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  1. Article ; Online: The Modulation of Beneficial and/or Harmful Effects of Free Oxygen Radicals in the Context of Molecular Mechanisms Regarding Drug - PART I.

    Aliev, Gjumrakch

    Current topics in medicinal chemistry

    2020  Volume 19, Issue 32, Page(s) 2937–2939

    Abstract: This special issue of Current Topic in Medicinal Chemistry (CTMC) covers outcomes and ideas for future molecular modifications leading to the novel derivatives with better constructive pharmacological potential for treatment of the different human ... ...

    Abstract This special issue of Current Topic in Medicinal Chemistry (CTMC) covers outcomes and ideas for future molecular modifications leading to the novel derivatives with better constructive pharmacological potential for treatment of the different human disorders but also may considering anatomical features of the underlying tissues, and non-chemical based treatment strategies.
    MeSH term(s) Drug Therapy ; Humans ; Reactive Oxygen Species/metabolism
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2020-02-04
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/156802661932200108160511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5572: Show issues Location:
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  2. Article ; Online: Pharmacological Approaches Targeting Brain Cell Survival in the Context of Neurodegeneration and Potential Treatment Strategies.

    Aliev, Gjumrakch

    Current neuropharmacology

    2018  Volume 17, Issue 3, Page(s) 198–200

    MeSH term(s) Animals ; Brain/drug effects ; Cell Survival/drug effects ; Humans ; Neurodegenerative Diseases/drug therapy ; Neuroprotective Agents/therapeutic use
    Chemical Substances Neuroprotective Agents
    Language English
    Publishing date 2018-12-23
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X17666181227163039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6150: Show issues Location:
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  3. Article ; Online: Preface.

    Aliev, Gjumrakch

    Central nervous system agents in medicinal chemistry

    2015  Volume 15, Issue 1, Page(s) 3

    MeSH term(s) Drug Design ; Drug Industry/trends ; Editorial Policies ; Humans
    Language English
    Publishing date 2015-02-26
    Publishing country United Arab Emirates
    Document type Introductory Journal Article
    ZDB-ID 2227560-5
    ISSN 1875-6166 ; 1871-5249
    ISSN (online) 1875-6166
    ISSN 1871-5249
    DOI 10.2174/187152491501150303000937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5594: Show issues Location:
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  4. Article ; Online: Metabolic Disorders, Drug Development, Drug Design and Biomarkers.

    Aliev, Gjumrakch

    Current pharmaceutical design

    2015  Volume 22, Issue 7, Page(s) 765–767

    MeSH term(s) Animals ; Biomarkers/metabolism ; Drug Design ; Humans ; Metabolic Diseases/drug therapy ; Metabolic Diseases/epidemiology ; Metabolic Diseases/physiopathology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2015-11-20
    Publishing country United Arab Emirates
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/138161282207160127173155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4714: Show issues Location:
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  5. Article: Editorial: Infection, Inflammation, Cardiovascular Diseases, and Neurodegeneration.

    Zhang, Deng-Feng / Bu, Xian-Le / Aliev, Gjumrakch / Zhu, Feiqi

    Frontiers in neuroscience

    2021  Volume 15, Page(s) 750172

    Language English
    Publishing date 2021-09-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2021.750172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Recent Reports on Redox Stress-Induced Mitochondrial DNA Variations, Neuroglial Interactions, and NMDA Receptor System in Pathophysiology of Schizophrenia.

    Beeraka, Narasimha M / Avila-Rodriguez, Marco F / Aliev, Gjumrakch

    Molecular neurobiology

    2022  Volume 59, Issue 4, Page(s) 2472–2496

    Abstract: Schizophrenia (SZ) is a chronic psychiatric disorder affecting several people worldwide. Mitochondrial DNA (mtDNA) variations could invoke changes in the OXPHOS system, calcium buffering, and ROS production, which have significant implications for glial ... ...

    Abstract Schizophrenia (SZ) is a chronic psychiatric disorder affecting several people worldwide. Mitochondrial DNA (mtDNA) variations could invoke changes in the OXPHOS system, calcium buffering, and ROS production, which have significant implications for glial cell survival during SZ. Oxidative stress has been implicated in glial cells-mediated pathogenesis of SZ; the brain comparatively more prone to oxidative damage through NMDAR. A confluence of scientific evidence points to mtDNA alterations, Nrf2 signaling, dynamic alterations in dorsolateral prefrontal cortex (DLPFC), and provocation of oxidative stress that enhance pathophysiology of SZ. Furthermore, the alterations in excitatory signaling related to NMDAR signaling were particularly reported for SZ pathophysiology. Current review reported the recent evidence for the role of mtDNA variations and oxidative stress in relation to pathophysiology of SZ, NMDAR hypofunction, and glutathione deficiency. NMDAR system is influenced by redox dysregulation in oxidative stress, inflammation, and antioxidant mediators. Several studies have demonstrated the relationship of these variables on severity of pathophysiology in SZ. An extensive literature search was conducted using Medline, PubMed, PsycINFO, CINAHL PLUS, BIOSIS Preview, Google scholar, and Cochrane databases. We summarize consistent evidence pointing out a plausible model that may elucidate the crosstalk between mtDNA alterations in glial cells and redox dysregulation during oxidative stress and the perturbation of NMDA neurotransmitter system during current therapeutic modalities for the SZ treatment. This review can be beneficial for the development of promising novel diagnostics, and therapeutic modalities by ascertaining the mtDNA variations, redox state, and efficacy of pharmacological agents to mitigate redox dysregulation and augment NMDAR function to treat cognitive and behavioral symptoms in SZ.
    MeSH term(s) DNA, Mitochondrial/genetics ; Humans ; Neuroglia/metabolism ; Oxidation-Reduction ; Receptors, N-Methyl-D-Aspartate/metabolism ; Schizophrenia/genetics
    Chemical Substances DNA, Mitochondrial ; Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-021-02703-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2411: Show issues Location:
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  7. Article: Editorial: Genomics and Epigenomics of Tumor and Aging Cells.

    Aliev, Gjumrakch / Barreto, George E / Cacabelos, Ramón

    Current genomics

    2017  Volume 18, Issue 5, Page(s) 375–377

    Language English
    Publishing date 2017-09-26
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2033677-9
    ISSN 1875-5488 ; 1389-2029
    ISSN (online) 1875-5488
    ISSN 1389-2029
    DOI 10.2174/138920291805170817124855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5571: Show issues Location:
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  8. Article ; Online: Oxidative stress induced-metabolic imbalance, mitochondrial failure, and cellular hypoperfusion as primary pathogenetic factors for the development of Alzheimer disease which can be used as a alternate and successful drug treatment strategy: past, present and future.

    Aliev, Gjumrakch

    CNS & neurological disorders drug targets

    2010  Volume 10, Issue 2, Page(s) 147–148

    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Humans ; Mitochondria/metabolism ; Mitochondria/pathology ; Molecular Targeted Therapy ; Oxidative Stress
    Language English
    Publishing date 2010-12-20
    Publishing country United Arab Emirates
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2228394-8
    ISSN 1996-3181 ; 1871-5273
    ISSN (online) 1996-3181
    ISSN 1871-5273
    DOI 10.2174/187152711794480492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5892: Show issues Location:
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  9. Article ; Online: The Hydroxamic Acids as Potential Anticancer and Neuroprotective Agents.

    Neganova, Margarita E / Klochkov, Sergey G / Aleksandrova, Yulia R / Aliev, Gjumrakch

    Current medicinal chemistry

    2020  Volume 28, Issue 39, Page(s) 8139–8162

    Abstract: Hydroxamic acids are a promising class of chemical compounds with proven antitumor potential, primarily due to their ability to inhibit the activity of histone deacetylase enzymes. The analysis of modern experimental data shows a wide range of biological ...

    Abstract Hydroxamic acids are a promising class of chemical compounds with proven antitumor potential, primarily due to their ability to inhibit the activity of histone deacetylase enzymes. The analysis of modern experimental data shows a wide range of biological activities of hydroxamic acids, which make them equally worthy candidates for the fight against neuropathologies. A characteristic feature of hydroxamic acids is their ability to act simultaneously on several promising molecular targets for the correction of both neuropathologies and oncological diseases, thereby exhibiting multifunctionality. This review discusses the effect of hydroxamic acids on key parts of cancer and neurodegenerative disorders' pathogenesis. Pathological changes in the processes associated with oxidative stress, the functioning of mitochondria, and the activity of metal enzymes of the class of histone deacetylases, as the main links in the epigenetic regulation of pathological conditions, are such molecular targets.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Epigenesis, Genetic ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Humans ; Hydroxamic Acids/pharmacology ; Neuroprotective Agents/pharmacology
    Chemical Substances Antineoplastic Agents ; Histone Deacetylase Inhibitors ; Hydroxamic Acids ; Neuroprotective Agents
    Language English
    Publishing date 2020-12-11
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867328666201218123154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4432: Show issues Location:
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  10. Article ; Online: Histone modifications in epigenetic regulation of cancer: Perspectives and achieved progress.

    Neganova, Margarita E / Klochkov, Sergey G / Aleksandrova, Yulia R / Aliev, Gjumrakch

    Seminars in cancer biology

    2020  Volume 83, Page(s) 452–471

    Abstract: Epigenetic changes associated with histone modifications play an important role in the emergence and maintenance of the phenotype of various cancer types. In contrast to direct mutations in the main DNA sequence, these changes are reversible, which makes ...

    Abstract Epigenetic changes associated with histone modifications play an important role in the emergence and maintenance of the phenotype of various cancer types. In contrast to direct mutations in the main DNA sequence, these changes are reversible, which makes the development of inhibitors of enzymes of post-translational histone modifications one of the most promising strategies for the creation of anticancer drugs. To date, a wide variety of histone modifications have been found that play an important role in the regulation of chromatin state, gene expression, and other nuclear events. This review examines the main features of the most common and studied epigenetic histone modifications with a proven role in the pathogenesis of a wide range of malignant neoplasms: acetylation / deacetylation and methylation / demethylation of histone proteins, as well as the role of enzymes of the HAT / HDAC and HMT / HDMT families in the development of oncological pathologies. The data on the relationship between histone modifications and certain types of cancer are presented and discussed. Special attention is devoted to the consideration of various strategies for the development of epigenetic inhibitors. The main directions of the development of inhibitors of histone modifications are analyzed and effective strategies for their creation are identified and discussed. The most promising strategy is the use of multitarget drugs, which will affect multiple molecular targets of cancer. A critical analysis of the current status of approved epigenetic anticancer drugs has also been performed.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; DNA Methylation ; Epigenesis, Genetic ; Histone Code ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2020-08-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2020.07.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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