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Article ; Online: Dual Blockade of the Renin-Angiotensin System in Glomerular Diseases.

Gigante, Antonietta / Cianci, Rosario

2023 Volume 21, Issue 2, Page(s) 75–77

MeSH term(s)	Humans ; Renin-Angiotensin System ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Kidney Diseases/drug therapy ; Angiotensin Receptor Antagonists/therapeutic use ; Drug Therapy, Combination
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Angiotensin Receptor Antagonists
Language	English
Publishing date	2023-02-17
Publishing country	United Arab Emirates
Document type	Editorial
ZDB-ID	2192362-0
ISSN	1875-6212 ; 1570-1611
ISSN (online)	1875-6212
ISSN	1570-1611
DOI	10.2174/1570161121666230220123207
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Article ; Online: When pulmonary arterial hypertension complicates connective tissue diseases: we still have not found what we are looking for.

Gigante, Antonietta / Papa, Silvia / Rosato, Edoardo / Badagliacca, Roberto / Marra, Alberto Maria

Internal and emergency medicine

2024

Language	English
Publishing date	2024-04-18
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-024-03598-4
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Article ; Online: WITHDRAWN: Are high heart rate variability and parasympathetic activity a key for wellness?

Gigante, Antonietta

International journal of cardiology

2018

Abstract: This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/ ... ...

Abstract	This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
Language	English
Publishing date	2018-09-10
Publishing country	Netherlands
Document type	Retraction of Publication
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2018.09.034
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Article ; Online: The importance of early detecting high-risk patients with acute kidney injury requiring continuous kidney replacement therapy.

Gigante, Antonietta / Di Mario, Francesca / Basili, Stefania

Internal and emergency medicine

2022 Volume 18, Issue 1, Page(s) 11–13

MeSH term(s)	Humans ; Renal Replacement Therapy ; Retrospective Studies ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/therapy ; Critical Illness/therapy
Language	English
Publishing date	2022-10-22
Publishing country	Italy
Document type	Journal Article ; Comment
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-022-03136-0
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Article ; Online: A Novel Approach to the Old Issue of Ischemic Nephropathy.

Cianci, Rosario / Gigante, Antonietta / Ferri, Claudio

Current vascular pharmacology

2021 Volume 20, Issue 2, Page(s) 114–116

MeSH term(s)	Female ; Humans ; Kidney ; Kidney Diseases/diagnosis ; Kidney Diseases/therapy ; Male ; Vascular Diseases
Language	English
Publishing date	2021-12-27
Publishing country	United Arab Emirates
Document type	Editorial
ZDB-ID	2192362-0
ISSN	1875-6212 ; 1570-1611
ISSN (online)	1875-6212
ISSN	1570-1611
DOI	10.2174/1570161120666211227123720
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Article ; Online: Evaluation of Anorexia in Cancer and Its Association with Autonomic Nervous System Activity Assessed by Heart Rate Variability.

Molfino, Alessio / Gallicchio, Carmen / Imbimbo, Giovanni / Melena, Michele / Antonini, Silvia / Gigante, Antonietta / Muscaritoli, Maurizio

Nutrients

2023 Volume 15, Issue 23

Abstract: Alterations in the central nervous system in cancer patients are pivotal in determining appetite dysregulation and body weight loss (BWL). Autonomic nervous system activity was tested by measuring heart rate variability (HRV) in cancer patients ... ...

Abstract	Alterations in the central nervous system in cancer patients are pivotal in determining appetite dysregulation and body weight loss (BWL). Autonomic nervous system activity was tested by measuring heart rate variability (HRV) in cancer patients presenting with anorexia. We considered inpatients with different types of cancer and investigated anorexia using their FAACT scores. HRV was evaluated by a three-channel Holter ECG. The domains of low frequencies (LF, sympathetic activity) and high frequencies (HF, parasympathetic activity) were calculated. Also, SDNN (autonomic activity) and RMSSD (parasympathetic activity) were assessed. We enrolled 56 patients with cancer and 23 controls. In cancer patients, RMSSD and SDNN were lower than in controls (
MeSH term(s)	Humans ; Heart Rate/physiology ; Anorexia/etiology ; Autonomic Nervous System ; Electrocardiography, Ambulatory ; Neoplasms/complications
Language	English
Publishing date	2023-11-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15234936
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Article: Relevance of obesity-related organ damage and metabolic syndrome classification in cardiovascular and renal risk stratification in patients with essential hypertension.

Petramala, Luigi / Gigante, Antonietta / Sarlo, Francesca / Servello, Adriana / Circosta, Francesco / Marino, Luca / Ciccarelli, Antonello / Cavallaro, Giuseppe / Letizia, Claudio

Frontiers in cardiovascular medicine

2024 Volume 11, Page(s) 1369090

Abstract: Introduction: Hypertension is a relevant cardiovascular comorbidity. Adipose tissue represents a metabolically active tissue involved in the regulation of blood pressure and metabolic alterations. In recent decades, several classifications for the ... ...

Abstract	Introduction: Hypertension is a relevant cardiovascular comorbidity. Adipose tissue represents a metabolically active tissue involved in the regulation of blood pressure and metabolic alterations. In recent decades, several classifications for the metabolic syndrome (MS) have been proposed. Recently, a new syndrome called the "Cardiovascular-kidney-metabolic" (CKM) syndrome was identified, to determine patients at high cardiovascular and metabolic risk. The aim of the study was to compare different classifications in a large population of hypertensive patients. Materials and methods: Between September 2022 and August 2023, we consecutively enrolled 772 hypertensive patients (407 men; 365 women; mean age 52.2 ± 15.1 years), evaluating anthropometric, biochemical, and instrumental parameters (transthoracic echocardiogram, carotid echo-Doppler, 24-h ambulatory blood pressure monitoring, fundus oculi). Results: Using different classifications we found MS prevalence: Adult Treatment Panel III (ATP-III) 28.8%, International Diabetes Federation (IDF) 31.5%, CKM 40.7%. CKM Classes 3 and 4 showed higher body mass index and waist circumference compared with other groups. Compared with ATP-III and IDF, CKM Class 4 showed higher 24-h systolic blood pressure, lower percentage of controlled hypertension, increased interventricular septum and posterior wall, reduced ejection fraction, and greater prevalence of hypertensive arterial retinal damage. Discussion: Visceral obesity and MS are frequent conditions with healthy impact, becoming an important trigger for the development of cardiovascular and metabolic complications. The different MS classifications allow the early identification of patients at high risk of cardiometabolic complications. The new CKM syndrome proves useful to identify individuals at high risk for CKM morbidity and mortality.
Language	English
Publishing date	2024-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2024.1369090
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Article ; Online: GLIM-diagnosed malnutrition predicts mortality and risk of hospitalization in systemic sclerosis: A retrospective study.

Rosato, Edoardo / Gigante, Antonietta / Colalillo, Amalia / Pellicano, Chiara / Alunni Fegatelli, Danilo / Muscaritoli, Maurizio

European journal of internal medicine

2023 Volume 117, Page(s) 103–110

Abstract: Background: Malnutrition is a well-known risk factor for morbidity and mortality in many clinical settings and only few studies assessed the role of malnutrition on systemic sclerosis (SSc) patients' outcomes. The aim of this retrospective study was to ... ...

Abstract	Background: Malnutrition is a well-known risk factor for morbidity and mortality in many clinical settings and only few studies assessed the role of malnutrition on systemic sclerosis (SSc) patients' outcomes. The aim of this retrospective study was to evaluate the role of malnutrition as a predictive risk factor for mortality and/or hospitalization in SSc patients during a 4-year follow-up. Methods: One hundred and one SSc patients were included in the study. Biochemical analyses, disease activity index, disease severity scale and anthropometric data were recorded at enrollment. Malnutrition was assessed by the Global Leadership Initiative on Malnutrition (GLIM) criteria. Results: Malnutrition according to GLIM criteria was found in 22 patients (21.8%). During a 4-year follow-up, 20 (19.8%) SSc patients died or were hospitalized for all causes and 11 of them (55.0%) were malnourished. Kaplan-Meier curves showed that event free-survival for composite end-point of mortality and risk of hospitalization was significantly shorter in malnourished than in non-malnourished patients (p<0.001). The survival probability at 4 years was 0.885 (95% CI=0.818-0.959) in the non-malnourished group and 0.500 (95% CI=0.329-0.759) in the malnourished group (p<0.001). In multivariate analysis, malnutrition [HR=4.380 (95% CI=1.706-11.243), p = 0.002] was the most significant predictive risk factor for the composite end-point. Also, female gender [HR=0.157 (95% CI=0.055-0.449), p<0.001], age [HR=1.0450 (95% CI=1.011-1.090), p = 0.012] and disease severity scale [HR=1.269 (95% CI=1.089-1.479), p = 0.002] were predictive factors for the composite end-point. Conclusions: Malnutrition according to GLIM criteria represents a significant predictive risk factor for composite end-point of mortality and risk of hospitalization in SSc patients.
MeSH term(s)	Humans ; Female ; Retrospective Studies ; Leadership ; Hospitalization ; Malnutrition ; Scleroderma, Systemic/complications ; Nutrition Assessment ; Nutritional Status
Language	English
Publishing date	2023-07-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2023.07.017
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Article ; Online: Assessment of kidney involvement in systemic sclerosis: From scleroderma renal crisis to subclinical renal vasculopathy.

Gigante, Antonietta / Leodori, Giorgia / Pellicano, Chiara / Villa, Annalisa / Rosato, Edoardo

The American journal of the medical sciences

2022 Volume 364, Issue 5, Page(s) 529–537

Abstract: The spectrum of kidney involvement in systemic sclerosis (SSc) includes scleroderma renal crisis, widely recognized as the most severe renal-vascular complication, but also several forms of chronic renal vasculopathy and reduced renal function are ... ...

Abstract	The spectrum of kidney involvement in systemic sclerosis (SSc) includes scleroderma renal crisis, widely recognized as the most severe renal-vascular complication, but also several forms of chronic renal vasculopathy and reduced renal function are complications of scleroderma. Scleroderma renal crisis, myeloperoxidase-antineutrophil cytoplasmic antibody associated glomerulonephritis, penicillamine-associated renal disease, abnormal urinalysis, alteration of vascular endothelial markers, scleroderma associated-vasculopathy with abnormal renal resistance indices and cardiorenal syndromes type 5 were also reported in SSc patients. A frequent form of renal involvement in SSc patients is a subclinical renal vasculopathy, characterized by vascular damage and normal renal function. Indeed, asymptomatic renal changes, expressed by increase of intrarenal stiffness, are often non-progressive in SSc patients but can lead to a reduction in renal functional reserve. The purpose of this review is to provide an assessment of kidney involvement in SSc, from SRC to subclinical renal vasculopathy.
MeSH term(s)	Humans ; Peroxidase ; Antibodies, Antineutrophil Cytoplasmic ; Scleroderma, Systemic/complications ; Acute Kidney Injury/etiology ; Kidney ; Scleroderma, Localized ; Vascular Diseases/etiology ; Ureteral Diseases ; Penicillamine
Chemical Substances	Peroxidase (EC 1.11.1.7) ; Antibodies, Antineutrophil Cytoplasmic ; Penicillamine (GNN1DV99GX)
Language	English
Publishing date	2022-05-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	82078-7
ISSN	1538-2990 ; 0002-9629
ISSN (online)	1538-2990
ISSN	0002-9629
DOI	10.1016/j.amjms.2022.02.014
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Article ; Online: Estimated glomerular filtration rate and renal resistive index as possible predictive markers of mortality in systemic sclerosis.

Leodori, Giorgia / Pellicano, Chiara / Gigante, Antonietta / Rosato, Edoardo

European journal of internal medicine

2021 Volume 87, Page(s) 83–89

Abstract: Objective: Subclinical nephropathy is underestimated in systemic sclerosis (SSc). Study aim is to evaluate the role of renal resistance indices (RRI) and estimated glomerular filtration rate (eGFR) assessed by Chronic Kidney Disease Epidemiology ... ...

Abstract	Objective: Subclinical nephropathy is underestimated in systemic sclerosis (SSc). Study aim is to evaluate the role of renal resistance indices (RRI) and estimated glomerular filtration rate (eGFR) assessed by Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) as predictive markers of mortality during 10 years of follow-up in SSc patients. Methods: 181 SSc patients (60 years, 152 females) were enrolled. At baseline, the GFR was estimated in 181 SSc patients and RRI was measured in 122 SSc patients. During a follow-up of 10 years we recorded the main complications of disease, date and causes of death. Results: eGFR shows a linear negative correlation with RRI. RRI showed a correlation with systolic pulmonary artery pressure (sPAP). Overall survival is lower in SSc patients with eGFR<60 ml/min and RRI ≥0.70 than in SSc patients with eGFR≥60 ml/min (p<0.0001) and with RRI<0.70 (p<0.01) both for mortality due to SSc and all causes. In multivariate analysis, eGFR<60 ml/min [HR 6.429, 95%CI (1.006-41.08), p<0.05] and forced vital capacity (FVC) [HR 0.954, 95%CI (0.911-1), p<0.05] are predictive markers of mortality due to SSc, while eGFR [HR 3.617, 95%CI (1.370-9.554), p<0.01], RRI [HR 0.210, 95% CI (0.068-0.649), p<0.01], age [HR 1.062, 95%CI (1.023-1.103), p<0.01], FVC [HR 0.967, 95%CI (0.946-0.989), p<0.01] and disease activity index (DAI) [HR 1.663, 95%CI (1.262-2.191), p<0.0001] are predictive markers of mortality due to all causes. Conclusion: We demonstrate that eGFR is a predictive marker of mortality due to SSc and to all causes, conversely RRI is predictive marker of mortality due to all causes.
MeSH term(s)	Female ; Glomerular Filtration Rate ; Humans ; Kidney ; Renal Insufficiency, Chronic ; Scleroderma, Systemic/complications
Language	English
Publishing date	2021-02-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2021.01.025
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