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Article ; Online: Misoprostol with balloon vs oxytocin with balloon in high-risk pregnancy induction: a randomized controlled trial.

Al-Hafez, Leen / Khanuja, Kavisha / Mendez-Figueroa, Hector / Al-Kouatly, Huda B / Mascio, Daniele Di / Chauhan, Suneet P / Berghella, Vincenzo

American journal of obstetrics & gynecology MFM

2023 Volume 5, Issue 12, Page(s) 101175

Abstract: Background: Pregnancies at high risk for maternal, fetal, or placental complications often necessitate induction of labor in the late preterm or early term period for delivery. Limited data exist on the safest method of induction to use in this specific ...

Abstract	Background: Pregnancies at high risk for maternal, fetal, or placental complications often necessitate induction of labor in the late preterm or early term period for delivery. Limited data exist on the safest method of induction to use in this specific patient population. Objective: This study aimed to compare the combination of oxytocin plus a Cook balloon vs misoprostol plus a Cook balloon for induction of labor in high-risk pregnancies. Study design: We conducted an open-label, randomized controlled trial at a single institution from July 2020 to May 2022. The study was approved by the institutional review board and registered with ClinicalTrials.gov (NCT04492072). Individuals with a high-risk pregnancy, at least ≥22 weeks' gestation, with a singleton in cephalic presentation, Bishop score ≤6, and intact membranes were offered enrollment. A high-risk pregnancy was defined as a pregnancy with any of the following complications: hypertensive disease of pregnancy, fetal growth restriction, oligohydramnios, suspected placental abruption requiring delivery, uncontrolled pregestational diabetes, or abnormal biophysical profile or nonstress test requiring delivery. The primary outcome was the rate of cesarean delivery. Secondary maternal outcomes included induction to delivery interval, number of vaginal deliveries within 24 hours, rates of uterine tachysystole, intraamniotic infection, operative vaginal delivery, and postpartum hemorrhage. Secondary fetal outcomes included fetal heart rate abnormalities, stillbirth, Apgar scores <7 at 5 minutes, admission to the neonatal intensive care unit, arterial umbilical blood pH <7.1, sepsis, and neonatal death. A subgroup analysis was planned for the primary outcome to assess the different indications for cesarean delivery. An intent-to-treat analysis was performed. Results: During the 22 months of the trial, a total of 150 patients were randomized, and 73 (49%) of those were induced with oxytocin and a Cook balloon and 77 (51%) were induced with misoprostol and a Cook balloon. There was no significant difference in the overall rate of cesarean delivery between the study groups, (21.9% vs 31.1%; relative risk, 0.70; 95% confidence interval, 0.41-1.21), nor among those for which the cesarean delivery was performed for a specific indication. There were no differences in the secondary maternal and fetal or neonatal adverse outcomes. Conclusion: In high-risk pregnancies, the rate of cesarean delivery and adverse maternal and fetal outcomes were similar for induction of labor with oxytocin and a Cook balloon and for induction with misoprostol and a Cook balloon.
MeSH term(s)	Infant, Newborn ; Pregnancy ; Humans ; Female ; Misoprostol/adverse effects ; Oxytocin/adverse effects ; Oxytocics/adverse effects ; Pregnancy, High-Risk ; Labor, Induced/adverse effects ; Labor, Induced/methods ; Placenta ; Cervical Ripening
Chemical Substances	Misoprostol (0E43V0BB57) ; Oxytocin (50-56-6) ; Oxytocics
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ISSN	2589-9333
ISSN (online)	2589-9333
DOI	10.1016/j.ajogmf.2023.101175
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Article: Nitric Oxide Detection Using a Chemical Trap Method for Applications in Bacterial Systems.

Oliveira, Marilene Silva / Santos, Karina F D N / de Paula, Railane Monteiro / Vitorino, Luciana C / Bessa, Layara A / Greer, Alexander / Di Mascio, Paolo / de Souza, João C P / Martin-Didonet, Claudia C G

Microorganisms

2023 Volume 11, Issue 9

Abstract: Plant growth-promoting bacteria (PGPB) can be incorporated in biofertilizer formulations, which promote plant growth in different ways, such as fixing nitrogen and producing phytohormones and nitric oxide (NO). NO is a free radical involved in the growth ...

Abstract	Plant growth-promoting bacteria (PGPB) can be incorporated in biofertilizer formulations, which promote plant growth in different ways, such as fixing nitrogen and producing phytohormones and nitric oxide (NO). NO is a free radical involved in the growth and defense responses of plants and bacteria. NO detection is vital for further investigation in different agronomically important bacteria. NO production in the presence of KNO
Language	English
Publishing date	2023-08-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11092210
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Article ; Online: Chemiexcited Neurotransmitters and Hormones Create DNA Photoproducts in the Dark.

Gonçalves, Leticia C P / Angelé-Martínez, Carlos / Premi, Sanjay / Palmatier, Meg A / Prado, Fernanda Manso / Di Mascio, Paolo / Bastos, Erick L / Brash, Douglas E

ACS chemical biology

2023 Volume 18, Issue 3, Page(s) 484–493

Abstract: In DNA, electron excitation allows adjacent pyrimidine bases to dimerize by [2 + 2] cycloaddition, creating chemically stable but lethal and mutagenic cyclobutane pyrimidine dimers (CPDs). The usual cause is ultraviolet radiation. Alternatively, CPDs can ...

Abstract	In DNA, electron excitation allows adjacent pyrimidine bases to dimerize by [2 + 2] cycloaddition, creating chemically stable but lethal and mutagenic cyclobutane pyrimidine dimers (CPDs). The usual cause is ultraviolet radiation. Alternatively, CPDs can be made in the dark (dCPDs) via chemically mediated electron excitation of the skin pigment melanin, after it is oxidized by peroxynitrite formed from the stress-induced radicals superoxide and nitric oxide. We now show that the dark process is not limited to the unusual structural molecule melanin: signaling biomolecules such as indolamine and catecholamine neurotransmitters and hormones can also be chemiexcited to energy levels high enough to form dCPDs. Oxidation of serotonin, dopamine, melatonin, and related biogenic amines by peroxynitrite created triplet-excited species, evidenced by chemiluminescence, energy transfer to a triplet-state reporter, or transfer to O
MeSH term(s)	Animals ; DNA Damage ; Ultraviolet Rays ; Melanins/genetics ; Peroxynitrous Acid ; Pyrimidine Dimers/chemistry ; Neurotransmitter Agents ; Hormones ; DNA/chemistry ; Mammals/genetics ; Mammals/metabolism
Chemical Substances	Melanins ; Peroxynitrous Acid (14691-52-2) ; Pyrimidine Dimers ; Neurotransmitter Agents ; Hormones ; DNA (9007-49-2)
Language	English
Publishing date	2023-02-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1554-8937
ISSN (online)	1554-8937
DOI	10.1021/acschembio.2c00787
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Article ; Online: Removal versus retention of cervical cerclage with preterm prelabor rupture of membranes: Systematic review and meta-analysis.

Zullo, Fabrizio / Di Mascio, Daniele / Chauhan, Suneet P / Chrysostomou, Spyridakis / Suff, Natalie / Pecorini, Francesco / D'Ambrosio, Valentina / Sorrenti, Sara / D'Alberti, Elena / Galoppi, Paola / Muzii, Ludovico / Giancotti, Antonella / Brunelli, Roberto

European journal of obstetrics, gynecology, and reproductive biology

2023 Volume 288, Page(s) 83–89

Abstract: ... significantly lower in the removal compared to retention group (OR 0.15, 95% CI 0.07-0.31; p < 0.0001), as well ... as the rate of pregnancy prolongation >7 days (OR 0.30 95% CI 0.11-0.83; p = 0.02) and pregnancy latency expressed in days ... MD -2.84 days, 95% CI -5.40 to -0.29; p = 0.03). The rate of chorioamnionitis was significantly lower ...

Abstract	Objective: To evaluate maternal and perinatal outcomes of removal versus retention of cervical cerclage after premature preterm rupture of membranes (pPROM). Study design: Medline, Embase and Cochrane databases were searched electronically on February 2023 utilizing combinations of the relevant medical subject heading (MeSH) terms, keywords, and word variants that were considered suitable for the topic. Either prospective or retrospective trials were considered suitable for the inclusion. The coprimary outcome of this study were pregnancy latency >7 days from pPROM and pregnancy latency >48 h from pPROM. Random effect head to-head meta-analyses were performed to directly compare each outcome, expressing the results as summary odds ratio (OR) for dichotomous outcomes and as mean difference (MD) for continuous outcomes, plus relative 95% confidence interval (CI). Quality assessment of the included studies was performed using the Newcastle-Ottawa Scale. Results: Six studies involving a total of 377 women (169 in the "removal" and 208 in the "retention" group) were included. The rate of pregnancy prolongation >48 h was significantly lower in the removal compared to retention group (OR 0.15, 95% CI 0.07-0.31; p < 0.0001), as well as the rate of pregnancy prolongation >7 days (OR 0.30 95% CI 0.11-0.83; p = 0.02) and pregnancy latency expressed in days (MD -2.84 days, 95% CI -5.40 to -0.29; p = 0.03). The rate of chorioamnionitis was significantly lower in the removal compared to the retention group (OR 0.57 95% CI 0.34-0.96p = 0.03) as was the rate of Apgar score < 7 at 5 min (OR 0.22 95% CI 0.08-0.56; p = 0.002). There was no difference between removal and retention groups for all the other maternal and perinatal outcomes. Conclusions: The decision whether to remove or retain cerclage in case of pPROM should balance the prematurity-related risks with that of infectious complications, thus highlighting the need for tailored management based on gestational age at occurrence of pPROM.
MeSH term(s)	Pregnancy ; Infant, Newborn ; Female ; Humans ; Cerclage, Cervical ; Retrospective Studies ; Prospective Studies ; Fetal Membranes, Premature Rupture/epidemiology ; Pregnancy Outcome ; Premature Birth/etiology ; Premature Birth/prevention & control
Language	English
Publishing date	2023-07-20
Publishing country	Ireland
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2023.07.006
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Article: Airport landside sustainable capacity and level of service of terminal functional subsystems

Di Mascio, P. / Moretti, L. / Piacitelli, M.

Sustainability (Switzerland)

Abstract: The airport terminal is a complex building composed of many functional subsystems dimensioned to host passenger traffic, considering an appropriate level of service (LoS) The most widely known method to assess the LoS and design the terminal areas is the ...

Abstract	The airport terminal is a complex building composed of many functional subsystems dimensioned to host passenger traffic, considering an appropriate level of service (LoS) The most widely known method to assess the LoS and design the terminal areas is the Airport Development Reference Manual by the International Air Transport Association (IATA) Based on this, a calculation tool in Microsoft Excel® was implemented to assess the capacity and dimension of the facilities for each functional subsystem of the terminal The tool, composed of nine correlated spreadsheets, is a useful model to design new structures, evaluate the LoS currently offered, plan interventions, and face the new rules of passenger distancing due to the COVID-19 emergency An international airport terminal with 20 million/year including Schengen and extra-Schengen passengers was studied The LoS of the terminal subsystems was assessed and the areas needed for each subsystem were calculated In the analyzed case study, most subsystems (departure hall, check-in, boarding gates, baggage claim, and arrival halls) were over-designed, according to the definition of the IATA LoS This means that available spaces for queues and holding are sufficiently large to easily face the new rules of social distancing for passengers due to the recent COVID-19 emergency © 2020 by the authors
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #908354
Database	COVID19

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Article ; Online: Three-tiered fetal heart rate interpretation system and adverse neonatal and maternal outcomes: a systematic review and meta-analysis.

Zullo, Fabrizio / Di Mascio, Daniele / Raghuraman, Nandini / Wagner, Steve / Brunelli, Roberto / Giancotti, Antonella / Mendez-Figueroa, Hector / Cahill, Alison G / Gupta, Megha / Berghella, Vincenzo / Blackwell, Sean C / Chauhan, Suneet P

American journal of obstetrics and gynecology

2023 Volume 229, Issue 4, Page(s) 377–387

Abstract: Objective: This study aimed to evaluate the rate of adverse neonatal or maternal outcomes in parturients with fetal heart rate tracings categorized as I, II or, III within the last 30 to 120 minutes of delivery.: Data sources: The MEDLINE Ovid, ... ...

Abstract	Objective: This study aimed to evaluate the rate of adverse neonatal or maternal outcomes in parturients with fetal heart rate tracings categorized as I, II or, III within the last 30 to 120 minutes of delivery. Data sources: The MEDLINE Ovid, Scopus, Embase, CINAHL, and Clinicaltrials.gov databases were searched electronically up to May 2022, using combinations of the relevant medical subject heading terms, keywords, and word variants that were considered suitable for the topic. Study eligibility criteria: Only observational studies of term infants reporting outcomes of interest with category I, II, or III fetal heart rate tracings were included. Study appraisal and synthesis methods: The coprimary outcome was the rate of either Apgar score <7 at 5 minutes or umbilical artery pH <7.00. Secondary outcomes were divided into neonatal and maternal adverse outcomes. Quality assessment of the included studies was performed using the Newcastle-Ottawa Scale. Random-effect meta-analyses of proportions were used to estimate the pooled rates of each categorical outcome in fetal heart rate tracing category I, II, and III patterns, and random-effect head-to-head meta-analyses were used to directly compare fetal heart rate tracings category I vs II and fetal heart rate tracing category II vs III, expressing the results as summary odds ratio or as mean differences with relative 95% confidence intervals. Results: Of the 671 articles reviewed, 3 publications met the inclusion criteria. Among them were 47,648 singletons at ≥37 weeks' gestation. Fetal heart rate tracings in the last 30 to 120 minutes before delivery were characterized in the following manner: 27.0% of deliveries had category I tracings, 72.9% had category II tracings, and 0.1% had category III tracings. A single study, which was rated to be of poor quality, contributed 82.1% of the data and it did not provide any data for category III fetal heart rate tracings. When compared with category I fetal heart rate tracings (0.74%), the incidence of an Apgar score <7 at 5 minutes were significantly higher among deliveries with category II fetal heart rate tracings (1.51%) (odds ratio, 1.56; 95% confidence interval, 1.23-1.99) and among those with category III tracings (14.63%) (odds ratio, 14.46; 95% confidence interval, 2.77-75.39). When compared with category II tracings, category III tracings also had a significantly higher likelihood of a low Apgar score at 5 minutes (odds ratio, 14.46; 95% confidence interval, 2.77-75.39). The incidence of an umbilical artery pH <7.00 were similar among those with category I and those with category II tracings (0.08% vs 0.24%; odds ratio, 2.85; 95% confidence interval, 0.41-19.55). When compared with category I tracings, the incidence of an umbilical artery pH <7.00 was significantly more common among those with category III tracings (31.04%; odds ratio, 161.56; 95% confidence interval, 25.18-1036.42); likewise, when compared with those with category II tracings, those with category III tracings had a significantly higher likelihood of having an umbilical artery pH <7.00 (odds ratio, 42.29; 95% confidence interval, 14.29-125.10). Hypoxic-ischemic encephalopathy occurred with similar frequency among those with categories I and those with category II tracings (0 vs 0.81%; odds ratio, 5.86; 95% confidence interval, 0.75-45.89) but was significantly more common among those with category III tracings (0 vs 18.97%; odds ratio, 61.43; 95% confidence interval, 7.49-503.50). Cesarean delivery occurred with similar frequency among those with category I (13.41%) and those with category II tracings (11.92%) (odds ratio, 0.87; 95% confidence interval, 0.72-1.05) but was significantly more common among those with with category III tracings (14.28%) (odds ratio, 3.97; 95% confidence interval, 1.62-9.75). When compared with those with category II tracings, cesarean delivery was more common among those with category III tracings (odds ratio, 4.55; 95% confidence interval, 1.88-11.01). Conclusion: Although the incidence of an Apgar score <7 at 5 minutes and umbilical artery pH <7.00 increased significantly with increasing fetal heart rate tracing category, about 98% of newborns with category II tracings do not have these adverse outcomes. The 3-tiered fetal heart rate tracing interpretation system provides an approximate but imprecise measurement of neonatal prognosis.
MeSH term(s)	Pregnancy ; Infant ; Female ; Infant, Newborn ; Humans ; Heart Rate, Fetal ; Cardiotocography/methods ; Cesarean Section ; Infant, Newborn, Diseases/epidemiology ; Prognosis
Language	English
Publishing date	2023-04-11
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2023.04.008
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Article ; Online: In Reply.

Huntley, Benjamin J F / Huntley, Erin S / Di Mascio, Daniele / Chen, Tracy / Berghella, Vincenzo / Chauhan, Suneet P

Obstetrics and gynecology

2020 Volume 136, Issue 4, Page(s) 849–850

MeSH term(s)	Humans ; Betacoronavirus ; Coronavirus ; Coronavirus Infections ; COVID-19 ; Pandemics ; Perinatal Mortality ; Pneumonia, Viral ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome ; Female ; Pregnancy ; Infant, Newborn
Language	English
Publishing date	2020-09-21
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	207330-4
ISSN	1873-233X ; 0029-7844
ISSN (online)	1873-233X
ISSN	0029-7844
DOI	10.1097/AOG.0000000000004110
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Article: Collision risk assessment between aircraft and obstacles in the areas surrounding airports.

Moretti, Laura / Dinu, Raducu / Di Mascio, Paola

Heliyon

2023 Volume 9, Issue 7, Page(s) e18378

Abstract: The topographical features of a site and the anthropogenic artefacts inside and outside the airport boundaries influence the infrastructure use. Objects penetrating the obstacle limitation surfaces (OLS) or standing outside those surfaces have to be ... ...

Abstract	The topographical features of a site and the anthropogenic artefacts inside and outside the airport boundaries influence the infrastructure use. Objects penetrating the obstacle limitation surfaces (OLS) or standing outside those surfaces have to be mapped and risk-assessed because they could be a hazard to air navigation. This study aims to quantify the risk of collision between aircraft and obstacles in the airspace. There are no available procedures in the literature: the authors supposed that the obstacle type and the examined OLS affect the collision risk. The proposed risk values and amplification factors derive from interviews with technicians. The methodology has been implemented in an existing airport with 589 penetrating obstacles: the results highlight that 69.8% of obstacles imply a negligible risk, and 3.7% require further analyses by the competent aviation authority. In this study, buildings and pylons penetrating the Transitional Surface are the most hazardous obstacles.
Language	English
Publishing date	2023-07-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e18378
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Article ; Online: Adverse Pregnancy Outcomes Among Individuals With and Without Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Systematic Review and Meta-analysis.

Huntley, Benjamin J F / Mulder, Isabelle A / Di Mascio, Daniele / Vintzileos, William S / Vintzileos, Anthony M / Berghella, Vincenzo / Chauhan, Suneet P

Obstetrics and gynecology

2021 Volume 137, Issue 4, Page(s) 585–596

Abstract: ... who tested negative (P=.60). Neonatal death occurred in 0 of 432 (0.0%) patients who tested positive and 5 ... of 2,400 (0.2%) who tested negative (P=.90). Preterm birth occurred in 95 of 714 (13.3%) patients ... who tested positive and 446 of 3,759 (11.9%) who tested negative (P=.31). Maternal death occurred in 3 of 559 ...

Abstract	Objective: To compare the risk of intrauterine fetal death (20 weeks of gestation or later) and neonatal death among individuals who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared with those who tested negative for SARS-CoV-2 on admission for delivery. Data sources: MEDLINE, Ovid, EMBASE, Cumulative Index to Nursing and Allied Health, and Cochrane Library were searched from their inception until July 17, 2020. Hand search for additional articles continued through September 24, 2020. ClinicalTrials.gov was searched on October 21, 2020. Methods of study selection: The inclusion criteria were publications that compared at least 20 cases of both pregnant patients who tested positive for SARS-CoV-2 on admission to labor and delivery and those who tested negative. Exclusion criteria were publications with fewer than 20 individuals in either category or those lacking data on primary outcomes. A systematic search of the selected databases was performed, with co-primary outcomes being rates of intrauterine fetal death and neonatal death. Secondary outcomes included rates of maternal and neonatal adverse outcomes. Tabulation, integration, and results: Of the 941 articles and completed trials identified, six studies met criteria. Our analysis included 728 deliveries to patients who tested positive for SARS-CoV-2 and 3,836 contemporaneous deliveries to patients who tested negative. Intrauterine fetal death occurred in 8 of 728 (1.1%) patients who tested positive and 44 of 3,836 (1.1%) who tested negative (P=.60). Neonatal death occurred in 0 of 432 (0.0%) patients who tested positive and 5 of 2,400 (0.2%) who tested negative (P=.90). Preterm birth occurred in 95 of 714 (13.3%) patients who tested positive and 446 of 3,759 (11.9%) who tested negative (P=.31). Maternal death occurred in 3 of 559 (0.5%) patients who tested positive and 8 of 3,155 (0.3%) who tested negative (P=.23). Conclusion: The incidences of intrauterine fetal death and neonatal death were similar among individuals who tested positive compared with negative for SARS-CoV-2 when admitted to labor and delivery. Other immediate outcomes of the newborns were also similar among those born to individuals who tested positive compared with negative for SARS-CoV-2. Systematic review registration: PROSPERO, CRD42020203475.
MeSH term(s)	COVID-19/diagnosis ; COVID-19/epidemiology ; Female ; Fetal Mortality ; Gestational Age ; Humans ; Infant, Newborn ; Maternal Mortality ; Patient Admission ; Perinatal Mortality ; Pregnancy ; Premature Birth/epidemiology ; SARS-CoV-2
Language	English
Publishing date	2021-03-11
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	207330-4
ISSN	1873-233X ; 0029-7844
ISSN (online)	1873-233X
ISSN	0029-7844
DOI	10.1097/AOG.0000000000004320
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Article ; Online: Reply to "Do we really need a randomized trial comparing vaginal delivery vs cesarean delivery?"

Adewale, Victoria / Varotsis, Dante / Iyer, Neel / Di Mascio, Daniele / Steer, Philip / Berghella, Vincenzo

American journal of obstetrics & gynecology MFM

2024 Volume 6, Issue 3, Page(s) 101293

MeSH term(s)	Pregnancy ; Female ; Humans ; Delivery, Obstetric ; Cesarean Section
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Randomized Controlled Trial ; Letter
ISSN	2589-9333
ISSN (online)	2589-9333
DOI	10.1016/j.ajogmf.2024.101293
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