LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 3868

Search options

  1. Article ; Online: Response to: John Gregory's medical ethics elucidates the concepts of compassion and empathy.

    Low, Wei Yin Jessie / Tan, Jaclyn

    Medical teacher

    2021  Volume 44, Issue 8, Page(s) 941–942

    MeSH term(s) Empathy ; Ethics, Medical ; Humans ; Physician-Patient Relations
    Language English
    Publishing date 2021-10-04
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424426-6
    ISSN 1466-187X ; 0142-159X
    ISSN (online) 1466-187X
    ISSN 0142-159X
    DOI 10.1080/0142159X.2021.1984411
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2176: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book ; Online: A near-optimal algorithm for approximating the John Ellipsoid

    Cohen, Michael B. / Cousins, Ben / Lee, Yin Tat / Yang, Xin

    2019  

    Abstract: We develop a simple and efficient algorithm for approximating the John Ellipsoid of a symmetric ...

    Abstract We develop a simple and efficient algorithm for approximating the John Ellipsoid of a symmetric polytope. Our algorithm is near optimal in the sense that our time complexity matches the current best verification algorithm. We also provide the MATLAB code for further research.

    Comment: COLT 2019
    Keywords Computer Science - Data Structures and Algorithms
    Publishing date 2019-05-27
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Reply to: Jerry R. John, M.Ch. Respond to "microsurgery and limb salvage after electrical burn injury".

    Hsiao, Yen-Chang / Yang, Jui-Yung / Chang, Cheng-Jen / Lin, Chih-Hung / Chang, Shu-Yin / Chuang, Shiow-Shuh

    Burns : journal of the International Society for Burn Injuries

    2013  Volume 39, Issue 8, Page(s) 1648–1649

    MeSH term(s) Burns, Electric/surgery ; Free Tissue Flaps/blood supply ; Humans ; Male ; Reconstructive Surgical Procedures/methods ; Upper Extremity/injuries
    Language English
    Publishing date 2013-12
    Publishing country Netherlands
    Document type Comment ; Letter
    ZDB-ID 197308-3
    ISSN 1879-1409 ; 0305-4179
    ISSN (online) 1879-1409
    ISSN 0305-4179
    DOI 10.1016/j.burns.2013.06.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1250: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Audio / Video: Highly Variable Contents of Phenolics in St. John’s Wort Products Affect Their Transport in the Human Intestinal Caco-2 Cell Model: Pharmaceutical and Biopharmaceutical Rationale for Product Standardization

    Gao, Song / Jiang, Wen / Yin, Taijun / Hu, Ming

    Journal of agricultural and food chemistry. 2010 June 9, v. 58, no. 11

    2010  

    Abstract: The purposes of this study were to determine content uniformity of phenolics in the St. John’s wort ...

    Abstract The purposes of this study were to determine content uniformity of phenolics in the St. John’s wort (SJW) supplements and to demonstrate how variations in the product matrices affect their absorption and efflux. LC and LC-MS/MS methods were used to determine the phenolic contents of 12 different products purchased locally or from the Internet. Three representative extracts were further submitted to Caco-2 cell transport experiment, and transport of rutin, hyperoside, and isoquercitrin was evaluated. The results indicated that the 12 different products displayed 12 different HPLC fingerprints, but all products contained the following major compounds: rutin, hyperoside, isoquercitrin, quercitrin, quercetin, and amentoflavone. The content uniformity of these major compounds was poor across products, with the smallest difference in the amounts of amentoflavone (3.6-fold) and largest difference in that of isoquercitrin (28.8-fold). The Caco-2 experiments indicated transport of rutin in products was vectorial, with the permeabilities varied about 3.6-fold in both directions of transport. The vectorial permeabilities of hyperoside and isoquercitrin were similarly different. Use of efflux transporter inhibitor studies suggested that MRP2 was involved in isoquercitrin’s efflux and the product matrix affected the extent of its efflux. In conclusion, different SJW supplements had highly variable contents of phenolics, and the variability in product matrix and phytochemical compositions affected the permeabilities of key phenolics across the Caco-2 monolayers, which may further affect their bioavailabilities. Therefore, standardization will be necessary to ensure safe and efficacious using of supplements such as SJW.
    Keywords phenolic compounds ; medicinal plants ; dietary supplements ; in vitro studies ; phytochemicals ; intestinal mucosa ; intestinal absorption ; physiological transport ; product quality standards ; chemical composition ; Hypericum perforatum ; plant products ; rutin ; quercitrin ; quercetin ; isoquercitrin ; permeability ; bioavailability ; chemical structure
    Language English
    Dates of publication 2010-0609
    Size p. 6650–6659.
    Document type Article ; Audio / Video
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/jf904459u
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 1185: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Introduction: Smart Materials.

    Yin, Yadong / Rogers, John A

    Chemical reviews

    2022  Volume 122, Issue 5, Page(s) 4885–4886

    MeSH term(s) Smart Materials
    Chemical Substances Smart Materials
    Language English
    Publishing date 2022-03-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.2c00074
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 49/78: Show issues
    Z 4.4: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: Advances in Development of Novel Therapeutic Strategies against Multi-Drug Resistant

    Yin, Changhong / Alam, Md Zahidul / Fallon, John T / Huang, Weihua

    Antibiotics (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics13020119
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Computational multigene interactions in virus growth and infection spread.

    Schwab, Bradley / Yin, John

    Virus evolution

    2023  Volume 10, Issue 1, Page(s) vead082

    Abstract: Viruses persist in nature owing to their extreme genetic heterogeneity and large population sizes, which enable them to evade host immune defenses, escape antiviral drugs, and adapt to new hosts. The persistence of viruses is challenging to study because ...

    Abstract Viruses persist in nature owing to their extreme genetic heterogeneity and large population sizes, which enable them to evade host immune defenses, escape antiviral drugs, and adapt to new hosts. The persistence of viruses is challenging to study because mutations affect multiple virus genes, interactions among genes in their impacts on virus growth are seldom known, and measures of viral fitness are yet to be standardized. To address these challenges, we employed a data-driven computational model of cell infection by a virus. The infection model accounted for the kinetics of viral gene expression, functional gene-gene interactions, genome replication, and allocation of host cellular resources to produce progeny of vesicular stomatitis virus, a prototype RNA virus. We used this model to computationally probe how interactions among genes carrying up to eleven deleterious mutations affect different measures of virus fitness: single-cycle growth yields and multicycle rates of infection spread. Individual mutations were implemented by perturbing biophysical parameters associated with individual gene functions of the wild-type model. Our analysis revealed synergistic epistasis among deleterious mutations in their effects on virus yield; so adverse effects of single deleterious mutations were amplified by interaction. For the same mutations, multicycle infection spread indicated weak or negligible epistasis, where single mutations act alone in their effects on infection spread. These results were robust to simulation in high- and low-host resource environments. Our work highlights how different types and magnitudes of epistasis can arise for genetically identical virus variants, depending on the fitness measure. More broadly, gene-gene interactions can differently affect how viruses grow and spread.
    Language English
    Publishing date 2023-12-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2818949-8
    ISSN 2057-1577
    ISSN 2057-1577
    DOI 10.1093/ve/vead082
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Glycine to Oligoglycine via Sequential Trimetaphosphate Activation Steps in Drying Environments.

    Boigenzahn, Hayley / Yin, John

    Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life

    2022  

    Abstract: Polyphosphate-mediated peptide bond formation is central to protein synthesis in modern organisms, but a simpler form of activation likely preceded the emergence of proteins and RNA. One suggested scenario involves trimetaphosphate (TP), an inorganic ... ...

    Abstract Polyphosphate-mediated peptide bond formation is central to protein synthesis in modern organisms, but a simpler form of activation likely preceded the emergence of proteins and RNA. One suggested scenario involves trimetaphosphate (TP), an inorganic phosphate that promotes peptide condensation. Peptide bond formation can also be promoted by high pH and drying, but the interaction of these factors with TP has yet to be characterized kinetically. We studied the formation of glycine oligomers formed under initially alkaline conditions in the presence of TP during the process of drying. Oligopeptide products sampled over 24 h were analyzed by functionalization and high-performance liquid chromatography with ultraviolet absorption (UV-HPLC). As they dried, two different pH-dependent mechanisms dominated during different stages of the process. The first mechanism occurs in alkaline solutions and activates monomer amino acids to form dimers while reducing the pH. Our results then become consistent with a second mechanism that proceeds at neutral pH and consumes dimers to form longer products. The possibility that a series of reactions might occur where the first reaction changes the environment to favor the second, and so on, may have broader implications for prebiotic polymerization. Studying how the environment changes during time-varying conditions, like drying, could help us understand how organic polymers formed during the origin of life.
    Language English
    Publishing date 2022-12-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2018578-9
    ISSN 1573-0875 ; 0169-6149
    ISSN (online) 1573-0875
    ISSN 0169-6149
    DOI 10.1007/s11084-022-09634-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Gambling demon and stopping-time fluctuation relation of a Brownian particle under a time-dependent trapping potential.

    Albay, John A C / Jun, Yonggun / Lai, Pik-Yin

    Physical review. E

    2024  Volume 109, Issue 1-1, Page(s) 14124

    Abstract: A gambling demon is an external agent that can terminate a time-dependent driving protocol when a certain observable of the system exceeds a prescribed threshold. The gambling demon is examined in detail both theoretically and experimentally in a ... ...

    Abstract A gambling demon is an external agent that can terminate a time-dependent driving protocol when a certain observable of the system exceeds a prescribed threshold. The gambling demon is examined in detail both theoretically and experimentally in a Brownian particle system under a compressing potential trap. Insight for choosing an appropriate work threshold for stopping is discussed. The energetics and the distributions of the stopping positions and stopping times are measured in simulations to gain further understanding of the process. Furthermore, the nonstationary and far-from-equilibrium stochastic process in the action of the gambling demon allows us to examine in detail some fundamental issues in stochastic thermodynamics, such as irreversibility and stopping-time fluctuation relation. Paradoxical violation of the stopping-time fluctuation relation can be reconciled in terms of the entropy production associated with fast hidden internal degrees of freedom. All the simulation or theoretical results are confirmed experimentally.
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.109.014124
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Enhancement of Prebiotic Peptide Formation in Cyclic Environments.

    Boigenzahn, Hayley / Gagrani, Praful / Yin, John

    Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life

    2023  Volume 53, Issue 3-4, Page(s) 157–173

    Abstract: The dynamic behaviors of prebiotic reaction networks may be critically important to understanding how larger biopolymers could emerge, despite being unfavorable to form in water. We focus on understanding the dynamics of simple systems, prior to the ... ...

    Abstract The dynamic behaviors of prebiotic reaction networks may be critically important to understanding how larger biopolymers could emerge, despite being unfavorable to form in water. We focus on understanding the dynamics of simple systems, prior to the emergence of replication mechanisms, and what role they may have played in biopolymer formation. We specifically consider the dynamics in cyclic environments using both model and experimental data. Cyclic environmental conditions prevent a system from reaching thermodynamic equilibrium, improving the chance of observing interesting kinetic behaviors. We used an approximate kinetic model to simulate the dynamics of trimetaphosphate (TP)-activated peptide formation from glycine in cyclic wet-dry conditions. The model predicts that environmental cycling allows trimer and tetramer peptides to sustain concentrations above the predicted fixed points of the model due to overshoot, a dynamic phenomenon. Our experiments demonstrate that oscillatory environments can shift product distributions in favor of longer peptides. However, experimental validation of certain behaviors in the kinetic model is challenging, considering that open systems with cyclic environmental conditions break many of the common assumptions in classical chemical kinetics. Overall, our results suggest that the dynamics of simple peptide reaction networks in cyclic environments may have been important for the formation of longer polymers on the early Earth. Similar phenomena may have also contributed to the emergence of reaction networks with product distributions determined not by thermodynamics, but rather by kinetics.
    MeSH term(s) Peptides ; Peptide Biosynthesis ; Thermodynamics ; Polymers
    Chemical Substances Peptides ; Polymers
    Language English
    Publishing date 2023-10-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2018578-9
    ISSN 1573-0875 ; 0169-6149
    ISSN (online) 1573-0875
    ISSN 0169-6149
    DOI 10.1007/s11084-023-09641-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top