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  1. Article: Discovery and Development of Calcium Channel Blockers.

    Godfraind, Théophile

    Frontiers in pharmacology

    2017  Volume 8, Page(s) 286

    Abstract: In the mid 1960s, experimental work on molecules under screening as coronary dilators allowed the discovery of the mechanism of calcium entry blockade by drugs later named calcium channel blockers. This paper summarizes scientific research on these small ...

    Abstract In the mid 1960s, experimental work on molecules under screening as coronary dilators allowed the discovery of the mechanism of calcium entry blockade by drugs later named calcium channel blockers. This paper summarizes scientific research on these small molecules interacting directly with L-type voltage-operated calcium channels. It also reports on experimental approaches translated into understanding of their therapeutic actions. The importance of calcium in muscle contraction was discovered by Sidney Ringer who reported this fact in 1883. Interest in the intracellular role of calcium arose 60 years later out of Kamada (Japan) and Heibrunn (USA) experiments in the early 1940s. Studies on pharmacology of calcium function were initiated in the mid 1960s and their therapeutic applications globally occurred in the the 1980s. The first part of this report deals with basic pharmacology in the cardiovascular system particularly in isolated arteries. In the section entitled from calcium antagonists to calcium channel blockers, it is recalled that drugs of a series of diphenylpiperazines screened
    Language English
    Publishing date 2017-05-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2017.00286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Conference proceedings: Pharmacological control of calcium and potassium homeostasis

    Godfraind, Théophile

    biological, therapeutical, and clinical aspects ; [presented at the 6th International Symposium on Pharmacological Control of Calcium und Potassium Homeostasis: Biological, Therapeutical, and Clinical Aspects, in Florence, Italy, on October 4 - 6, 1994]

    (Medical science symposia series ; 9)

    1995  

    Event/congress International Symposium on Pharmacological Control of Calcium and Potassium Homeostasis: Biological, Therapeutical, and Clinical Aspects (6, 1994, Florenz)
    Author's details ed. by T. Godfraind
    Series title Medical science symposia series ; 9
    Collection
    Keywords Cardiovascular System / metabolism / congresses ; Cardiovascular Diseases / drug therapy / congresses ; Calcium / physiology / congresses ; Calcium / antagonists & inhibitors / congresses ; Potassium / metabolism / congresses ; Potassium Channels / physiology / congresses ; Homeostasis / congresses ; Kardiovaskuläre Krankheit ; Kaliumkanal ; Calciumkanal
    Subject Kalziumkanal ; Herz-Kreislauf-Krankheit ; Herz-Kreislauf-Erkrankung ; Kardiovaskuläres System ; Cardiovasculäre Krankheit ; Kardiovaskuläre Krankheiten
    Language English
    Size XVIII, 273 S. : Ill., graph. Darst.
    Publisher Kluwer u.a.
    Publishing place Dordrecht
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT007245435
    ISBN 0-7923-3604-6 ; 978-0-7923-3604-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 3930 order for loan Magazin

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  3. Book ; Conference proceedings: Calcium antagonists

    Godfraind, Théophile

    pharmacology and clinical research

    (Medical science symposia series ; 3)

    1993  

    Event/congress International Symposium on Calcium Antagonists - Pharmacology and Clinical Research (5, 1991, HoustonTex.)
    Author's details [5th International Symposium on Calcium Antagonists: Pharmacology and Clinical Research ... September 5 - 8, 1991, Houston, Texas (USA)]. Ed. by T. Godfraind
    Series title Medical science symposia series ; 3
    Collection
    Keywords Calcium Channel Blockers / pharmacology / congresses ; Calcium Channel Blockers / therapeutic use / congresses ; Calciumantagonist ; Pharmakologie ; Pharmakotherapie
    Subject Arzneimitteltherapie ; Arzneitherapie ; Medikamentöse Therapie ; Calciumblocker ; Kalziumantagonist ; Calcium ; Ca-Antagonist ; Calciumkanalblocker ; Arzneimittellehre ; Arzneimittelwirkung ; Arzneiwirkung ; Experimentelle Pharmakologie
    Language English
    Size XXV, 380 S. : Ill., graph. Darst.
    Publisher Kluwer
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT006219983
    ISBN 0-7923-2259-2 ; 978-0-7923-2259-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1994 A 1545 order for loan Magazin

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  4. Book ; Conference proceedings: Inodilators

    Godfraind, Théophile

    a new strategy in the therapy of heart failure ; proceedings of a symposium held at the University of Brescia, Italy during the 24th national congress of the Italian Society for Pharmacology, September 28, 1988

    (Journal of cardiovascular pharmacology ; 14, Suppl. 8)

    1989  

    Institution Società Italiana di Farmacologia
    Event/congress Symposium on Inodilators: a New Strategy in the Therapy of Heart Failure (1988, Brescia)
    Author's details [Symposium on Inodilators: A New Strategy in the Therapy of Heart Failure]. Guest ed. Théophile Godfraind
    Series title Journal of cardiovascular pharmacology ; 14, Suppl. 8
    Collection
    Keywords Heart Failure, Congestive / drug therapy / congresses ; Cardiotonic Agents / therapeutic use / congresses
    Language English
    Size V, S132 S. : Ill., graph. Darst.
    Publisher Raven Pr
    Publishing place New York
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003530726
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1471 -14,Suppl.8- verfügbar in Königswinter Königswinter

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  5. Book: Calcium entry blockers and tissue protection

    Godfraind, Théophile

    1985  

    Keywords CALCIUM CHANNEL BLOCKERS / PHARMACOLOGY ; CALCIUM CHANNEL BLOCKERS / THERAPEUTIC USE ; CELLS / METABOLISM ; Calciumantagonist
    Subject Calciumblocker ; Kalziumantagonist ; Calcium ; Ca-Antagonist ; Calciumkanalblocker
    Language English
    Size 261 S.
    Publisher Raven Pr
    Publishing place New York
    Document type Book
    HBZ-ID HT002729658
    ISBN 0-89004-719-7 ; 978-0-89004-719-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1985 A 1627 order for loan Magazin

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  6. Book: Calcium entry blockers in cardiovascular and cerebral dysfunctions

    Godfraind, Théophile

    (Developments in cardiovascular medicine ; 40)

    1984  

    Author's details ed. by Théophile Godfraind
    Series title Developments in cardiovascular medicine ; 40
    Collection
    Keywords CALCIUM CHANNEL BLOCKERS / PHARMACOLOGY ; CALCIUM CHANNEL BLOCKERS / THERAPEUTIC USE ; CARDIOVASCULAR DISEASES / DRUG THERAPY ; CEREBROVASCULAR DISORDERS / DRUG THERAPY ; Calciumantagonist ; Hirngefäßkrankheit ; Chemotherapie ; Kreislaufmittel
    Subject Calciumblocker ; Kalziumantagonist ; Calcium ; Ca-Antagonist ; Calciumkanalblocker ; Kardiovaskuläres Arzneimittel ; Cerebrovaskuläre Krankheit ; Zerebrovaskuläre Krankheit ; Hirngefäßkrankheiten
    Size 322 S.
    Publisher Nijhoff
    Publishing place Boston u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT002522002
    ISBN 0-89838-658-6 ; 978-0-89838-658-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1984 A 3228 order for loan Magazin

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  7. Article ; Online: Calcium channel blockers in cardiovascular pharmacotherapy.

    Godfraind, Theophile

    Journal of cardiovascular pharmacology and therapeutics

    2014  Volume 19, Issue 6, Page(s) 501–515

    Abstract: This paper summarizes the pharmacological properties of calcium channel blockers (CCBs), their established therapeutic uses for cardiovascular disorders and the current improvement of their clinical effects through drug combinations. Their identification ...

    Abstract This paper summarizes the pharmacological properties of calcium channel blockers (CCBs), their established therapeutic uses for cardiovascular disorders and the current improvement of their clinical effects through drug combinations. Their identification resulted from study of small molecules including coronary dilators, which were named calcium antagonists. Further experiments showed that they reduced contraction of arteries by inhibiting calcium entry and by interacting with binding sites identified on voltage-dependent calcium channels. This led to the denomination calcium channel blockers. In short-term studies, by decreasing total peripheral resistance, CCBs lower arterial pressure. By unloading the heart and increasing coronary blood flow, CCBs improve myocardial oxygenation. In long-term treatment, the decrease in blood pressure is more pronounced in hypertensive than in normotensive patients. A controversy on the safety of CCBs ended after a large antihypertensive trial (ALLHAT) sponsored by the National Heart, Lung, and Blood Institute. There are two main types of CCBs: dihydopyridine and non-dihydropyridine; the first type is vascular selective. Dihydropyrines are indicated for hypertension, chronic, stable and vasospastic angina. Non-dihydropyridines have the same indications plus antiarrythmic effects in atrial fibrillation or flutter and paroxysmal supraventricular tachycardia. In addition, CCBs reduced newly formed coronary lesions in atherosclerosis. In order to reach recommended blood pressure goals, there is a recent therapeutic move by combination of CCBs with other antihypertensive agents particularly with inhibitors acting at the level of the renin-angiotensin system. They are also combined with statins. Prevention of dementia has been reported in hypertensive patients treated with nitrendipine, opening a way for further studies on CCBs' beneficial effect in cognitive deterioration associated with aging.
    MeSH term(s) Animals ; Anti-Arrhythmia Agents/therapeutic use ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Calcium Channel Blockers/adverse effects ; Calcium Channel Blockers/therapeutic use ; Drug Therapy, Combination ; Humans ; Hypertension/complications ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/physiopathology ; Treatment Outcome ; Vasodilation/drug effects ; Vasodilator Agents/adverse effects ; Vasodilator Agents/therapeutic use
    Chemical Substances Anti-Arrhythmia Agents ; Antihypertensive Agents ; Calcium Channel Blockers ; Vasodilator Agents
    Language English
    Publishing date 2014-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1329372-2
    ISSN 1940-4034 ; 1074-2484
    ISSN (online) 1940-4034
    ISSN 1074-2484
    DOI 10.1177/1074248414530508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4895: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Conference proceedings: CALCIUM MODULATORS

    Godfraind, Théophile

    PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON CALCIUM MODULATORS (FROM CALCIUM ANTAGONISTS TO CALCIUM ENTRY BLOCKERS) HELD IN VENICE, ITALY, JUNE 17 - 18, 1982

    (SYMPOSIA OF THE GIOVANNI LORENZINI FOUNDATION ; 15)

    1982  

    Author's details EDS.: THEOPHILE GODFRAIND
    Series title SYMPOSIA OF THE GIOVANNI LORENZINI FOUNDATION ; 15
    Symposia of the Giovanni Lorenzini Foundation
    Collection Symposia of the Giovanni Lorenzini Foundation
    Keywords Calcium / physiology / congresses ; Calcium Channel Blockers / therapeutic use / congresses ; Calcium Channel Blockers / pharmacology / congresses ; Calciumantagonist
    Subject Calciumblocker ; Kalziumantagonist ; Calcium ; Ca-Antagonist ; Calciumkanalblocker
    Size VII, 377 S.
    Publisher ELSEVIER BIOMEDICAL PRESS
    Publishing place AMSTERDAM (U.A.)
    Document type Book ; Conference proceedings
    HBZ-ID HT002467041
    ISBN 0-444-80464-1 ; 978-0-444-80464-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1983 A 1331 order for loan Magazin

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  9. Book ; Conference proceedings: Cell membrane in function and dysfunction of vascular tissue

    Godfraind, Théophile

    proceedings of the Fifth Argenteuil Symposium held under the auspices of the Fondation Cardiologique Princesse Liliane in Waterloo, Belgium, 30 June and 1 July 1980

    1981  

    Event/congress Argenteuil Symposium (5, 1980, Waterloo)
    Author's details ed. T. Godfraind
    Keywords Biological Transport / congresses ; Cell Membrane / congresses ; Cardiovascular Diseases / congresses ; Cardiovascular System / congresses
    Size XXI, 270 S. : Ill., graph. Darst.
    Publisher Elsevier u.a.
    Publishing place AMSTERDAM (U.A.)
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT002555286
    ISBN 0-444-80316-5 ; 978-0-444-80316-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1984 A 2434 order for loan Magazin

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  10. Article ; Online: The quest for medicines, a grand challenge in the twenty-first century.

    Godfraind, Theophile

    Frontiers in pharmacology

    2010  Volume 1, Page(s) 134

    Language English
    Publishing date 2010-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812 ; 1663-9812
    ISSN (online) 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2010.00134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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