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Article: Yiwei decoction promotes apoptosis of gastric cancer cells through spleen-derived exosomes.

Chen, Yingzhi / Li, Yu / Wu, Yue / Chen, Shiyong / Jin, Xiaoming / Chen, Xuan / Fei, Baoying / Xue, Xiaomin / Wu, Renzhao / Chai, Kequn

Frontiers in pharmacology

2023 Volume 14, Page(s) 1144955

Abstract: Yiwei decoction (YWD) is a formula of traditional Chinese medicine (TCM) that is clinically ...

Abstract	Yiwei decoction (YWD) is a formula of traditional Chinese medicine (TCM) that is clinically effective for the prevention and treatment of gastric cancer recurrence and metastasis. According to the theory of TCM, YWD tonifies the body and strengthens the body's resistance to gastric cancer recurrence and metastasis potentially via the immune regulation of the spleen. The aims of the present study were to investigate whether YWD-treated spleen-derived exosomes in rats inhibit the proliferation of tumor cells, to elucidate the anticancer effects of YWD, and to provide evidence supporting the use of YWD as a new clinical treatment for gastric cancer. Spleen-derived exosomes were obtained by ultracentrifugation and identified by transmission electron microscopy, nanoparticle tracking analysis, and western blot analysis. The location of the exosomes in tumor cells was then determined by immunofluorescence staining. After tumor cells were treated with different concentrations of exosomes, the effect of exosomes on cell proliferation was determined by cell counting kit 8 (CCK8) and colony formation assays. Tumor cell apoptosis was detected by flow cytometry. Particle analysis and western blot analysis identified the material extracted from spleen tissue supernatant as exosomes. Immunofluorescence staining showed that spleen-derived exosomes were taken up by HGC-27 cells, and the CCK8 assay confirmed that the relative tumor inhibition rate of YWD-treated spleen-derived exosomes in the 30 μg/mL reached 70.78% compared to control exosomes in the 30 μg/mL (
Language	English
Publishing date	2023-06-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1144955
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Yiwei decoction promotes apoptosis of gastric cancer cells through spleen-derived exosomes

Yingzhi Chen / Yu Li / Yue Wu / Shiyong Chen / Xiaoming Jin / Xuan Chen / Baoying Fei / Xiaomin Xue / Renzhao Wu / Kequn Chai

Frontiers in Pharmacology, Vol

2023 Volume 14

Abstract: Yiwei decoction (YWD) is a formula of traditional Chinese medicine (TCM) that is clinically ...

Abstract	Yiwei decoction (YWD) is a formula of traditional Chinese medicine (TCM) that is clinically effective for the prevention and treatment of gastric cancer recurrence and metastasis. According to the theory of TCM, YWD tonifies the body and strengthens the body’s resistance to gastric cancer recurrence and metastasis potentially via the immune regulation of the spleen. The aims of the present study were to investigate whether YWD-treated spleen-derived exosomes in rats inhibit the proliferation of tumor cells, to elucidate the anticancer effects of YWD, and to provide evidence supporting the use of YWD as a new clinical treatment for gastric cancer. Spleen-derived exosomes were obtained by ultracentrifugation and identified by transmission electron microscopy, nanoparticle tracking analysis, and western blot analysis. The location of the exosomes in tumor cells was then determined by immunofluorescence staining. After tumor cells were treated with different concentrations of exosomes, the effect of exosomes on cell proliferation was determined by cell counting kit 8 (CCK8) and colony formation assays. Tumor cell apoptosis was detected by flow cytometry. Particle analysis and western blot analysis identified the material extracted from spleen tissue supernatant as exosomes. Immunofluorescence staining showed that spleen-derived exosomes were taken up by HGC-27 cells, and the CCK8 assay confirmed that the relative tumor inhibition rate of YWD-treated spleen-derived exosomes in the 30 μg/mL reached 70.78% compared to control exosomes in the 30 μg/mL (p < 0.05). Compared to control exosomes in the 30 μg/mL, the colony formation assay indicated that YWD-treated spleen-derived exosomes in the 30 μg/mL colonies have decreased by 99.03% (p < 0.01). Moreover, flow cytometry analysis showed that treatment with YWD-treated exosomes in the 30 μg/mL increased the apoptosis rate to 43.27%, which was significantly higher than that of the control group in the 30 μg/mL (25.91%) (p < 0.05). In conclusion, spleen-derived ...
Keywords	yiwei decoction (YWD) ; traditional chinese medicine (TCM) ; gastric cancer HGC-27 cells ; apoptosis ; tumour ; spleen-derived exosomes ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: To investigate the mechanism of Yiwei Decoction in the treatment of premature ovarian insufficiency-related osteoporosis using transcriptomics, network pharmacology and molecular docking techniques.

Fan, Weisen / Meng, Yan / Zhang, Jing / Li, Muzhen / Zhang, Yingjie / Qu, Xintian / Xiu, Xin

Scientific reports

2023 Volume 13, Issue 1, Page(s) 19016

Abstract: To investigate the molecular mechanism of Yiwei Decoction (YWD) in preventing Premature ovarian ...

Abstract	To investigate the molecular mechanism of Yiwei Decoction (YWD) in preventing Premature ovarian insufficiency (POI)-related osteoporosis from the hypothalamic perspective , and to screen for the key active and acting molecules in YWD. Cyclophosphamide was used to create the POI rat model. Groups A, B, and C were established. The Model + YWD group was group A, the model control group was group B, and the normal control group was group C. ELISA was used to determine serum GnRH and FSH levels after gavage. The transcription levels of mRNAs in each group's hypothalamus tissues were examined using RNA-seq sequencing technology. The GSEA method was used to enrich pathways based on the gene expression levels of each group. The TCM-active ingredient-target-disease network map was created using differentially expressed mRNAs (DEmRNAs) and network pharmacology. The molecular docking method was employed to investigate the affinity of the active ingredient with key targets. GnRH and FSH levels in POI rats' serum were reduced by YWD. Between groups A and B, there were 638 DEmRNAs (P < 0.05) and 55 high-significance DEmRNAs (P-adjust < 0.01). The MAPK, Hedgehog, Calcium, and B cell receptor pathways are primarily enriched in DEmRNAs from Group A and Group B. The GSEA pathway enrichment analysis indicates that YWD may regulate Long-term potentiation, Amphetamine addiction, and the Renin-angiotensin system and play a role in preventing osteoporosis. The Chinese herbal medicine (CHM)-Active ingredient-Target-disease network map includes 137 targets, 4 CHMs, and 22 active ingredients. The result of docking indicated that Stigmasterol, interacts well with the core proteins ALB, VCL and KAT5. Following the screening, we identified the targets, active components, and key pathways associated with YWD osteoporosis prevention. Most of these key targets and pathways are associated with osteoporosis, but further experimental validation is required.
MeSH term(s)	Animals ; Rats ; Female ; Humans ; Molecular Docking Simulation ; Network Pharmacology ; Transcriptome ; Primary Ovarian Insufficiency/drug therapy ; Primary Ovarian Insufficiency/genetics ; Osteoporosis/drug therapy ; Osteoporosis/genetics ; Gonadotropin-Releasing Hormone ; Follicle Stimulating Hormone ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
Chemical Substances	Gonadotropin-Releasing Hormone (33515-09-2) ; Follicle Stimulating Hormone (9002-68-0) ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-11-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45699-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Preventive and inhibitive effects of Yiwei Xiaoyu granules on the development and progression of spasmolytic polypeptide-expressing metaplasia lesions.

Chen, Wan-Qun / Tian, Feng-Liang / Zhang, Jin-Wei / Yang, Xiao-Jun / Li, Yan-Ping

World journal of gastrointestinal oncology

2021 Volume 13, Issue 11, Page(s) 1741–1754

Abstract: ... lesion.: Aim: To elucidate the microRNA (miR)-7-mediated preventive and inhibitive effects of Yiwei ...

Abstract	Background: Spasmolytic polypeptide-expressing metaplasia (SPEM) is a potential preneoplastic lesion. Aim: To elucidate the microRNA (miR)-7-mediated preventive and inhibitive effects of Yiwei Xiaoyu granules (YWXY) in SPEM lesions. Methods: Gastric mucosa biopsies were collected from chronic atrophic gastritis patients and healthy people with signed informed consent. YWXY was administered to the mice with induced SPEM by tamoxifen, and the gastric mucosa was harvested on the tenth day of the experiment. Then immunohistochemistry and immunofluorescence were performed to validate the SPEM, lesions and the potential mechanism was investigated. RNA transcripts were detected with reverse transcription-quantitative polymerase chain reaction. Results: The expression of miR-7 was downregulated in the SPEM lesions, and expression of trefoil factor 2 (TFF2) and clusterin was high in the human gastric mucosa. Conclusion: miR-7 downregulation is an early event in SPEM through regulation of TFF2 in human gastric mucosa. YWXY is able to inhibit the cell proliferation and restore the expression of miR-7 by mediating TFF2 in the SPEM mouse model.
Language	English
Publishing date	2021-10-15
Publishing country	China
Document type	Journal Article
ZDB-ID	2573696-6
ISSN	1948-5204
ISSN	1948-5204
DOI	10.4251/wjgo.v13.i11.1741
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Article ; Online: To investigate the mechanism of Yiwei Decoction in the treatment of premature ovarian insufficiency-related osteoporosis using transcriptomics, network pharmacology and molecular docking techniques

Weisen Fan / Yan Meng / Jing Zhang / Muzhen Li / Yingjie Zhang / Xintian Qu / Xin Xiu

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 14

Abstract: Abstract To investigate the molecular mechanism of Yiwei Decoction (YWD) in preventing Premature ...

Abstract	Abstract To investigate the molecular mechanism of Yiwei Decoction (YWD) in preventing Premature ovarian insufficiency (POI)-related osteoporosis from the hypothalamic perspective , and to screen for the key active and acting molecules in YWD. Cyclophosphamide was used to create the POI rat model. Groups A, B, and C were established. The Model + YWD group was group A, the model control group was group B, and the normal control group was group C. ELISA was used to determine serum GnRH and FSH levels after gavage. The transcription levels of mRNAs in each group's hypothalamus tissues were examined using RNA-seq sequencing technology. The GSEA method was used to enrich pathways based on the gene expression levels of each group. The TCM–active ingredient–target–disease network map was created using differentially expressed mRNAs (DEmRNAs) and network pharmacology. The molecular docking method was employed to investigate the affinity of the active ingredient with key targets. GnRH and FSH levels in POI rats' serum were reduced by YWD. Between groups A and B, there were 638 DEmRNAs (P < 0.05) and 55 high-significance DEmRNAs (P-adjust < 0.01). The MAPK, Hedgehog, Calcium, and B cell receptor pathways are primarily enriched in DEmRNAs from Group A and Group B. The GSEA pathway enrichment analysis indicates that YWD may regulate Long-term potentiation, Amphetamine addiction, and the Renin-angiotensin system and play a role in preventing osteoporosis. The Chinese herbal medicine (CHM)—Active ingredient-Target-disease network map includes 137 targets, 4 CHMs, and 22 active ingredients. The result of docking indicated that Stigmasterol, interacts well with the core proteins ALB, VCL and KAT5. Following the screening, we identified the targets, active components, and key pathways associated with YWD osteoporosis prevention. Most of these key targets and pathways are associated with osteoporosis, but further experimental validation is required.
Keywords	Medicine ; R ; Science ; Q
Subject code	630
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical Efficacy of Modified Yiwei Shengyang Decoction Combined with FOLFOX4 Chemotherapy Regimen in the Treatment of Advanced Gastric Cancer and Its Effect on Tumor Marker Levels

Hongying Wu / Xiaomei Miao / Yan Liu / Shu Zhang / Chaohui Li / Jie Hao

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: Objective. To study the clinical efficacy of modified Yiwei Shengyang decoction combined ... either FOLFOX4 chemotherapy (control group) or modified Yiwei Shengyang decoction plus FOLFOX4 chemotherapy ... Yiwei Shengyang decoction plus FOLFOX4 chemotherapy was associated with a significantly higher efficacy ...

Abstract	Objective. To study the clinical efficacy of modified Yiwei Shengyang decoction combined with FOLFOX4 chemotherapy regimen in the treatment of advanced gastric cancer and its effect on tumor marker levels. Methods. A total of 106 patients with advanced gastric cancer who were treated in our hospital from September 2019 to September 2021 were recruited and assigned via random number allocation to receive either FOLFOX4 chemotherapy (control group) or modified Yiwei Shengyang decoction plus FOLFOX4 chemotherapy (observation group). Outcome measures included clinical efficacy and tumor marker levels. Results. Modified Yiwei Shengyang decoction plus FOLFOX4 chemotherapy was associated with a significantly higher efficacy (86.79%, including 22 (41.51%) cases of complete response (CR), 24 (45.28%) cases of partial response (PR), 6 (11.32%) cases of stable disease (SD), and 1 (1.89%) case of progressive disease (PD)) compared to FOLFOX4 chemotherapy alone (47.16%, including 10 (18.87%) cases of CR, 15 (28.30%) cases of PR, 21 (39.62%) cases of SD, and 7 (13.21%) cases of PD) (P<0.05). There was no significant difference in the levels of CEA and CA19-9 between the two groups before treatment (P>0.05). Modified Yiwei Shengyang decoction plus FOLFOX4 chemotherapy resulted in significantly lower levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) (2.08 ± 0.47, 15.12 ± 6.74) compared to FOLFOX4 chemotherapy alone (5.46 ± 1.84, 31.82 ± 7.48) (P<0.05). Conclusion. Modified Yiwei Shengyang decoction plus FOLFOX4 chemotherapy regimen is effective in the treatment of advanced gastric cancer. It regulates the levels of various serum tumor markers in patients and controls the disease, so it is worthy of clinical application and promotion.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Urothelial carcinoma recurrence in an ileal conduit and unilateral upper urinary tract: A case report.

Huang, Yiwei / Xu, Chunru / Li, Xuesong / Li, Xiaoying

Asian journal of surgery

2024

Language	English
Publishing date	2024-04-20
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.04.075
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Article ; Online: A graphene microelectrode array based microfluidic device for

Song, Jin / Ali, Ashaq / Ma, Yaohong / Li, Yiwei

Nanoscale advances

2023 Volume 5, Issue 18, Page(s) 4681–4686

Abstract: ... In ... ...

Abstract	In situ
Language	English
Publishing date	2023-08-11
Publishing country	England
Document type	Journal Article
ISSN	2516-0230
ISSN (online)	2516-0230
DOI	10.1039/d3na00482a
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Article ; Online: The "Hand as Foot" teaching method in the rotator-cuff muscle group.

Chen, Silong / Lin, Yiwei / Zhou, Kun / Xu, Li

Asian journal of surgery

2023 Volume 46, Issue 12, Page(s) 5557–5558

MeSH term(s)	Humans ; Upper Extremity ; Hand ; Foot ; Lower Extremity ; Muscles
Language	English
Publishing date	2023-08-31
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.08.002
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Article: Mechanism research on digital inclusive finance promoting high-quality economic development: Evidence from China.

Li, Enze / Tang, Yuanxiu / Zhang, Yiwei / Yu, Jiahui

Heliyon

2024 Volume 10, Issue 3, Page(s) e25671

Abstract: This article aims to precisely evaluate the catalytic impact of digital inclusive finance on economic growth, enhance the implementation of policies pertaining to digital inclusive finance, and foster high-quality economic development. Based on China's ... ...

Abstract	This article aims to precisely evaluate the catalytic impact of digital inclusive finance on economic growth, enhance the implementation of policies pertaining to digital inclusive finance, and foster high-quality economic development. Based on China's provincial panel data and the digital inclusive finance index from 2011 to 2021, this research investigates the influence of digital inclusive finance on high-quality economic development and the associated underlying mechanisms. The findings suggest that digital inclusive finance exerts a notable spatial impact on high-quality economic development. Moreover, there is heterogeneity in the spatial effects between different dimensions of digital inclusive finance and high-quality economic development. Through the threshold model and intermediary effect model, it is found that the Internet penetration rate has a dual-threshold effect on the impact of digital inclusive finance on promoting high-quality economic development. Specifically, digital inclusive finance contributes to elevating the level of high-quality economic development through its role in promoting the transformation of consumption structure. The findings of this study offer valuable insights for countries aiming to attain high-quality economic development through the enhancement of digital inclusive finance.
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e25671
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