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  1. Article: Interview: Jens Kurreck, Biochemiker aus Berlin

    Kurreck, Jens

    Laborjournal

    2005  Volume -, Issue 12, Page(s) 20

    Language German
    Document type Article
    ZDB-ID 1237282-1
    ISSN 1612-8354
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4842: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Book: Kursbuch Bioethik

    Kurreck, Jens / Beck, Birgit

    2019  

    Author's details Hrsg.: Jens Kurreck, Birgit Beck
    Keywords Bioethik
    Language German
    Size 191 Seiten, Illustrationen, 24 cm x 17 cm, 475 g
    Publisher Universitätsverlag der TU Berlin
    Publishing place Berlin
    Publishing country Germany
    Document type Book
    HBZ-ID HT020287760
    ISBN 978-3-7983-3028-3 ; 3-7983-3028-X ; 9783798330290 ; 3798330298
    Database Catalogue ZB MED Medicine, Health

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 81 available for loan (reading room) Lesesaal EG

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  3. Book: Bioanalytik

    Kurreck, Jens / Engels, Joachim W. / Lottspeich, Friedrich

    2022  

    Author's details Jens Kurreck, Joachim W. Engels, Friedrich Lottspeich, Hrsg
    Keywords Lipidanalytik ; Organ-on-a-chip ; Next Generation Sequencing ; Funktionsanalytik ; chemische Biologie ; Orbitrap ; Toponomanalyse ; Metabolomics ; Massenspektrometrie ; Proteomics ; Molekularbiologie ; Proteinanalytik ; Nucleinsäureanalytik ; Analytik ; Kohlenhydratanalytik ; Metabolomanalyse ; CRISPR-Cas ; OMICs ; Systembiologie ; Nucleotidanalytik ; Biochemische Analyse
    Subject Bioanalytische Chemie ; Bioanalytik ; Analytische Biochemie
    Language German
    Size XXXIV, 1183 Seiten, Illustrationen, 27.9 cm x 21 cm
    Edition 4. Auflage
    Publisher Springer Spektrum
    Publishing place Berlin
    Publishing country Germany
    Document type Book
    Old title Vorangegangen ist
    HBZ-ID HT020931788
    ISBN 978-3-662-61706-9 ; 3-662-61706-4 ; 9783662617076 ; 3662617072
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 A 432 available for loan (reading room) Lesesaal EG

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  4. Book: Molecular medicine

    Kurreck, Jens / Stein, Cy Aaron

    an introduction

    2016  

    Author's details Jens Kurreck and Cy Aaron Stein
    Keywords Biowissenschaften ; Cell & Molecular Biology ; Cellular & Molecular Medicine ; Chemie ; Chemistry ; Life Sciences ; Medical Science ; Medizin ; Molecular Genetics ; Molecular Pharmacology ; Molekularbiologie ; Molekulare Pharmakologie ; Molekulargenetik ; Molekularmedizin ; Molekularpharmakologie ; Zell- u. Molekularbiologie ; Zell- u. Molekularmedizin ; Molekulare Medizin
    Subject Medizin ; Genmedizin
    Language English
    Size XIV, 389 S., zahlr. Ill., 276 mm x 210 mm
    Publisher Wiley-VCH
    Publishing place Weinheim
    Publishing country Germany
    Document type Book
    HBZ-ID HT018681527
    ISBN 978-3-527-33189-5 ; 3-527-33189-1 ; 9783527675081 ; 9783527675074 ; 9783527675111 ; 3527675086 ; 3527675078 ; 3527675116
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 4276 available for loan (reading room) Lesesaal EG

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  5. Book: Therapeutic oligonucleotides

    Kurreck, Jens

    (RSC biomolecular sciences ; [12])

    2008  

    Author's details ed. by Jens Kurreck
    Series title RSC biomolecular sciences ; [12]
    Collection
    Keywords Oligonucleotides/Therapeutic use
    Subject code 615.31
    Language English
    Size XVII, 343 S. : Ill., graph. Darst.
    Publisher RSC Publ
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index ; Bandzählung einer Auflistung in Bd. 21 entnommen
    HBZ-ID HT015541153
    ISBN 978-0-85404-116-9 ; 0-85404-116-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 3424 order for loan Magazin

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  6. Article ; Online: Development of a highly stable, active small interfering RNA with broad activity against SARS-CoV viruses.

    Tolksdorf, Beatrice / Heinze, Julian / Niemeyer, Daniela / Röhrs, Viola / Berg, Johanna / Drosten, Christian / Kurreck, Jens

    Antiviral research

    2024  Volume 226, Page(s) 105879

    Abstract: Treatment options for COVID-19 remain limited. Here, we report the optimization of an siRNA targeting the highly conserved leader region of SARS-CoV-2. The siRNA was rendered nuclease resistant by the introduction of modified nucleotides without loss of ... ...

    Abstract Treatment options for COVID-19 remain limited. Here, we report the optimization of an siRNA targeting the highly conserved leader region of SARS-CoV-2. The siRNA was rendered nuclease resistant by the introduction of modified nucleotides without loss of activity. Importantly, the siRNA also retained its inhibitory activity against the emerged omicron sublineage variant BA.2, which occurred after the siRNA was designed and is resistant to other antiviral agents such as antibodies. In addition, we show that a second highly active siRNA designed against the viral 5'-UTR can be applied as a rescue molecule, to minimize the spread of escape mutations. We therefore consider our siRNA-based molecules to be promising broadly active candidates for the treatment of current and future SARS-CoV-2 variants.
    Language English
    Publishing date 2024-04-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2024.105879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Generation of a Perfusable 3D Lung Cancer Model by Digital Light Processing.

    Mei, Yikun / Wu, Dongwei / Berg, Johanna / Tolksdorf, Beatrice / Roehrs, Viola / Kurreck, Anke / Hiller, Thomas / Kurreck, Jens

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: Lung cancer still has one of the highest morbidity and mortality rates among all types of cancer. Its incidence continues to increase, especially in developing countries. Although the medical field has witnessed the development of targeted therapies, new ...

    Abstract Lung cancer still has one of the highest morbidity and mortality rates among all types of cancer. Its incidence continues to increase, especially in developing countries. Although the medical field has witnessed the development of targeted therapies, new treatment options need to be developed urgently. For the discovery of new drugs, human cancer models are required to study drug efficiency in a relevant setting. Here, we report the generation of a non-small cell lung cancer model with a perfusion system. The bioprinted model was produced by digital light processing (DLP). This technique has the advantage of including simulated human blood vessels, and its simple assembly and maintenance allow for easy testing of drug candidates. In a proof-of-concept study, we applied gemcitabine and determined the IC
    MeSH term(s) Humans ; Endothelial Cells/physiology ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/drug therapy ; Hydrogels/chemistry ; Cell Culture Techniques/methods ; Bioprinting/methods ; Printing, Three-Dimensional ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry
    Chemical Substances Hydrogels
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Clean bioprinting - Fabrication of 3D organ models devoid of animal components

    Berg, Johanna / Kurreck, Jens

    ALTEX

    2020  Volume 38, Issue 2, Page(s) 269–288

    Abstract: Bioprinting is a rapidly developing technology that enables the exact positioning of living cells embedded in bio-materials in precise spatial arrangements to fabricate engineered tissues and organs. While the ultimate goal of bio­printing approaches is ... ...

    Abstract Bioprinting is a rapidly developing technology that enables the exact positioning of living cells embedded in bio-materials in precise spatial arrangements to fabricate engineered tissues and organs. While the ultimate goal of bio­printing approaches is to produce organs for transplantation purposes, bioprinted organ models also hold great potential for research purposes to serve as alternatives to animal experiments. By using human cells, humanized organ models can be generated that may produce more relevant results for human (patho-)physiology than animal models. However, standard bioprinting procedures currently use numerous hidden animal components. Virtually all studies published in the field to date make use of cells grown in media with fetal bovine serum (FBS). In addition, Matrigel, the extracellular matrix (ECM) harvested from Engelbreth-Holm-Swarm sarcoma grown in mice, is widely employed to cultivate stem cells and 3D organ models. Finally, most bioinks currently in use contain gelatin or comparable animal components to improve cell viability and adhesion. The present review will give an introduction to the potential of bioprinting to fabricate 3D models that may be substituted for animal experiments and will go on to describe strategies to replace animal components cur­rently included in standard procedures of bioprinting. These approaches comprise the adaptation of cells to FBS-free media, the use of bioinks composed of synthetic or plant material, and the replacement of animal ingredients by materials of human origin. We propose denoting bioprinting strategies devoid of animal components as clean bioprinting.
    MeSH term(s) Animals ; Bioprinting ; Cell Survival ; Extracellular Matrix ; Mice ; Printing, Three-Dimensional ; Tissue Engineering
    Language English
    Publishing date 2020-12-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 165707-0
    ISSN 1868-596X ; 1018-4562 ; 0946-7785
    ISSN 1868-596X ; 1018-4562 ; 0946-7785
    DOI 10.14573/altex.2009151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2971: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Animal experiments: EU is pushing to find substitutes fast.

    Hippenstiel, Stefan / Thöne-Reineke, Christa / Kurreck, Jens

    Nature

    2021  Volume 600, Issue 7887, Page(s) 37

    MeSH term(s) Animal Use Alternatives/trends ; Animals ; European Union ; Humans ; Models, Animal ; Models, Biological ; Organoids ; Research Design/trends
    Language English
    Publishing date 2021-11-30
    Publishing country England
    Document type Letter
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-021-03539-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  10. Article ; Online: Xeno-Free 3D Bioprinted Liver Model for Hepatotoxicity Assessment.

    Ali, Ahmed S M / Berg, Johanna / Roehrs, Viola / Wu, Dongwei / Hackethal, Johannes / Braeuning, Albert / Woelken, Lisa / Rauh, Cornelia / Kurreck, Jens

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Three-dimensional (3D) bioprinting is one of the most promising methodologies that are currently in development for the replacement of animal experiments. Bioprinting and most alternative technologies rely on animal-derived materials, which compromises ... ...

    Abstract Three-dimensional (3D) bioprinting is one of the most promising methodologies that are currently in development for the replacement of animal experiments. Bioprinting and most alternative technologies rely on animal-derived materials, which compromises the intent of animal welfare and results in the generation of chimeric systems of limited value. The current study therefore presents the first bioprinted liver model that is entirely void of animal-derived constituents. Initially, HuH-7 cells underwent adaptation to a chemically defined medium (CDM). The adapted cells exhibited high survival rates (85-92%) after cryopreservation in chemically defined freezing media, comparable to those preserved in standard medium (86-92%). Xeno-free bioink for 3D bioprinting yielded liver models with high relative cell viability (97-101%), akin to a Matrigel-based liver model (83-102%) after 15 days of culture. The established xeno-free model was used for toxicity testing of a marine biotoxin, okadaic acid (OA). In 2D culture, OA toxicity was virtually identical for cells cultured under standard conditions and in CDM. In the xeno-free bioprinted liver model, 3-fold higher concentrations of OA than in the respective monolayer culture were needed to induce cytotoxicity. In conclusion, this study describes for the first time the development of a xeno-free 3D bioprinted liver model and its applicability for research purposes.
    MeSH term(s) Animals ; Drug-Related Side Effects and Adverse Reactions ; Chemical and Drug Induced Liver Injury ; Bioprinting ; Printing, Three-Dimensional ; Tissue Engineering ; Tissue Scaffolds
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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