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  1. Article ; Online: Variability of neonatal premedication practices for endotracheal intubation and LISA in the UK (NeoPRINT survey).

    Mimoglu, Ecem / Joyce, Katie / Mohamed, Basma / Sathiyamurthy, Sundar / Banerjee, Jay

    Early human development

    2023  Volume 183, Page(s) 105808

    Abstract: Objective: The NeoPRINT Survey was designed to assess premedication practices throughout UK NHS Trusts for both neonatal endotracheal intubation and less invasive surfactant administration (LISA).: Design: An online survey consisting of multiple ... ...

    Abstract Objective: The NeoPRINT Survey was designed to assess premedication practices throughout UK NHS Trusts for both neonatal endotracheal intubation and less invasive surfactant administration (LISA).
    Design: An online survey consisting of multiple choice and open answer questions covering preferences of premedication for endotracheal intubation and LISA was distributed over a 67-day period. Responses were then analysed using STATA IC 16.0.
    Setting: Online survey distributed to all UK Neonatal Units (NNUs).
    Participants: The survey evaluated premedication practices for endotracheal intubation and LISA in neonates requiring these procedures.
    Main outcome measures: The use of different premedication categories as well as individual medications within each category was analysed to create a picture of typical clinical practice across the UK.
    Results: The response rate for the survey was 40.8 % (78/191). Premedication was used in all hospitals for endotracheal intubation but overall, 50 % (39/78) of the units that have responded, use premedications for LISA. Individual clinician preference had an impact on premedication practices within each NNU.
    Conclusion: The wide variability on first-line premedication for endotracheal intubation noted in this survey could be overcome using best available evidence through consensus guidance driven by organisations such as British Association of Perinatal |Medicine (BAPM). Secondly, the divisive view around LISA premedication practices noted in this survey requires an answer through a randomised controlled trial.
    MeSH term(s) Infant, Newborn ; Humans ; Premedication/methods ; Surveys and Questionnaires ; Intubation, Intratracheal/methods ; Pulmonary Surfactants ; United Kingdom
    Chemical Substances Pulmonary Surfactants
    Language English
    Publishing date 2023-06-15
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 752532-1
    ISSN 1872-6232 ; 0378-3782
    ISSN (online) 1872-6232
    ISSN 0378-3782
    DOI 10.1016/j.earlhumdev.2023.105808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Continuous non-invasive measurement of cardiac output in neonatal intensive care using regional impedance cardiography: a prospective observational study.

    Banerjee, Jayanta / Khatib, Nidal / Mansfield, Roshni C / Sathiyamurthy, Sundar / Kariholu, Ujwal / Lees, Christoph

    Archives of disease in childhood. Fetal and neonatal edition

    2023  

    Abstract: Objectives: To compare agreement between echocardiography and regional impedance cardiography (RIC)-derived cardiac output (CO), and to construct indicative normative ranges of CO for gestational age groups.: Design, setting and participants: ... ...

    Abstract Objectives: To compare agreement between echocardiography and regional impedance cardiography (RIC)-derived cardiac output (CO), and to construct indicative normative ranges of CO for gestational age groups.
    Design, setting and participants: Prospective cohort observational study performed in a tertiary centre in London, UK, including neonates born between 25 and 42 weeks' gestational age.
    Exposures: Neonates on the postnatal ward had 2 hours of RIC monitoring; neonates in intensive care had RIC monitoring for the first 72 hours, then weekly for 2 hours, with concomitant echocardiography measures.
    Main outcomes and measures: RIC was used to measure CO continuously. Statistical analyses were performed using R (V.4.2.2; R Core Team 2022). RIC-derived CO and echocardiography-derived CO were compared using Pearson's correlations and Bland-Altman analyses. Differences in RIC-derived CO between infants born extremely, very and late preterm were assessed using analyses of variance and mixed-effects modelling.
    Results: 127 neonates (22 extremely, 46 very, 29 late preterm and 30 term) were included. RIC and echocardiography-measured weight-adjusted CO were correlated (r=0.62, p<0.001) with a Bland-Altman bias of -31 mL/min/kg (limits of agreement -322 to 261 mL/min/kg). The RIC-derived CO fell over 12 hours, then increased until 72 hours after birth. The 72-hour weight-adjusted mean CO was higher in extremely preterm (424±158 mL/min/kg) compared with very (325±131 mL/min/kg, p<0.001) and late preterm (237±81 mL/min/kg, p<0.001) neonates; this difference disappeared by 2-3 weeks of age.
    Conclusions: RIC is valid for continuous, non-invasive CO measurement in neonates. Indicative normative CO ranges could help clinicians to make more informed haemodynamic management decisions, which should be explored in future studies.
    Trial registration number: NCT04064177.
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2007331-8
    ISSN 1468-2052 ; 1359-2998
    ISSN (online) 1468-2052
    ISSN 1359-2998
    DOI 10.1136/archdischild-2023-325941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cardiac Output Measurement in Neonates and Children Using Noninvasive Electrical Bioimpedance Compared With Standard Methods: A Systematic Review and Meta-Analysis.

    Mansfield, Roshni C / Kaza, Nandita / Charalambous, Anna / Milne, Andrew C / Sathiyamurthy, Sundar / Banerjee, Jayanta

    Critical care medicine

    2021  Volume 50, Issue 1, Page(s) 126–137

    Abstract: Objective: To systematically review and meta-analyze the validity of electrical bioimpedance-based noninvasive cardiac output monitoring in pediatrics compared with standard methods such as thermodilution and echocardiography.: Data sources: ... ...

    Abstract Objective: To systematically review and meta-analyze the validity of electrical bioimpedance-based noninvasive cardiac output monitoring in pediatrics compared with standard methods such as thermodilution and echocardiography.
    Data sources: Systematic searches were conducted in MEDLINE and EMBASE (2000-2019).
    Study selection: Method-comparison studies of transthoracic electrical velocimetry or whole body electrical bioimpedance versus standard cardiac output monitoring methods in children (0-18 yr old) were included.
    Data extraction: Two reviewers independently performed study selection, data extraction, and risk of bias assessment. Mean differences of cardiac output, stroke volume, or cardiac index measurements were pooled using a random-effects model (R Core Team, R Foundation for Statistical Computing, Vienna, Austria, 2019). Bland-Altman statistics assessing agreement between devices and author conclusions about inferiority/noninferiority were extracted.
    Data synthesis: Twenty-nine of 649 identified studies were included in the qualitative analysis, and 25 studies in the meta-analyses. No significant difference was found between means of cardiac output, stroke volume, and cardiac index measurements, except in exclusively neonatal/infant studies reporting stroke volume (mean difference, 1.00 mL; 95% CI, 0.23-1.77). Median percentage error in child/adolescent studies approached acceptability (percentage error less than or equal to 30%) for cardiac output in L/min (31%; range, 13-158%) and stroke volume in mL (26%; range, 14-27%), but not in neonatal/infant studies (45%; range, 29-53% and 45%; range, 28-70%, respectively). Twenty of 29 studies concluded that transthoracic electrical velocimetry/whole body electrical bioimpedance was noninferior. Transthoracic electrical velocimetry was considered inferior in six of nine studies with heterogeneous congenital heart disease populations.
    Conclusions: The meta-analyses demonstrated no significant difference between means of compared devices (except in neonatal stroke volume studies). The wide range of percentage error reported may be due to heterogeneity of study designs, devices, and populations included. Transthoracic electrical velocimetry/whole body electrical bioimpedance may be acceptable for use in child/adolescent populations, but validity in neonates and congenital heart disease patients remains uncertain. Larger studies in specific clinical contexts with standardized methodologies are required.
    MeSH term(s) Adolescent ; Cardiac Output/physiology ; Cardiography, Impedance/standards ; Child ; Child, Preschool ; Echocardiography/standards ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Monitoring, Physiologic/methods ; Stroke Volume/physiology ; Thermodilution/standards
    Language English
    Publishing date 2021-07-28
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of perinatal factors on biomarkers of cardiovascular disease risk in preadolescent children.

    Mansfield, Roshni / Cecula, Paulina / Pedraz, Carmen Traseira / Zimianiti, Ioanna / Elsaddig, Malaz / Zhao, Rebecca / Sathiyamurthy, Sundar / McEniery, Carmel M / Lees, Christoph / Banerjee, Jayanta

    Journal of hypertension

    2023  Volume 41, Issue 7, Page(s) 1059–1067

    Abstract: Background: This review aims to summarize associations of the perinatal environment with arterial biophysical properties in childhood, to elucidate possible perinatal origins of adult cardiovascular disease (CVD).: Methods: A systematic search of ... ...

    Abstract Background: This review aims to summarize associations of the perinatal environment with arterial biophysical properties in childhood, to elucidate possible perinatal origins of adult cardiovascular disease (CVD).
    Methods: A systematic search of PubMed database was performed (December 2020). Studies exploring associations of perinatal factors with arterial biophysical properties in children 12 years old or less were included. Properties studied included: pulse wave velocity; arterial stiffness or distensibility; augmentation index; intima-media thickness of aorta (aIMT) or carotids; endothelial function (laser flow Doppler, flow-mediated dilatation). Two reviewers independently performed study selection and data extraction.
    Results: Fifty-two of 1084 identified records were included. Eleven studies explored associations with prematurity, 14 explored maternal factors during pregnancy, and 27 explored effects of low birth weight, small-for-gestational age and foetal growth restriction (LBW/SGA/FGR). aIMT was consistently higher in offspring affected by LBW/SGA/FGR in all six studies examining this variable. The cause of inconclusive or conflicting associations found with other arterial biophysical properties and perinatal factors may be multifactorial: in particular, measurements and analyses of related properties differed in technique, equipment, anatomical location, and covariates used.
    Conclusion: aIMT was consistently higher in LBW/SGA/FGR offspring, which may relate to increased long-term CVD risk. Larger and longer term cohort studies may help to elucidate clinical significance, particularly in relation to established CVD risk factors. Experimental studies may help to understand whether lifestyle or medical interventions can reverse perinatal changes aIMT. The field could be advanced by validation and standardization of techniques assessing arterial structure and function in children.
    MeSH term(s) Child ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Biomarkers ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/etiology ; Carotid Arteries/diagnostic imaging ; Carotid Intima-Media Thickness ; Fetal Growth Retardation ; Infant, Small for Gestational Age ; Pulse Wave Analysis ; Risk Factors ; Infant ; Child, Preschool
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-04-27
    Publishing country Netherlands
    Document type Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000003452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Biphasic positive airway pressure prevented the reintubation of extremely preterm infants more effectively than continuous positive airway pressure.

    Rallis, Dimitrios / Sathiyamurthy, Sundar / Deierl, Aniko / Atreja, Gaurav / Chaban, Badr / Banerjee, Jayanta

    Acta paediatrica (Oslo, Norway : 1992)

    2019  Volume 108, Issue 9, Page(s) 1725–1726

    MeSH term(s) Continuous Positive Airway Pressure/statistics & numerical data ; Female ; Humans ; Infant, Extremely Premature ; Infant, Newborn ; Intermittent Positive-Pressure Ventilation/statistics & numerical data ; Male ; Retrospective Studies
    Language English
    Publishing date 2019-06-17
    Publishing country Norway
    Document type Comparative Study ; Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.14875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Antiseptic use in the neonatal intensive care unit - a dilemma in clinical practice: An evidence based review.

    Sathiyamurthy, Sundar / Banerjee, Jayanta / Godambe, Sunit V

    World journal of clinical pediatrics

    2016  Volume 5, Issue 2, Page(s) 159–171

    Abstract: Infants in the neonatal intensive care unit are highly susceptible to healthcare associated infections (HAI), with a substantial impact on mortality, morbidity and healthcare costs. Effective skin disinfection with topical antiseptic agents is an ... ...

    Abstract Infants in the neonatal intensive care unit are highly susceptible to healthcare associated infections (HAI), with a substantial impact on mortality, morbidity and healthcare costs. Effective skin disinfection with topical antiseptic agents is an important intervention in the prevention or reduction of HAI. A wide array of antiseptic preparations in varying concentrations and combinations has been used in neonatal units worldwide. In this article we have reviewed the current evidence of a preferred antiseptic of choice over other agents for topical skin disinfection in neonates. Chlorhexidine (CHG) appears to be a promising antiseptic agent; however there exists a significant concern regarding the safety of all agents used including CHG especially in preterm and very low birth weight infants. There is substantial evidence to support the use of CHG for umbilical cord cleansing and some evidence to support the use of topical emollients in reducing the mortality in infants born in developing countries. Well-designed large multicentre randomized clinical trials are urgently needed to guide us on the most appropriate and safe antiseptic to use in neonates undergoing intensive care, especially preterm infants.
    Language English
    Publishing date 2016-05-08
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2219-2808
    ISSN 2219-2808
    DOI 10.5409/wjcp.v5.i2.159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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