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  1. Article ; Online: Daratumumab for donor-specific anti-HLA antibody desensitization in a case of HLA-mismatched allogeneic stem cell transplantation.

    Ibrahim, Uroosa / Keyzner, Alla

    Hematology, transfusion and cell therapy

    2022  Volume 45, Issue 4, Page(s) 510–512

    Language English
    Publishing date 2022-01-25
    Publishing country Brazil
    Document type Case Reports
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2021.11.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Autoimmune hematologic complications of umbilical cord blood transplantation.

    Ibrahim, Uroosa / Keyzner, Alla

    Hematology/oncology and stem cell therapy

    2020  Volume 14, Issue 2, Page(s) 104–109

    Abstract: While umbilical cord blood is increasingly utilized as a stem cell source, immune complications associated with the procedure have been recognized. These complications result from significant immune system dysregulation and defective reconstitution ... ...

    Abstract While umbilical cord blood is increasingly utilized as a stem cell source, immune complications associated with the procedure have been recognized. These complications result from significant immune system dysregulation and defective reconstitution following transplant causing an imbalance between T-cell subsets, aberrant B cells, and abnormal antibody production. This may occur up to 12 months after transplant coinciding with thymic regeneration in adults. The aim of our review is to describe the incidence, pathophysiology, clinical features, and prognosis of autoimmune cytopenias following umbilical cord blood transplant. Furthermore, we review the treatment strategies reported in the existing literature, describe the authors' experience with the complication, and highlight novel treatment options being studied. The knowledge of the occurrence and timing of autoimmune complications of umbilical cord blood transplantation is essential for detection and treatment of the disease. Emerging therapeutic options include interleukin-2 (IL-2), which is also being studied for the treatment of acute and chronic graft-versus-host disease. IL-2 has favorable effects on growth, differentiation, and function of regulatory T cells. Monoclonal antibody treatments, such as daratumumab, are also on the forefront and more experience with them will guide further treatment strategies.
    MeSH term(s) Anemia/etiology ; Anemia/immunology ; Anemia/pathology ; Anemia/therapy ; Animals ; Antibodies, Monoclonal/therapeutic use ; Autoimmune Diseases/etiology ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Autoimmune Diseases/therapy ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; Cord Blood Stem Cell Transplantation/adverse effects ; Humans ; Interleukin-2/therapeutic use ; Neutropenia/etiology ; Neutropenia/immunology ; Neutropenia/pathology ; Neutropenia/therapy ; Purpura, Thrombocytopenic, Idiopathic/etiology ; Purpura, Thrombocytopenic, Idiopathic/immunology ; Purpura, Thrombocytopenic, Idiopathic/pathology ; Purpura, Thrombocytopenic, Idiopathic/therapy ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology
    Chemical Substances Antibodies, Monoclonal ; Interleukin-2 ; daratumumab (4Z63YK6E0E)
    Language English
    Publishing date 2020-08-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2651893-4
    ISSN 1658-3876
    ISSN 1658-3876
    DOI 10.1016/j.hemonc.2020.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6950: Show issues Location:
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  3. Article ; Online: Gastric and small bowel perforations secondary to mucormycosis and graft versus host disease in an allogeneic transplant host.

    Ibrahim, Uroosa / Mehta, Suchita / Ward, Stephen / Keyzner, Alla

    Hematology, transfusion and cell therapy

    2020  Volume 43, Issue 4, Page(s) 507–511

    Language English
    Publishing date 2020-12-11
    Publishing country Brazil
    Document type Case Reports
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2020.10.962
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  4. Article ; Online: CAR T Cell Therapy for Post-Transplant Lymphoproliferative Disorder After Solid Organ Transplantation: A Safe and Feasible Therapy for an Orphan Disease.

    Ibrahim, Uroosa / Bassil, Claude / Chavez, Julio C / Khimani, Farhad / Jain, Michael D / Locke, Frederick L / Osman, Keren / Lazaryan, Aleksandr

    Clinical lymphoma, myeloma & leukemia

    2023  Volume 23, Issue 10, Page(s) 772–778

    MeSH term(s) Humans ; Immunotherapy, Adoptive/adverse effects ; Rare Diseases ; Organ Transplantation/adverse effects ; Kidney Transplantation ; Lymphoproliferative Disorders/diagnosis ; Lymphoproliferative Disorders/etiology ; Lymphoproliferative Disorders/therapy ; Epstein-Barr Virus Infections
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2023.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5903: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article: Characterization of a novel end product tolerant and thermostable cellulase from Neobacillus sedimentimangrovi UE25

    Ejaz, Uroosa / Moin, Syed Faraz / Sohail, Muhammad / Mersal, Gaber A.M. / Ibrahim, Mohamed M. / El-Bahy, Salah M.

    Enzyme and microbial technology. 2023 Jan., v. 162

    2023  

    Abstract: Recent advancements in biorefinery processes necessitate search for cost effective and thermostable cellulases. This study was designed to characterize the cellulase obtained from a thermophilic bacterium, Neobacillus sedimentimangrovi UE25. A combined ... ...

    Abstract Recent advancements in biorefinery processes necessitate search for cost effective and thermostable cellulases. This study was designed to characterize the cellulase obtained from a thermophilic bacterium, Neobacillus sedimentimangrovi UE25. A combined pretreatment of NaOH and methyltrioctylammonium chloride was given to sugarcane bagasse (SB) for lignin removal and the pretreated SB was utilized as a carbon source for the cellulase production. The thermostable cellulase thus obtained was characterized by adopting central composite design which has not been reported earlier for this purpose. Cellulase showed its maximum activity at pH 7 and temperature 60 ℃ and it remained active in the presence of many salts and detergents. Endoglucanase (EG) was found to be stable for 30 min at 80 ℃. The purification of EG by using DEAE column yielded specific activity and purification fold of 365.866 IU mg⁻¹ and 4.264, respectively. The purified EG had a molecular weight of ∼45 kDa. End product tolerance of EG was also evident, as an activity of 228.57 IU mL⁻¹ was observed in the presence of 60 mM glucose which revealed that it does not lose its activity upon accumulation of end-product when the reaction is prolonged. The purified EG exhibited Vₘₐₓ and Kₘ of 294 U mL⁻¹ min⁻¹ and 36 µM, respectively, in the presence of 60 mM glucose. This novel thermostable cellulase can finds its applications in industrial sector.
    Keywords biorefining ; carbon ; chlorides ; cost effectiveness ; endo-1,4-beta-glucanase ; glucose ; lignin ; molecular weight ; pH ; sugarcane bagasse ; temperature ; thermal stability ; thermophilic bacteria
    Language English
    Dates of publication 2023-01
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 423729-8
    ISSN 1879-0909 ; 0141-0229
    ISSN (online) 1879-0909
    ISSN 0141-0229
    DOI 10.1016/j.enzmictec.2022.110133
    Database NAL-Catalogue (AGRICOLA)

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    Zs.B 2182: Show issues Location:
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  6. Article ; Online: Peritransplantation Use of Ruxolitinib in Myelofibrosis.

    Ibrahim, Uroosa / Petrone, Giulia Eva Maria / Mascarenhas, John / Keyzner, Alla

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2020  Volume 26, Issue 12, Page(s) 2177–2180

    Abstract: Ruxolitinib is an oral JAK1/2 inhibitor that is approved for use in patients with intermediate and high-risk myelofibrosis (MF) based on its proven spleen and symptom burden reduction. Its impact on hematopoietic stem cell transplantation (HSCT) outcomes ...

    Abstract Ruxolitinib is an oral JAK1/2 inhibitor that is approved for use in patients with intermediate and high-risk myelofibrosis (MF) based on its proven spleen and symptom burden reduction. Its impact on hematopoietic stem cell transplantation (HSCT) outcomes is largely unknown, however. A significant number of patients proceeding to HSCT have been treated with ruxolitinib, and the specifics of its peritransplantation use vary widely in the published literature. Here we review the currently published data and experience to guide management of patients with MF on ruxolitinib proceeding to HSCT.
    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Humans ; Primary Myelofibrosis/drug therapy ; Protein Kinase Inhibitors/therapeutic use ; Pyrazoles/therapeutic use
    Chemical Substances Protein Kinase Inhibitors ; Pyrazoles ; ruxolitinib (82S8X8XX8H)
    Language English
    Publishing date 2020-08-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2020.08.015
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    Zs.A 5082: Show issues Location:
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    Zs.MO 462: Show issues

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  7. Article ; Online: Characterization of a novel end product tolerant and thermostable cellulase from Neobacillus sedimentimangrovi UE25.

    Ejaz, Uroosa / Moin, Syed Faraz / Sohail, Muhammad / Mersal, Gaber A M / Ibrahim, Mohamed M / El-Bahy, Salah M

    Enzyme and microbial technology

    2022  Volume 162, Page(s) 110133

    Abstract: Recent advancements in biorefinery processes necessitate search for cost effective and thermostable cellulases. This study was designed to characterize the cellulase obtained from a thermophilic bacterium, Neobacillus sedimentimangrovi UE25. A combined ... ...

    Abstract Recent advancements in biorefinery processes necessitate search for cost effective and thermostable cellulases. This study was designed to characterize the cellulase obtained from a thermophilic bacterium, Neobacillus sedimentimangrovi UE25. A combined pretreatment of NaOH and methyltrioctylammonium chloride was given to sugarcane bagasse (SB) for lignin removal and the pretreated SB was utilized as a carbon source for the cellulase production. The thermostable cellulase thus obtained was characterized by adopting central composite design which has not been reported earlier for this purpose. Cellulase showed its maximum activity at pH 7 and temperature 60 ℃ and it remained active in the presence of many salts and detergents. Endoglucanase (EG) was found to be stable for 30 min at 80 ℃. The purification of EG by using DEAE column yielded specific activity and purification fold of 365.866 IU mg
    MeSH term(s) Cellulase/metabolism ; Cellulose/chemistry ; Saccharum/metabolism ; Enzyme Stability ; Cellulases ; Bacillaceae ; Temperature ; Glucose ; Hydrogen-Ion Concentration
    Chemical Substances Cellulase (EC 3.2.1.4) ; Cellulose (9004-34-6) ; Cellulases (EC 3.2.1.-) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-09-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423729-8
    ISSN 1879-0909 ; 0141-0229
    ISSN (online) 1879-0909
    ISSN 0141-0229
    DOI 10.1016/j.enzmictec.2022.110133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2182: Show issues Location:
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  8. Article: An unusual complication of pigtail catheter insertion.

    Saqib, Amina / Ibrahim, Uroosa / Maroun, Rabih

    Journal of thoracic disease

    2018  Volume 10, Issue 10, Page(s) 5964–5967

    Abstract: Thoracostomy tubes are indicated for management of air or fluid in the pleural cavity. Pigtail catheters have emerged as an effective and less morbid alternative to traditional large bore chest tubes for evacuation of pleural air or fluid. However, they ... ...

    Abstract Thoracostomy tubes are indicated for management of air or fluid in the pleural cavity. Pigtail catheters have emerged as an effective and less morbid alternative to traditional large bore chest tubes for evacuation of pleural air or fluid. However, they do not come without complications which commonly include pneumothorax and hemothorax. Rare complications in the literature such as left ventricular penetration, subclavian artery laceration and cerebral air embolism have been reported. We report a case of a 72-year-old male who presented with dyspnea and was found to have a right-sided pleural effusion requiring thoracentesis and subsequent pigtail catheter placement because of re-accumulation of the fluid. After accidental dislodgement of the catheter, it was replaced and the following day a chest X-ray (CXR) demonstrated diffuse subcutaneous emphysema. Computed tomography (CT) scan of the chest demonstrated the pigtail catheter tracking through the right middle and lower lobes reaching the posterior pleural space. We discuss the implications of this occurrence and recommended management based on our experience.
    Language English
    Publishing date 2018-06-25
    Publishing country China
    Document type Case Reports
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.05.65
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Dasatinib-induced pulmonary arterial hypertension - A rare late complication.

    Ibrahim, Uroosa / Saqib, Amina / Dhar, Vidhya / Odaimi, Marcel

    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

    2018  Volume 25, Issue 3, Page(s) 727–730

    Abstract: Dasatinib is a dual Src/Abl tyrosine kinase inhibitor approved for frontline and second line treatment of chronic phase chronic myelogenous leukemia. Pulmonary arterial hypertension is defined by an increase in mean pulmonary arterial pressure >25 mmHg ... ...

    Abstract Dasatinib is a dual Src/Abl tyrosine kinase inhibitor approved for frontline and second line treatment of chronic phase chronic myelogenous leukemia. Pulmonary arterial hypertension is defined by an increase in mean pulmonary arterial pressure >25 mmHg at rest. Dasatinib-induced pulmonary hypertension has been reported in less than 1% of patients on chronic dasatinib treatment for chronic myelogenous leukemia. The pulmonary arterial hypertension from dasatinib may be categorized as either group 1 (drug-induced) or group 5 based on various mechanisms that may be involved including the pathogenesis of the disease process of chronic myelogenous leukemia. There have been reports of dasatinib-induced pulmonary arterial hypertension being reversible. We report a case of pulmonary arterial hypertension in a 46-year-old female patient with chronic phase chronic myelogenous leukemia on dasatinib treatment for over 10 years. She had significant improvement in symptoms after discontinuation of dasatinib and initiation of vasodilators. Several clinical questions arise once patients experience significant adverse effects as discussed in our case.
    MeSH term(s) Antineoplastic Agents/adverse effects ; Dasatinib/adverse effects ; Female ; Humans ; Hypertension, Pulmonary/chemically induced ; Leukemia, Myeloid, Chronic-Phase/drug therapy ; Middle Aged ; Protein Kinase Inhibitors/adverse effects
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors ; Dasatinib (RBZ1571X5H)
    Language English
    Publishing date 2018-01-17
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1330764-2
    ISSN 1477-092X ; 1078-1552
    ISSN (online) 1477-092X
    ISSN 1078-1552
    DOI 10.1177/1078155217753740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4488: Show issues Location:
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  10. Article ; Online: Synchronous Presence of

    Thumallapally, Nishitha / Parylo, Sara / Vennepureddy, Adarsh / Ibrahim, Uroosa / Sokoloff, Alisa

    World journal of oncology

    2018  Volume 9, Issue 2, Page(s) 50–55

    Abstract: Treatment of lung cancer has been revolutionized with development of drugs that target key driver mutations and immune checkpoints. Until recently, it was believed that these driver mutations are mutually exclusive. However, few reports have emerged ... ...

    Abstract Treatment of lung cancer has been revolutionized with development of drugs that target key driver mutations and immune checkpoints. Until recently, it was believed that these driver mutations are mutually exclusive. However, few reports have emerged citing the presence of both mutations either synchronously or metachronously. We describe a case report of lung adenocarcinoma harboring two driver mutations in the same tumor cells as well as exhibiting high PDL1 expression. We further discuss the possible association of these driver mutations with PDL1 expression.
    Language English
    Publishing date 2018-05-01
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 2548989-6
    ISSN 1920-454X ; 1920-4531
    ISSN (online) 1920-454X
    ISSN 1920-4531
    DOI 10.14740/wjon1090e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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