, the PK of a single dose of 4-mg saroglitazar magnesium was investigated in subjects having varying degrees of hepatic impairment with and without portal hypertension compared with appropriately matched individuals having normal hepatic function. Treatment-emergent adverse events for safety were also evaluated. Thirty-two subjects were enrolled in the hepatic-impaired groups and 23 subjects in the normal hepatic function group. Mild and moderate hepatic impairment did not significantly affect the PK of saroglitazar, compared with normal hepatic function. Although severe hepatic impairment did not alter maximum observed plasma concentration and half-life; saroglitazar exposure (area under the plasma concentration-time curve from time 0 to infinity) increased 3-fold, while the clearance was 61% lower compared to the subjects with normal hepatic function. This may require close monitoring or dose adjustments in individuals with severe hepatic impairment. A single oral dose of saroglitazar magnesium 4 mg was found to be safe and well tolerated in subjects with varying degrees of hepatic function.
MeSH term(s)	Humans ; Area Under Curve ; Liver Diseases/drug therapy ; Phenylpropionates/pharmacokinetics ; Pyrroles/pharmacokinetics
Chemical Substances	Phenylpropionates ; Pyrroles ; saroglitazar (E0YMX3S4JD)
Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Clinical Trial, Phase I ; Journal Article
ZDB-ID	2649010-9
ISSN	2160-7648 ; 2160-763X
ISSN (online)	2160-7648
ISSN	2160-763X
DOI	10.1002/cpdd.1339
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