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  1. Article ; Online: M

    Downes, Marley / Shuck, Christopher E / Lord, Robert W / Anayee, Mark / Shekhirev, Mikhail / Wang, Ruocun John / Hryhorchuk, Tetiana / Dahlqvist, Martin / Rosen, Johanna / Gogotsi, Yury

    ACS nano

    2023  Volume 17, Issue 17, Page(s) 17158–17168

    Abstract: ... a wide range of properties, which can be altered by their chemistry (M, X) and the number of metal layers ... in the structure, ranging from two in M ...

    Abstract MXenes are two-dimensional (2D) transition metal carbides, nitrides, and carbonitrides typically synthesized from layered MAX-phase precursors. With over 50 experimentally reported MXenes and a near-infinite number of possible chemistries, MXenes make up the fastest-growing family of 2D materials. They offer a wide range of properties, which can be altered by their chemistry (M, X) and the number of metal layers in the structure, ranging from two in M
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c04967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: m

    Ke, Shengdong / Pandya-Jones, Amy / Saito, Yuhki / Fak, John J / Vågbø, Cathrine Broberg / Geula, Shay / Hanna, Jacob H / Black, Douglas L / Darnell, James E / Darnell, Robert B

    Genes & development

    2017  Volume 31, Issue 10, Page(s) 990–1006

    Abstract: Understanding the biologic role ... ...

    Abstract Understanding the biologic role of
    MeSH term(s) Animals ; Chromatin/metabolism ; Cytoplasm/metabolism ; Embryonic Stem Cells ; Exons/genetics ; Gene Knockout Techniques ; HeLa Cells ; Humans ; Introns/genetics ; Methylation ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Mice ; RNA Precursors/metabolism ; RNA Splicing ; RNA, Messenger/metabolism
    Chemical Substances Chromatin ; RNA Precursors ; RNA, Messenger ; Methyltransferases (EC 2.1.1.-) ; Mettl3 protein, mouse (EC 2.1.1.-)
    Language English
    Publishing date 2017-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.301036.117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2292: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 54: Show issues

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  3. Article ; Online: The m

    Xiao, Yiren / Thakkar, Kaushik N / Zhao, Hongjuan / Broughton, James / Li, Yang / Seoane, Jose A / Diep, Anh N / Metzner, Thomas J / von Eyben, Rie / Dill, David L / Brooks, James D / Curtis, Christina / Leppert, John T / Ye, Jiangbin / Peehl, Donna M / Giaccia, Amato J / Sinha, Subarna / Rankin, Erinn B

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 35, Page(s) 21441–21449

    Abstract: ... transcriptomic data. Using this approach, we identified a synthetic lethal interaction between VHL and the m ...

    Abstract Loss of the von Hippel-Lindau (VHL) tumor suppressor is a hallmark feature of renal clear cell carcinoma. VHL inactivation results in the constitutive activation of the hypoxia-inducible factors (HIFs) HIF-1 and HIF-2 and their downstream targets, including the proangiogenic factors VEGF and PDGF. However, antiangiogenic agents and HIF-2 inhibitors have limited efficacy in cancer therapy due to the development of resistance. Here we employed an innovative computational platform, Mining of Synthetic Lethals (MiSL), to identify synthetic lethal interactions with the loss of VHL through analysis of primary tumor genomic and transcriptomic data. Using this approach, we identified a synthetic lethal interaction between VHL and the m
    MeSH term(s) Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/metabolism ; Amino Acid Transport System ASC/metabolism ; Animals ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Cell Line, Tumor ; Computer Simulation ; Humans ; Hypoxia-Inducible Factor 1/metabolism ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Mice, Knockout ; Minor Histocompatibility Antigens/metabolism ; Synthetic Lethal Mutations ; Von Hippel-Lindau Tumor Suppressor Protein/genetics
    Chemical Substances Amino Acid Transport System ASC ; Basic Helix-Loop-Helix Transcription Factors ; Hypoxia-Inducible Factor 1 ; Minor Histocompatibility Antigens ; SLC1A5 protein, human ; endothelial PAS domain-containing protein 1 (1B37H0967P) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; FTO protein, human (EC 1.14.11.33) ; Von Hippel-Lindau Tumor Suppressor Protein (EC 2.3.2.27) ; VHL protein, human (EC 6.3.2.-)
    Language English
    Publishing date 2020-08-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2000516117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The M

    Marsango, Sara / Jenkins, Laura / Pediani, John D / Bradley, Sophie J / Ward, Richard J / Hesse, Sarah / Biener, Gabriel / Stoneman, Michael R / Tobin, Andrew B / Raicu, Valerica / Milligan, Graeme

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 24, Page(s) e2201103119

    Abstract: ... unknown. To address this we generated mice in which the M ...

    Abstract The quaternary organization of rhodopsin-like G protein-coupled receptors in native tissues is unknown. To address this we generated mice in which the M
    MeSH term(s) Animals ; Cerebral Cortex/metabolism ; Green Fluorescent Proteins ; Hippocampus/metabolism ; Ligands ; Mice ; Mice, Knockout ; Neurons/metabolism ; Optical Imaging ; Receptor, Muscarinic M1/chemistry ; Receptor, Muscarinic M1/genetics ; Receptor, Muscarinic M1/metabolism
    Chemical Substances Ligands ; Receptor, Muscarinic M1 ; enhanced green fluorescent protein ; Green Fluorescent Proteins (147336-22-9)
    Language English
    Publishing date 2022-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2201103119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
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  5. Article: Characterization of m

    George, Jitu W / Cancino, Rosa A / Miller, Jennifer L Griffin / Qiu, Fang / Lin, Qishan / Rowley, M Jordan / Chennathukuzhi, Varghese M / Davis, John S

    bioRxiv : the preprint server for biology

    2023  

    Abstract: ... these modifiers confirming our RNA-seq data. We then examined protein profiles of key m ...

    Abstract Uterine leiomyoma or fibroids are the most common prevalent noncancerous tumors of the uterine muscle layer. Common symptoms associated with fibroids include pelvic pain, heavy menstrual bleeding, anemia, and pelvic pressure. These tumors are a leading cause of gynecological care but lack long-term therapy as the origin and development of fibroids are not well understood. Several next-generation sequencing technologies have been performed to identify the underlying genetic and epigenetic basis of fibroids. However, there remains a systemic gap in our understanding of molecular and biological process that define uterine fibroids. Recent epitranscriptomics studies have unraveled RNA modifications that are associated with all forms of RNA and are thought to influence both normal physiological functions and the progression of diseases. We quantified RNA expression profiles by analyzing publicly available RNA-seq data for 15 known epigenetic mediators to identify their expression profile in uterine fibroids compared to myometrium. To validate our findings, we performed RT-qPCR on a separate cohort of uterine fibroids targeting these modifiers confirming our RNA-seq data. We then examined protein profiles of key m
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.08.07.552278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: M

    Cage, John

    Writings '67-'72

    2010  

    Abstract: Mainly mesostics inspired by music, mushrooms, Marcel Duchamp, Merce Cunningham, Marshall McCluhan, etc. and includes "Mureau"-composed from the writings of Henry David ... ...

    Abstract Mainly mesostics inspired by music, mushrooms, Marcel Duchamp, Merce Cunningham, Marshall McCluhan, etc. and includes "Mureau"-composed from the writings of Henry David Thoreau
    Language English
    Size Online-Ressource (234 p.)
    Publisher Wesleyan University Press
    Publishing place Middletown
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780819560353 ; 0819560359
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Article ; Online: Presentation of the Julius M. Friedenwald Medal to M. Bishr Omary.

    Lok, Anna S / Inadomi, John M

    Gastroenterology

    2024  

    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2024.03.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui V Zs.44: Show issues Location:
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    Zs.MO 572: Show issues

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  8. Article: SARS-CoV-2 M

    Chen, Sizhu Amelia / Arutyunova, Elena / Lu, Jimmy / Khan, Muhammad Bashir / Rut, Wioletta / Zmudzinski, Mikolaj / Shahbaz, Shima / Iyyathurai, Jegan / Moussa, Eman W / Turner, Zoe / Bai, Bing / Lamer, Tess / Nieman, James A / Vederas, John C / Julien, Olivier / Drag, Marcin / Elahi, Shokrollah / Young, Howard S / Lemieux, M Joanne

    ACS central science

    2023  Volume 9, Issue 4, Page(s) 696–708

    Abstract: The main protease of SARS-CoV-2 (M ...

    Abstract The main protease of SARS-CoV-2 (M
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article
    ISSN 2374-7943
    ISSN 2374-7943
    DOI 10.1021/acscentsci.3c00054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Single-cell m

    Li, Yanjiao / Wang, Yunhao / Vera-Rodriguez, Maria / Lindeman, Leif Christopher / Skuggen, Linda Ellevog / Rasmussen, Erik M K / Jermstad, Ingunn / Khan, Shaista / Fosslie, Madeleine / Skuland, Trine / Indahl, Marie / Khodeer, Sherif / Klemsdal, Eva Kristine / Jin, Kang-Xuan / Dalen, Knut Tomas / Fedorcsak, Peter / Greggains, Gareth D / Lerdrup, Mads / Klungland, Arne /
    Au, Kin Fai / Dahl, John Arne

    Nature biotechnology

    2023  Volume 42, Issue 4, Page(s) 591–596

    Abstract: ... Current ... ...

    Abstract Current N
    MeSH term(s) Animals ; Mice ; Zebrafish/genetics ; Zebrafish/metabolism ; RNA/genetics ; RNA, Messenger/genetics ; Embryonic Stem Cells ; Cells, Cultured
    Chemical Substances RNA (63231-63-0) ; RNA, Messenger
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/s41587-023-01831-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2167: Show issues Location:
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    Zs.MO 137: Show issues
    Zs.MG 43: Show issues

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  10. Article ; Online: Diastereomer Resolution of M

    Pfrunder, Michael C / Marshall, David L / Poad, Berwyck L J / Fulloon, Therese M / Clegg, Jack K / Blanksby, Stephen J / McMurtrie, John C / Mullen, Kathleen M

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 27, Page(s) e202302229

    Abstract: Coordination cages can be used for enantio- and regioselective catalysis and for the selective sensing and separation of isomeric guest molecules. Here, stereoisomers of a family of coordination cages are resolved using ultra-high-resolution cyclic ion- ... ...

    Abstract Coordination cages can be used for enantio- and regioselective catalysis and for the selective sensing and separation of isomeric guest molecules. Here, stereoisomers of a family of coordination cages are resolved using ultra-high-resolution cyclic ion-mobility mass spectrometry (cIM-MS). The observed ratio of diastereomers is dependent on both the metal ion and counter ion. Moreover, the point groups can be assigned through complementary NMR experiments. This method enables the identification and interrogation of the individual isomers in complex mixtures of cages which cannot be performed in solution. Furthermore, these techniques allow the stability of individual isomers within the mixture to be probed, with the T-symmetric isomers in this case shown to be more robust than the C
    Language English
    Publishing date 2023-05-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202302229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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