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  1. Article ; Online: A feasibility study on the association between residential greenness and neurocognitive function in middle-aged Bulgarians.

    Dzhambov, Angel M / Bahchevanov, Karamfil M / Chompalov, Kostadin A / Atanassova, Penka A

    Arhiv za higijenu rada i toksikologiju

    2020  Volume 70, Issue 3, Page(s) 173–185

    Abstract: Recent research has indicated that exposure to residential vegetation ("greenness") may be protective against cognitive decline and may support the integrity of the corresponding brain structures. However, not much is known about these effects, ... ...

    Abstract Recent research has indicated that exposure to residential vegetation ("greenness") may be protective against cognitive decline and may support the integrity of the corresponding brain structures. However, not much is known about these effects, especially in less affluent countries and in middle-aged populations. In this study, we investigated the associations between greenness and neurocognitive function. We used a convenience sample of 112 middle-aged Bulgarians and two cognitive tests: the Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Battery (CERAD-NB) and the Montreal Cognitive Assessment (MoCA). In addition, structural brain imaging data were available for 25 participants. Participants' home address was used to link cognition scores to the normalised difference vegetation index (NDVI), a measure of overall neighbourhood vegetation level (radii from 100 to 1,000 m). Results indicated that higher NDVI was consistently associated with higher CERAD-NB and MoCA scores across radial buffers and adjustment scenarios. Lower waist circumference mediated the effect of NDVI on CERAD-NB. NDVI100-m was positively associated with average cortical thickness across both hemispheres, but these correlations turned marginally significant (P<0.1) after correction for false discovery rate due to multiple comparisons. In conclusion, living in a greener neighbourhood might be associated with better cognitive function in middle-aged Bulgarians, with lower central adiposity partially accounting for this effect. Tentative evidence suggests that greenness might also contribute to structural integrity in the brain regions regulating cognitive functions. Future research should build upon our findings and investigate larger and more representative population groups.
    MeSH term(s) Adult ; Bulgaria ; Cognition ; Environment ; Feasibility Studies ; Female ; Humans ; Male ; Middle Aged ; Residence Characteristics ; Socioeconomic Factors
    Language English
    Publishing date 2020-06-28
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 127289-5
    ISSN 1848-6312 ; 0004-1254
    ISSN (online) 1848-6312
    ISSN 0004-1254
    DOI 10.2478/aiht-2019-70-3326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Homocysteinemia may be equally important to stroke subtype in predicting cognition impairment.

    Atanassova, Penka A

    Journal of the neurological sciences

    2007  Volume 260, Issue 1-2, Page(s) 298–299

    MeSH term(s) Biomarkers/analysis ; Biomarkers/blood ; Cerebral Arteries/metabolism ; Cerebral Arteries/physiopathology ; Cerebrovascular Disorders/complications ; Cerebrovascular Disorders/metabolism ; Cerebrovascular Disorders/physiopathology ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Cognition Disorders/metabolism ; Homocysteine/analysis ; Homocysteine/blood ; Homocystinuria/complications ; Homocystinuria/physiopathology ; Humans ; Models, Neurological ; Predictive Value of Tests ; Regression Analysis ; Risk Factors ; Stroke/complications ; Stroke/metabolism ; Stroke/physiopathology
    Chemical Substances Biomarkers ; Homocysteine (0LVT1QZ0BA)
    Language English
    Publishing date 2007-09-15
    Publishing country Netherlands
    Document type Comment ; Letter
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2007.03.022
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  3. Article ; Online: Previous cardiac abnormalities in subarachnoid hemorrhage may also have background genetic polymorphisms.

    Atanassova, Penka A

    Stroke

    2006  Volume 37, Issue 12, Page(s) 2872; author reply 2873

    MeSH term(s) Heart Defects, Congenital/complications ; Heart Defects, Congenital/genetics ; Humans ; Polymorphism, Genetic ; Receptors, Adrenergic/genetics ; Subarachnoid Hemorrhage/etiology ; Subarachnoid Hemorrhage/genetics
    Chemical Substances Receptors, Adrenergic
    Language English
    Publishing date 2006-12
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/01.STR.0000248216.77876.5c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bureau-Barriere syndrome in a patient with psoriasis vulgaris.

    Dobrev, Hristo P / Atanassova, Penka A / Dimitrov, Borislav D

    European journal of dermatology : EJD

    2015  Volume 25, Issue 5, Page(s) 496–497

    MeSH term(s) Drug Therapy, Combination ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Psoriasis/complications ; Psoriasis/diagnosis ; Psoriasis/drug therapy ; Rare Diseases ; Recurrence ; Skin Ulcer/complications ; Skin Ulcer/diagnosis ; Skin Ulcer/drug therapy ; Syndrome ; Toes ; Treatment Outcome
    Language English
    Publishing date 2015-09
    Publishing country France
    Document type Case Reports ; Letter
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2015.2638
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  5. Article: Antiphospholipid syndrome and vascular ischemic (occlusive) diseases: an overview.

    Atanassova, Penka A

    Yonsei medical journal

    2007  Volume 48, Issue 6, Page(s) 901–926

    Abstract: Antiphospholipid syndrome (APS) is primarily considered to be an autoimmune pathological condition that is also referred to as "Hughes syndrome". It is characterized by arterial and/or venous thrombosis and pregnancy pathologies in the presence of ... ...

    Abstract Antiphospholipid syndrome (APS) is primarily considered to be an autoimmune pathological condition that is also referred to as "Hughes syndrome". It is characterized by arterial and/or venous thrombosis and pregnancy pathologies in the presence of anticardiolipin antibodies and/or lupus anticoagulant. APS can occur either as a primary disease or secondary to a connective tissue disorder, most frequently systemic lupus erythematosus (SLE). Damage to the nervous system is one of the most prominent clinical constellations of sequelae in APS and includes (i) arterial/ venous thrombotic events, (ii) psychiatric features and (iii) other non- thrombotic neurological syndromes. In this overview we compare the most important vascular ischemic (occlusive) disturbances (VIOD) with neuro-psychiatric symptomatics, together with complete, updated classifications and hypotheses for the etio-pathogenesis of APS with underlying clinical and laboratory criteria for optimal diagnosis and disease management.
    MeSH term(s) Antibodies, Antiphospholipid/immunology ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/immunology ; Antiphospholipid Syndrome/therapy ; Arterial Occlusive Diseases/diagnosis ; Arterial Occlusive Diseases/immunology ; Arterial Occlusive Diseases/therapy ; Cerebrovascular Disorders/diagnosis ; Cerebrovascular Disorders/immunology ; Cerebrovascular Disorders/therapy ; Humans ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/therapy
    Chemical Substances Antibodies, Antiphospholipid
    Language English
    Publishing date 2007-12-31
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 303740-x
    ISSN 1976-2437 ; 0513-5796
    ISSN (online) 1976-2437
    ISSN 0513-5796
    DOI 10.3349/ymj.2007.48.6.901
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    Zs.B 944: Show issues Location:
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  6. Article ; Online: Atypical clinical and radiologic findings in a patient with brain metastatic lesions.

    Halil, Eray / Viteva, Ekaterina / Vasilev, Georgi / Shukerski, Krasimir / Atanassova, Penka

    Folia medica

    2024  Volume 65, Issue 5, Page(s) 844–848

    Abstract: We report the case of a 47-year-old man who was admitted to our clinic with an intractable headache, nausea, and sporadic vomiting, as well as speech difficulties and a 'floating' sensation. This man had no prior medical history. MRI of the brain showed ... ...

    Abstract We report the case of a 47-year-old man who was admitted to our clinic with an intractable headache, nausea, and sporadic vomiting, as well as speech difficulties and a 'floating' sensation. This man had no prior medical history. MRI of the brain showed evidence of over 20 supra- and infratentorial capsulated ring-enhancing lesions. All other paraclinical investigations done in our clinic were unremarkable and we excluded our first assumption of neurocysticercosis, as well as other parasitic infections. The patient was then referred to the Oral and Maxillofacial Surgery Clinic for an excisional biopsy of a submandibular formation, which was later verified to represent a lymph node metastasis from a poorly differentiated adenocarcinoma. A chest X-ray failed to demonstrate any significant pathology and the immunohistochemical constellation of the lymph node metastasis excluded the possibility of the primary tumor originating in the lung or the prostate. Due to the unresolved diagnostic query, a whole-body PET/CT was performed demonstrating a formation with malignant characteristics in the basal segment of the left lung, reaching the pleura and the left hilum, as well as solitary enlarged mesenteric and mediastinal lymph nodes. Following clinical consultations, it was determined that the patient was inoperable and chemotherapy and palliative CNS irradiation were recommended.
    MeSH term(s) Male ; Humans ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Lymphatic Metastasis ; Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/therapy ; Magnetic Resonance Imaging ; Brain
    Language English
    Publishing date 2024-02-14
    Publishing country Bulgaria
    Document type Case Reports ; Journal Article
    ZDB-ID 300275-5
    ISSN 1314-2143 ; 0430-8638 ; 0204-8043
    ISSN (online) 1314-2143
    ISSN 0430-8638 ; 0204-8043
    DOI 10.3897/folmed.65.e84810
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    Zs.A 972: Show issues Location:
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  7. Article ; Online: Contribution of Components of Metabolic Syndrome to Cognitive Performance in Middle-Aged Adults.

    Bahchevanov, Karamfil M / Dzhambov, Angel M / Chompalov, Kostadin A / Massaldjieva, Radka I / Atanassova, Penka A / Mitkov, Mitko D

    Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

    2020  Volume 36, Issue 4, Page(s) 498–506

    Abstract: Introduction: Metabolic syndrome (MetS) has been associated with impaired cognition in different cognitive domains. This study investigated the association between MetS and cognitive functioning in middle-aged Bulgarians across different definitions of ... ...

    Abstract Introduction: Metabolic syndrome (MetS) has been associated with impaired cognition in different cognitive domains. This study investigated the association between MetS and cognitive functioning in middle-aged Bulgarians across different definitions of MetS severity.
    Material and methods: Our cross-sectional sample included 112 participants (67 free of MetS and 45 with MetS) with a mean age of 50.04 ± 3.31 years. The following MetS variables were considered-presence of MetS, continuously measured MetS components, dichotomized MetS components, number of MetS components present, and Metabolic Syndrome Severity Score (MSSS). Participants' cognitive performance was assessed using the Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Battery (CERAD-NB). We employed multivariate regression models to investigate the associations between different measures of MetS severity and CERAD-NB total and subtest scores.
    Results: Bivariate analyses showed that the CERAD-NB total score was significantly higher in women, participants with a university degree, those with normal blood pressure, normal waist circumference, and low triglyceride levels, compared with their counterparts. MetS participants had lower CERAD-NB total score (78.87 ± 6.89 vs. 84.97 ± 7.84) and specifically performed poorer on the subtest Word List Recall (7.16 ± 1.52 vs. 7.99 ± 1.52). These findings persisted after controlling for age, gender, and education. Next, generalized linear regression indicated that the CERAD-NB total score was lower in participants with MetS (β = -4.86; 95% confidence interval [CI]: -7.60, -2.11), those with more MetS components (β = -8.31; 95% CI: -14.13, -2.50 for fours vs. 0 components) and with an increase in MSSS (β = -3.19; 95% CI: -4.67, -1.71). Hypertension independently contributed to lower CERAD-NB total score (β = -4.00; 95% CI: -6.81, -1.19).
    Conclusions: Across several definitions, MetS was associated with lower cognitive functioning, and MetS severity appeared to be a better predictor than most MetS components. Recognizing and reducing severity of MetS components might be helpful in supporting cognitive functioning. Further longitudinal research is needed to shed more light on the relationship between MetS and cognitive functioning across the life span.
    MeSH term(s) Adult ; Alzheimer Disease ; Cognition ; Cross-Sectional Studies ; Female ; Humans ; Metabolic Syndrome/complications ; Middle Aged ; Neuropsychological Tests
    Language English
    Publishing date 2020-10-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632972-x
    ISSN 1873-5843 ; 0887-6177
    ISSN (online) 1873-5843
    ISSN 0887-6177
    DOI 10.1093/arclin/acaa081
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  8. Article ; Online: Hip and knee implants in Bulgaria.

    Atanassova, Penka A / Dimitrov, Borislav D

    Health affairs (Project Hope)

    2009  Volume 28, Issue 2, Page(s) 603–604

    MeSH term(s) Economics, Hospital/organization & administration ; Hip Prosthesis/economics ; Humans ; Knee Prosthesis/economics
    Language English
    Publishing date 2009-03
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 632712-6
    ISSN 1544-5208 ; 0278-2715
    ISSN (online) 1544-5208
    ISSN 0278-2715
    DOI 10.1377/hlthaff.28.2.603-a
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    Zs.A 2118: Show issues Location:
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  9. Article ; Online: Vascular Risk Factors in Bulgarian Volunteers in Middle Adulthood.

    Chompalov, Kostadin A / Atanassova, Penka A / Massaldjieva, Radka I / Bahchevanov, Karamfil M / Milev, Borislav A / Naydenov, Valcho A / Dosheva, Veselina S / Semerdzhieva, Mariya A

    Folia medica

    2019  Volume 60, Issue 4, Page(s) 565–570

    Abstract: The present study in Bulgarian volunteers aged 45-55 years focuses on the type and frequency of some vascular risk factors (VRF); it analyzes physical data and results of instrumental investigations (ophthalmoscopy, electrocardiography, Doppler ... ...

    Abstract The present study in Bulgarian volunteers aged 45-55 years focuses on the type and frequency of some vascular risk factors (VRF); it analyzes physical data and results of instrumental investigations (ophthalmoscopy, electrocardiography, Doppler sonography) as well as magnetic resonance imaging (MRI). The study participants have neither subjective memory complaints nor previous cerebrovascular and cardiovascular incidents. The neurological examination and the mental status is normal and VRF are not considered to aff ect their normal daily living. The arterial hypertension (I degree), dyslipidemia and increased LDL-cholesterol correlate with the pathological findings from Doppler/MRI. The regression model explains 35% of the dispersion in statistics and correctly classifies 76.8% of the observations as independent prognostic factors for the presence of abnormal findings from Doppler/MRI at the age from 45 to 55 years, which corresponds to subclinical cerebrovascular disease.
    MeSH term(s) Blood Pressure ; Brain/diagnostic imaging ; Bulgaria ; Cerebrovascular Disorders/diagnostic imaging ; Cerebrovascular Disorders/etiology ; Cerebrovascular Disorders/physiopathology ; Female ; Healthy Volunteers ; Humans ; Lipids/blood ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Ophthalmoscopy ; Prognosis ; Risk Factors ; Ultrasonography, Doppler, Transcranial
    Chemical Substances Lipids
    Language English
    Publishing date 2019-06-26
    Publishing country Bulgaria
    Document type Journal Article ; Observational Study
    ZDB-ID 300275-5
    ISSN 1314-2143 ; 0430-8638 ; 0204-8043
    ISSN (online) 1314-2143
    ISSN 0430-8638 ; 0204-8043
    DOI 10.2478/folmed-2018-0039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Neurological and systemic disorders in antiphospholipid syndrome: novel constellations on a genetic basis.

    Atanassova, Penka A / Dimitrov, Borislav D

    Clinical neurology and neurosurgery

    2006  Volume 108, Issue 8, Page(s) 814

    MeSH term(s) Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/genetics ; Chorea/diagnosis ; Chorea/genetics ; Chromosome Aberrations ; Dystonia/diagnosis ; Dystonia/genetics ; Genes, Recessive ; Hepatolenticular Degeneration/diagnosis ; Hepatolenticular Degeneration/genetics ; Humans ; Parkinsonian Disorders/diagnosis ; Parkinsonian Disorders/genetics ; Risk Factors
    Language English
    Publishing date 2006-12
    Publishing country Netherlands
    Document type Comment ; Letter
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2006.06.009
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