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Article ; Online: Biofield Therapies: Guidelines for Reporting Clinical Trials.

Hammerschlag, Richard / Sprengel, Meredith / Baldwin, Ann L

Global advances in integrative medicine and health

2024 Volume 13, Page(s) 27536130231202501

Abstract: A set of guidelines has been developed to help improve reporting of clinical trials of biofield therapies. The need for enhanced transparency when reporting trials of this family of integrative health practices, eg, External Qigong, Healing Touch, Reiki ... ...

Abstract	A set of guidelines has been developed to help improve reporting of clinical trials of biofield therapies. The need for enhanced transparency when reporting trials of this family of integrative health practices, eg, External Qigong, Healing Touch, Reiki and Therapeutic Touch, has been advocated in systematic reviews of these studies. The guidelines, called Biofield Therapies: Reporting Evidence Guidelines (BiFi REGs), supplement CONsolidated Standards of Reporting Trials (CONSORT) 2010 by including details of the intervention protocols relevant to biofield therapy trials. BiFi REGs evolved through a draft document created by a core group, two rounds of a Delphi process with an international group of subject matter experts and two panels, meeting via Zoom, which included editors of complementary and integrative medicine journals. BiFi REGs comprises a 15-item Intervention checklist. Modifications of two other CONSORT topic areas are also proposed to enhance their relevance to trials of biofield therapies. Included for each item are an explanation, and exemplars of reporting from peer-reviewed published reports of biofield therapy trials. When used in conjunction with all other items from CONSORT 2010, we anticipate that BiFi REGs will expedite the peer review process for biofield therapy trials, facilitate attempts at trial replication and help to inform decision-making in the clinical practice of biofield therapies.
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ISSN	2753-6130
ISSN (online)	2753-6130
DOI	10.1177/27536130231202501
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Article ; Online: Biofield Therapies: Guidelines for Reporting Clinical Trials.

Hammerschlag, Richard / Sprengel, Meredith / Baldwin, Ann L

Journal of integrative and complementary medicine

2024 Volume 30, Issue 2, Page(s) 133–145

Abstract: Highlights Guidelines have been created to improve the reporting of clinical trials of biofield therapies, e.g. External Qigong, Healing Touch, Reiki, and Therapeutic Touch. Appropriate use of these guidelines is likely to strengthen the evidence base ... ...

Abstract	Highlights Guidelines have been created to improve the reporting of clinical trials of biofield therapies, e.g. External Qigong, Healing Touch, Reiki, and Therapeutic Touch. Appropriate use of these guidelines is likely to strengthen the evidence base for biofield therapies as well as increase their usage as stand-alone practices and as complementary therapies within mainstream healthcare.
MeSH term(s)	Complementary Therapies ; Mind-Body Therapies ; Qigong ; Therapeutic Touch ; Clinical Trials as Topic ; Guidelines as Topic
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ISSN	2768-3613
ISSN (online)	2768-3613
DOI	10.1089/jicm.2024.29128.rh
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Article ; Online: Tribute to Hugh MacPherson, PhD

Hammerschlag, Richard / Wayne, Peter M

Journal of alternative and complementary medicine (New York, N.Y.)

2020 Volume 26, Issue 10, Page(s) 845–846

MeSH term(s)	Acupuncture/history ; Biomedical Research/history ; Faculty/history ; History, 20th Century ; History, 21st Century ; Humans ; Integrative Medicine/history ; United Kingdom
Language	English
Publishing date	2020-08-13
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	1237383-7
ISSN	1557-7708 ; 1075-5535
ISSN (online)	1557-7708
ISSN	1075-5535
DOI	10.1089/acm.2020.29084.hma
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Article ; Online: Systematic Review: Molecular Studies of Common Genetic Variation in Child and Adolescent Psychiatric Disorders.

Akingbuwa, Wonuola A / Hammerschlag, Anke R / Bartels, Meike / Middeldorp, Christel M

Journal of the American Academy of Child and Adolescent Psychiatry

2021 Volume 61, Issue 2, Page(s) 227–242

Abstract: Objective: A systematic review of studies using molecular genetics and statistical approaches to investigate the role of common genetic variation in the development, persistence, and comorbidity of childhood psychiatric traits was conducted.: Method: ...

Abstract	Objective: A systematic review of studies using molecular genetics and statistical approaches to investigate the role of common genetic variation in the development, persistence, and comorbidity of childhood psychiatric traits was conducted. Method: A literature review was performed using the PubMed database, following PRISMA guidelines. There were 131 studies meeting inclusion criteria, having investigated at least one type of childhood-onset or childhood-measured psychiatric disorder or trait with the aim of identifying trait-associated common genetic variants, estimating the contribution of single nucleotide polymorphisms (SNPs) to the amount of variance explained (SNP-based heritability), investigating genetic overlap between psychiatric traits, or investigating whether the stability in traits or the association with adult traits is explained by genetic factors. Results: The first robustly associated genetic variants have started to be identified for childhood psychiatric traits. There were substantial contributions of common genetic variants to many traits, with variation in single nucleotide polymorphism heritability estimates depending on age and raters. Moreover, genetic variants also appeared to explain comorbidity as well as stability across a range of psychiatric traits in childhood and across the life span. Conclusion: Common genetic variation plays a substantial role in childhood psychiatric traits. Increased sample sizes will lead to increased power to identify genetic variants and to understand genetic architecture, which will ultimately be beneficial to targeted and prevention strategies. This can be achieved by harmonizing phenotype measurements, as is already proposed by large international consortia and by including the collection of genetic material in every study.
MeSH term(s)	Adolescent ; Child ; Family ; Genome-Wide Association Study ; Humans ; Mental Disorders/genetics ; Phenotype ; Polymorphism, Single Nucleotide
Language	English
Publishing date	2021-04-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
ZDB-ID	392535-3
ISSN	1527-5418 ; 0890-8567
ISSN (online)	1527-5418
ISSN	0890-8567
DOI	10.1016/j.jaac.2021.03.020
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Article ; Online: Parental characteristics and offspring mental health and related outcomes: a systematic review of genetically informative literature.

Jami, Eshim S / Hammerschlag, Anke R / Bartels, Meike / Middeldorp, Christel M

Translational psychiatry

2021 Volume 11, Issue 1, Page(s) 197

Abstract: Various parental characteristics, including psychiatric disorders and parenting behaviours, are associated with offspring mental health and related outcomes in observational studies. The application of genetically informative designs is crucial to ... ...

Abstract	Various parental characteristics, including psychiatric disorders and parenting behaviours, are associated with offspring mental health and related outcomes in observational studies. The application of genetically informative designs is crucial to disentangle the role of genetic and environmental factors (as well as gene-environment correlation) underlying these observations, as parents provide not only the rearing environment but also transmit 50% of their genes to their offspring. This article first provides an overview of behavioural genetics, matched-pair, and molecular genetics designs that can be applied to investigate parent-offspring associations, whilst modelling or accounting for genetic effects. We then present a systematic literature review of genetically informative studies investigating associations between parental characteristics and offspring mental health and related outcomes, published since 2014. The reviewed studies provide reliable evidence of genetic transmission of depression, criminal behaviour, educational attainment, and substance use. These results highlight that studies that do not use genetically informative designs are likely to misinterpret the mechanisms underlying these parent-offspring associations. After accounting for genetic effects, several parental characteristics, including parental psychiatric traits and parenting behaviours, were associated with offspring internalising problems, externalising problems, educational attainment, substance use, and personality through environmental pathways. Overall, genetically informative designs to study intergenerational transmission prove valuable for the understanding of individual differences in offspring mental health and related outcomes, and mechanisms of transmission within families.
MeSH term(s)	Child of Impaired Parents ; Humans ; Mental Health ; Parent-Child Relations ; Parenting ; Parents
Language	English
Publishing date	2021-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-021-01300-2
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Article ; Online: Ultra-rare and common genetic variant analysis converge to implicate negative selection and neuronal processes in the aetiology of schizophrenia.

Akingbuwa, Wonuola A / Hammerschlag, Anke R / Bartels, Meike / Nivard, Michel G / Middeldorp, Christel M

Molecular psychiatry

2022 Volume 27, Issue 9, Page(s) 3699–3707

Abstract: Both common and rare genetic variants (minor allele frequency >1% and <0.1% respectively) have been implicated in the aetiology of schizophrenia. In this study, we integrate single-cell gene expression data with publicly available Genome-Wide Association ...

Abstract	Both common and rare genetic variants (minor allele frequency >1% and <0.1% respectively) have been implicated in the aetiology of schizophrenia. In this study, we integrate single-cell gene expression data with publicly available Genome-Wide Association Study (GWAS) and exome sequenced data in order to investigate in parallel, the enrichment of common and (ultra-)rare variants related to schizophrenia in several functionally relevant gene-sets. Four types of gene-sets were constructed 1) protein-truncating variant (PTV)-intolerant (PI) genes 2) genes expressed in brain cell types and neurons ascertained from mouse and human brain tissue 3) genes defined by synaptic function and location and 4) intersection genes, i.e., PI genes that are expressed in the human and mouse brain cell gene-sets. We show that common as well as ultra-rare schizophrenia-associated variants are overrepresented in PI genes, in excitatory neurons from the prefrontal cortex and hippocampus, medium spiny neurons, and genes enriched for synaptic processes. We also observed stronger enrichment in the intersection genes. Our findings suggest that across the allele frequency spectrum, genes and genetic variants likely to be under stringent selection, and those expressed in particular brain cell types, are involved in the same biological pathways influencing the risk for schizophrenia.
MeSH term(s)	Humans ; Mice ; Animals ; Schizophrenia/genetics ; Genome-Wide Association Study ; Genetic Predisposition to Disease/genetics ; Exome Sequencing ; Exome/genetics ; Polymorphism, Single Nucleotide/genetics
Language	English
Publishing date	2022-06-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-022-01621-8
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Article: The role of context in elucidating drivers of animal movement.

Lubitz, Nicolas / Bradley, Michael / Sheaves, Marcus / Hammerschlag, Neil / Daly, Ryan / Barnett, Adam

Ecology and evolution

2022 Volume 12, Issue 7, Page(s) e9128

Abstract: Despite its consequences for ecological processes and population dynamics, intra-specific variability is frequently overlooked in animal movement studies. Consequently, the necessary resolution to reveal drivers of individual movement decisions is often ... ...

Abstract	Despite its consequences for ecological processes and population dynamics, intra-specific variability is frequently overlooked in animal movement studies. Consequently, the necessary resolution to reveal drivers of individual movement decisions is often lost as animal movement data are aggregated to infer average or population patterns. Thus, an empirical understanding of why a given movement pattern occurs remains patchy for many taxa, especially in marine systems. Nonetheless, movement is often rationalized as being driven by basic life history requirements, such as acquiring energy (feeding), reproduction, predator-avoidance, and remaining in suitable environmental conditions. However, these life history requirements are central to every individual within a species and thus do not sufficiently account for the high intra-specific variability in movement behavior and hence fail to fully explain the occurrence of multiple movement strategies within a species. Animal movement appears highly context dependent as, for example, within the same location, the behavior of both resident and migratory individuals is driven by life history requirements, such as feeding or reproduction, however different movement strategies are utilized to fulfill them. A systematic taxa-wide approach that, instead of averaging population patterns, incorporates and utilizes intra-specific variability to enable predictions as to which movement patterns can be expected under a certain context, is needed. Here, we use intra-specific variability in elasmobranchs as a case study to introduce a stepwise approach for studying animal movement drivers that is based on a context-dependence framework. We examine relevant literature to illustrate how this context-focused approach can aid in reliably identifying drivers of a specific movement pattern. Ultimately, incorporating behavioral variability in the study of movement drivers can assist in making predictions about behavioral responses to environmental change, overcoming tagging biases, and establishing more efficient conservation measures.
Language	English
Publishing date	2022-07-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.9128
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Article ; Online: SARS-CoV-2 Positivity rates are lower in school compared with local rates in Brooklyn, New York.

Smith-Norowitz, Tamar A / Norowitz, Yitzchok M / Kohlhoff, Stephan / Hammerschlag, Margaret R

Acta paediatrica (Oslo, Norway : 1992)

2021 Volume 110, Issue 9, Page(s) 2576–2577

MeSH term(s)	COVID-19 ; Humans ; New York/epidemiology ; New York City/epidemiology ; SARS-CoV-2 ; Schools
Language	English
Publishing date	2021-06-29
Publishing country	Norway
Document type	Letter
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.16003
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Article ; Online: Universal Prenatal Screening and Testing and Chlamydia trachomatis Conjunctivitis in Infants.

Kohlhoff, Stephan / Roblin, Patricia M / Clement, Sheinese / Banniettis, Natalie / Hammerschlag, Margaret R

Sexually transmitted diseases

2021 Volume 48, Issue 9, Page(s) e122–e123

Abstract: Abstract: We retrospectively reviewed all infant Chlamydia trachomatis eye cultures submitted to the Chlamydia Research Laboratory from 1986 to 2002. The positivity rate was 15.6% during the period before the implementation of universal prenatal ... ...

Abstract	Abstract: We retrospectively reviewed all infant Chlamydia trachomatis eye cultures submitted to the Chlamydia Research Laboratory from 1986 to 2002. The positivity rate was 15.6% during the period before the implementation of universal prenatal screening (1986-1993) compared with 1.8% during the screening period (1994-2002).
MeSH term(s)	Chlamydia Infections/diagnosis ; Chlamydia Infections/epidemiology ; Chlamydia trachomatis ; Conjunctivitis ; Female ; Humans ; Infant ; Pregnancy ; Prenatal Diagnosis ; Retrospective Studies
Language	English
Publishing date	2021-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	435191-5
ISSN	1537-4521 ; 0148-5717
ISSN (online)	1537-4521
ISSN	0148-5717
DOI	10.1097/OLQ.0000000000001344
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Article ; Online: Factors impacting vaccine hesitancy toward Coronavirus disease-19 (COVID-19) vaccination in Brooklyn, New York.

Smith-Norowitz, Tamar A / Silverberg, Jonathan I / Norowitz, Esther M / Kohlhoff, Stephan / Hammerschlag, Margaret R

Human vaccines & immunotherapeutics

2021 Volume 17, Issue 11, Page(s) 4013–4014

Abstract: The Coronavirus disease-2019 (COVID-19) pandemic led to the development of several candidate vaccines. However, current research suggests that the potential of successful vaccines is tempered by vaccine skepticism or hesitancy. If vaccine efficacy is 80%, ...

Abstract	The Coronavirus disease-2019 (COVID-19) pandemic led to the development of several candidate vaccines. However, current research suggests that the potential of successful vaccines is tempered by vaccine skepticism or hesitancy. If vaccine efficacy is 80%, then the herd immunity required from vaccination is about 75-90%. The aim of the current study was to study factors impacting COVID-19 vaccine hesitancy in a representative sample of adults (age≥18 years) in a COVID-19 hotspot
MeSH term(s)	Adolescent ; Adult ; COVID-19 ; COVID-19 Vaccines ; Cross-Sectional Studies ; Humans ; New York ; SARS-CoV-2 ; Vaccination ; Vaccination Hesitancy ; Vaccine Efficacy
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2021-07-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2021.1948786
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