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Article ; Online: Regulation of follicular activation signaling pathways by in vitro inhibition of YAP/TAZ activity in mouse ovaries.

Devos, Melody / Dias Nunes, Joana / Donfack Jiatsa, Nathalie / Demeestere, Isabelle

2023 Volume 13, Issue 1, Page(s) 15346

Abstract: The Hippo pathway plays a crucial role in the regulation of follicular activation, which constitutes the first step of the folliculogenesis process. Disruption of this pathway occurs in several non-physiological contexts, after fragmentation for ovarian ... ...

Abstract	The Hippo pathway plays a crucial role in the regulation of follicular activation, which constitutes the first step of the folliculogenesis process. Disruption of this pathway occurs in several non-physiological contexts, after fragmentation for ovarian tissue cryopreservation procedures or chemotherapy exposure, leading to massive follicular growth and depletion. This study aimed to investigate the effect of controlling the Hippo pathway using verteporfin (VERT) during in vitro ovarian culture and to evaluate its potential preventive effects on chemotherapy-induced follicle activation using a mouse model. After exposure of cut ovaries to different concentrations of VERT for 3 h, a dose-dependent effect of VERT was observed that reached significant inhibition of YAP activity at 3 µmol/L. To assess the potential effect of controlling chemotherapy-induced Hippo pathway disruption, whole mouse ovaries were exposed to VERT alone or as a co-treatment with 4-hydroperoxycylophosphamide (4HC). VERT co-treatment prevented chemotherapy-induced YAP activation but had a limited impact on downstream effector gene, Ccn2. Surprisingly, VERT co-treatment also prevented mTOR and survival signaling pathway alterations following chemotherapy exposure. These results suggest an interaction between the two main signaling pathways regulating follicle activation and a protective effect of VERT on 4HC-induced DNA damage.
MeSH term(s)	Female ; Antineoplastic Agents ; Cryopreservation ; DNA Damage ; Hippo Signaling Pathway ; Ovary ; Verteporfin/pharmacology ; YAP-Signaling Proteins/metabolism ; Animals ; Mice
Chemical Substances	Antineoplastic Agents ; Verteporfin (0X9PA28K43) ; Wwtr1 protein, mouse ; YAP-Signaling Proteins
Language	English
Publishing date	2023-09-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-41954-0
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Article ; Online: Programmed cell death protein 1 is a marker for neoadjuvant chemotherapy response in triple-negative breast cancer.

Gaui, Maria de Fátima Dias / Amendola, Luis Claudio / Quintella, Danielle Carvalho / Canedo, Nathalie / Bonomo, Adriana

Revista da Associacao Medica Brasileira (1992)

2023 Volume 69, Issue 9, Page(s) e20230276

Abstract: Objective: Tumor-infiltrating lymphocytes are detectable in up to 75% of triple-negative breast cancer. The composition of these infiltrates may influence prognosis and is not known regarding regulatory or effector lymphocytes. The objectives of this ... ...

Abstract	Objective: Tumor-infiltrating lymphocytes are detectable in up to 75% of triple-negative breast cancer. The composition of these infiltrates may influence prognosis and is not known regarding regulatory or effector lymphocytes. The objectives of this study were to describe and quantify the composition of the tumor-infiltrating lymphocytes before and after chemotherapy (neoadjuvant chemotherapy) and to evaluate their association with complete pathological response and overall survival. Methods: This was a retrospective observational study. Clinical and pathological data from 38 triple-negative breast cancer patients treated with neoadjuvant chemotherapy at the University Hospital (HUCFF/UFRJ), between November 2004 and November 2018, were analyzed. The Stromal tumor-infiltrating lymphocytes (Stromal tumor-infiltrating lymphocytes) have been identified on hematoxylin and eosin-stained sections according to the guidelines of the "International tumor-infiltrating lymphocytes Working Group." Immunohistochemistry studies were performed to identify T-cell subsets (i.e., CD3, CD4, CD8, and FOXP3) and T-cell exhaustion (i.e., programmed cell death protein 1). Results: Statistically significant changes in stromal tumor-infiltrating lymphocyte categories were observed before and post-neoadjuvant chemotherapy, with 32% of intermediate cases becoming high. The correlation between pre-neoadjuvant chemotherapy stromal tumor-infiltrating lymphocytes and pathological response, pre-neoadjuvant chemotherapy and post-neoadjuvant chemotherapy, and stromal tumor-infiltrating lymphocytes and overall survival was not statistically significant. However, we noticed an increase of cells that favor the antitumor activity (i.e., CD3, CD8, and CD8/FOXP3 ratio) and decreased levels of cells inhibiting tumor activities (i.e., FOXP3 and programmed cell death protein 1) post-neoadjuvant chemotherapy. Importantly, programmed cell death protein 1 expression pre-neoadjuvant chemotherapy showed an association with pathological response. Conclusion: In this study, we observed that chemotherapy significantly increases stromal tumor-infiltrating lymphocytes, CD8 T cells, as well as CD8/FoxP3 ratio. Most importantly, programmed cell death protein 1 expression before neoadjuvant chemotherapy positively correlates with pathological response suggesting the use of programmed cell death protein 1 as a prognostic marker before neoadjuvant chemotherapy.
MeSH term(s)	Humans ; Programmed Cell Death 1 Receptor ; Triple Negative Breast Neoplasms/drug therapy ; Neoadjuvant Therapy ; CD8-Positive T-Lymphocytes ; Forkhead Transcription Factors
Chemical Substances	Programmed Cell Death 1 Receptor ; Forkhead Transcription Factors
Language	English
Publishing date	2023-09-18
Publishing country	Brazil
Document type	Observational Study ; Journal Article
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.20230276
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Article ; Online: Correction to: SVR-flaA typing of erythromycin- and ciprofloxacin-resistant Campylobacter jejuni strains isolated from poultry slaughterhouses in southern Brazil.

Dias, Thomas Salles / de Almeida Figueira, Arthur / Costa, Gisllany Alves / da Cunha, Nathalie Costa / Rossi, Daise Aparecida / de Melo, Roberta Torres / de Almeida Pereira, Virginia Léo / de Aquino, Maria Helena Cosendey

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

2023 Volume 54, Issue 2, Page(s) 1323

Language	English
Publishing date	2023-04-27
Publishing country	Brazil
Document type	Published Erratum
ZDB-ID	2017175-4
ISSN	1678-4405 ; 1517-8382
ISSN (online)	1678-4405
ISSN	1517-8382
DOI	10.1007/s42770-023-00983-7
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Article ; Online: Comparison of integrin α

Dietz, Matthieu / Dunet, Vincent / Mantziari, Styliani / Pomoni, Anastasia / Dias Correia, Ricardo / Testart Dardel, Nathalie / Boughdad, Sarah / Nicod Lalonde, Marie / Treglia, Giorgio / Schafer, Markus / Schaefer, Niklaus / Prior, John O

European journal of hybrid imaging

2023 Volume 7, Issue 1, Page(s) 3

Abstract: Background: The primary aims of this study were to compare in patients with esophageal or esophagogastric junction cancers the potential of : Methods: Ten : Results: 68: Conclusions: In conclusion, : Trial registration: Trial registration: ... ...

Abstract	Background: The primary aims of this study were to compare in patients with esophageal or esophagogastric junction cancers the potential of Methods: Ten Results: 68 Conclusions: In conclusion, Trial registration: Trial registration: NCT02666547. Registered January 28, 2016-Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02666547 .
Language	English
Publishing date	2023-02-01
Publishing country	England
Document type	Journal Article
ISSN	2510-3636
ISSN (online)	2510-3636
DOI	10.1186/s41824-023-00162-9
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Article ; Online: A comprehensive evolutionary scenario for the origin and neofunctionalization of the Drosophila speciation gene Odysseus (OdsH).

Nunes, William Vilas Boas / Oliveira, Daniel Siqueira / Dias, Guilherme de Rezende / Carvalho, Antonio Bernardo / Caruso, Ícaro Putinhon / Biselli, Joice Matos / Guegen, Nathalie / Akkouche, Abdou / Burlet, Nelly / Vieira, Cristina / Carareto, Claudia M A

G3 (Bethesda, Md.)

2023 Volume 14, Issue 3

Abstract: Odysseus (OdsH) was the first speciation gene described in Drosophila related to hybrid sterility in offspring of mating between Drosophila mauritiana and Drosophila simulans. Its origin is attributed to the duplication of the gene unc-4 in the subgenus ... ...

Abstract	Odysseus (OdsH) was the first speciation gene described in Drosophila related to hybrid sterility in offspring of mating between Drosophila mauritiana and Drosophila simulans. Its origin is attributed to the duplication of the gene unc-4 in the subgenus Sophophora. By using a much larger sample of Drosophilidae species, we showed that contrary to what has been previously proposed, OdsH origin occurred 62 MYA. Evolutionary rates, expression, and transcription factor-binding sites of OdsH evidence that it may have rapidly experienced neofunctionalization in male sexual functions. Furthermore, the analysis of the OdsH peptide allowed the identification of mutations of D. mauritiana that could result in incompatibility in hybrids. In order to find if OdsH could be related to hybrid sterility, beyond Sophophora, we explored the expression of OdsH in Drosophila arizonae and Drosophila mojavensis, a pair of sister species with incomplete reproductive isolation. Our data indicated that OdsH expression is not atypical in their male-sterile hybrids. In conclusion, we have proposed that the origin of OdsH occurred earlier than previously proposed, followed by neofunctionalization. Our results also suggested that its role as a speciation gene might be restricted to D. mauritiana and D. simulans.
MeSH term(s)	Animals ; Male ; Biological Evolution ; Drosophila/genetics ; Drosophila Proteins/genetics ; Hybridization, Genetic ; Infertility
Chemical Substances	Drosophila Proteins ; OdsH protein, Drosophila
Language	English
Publishing date	2023-12-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2629978-1
ISSN	2160-1836 ; 2160-1836
ISSN (online)	2160-1836
ISSN	2160-1836
DOI	10.1093/g3journal/jkad299
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Article ; Online: Detection of Mycoplasma species at various anatomical sites of dogs from different types of kennels.

Alves, Ana Beatriz Pinheiro / Dos Santos Machado, Leandro / de Souza, Jenif Braga / Spenchutt Vieira, Gabriela Paixão / Dias, Thomas Salles / de Almeida, Virgínia Léo / do Nascimento, Elmiro Rosendo / Barreto, Maria Lúcia / Da Cunha, Nathalie Costa

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

2023 Volume 54, Issue 2, Page(s) 1251–1255

Abstract: This work aimed to detect Mycoplasma cynos, M. canis, M. edwardii, and M. molare in different types of kennels, in addition to evaluating their distribution in different colonization sites. The dogs belonged to different kennels from armed forces (n = 3), ...

Abstract	This work aimed to detect Mycoplasma cynos, M. canis, M. edwardii, and M. molare in different types of kennels, in addition to evaluating their distribution in different colonization sites. The dogs belonged to different kennels from armed forces (n = 3), shelters (n = 3), and commercial purposes (n = 2). Samples of the oropharynx, genital mucosa, and ear canal were collected from each dog (n = 98), totaling 294 samples. Aliquots were submitted to isolation and the samples confirmed as Mycoplasma spp. were subjected to conventional PCR for M. canis and multiplex PCR for M. edwardii, M. molare, and M. cynos detection. Of the 98 dogs studied, 63.3% (62) were positive in at least one anatomical site evaluated for Mycoplasma spp. Among the 111 anatomical sites positive for Mycoplasma spp., M. canis, M. edwardii, and M. molare were detected in 29.7% (33/111), 40.5% (45/111), and 2.70% (3/111), respectively. No animal was positive for M. cynos.
MeSH term(s)	Dogs ; Animals ; Dog Diseases/microbiology ; Mycoplasma/genetics ; Mycoplasma Infections/veterinary ; Mycoplasma Infections/microbiology ; Multiplex Polymerase Chain Reaction
Language	English
Publishing date	2023-03-18
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2017175-4
ISSN	1678-4405 ; 1517-8382
ISSN (online)	1678-4405
ISSN	1517-8382
DOI	10.1007/s42770-023-00947-x
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Article ; Online: HLA-G

Bertol, Bruna C / Debortoli, Guilherme / Dias, Fabrício C / de Araújo, Jéssica N G / Maia, Luana S M / de Almeida, Bibiana S / de Figueiredo-Feitosa, Nathalie L / de Freitas, Luiz Carlos C / Castelli, Erick C / Mendes-Junior, Celso T / Silbiger, Vivian N / Maciel, Léa M Z / Donadi, Eduardo A

International journal of molecular sciences

2023 Volume 24, Issue 16

Abstract: Human leukocyte antigen (HLA)-G is an immune checkpoint molecule that is highly expressed in papillary thyroid carcinoma (PTC). ... ...

Abstract	Human leukocyte antigen (HLA)-G is an immune checkpoint molecule that is highly expressed in papillary thyroid carcinoma (PTC). The
MeSH term(s)	Humans ; Thyroid Cancer, Papillary/genetics ; HLA-G Antigens/genetics ; 3' Untranslated Regions ; Morbidity ; Thyroid Neoplasms/genetics ; GTP-Binding Proteins
Chemical Substances	HLA-G Antigens ; 3' Untranslated Regions ; GTP-Binding Proteins (EC 3.6.1.-)
Language	English
Publishing date	2023-08-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241612858
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Article ; Online: SVR-flaA typing of erythromycin- and ciprofloxacin-resistant Campylobacter jejuni strains isolated from poultry slaughterhouses in southern Brazil.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

2023 Volume 54, Issue 2, Page(s) 1065–1073

Abstract: The emergence of fluoroquinolone and macrolide resistance in C. jejuni, a recognized zoonotic pathogen, has increased worldwide. This study aimed to investigate phenotypic resistance to ciprofloxacin and erythromycin, the molecular mechanisms involved, ... ...

Abstract	The emergence of fluoroquinolone and macrolide resistance in C. jejuni, a recognized zoonotic pathogen, has increased worldwide. This study aimed to investigate phenotypic resistance to ciprofloxacin and erythromycin, the molecular mechanisms involved, and the strain of C. jejuni isolated from broiler carcasses. Eighty C. jejuni isolates from broiler carcasses in southern Brazil were investigated for their susceptibility to ciprofloxacin and erythromycin at minimal inhibitory concentrations. Mismatch amplification mutation assay-polymerase chain reaction (MAMA-PCR) was performed to detect substitutions of Thr-86-Ile, A2074C, and A2075G of domain V in the 23S rRNA. The presence of ermB gene and CmeABC operon were investigated by PCR. DNA sequencing was used to detect substitutions in the L4 and L22 proteins of the erythromycin-resistant strains. The Short Variable Region (SVR) of flaA was used to type all the strains resistant to both antimicrobials. Ciprofloxacin and erythromycin resistance were detected in 81.25% and 30.00% of the strains, respectively, and minimal inhibitory concentration values ranged from ≤ 0.125 to 64 µg/mL for ciprofloxacin and 0.5 to > 128 µg/mL for erythromycin. The Thr-86-Ile mutation in gyrA was observed in 100% of the ciprofloxacin-resistant strains. Mutations in both the A2074C and A2075G positions of 23S rRNA were observed in 62.5% of the erythromycin-resistant strains, while 37.5% had only the mutation A2075G. None of the strains harbored CmeABC operon, and ermB was not detected. Using DNA sequencing, the amino acid substitution T177S was detected in L4, and substitutions I65V, A103V, and S109A were detected in L22. Twelve flaA-SVR alleles were identified among the strains, with the most common SVR-flaA allele, type 287, covering 31.03% of ciprofloxacin- and erythromycin-resistant isolates. The present study revealed a high incidence and high levels of resistance to ciprofloxacin and erythromycin, as well as broad molecular diversity in C. jejuni isolates from broiler carcasses.
MeSH term(s)	Animals ; Ciprofloxacin/pharmacology ; Erythromycin/pharmacology ; Anti-Bacterial Agents/pharmacology ; Campylobacter jejuni/genetics ; Poultry ; Abattoirs ; Brazil ; RNA, Ribosomal, 23S/genetics ; Campylobacter Infections/microbiology ; Drug Resistance, Bacterial/genetics ; Macrolides/pharmacology ; Chickens/microbiology ; Microbial Sensitivity Tests
Chemical Substances	Ciprofloxacin (5E8K9I0O4U) ; Erythromycin (63937KV33D) ; Anti-Bacterial Agents ; RNA, Ribosomal, 23S ; Macrolides
Language	English
Publishing date	2023-04-13
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2017175-4
ISSN	1678-4405 ; 1517-8382
ISSN (online)	1678-4405
ISSN	1517-8382
DOI	10.1007/s42770-023-00969-5
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Article ; Online: GLI1-Altered Mesenchymal Tumors With ACTB or PTCH1 Fusion: A Molecular and Clinicopathologic Analysis.

Kerr, Darcy A / Cloutier, Jeffrey M / Margolis, Matthew / Mata, Douglas A / Rodrigues Simoes, Nathalie J / Faquin, William C / Dias-Santagata, Dora / Chopra, Shefali / Charville, Gregory W / Wangsiricharoen, Sintawat / Lazar, Alexander J / Wang, Wei-Lien / Rosenberg, Andrew E / Tse, Julie Y

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2023 Volume 37, Issue 2, Page(s) 100386

Abstract: Mesenchymal tumors with GLI1 fusions or amplifications have recently emerged as a distinctive group of neoplasms. The terms GLI1-altered mesenchymal tumor or GLI1-altered soft tissue tumor serve as a nosological category, although the exact boundaries/ ... ...

Abstract	Mesenchymal tumors with GLI1 fusions or amplifications have recently emerged as a distinctive group of neoplasms. The terms GLI1-altered mesenchymal tumor or GLI1-altered soft tissue tumor serve as a nosological category, although the exact boundaries/criteria require further elucidation. We examined 16 tumors affecting predominantly adults (median age: 40 years), without sex predilection. Several patients had tumors of longstanding duration (>10 years). The most common primary site was soft tissue (n = 9); other sites included epidural tissue (n = 1), vertebra (n = 1), tongue (n = 1), hard palate (n = 1), and liver (n = 1). Histologically, the tumors demonstrated multinodular growth of cytologically uniform, ovoid-to-epithelioid, occasionally short spindled cells with delicate intratumoral vasculature and frequent myxoid stroma. Mitotic activity ranged from 0 to 8 mitoses/2 mm
MeSH term(s)	Adult ; Humans ; Zinc Finger Protein GLI1/genetics ; Neoplasms, Connective and Soft Tissue ; Soft Tissue Neoplasms/genetics ; Soft Tissue Neoplasms/pathology ; S100 Proteins ; Sarcoma/pathology ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/analysis
Chemical Substances	Zinc Finger Protein GLI1 ; S100 Proteins ; Biomarkers, Tumor ; GLI1 protein, human
Language	English
Publishing date	2023-11-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1016/j.modpat.2023.100386
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Article ; Online: Comparison of integrin α v β 3 expression with 68Ga-NODAGA-RGD PET/CT and glucose metabolism with 18F-FDG PET/CT in esophageal or gastroesophageal junction cancers

Matthieu Dietz / Vincent Dunet / Styliani Mantziari / Anastasia Pomoni / Ricardo Dias Correia / Nathalie Testart Dardel / Sarah Boughdad / Marie Nicod Lalonde / Giorgio Treglia / Markus Schafer / Niklaus Schaefer / John O. Prior

European Journal of Hybrid Imaging, Vol 7, Iss 1, Pp 1-

2023 Volume 13

Abstract: Abstract Background The primary aims of this study were to compare in patients with esophageal or esophagogastric junction cancers the potential of 68Ga-NODAGA-RGD PET/CT with that of 18F-FDG PET/CT regarding tumoral uptake and distribution, as well as ... ...

Abstract	Abstract Background The primary aims of this study were to compare in patients with esophageal or esophagogastric junction cancers the potential of 68Ga-NODAGA-RGD PET/CT with that of 18F-FDG PET/CT regarding tumoral uptake and distribution, as well as histopathologic examination. Methods Ten 68Ga-NODAGA-RGD and ten 18F-FDG PET/CT were performed in nine prospectively included participants (1 woman; aged 58 ± 8.4 y, range 40–69 y). Maximum SUV (SUVmax) and metabolic tumor volumes (MTV) were calculated. The Mann–Whitney U test and Spearman correlation analysis (ρ) were used. Results 68Ga-NODAGA-RGD PET/CT detected positive uptake in 10 primary sites (8 for primary tumors and 2 for local relapse suspicion), 6 lymph nodes and 3 skeletal sites. 18F-FDG PET/CT detected positive uptake in the same sites but also in 16 additional lymph nodes and 1 adrenal gland. On a lesion-based analysis, SUVmax of 18F-FDG was significantly higher than those of 68Ga-NODAGA-RGD (4.9 [3.7–11.3] vs. 3.2 [2.6–4.2] g/mL, p = 0.014). Only one participant showed a higher SUVmax in an osseous metastasis with 68Ga-NODAGA-RGD as compared to 18F-FDG (6.6 vs. 3.9 g/mL). Correlation analysis showed positive correlation between 18F-FDG and 68Ga-NODAGA-RGD PET parameters (ρ = 0.56, p = 0.012 for SUVmax, ρ = 0.78, p < 0.001 for lesion-to-background ratios and ρ = 0.58, p = 0.024 for MTV). We observed that 18F-FDG uptake was homogenous inside all the confirmed primary sites (n = 9). In contrast, 68Ga-NODAGA-RGD PET showed more heterogenous uptake in 6 out of the 9 confirmed primary sites (67%), seen mostly in the periphery of the tumor in 5 out of the 9 confirmed primary sites (56%), and showed slight extensions into perilesional structures in 5 out of the 9 confirmed primary sites (56%). Conclusions In conclusion, 68Ga-NODAGA-RGD has lower potential in the detection of esophageal or esophagogastric junction malignancies compared to 18F-FDG. However, the results suggest that PET imaging of integrin α v β 3 expression may provide complementary ...
Keywords	Esophageal cancer ; PET ; 18F-FDG ; 68Ga-NODAGA-RGD ; Integrin α v β 3 ; Angiogenesis ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	571
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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