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  1. Article ; Online: Neuronal Plasticity and Age-Related Functional Decline in the Motor Cortex.

    Inoue, Ritsuko / Nishimune, Hiroshi

    Cells

    2023  Volume 12, Issue 17

    Abstract: Physiological aging causes a decline of motor function due to impairment of motor cortex function, losses of motor neurons and neuromuscular junctions, sarcopenia, and frailty. There is increasing evidence suggesting that the changes in motor function ... ...

    Abstract Physiological aging causes a decline of motor function due to impairment of motor cortex function, losses of motor neurons and neuromuscular junctions, sarcopenia, and frailty. There is increasing evidence suggesting that the changes in motor function start earlier in the middle-aged stage. The mechanism underlining the middle-aged decline in motor function seems to relate to the central nervous system rather than the peripheral neuromuscular system. The motor cortex is one of the responsible central nervous systems for coordinating and learning motor functions. The neuronal circuits in the motor cortex show plasticity in response to motor learning, including LTP. This motor cortex plasticity seems important for the intervention method mechanisms that revert the age-related decline of motor function. This review will focus on recent findings on the role of plasticity in the motor cortex for motor function and age-related changes. The review will also introduce our recent identification of an age-related decline of neuronal activity in the primary motor cortex of middle-aged
    MeSH term(s) Animals ; Mice ; Aging ; Brain ; Motor Cortex ; Neuronal Plasticity
    Language English
    Publishing date 2023-08-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12172142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Role of the nucleotide-binding oligomerization domain-containing protein 1 pathway in the development of periodontitis.

    Mao, Dan / Inoue, Hiroshi / Goda, Seiji

    Journal of oral biosciences

    2024  Volume 66, Issue 1, Page(s) 105–111

    Abstract: Objectives: During innate immune defense, host pattern recognition receptors, including toll-like receptors and nucleotide-binding oligomerization domain-like receptors (NLRs), can activate downstream pathways by recognizing pathogen-associated ... ...

    Abstract Objectives: During innate immune defense, host pattern recognition receptors, including toll-like receptors and nucleotide-binding oligomerization domain-like receptors (NLRs), can activate downstream pathways by recognizing pathogen-associated molecular patterns produced by microorganisms, triggering immune responses. NOD1, an important cell membrane protein in the NLR-like receptor protein family, exerts anti-infective effects through γ-D-glutamyl-meso-diaminopimelic acid (iE-DAP) recognition. Oral epithelial cells resist bacterial invasion through iE-DAP-induced interleukin (IL)-8 production, recruiting neutrophils to sites of inflammation in response to bacterial threats to periodontal tissues. To date, the regulatory mechanisms of iE-DAP in gingival epithelial cells (GECs) are poorly understood. This study was conducted to investigate the role of the NOD1 pathway in the development of periodontitis by examining the effect of iE-DAP on IL-8 production in Ca9-22 cells.
    Methods: IL-8 production by iE-DAP-stimulated-Ca9-22 cells was assessed using an enzyme-linked immunosorbent assay. Phosphorylation levels of intracellular signaling molecules were evaluated using western blot analyses.
    Results: iE-DAP induced NOD1 receptor expression in Ca9-22 cells. Additionally, iE-DAP induced expression of pro-IL-1β protein without extracellular secretion. Our results suggest that iE-DAP regulates IL-8 production by activating p38 mitogen-activated protein kinase (MAPK) and ERK1/2 signaling pathways. iE-DAP also promoted nuclear factor kappa-B p65 phosphorylation, facilitating its nuclear translocation. Notably, p38 MAPK and ERK1/2 inhibitors suppressed iE-DAP-stimulated IL-8 production, suggesting that JNK is not involved in this mechanism.
    Conclusions: Our results indicate that p38 MAPK and ERK1/2, but not JNK, are involved in innate immune responses in GECs.
    MeSH term(s) Humans ; Interleukin-8 ; Periodontitis ; Nucleotides ; p38 Mitogen-Activated Protein Kinases ; Diaminopimelic Acid/analogs & derivatives
    Chemical Substances Interleukin-8 ; N(2)-(gamma-D-glutamyl)-meso-2,2'-diaminopimelic acid (71974-09-9) ; Nucleotides ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Diaminopimelic Acid (583-93-7)
    Language English
    Publishing date 2024-01-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2218267-6
    ISSN 1880-3865 ; 1349-0079
    ISSN (online) 1880-3865
    ISSN 1349-0079
    DOI 10.1016/j.job.2023.12.008
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  3. Article: [Microneurosurgical Anatomy of the Posterior fossa and Craniocervical Junction].

    Abe, Hiroshi / Inoue, Tooru

    No shinkei geka. Neurological surgery

    2022  Volume 50, Issue 3, Page(s) 525–534

    Abstract: The posterior fossa is a site where blood vessels and nerves are very dense, so surgery can be very difficult. Therefore, serious sequelae may occur due to complications. Surgeons should be familiar with the complex anatomy of the posterior fossa. This ... ...

    Abstract The posterior fossa is a site where blood vessels and nerves are very dense, so surgery can be very difficult. Therefore, serious sequelae may occur due to complications. Surgeons should be familiar with the complex anatomy of the posterior fossa. This paper outlines the anatomy of the bone, brain, and nerves involved in the surgical approach from the lateral posterior to the cerebellar pontine angle and foramen magnum.
    MeSH term(s) Brain ; Cerebellum ; Cranial Fossa, Posterior/surgery ; Foramen Magnum/surgery ; Humans ; Pons
    Language Japanese
    Publishing date 2022-06-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 197053-7
    ISSN 1882-1251 ; 0301-2603
    ISSN (online) 1882-1251
    ISSN 0301-2603
    DOI 10.11477/mf.1436204583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1834: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 268: Show issues

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  4. Article ; Online: Demonstration of wavelength-swept laser using cholesteric liquid-crystal cavity and its application for laser scanning.

    Inoue, Yo / Moritake, Hiroshi

    Optics letters

    2022  Volume 47, Issue 6, Page(s) 1303–1306

    Abstract: A cholesteric liquid-crystal gel (ChLCG) is fabricated by photopolymerizing a ChLC doped with a mesogenic monomer at a high concentration of 38.2 wt%. The reflection band of the ChLCG exhibits a fast, continuous, and time-varying wavelength shift of the ... ...

    Abstract A cholesteric liquid-crystal gel (ChLCG) is fabricated by photopolymerizing a ChLC doped with a mesogenic monomer at a high concentration of 38.2 wt%. The reflection band of the ChLCG exhibits a fast, continuous, and time-varying wavelength shift of the order of kilohertz by applying a sine wave voltage. Swept lasing at a swept rate of 100 Hz and with a swept range of 12 nm can be achieved by irradiating a dye-doped ChLCG with a quasi-continuous-wave laser. When the swept laser light is introduced to a diffracting grating, a laser scanning device is demonstrated.
    Language English
    Publishing date 2022-03-15
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.451543
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  5. Article: Elevation of tacrolimus concentration after administration of methotrexate for treatment of graft-versus-host disease in pediatric patients received allogeneic hematopoietic stem cell transplantation.

    Inoue, Chiaki / Yamamoto, Takehito / Miyata, Hiroshi / Suzuki, Hiroshi / Takada, Tappei

    Journal of pharmaceutical health care and sciences

    2023  Volume 9, Issue 1, Page(s) 38

    Abstract: Background: Methotrexate (MTX) is used to treat graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recently, a case was encountered in which the blood concentration of tacrolimus (TCR) at steady ... ...

    Abstract Background: Methotrexate (MTX) is used to treat graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recently, a case was encountered in which the blood concentration of tacrolimus (TCR) at steady state increased after intravenous MTX administration for GVHD treatment (therapeutic IV-MTX administration). Therefore, this study aimed to investigate the effect of therapeutic IV-MTX administration on the pharmacokinetics of TCR.
    Methods: This single-center, retrospective, observational study included patients who underwent allo-HSCT and received therapeutic IV-MTX administration during immunosuppressive therapy with continuous intravenous infusion (CIV) of TCR from April 2004 to December 2021. Here, each therapeutic IV-MTX administration was defined as a case and independently subjected to subsequent analyses. The blood concentration of TCR at steady state (C
    Results: Ten patients (23 cases) were included in this study. The C/D value significantly increased after therapeutic IV-MTX administration (median: 697 vs. 771 (ng/mL)/(mg/kg), 1.16-fold increase, P < 0.05), indicating a reduction in the apparent clearance of TCR. Along with the increase in C/D, significant increases were observed in aspartate transaminase level (median: 51.0 vs. 92.9 U/L, P < 0.01) and alanine aminotransferase level (median: 74.5 vs. 99.4 U/L, P < 0.01) indicating that liver injury after therapeutic IV-MTX administration contributes to the observed C/D increase. In addition, the daily dose of TCR was reduced in 11 cases (47.8%) after therapeutic IV-MTX administration, and the relative frequency of dose reduction tended to be higher than that of dose increase (median: 37.5% vs. 0.0%, P = 0.0519, permuted Brunner-Munzel test). The magnitude of dose reduction was 18.8% (7.4-50.0%) in the 11 cases with dose reduction.
    Conclusions: Therapeutic IV-MTX administration cause a significant increase in C/D, which requires TCR dose reduction. Careful therapeutic drug monitoring of TCR is needed after therapeutic IV-MTX administration in patients receiving immunosuppressive therapy with TCR after allo-HSCT.
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2809913-8
    ISSN 2055-0294
    ISSN 2055-0294
    DOI 10.1186/s40780-023-00306-w
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  6. Article: Successful repositioning of the subcutaneous implantable cardioverter-defibrillator lead to avoid inappropriate shock.

    Fukunaga, Hiroshi / Inoue, Kanki / Sekiguchi, Yukio / Nitta, Junichi / Isobe, Mitsuaki

    Journal of arrhythmia

    2023  Volume 39, Issue 1, Page(s) 74–77

    Language English
    Publishing date 2023-01-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2696593-8
    ISSN 1883-2148 ; 1880-4276
    ISSN (online) 1883-2148
    ISSN 1880-4276
    DOI 10.1002/joa3.12805
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  7. Article ; Online: Coenzyme Q

    Inoue, Ritsuko / Miura, Masami / Yanai, Shuichi / Nishimune, Hiroshi

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 4323

    Abstract: Physiological aging causes motor function decline and anatomical and biochemical changes in the motor cortex. We confirmed that middle-aged mice at 15-18 months old show motor function decline, which can be restored to the young adult level by ... ...

    Abstract Physiological aging causes motor function decline and anatomical and biochemical changes in the motor cortex. We confirmed that middle-aged mice at 15-18 months old show motor function decline, which can be restored to the young adult level by supplementing with mitochondrial electron transporter coenzyme Q
    MeSH term(s) Humans ; Middle Aged ; Young Adult ; Mice ; Animals ; Infant ; Ubiquinone/pharmacology ; Ubiquinone/metabolism ; Motor Cortex/metabolism ; Mitochondria/metabolism ; Neurons/metabolism ; Dietary Supplements
    Chemical Substances Ubiquinone (1339-63-5)
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-31510-1
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  8. Article: A Case of Cervical Squamous Cell Carcinoma Developing 33 Years After Conization.

    Inoue, Kayo / Tsubamoto, Hiroshi / Narita, Sachiyo / Yoshida, Makoto / Yoshiyasu, Kanako

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52271

    Abstract: We report a fatal case of early postoperative peritoneal dissemination in a patient who was diagnosed with cervical squamous cell carcinoma after laparoscopic hysterectomy for hematometra. A 73-year-old multiparous woman with pyometra and lower abdominal ...

    Abstract We report a fatal case of early postoperative peritoneal dissemination in a patient who was diagnosed with cervical squamous cell carcinoma after laparoscopic hysterectomy for hematometra. A 73-year-old multiparous woman with pyometra and lower abdominal pain was referred to our hospital. Her medical history was remarkable for four open surgeries and conization at the age of 40 years. The cytology obtained from the mucosa of the palpated cervix was negative. The cytology and bacterial culture of the mucus collected from the uterine cavity were negative. Increasing fluid accumulation in the uterine cavity started to cause severe abdominal pain. A laparoscopy was performed. The small intestine showed extensive adhesions to the abdominal wall, which were dissected. A total hysterectomy was performed, and the uterus was placed in a collection bag, cut inside the bag, and retrieved transvaginally. Histopathological examination revealed nests of squamous cell carcinoma that replaced the entire uterine myometrium, and the tumor cells showed diffuse positivity for p16 on immunostaining. The patient was diagnosed with squamous cell carcinoma of the uterine cervix with invasion of the uterine myometrium. Three months later, the patient suffered from small bowel obstruction. A laparotomy was performed, and it revealed numerous disseminated lesions in the pelvic peritoneum and mesentery of the small intestine. Bypass surgery was performed. A biopsy of a disseminated lesion near the vaginal cuff revealed squamous cell carcinoma. The patient died within three weeks of bypass surgery.
    Language English
    Publishing date 2024-01-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52271
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  9. Article ; Online: A Quantitative Computed Tomography Analysis of Fissure Integrity and Emphysema Destruction in Japanese Patients with Severe Chronic Obstructive Pulmonary Disease.

    Mineshita, Masamichi / Nishine, Hiroki / Handa, Hiroshi / Kida, Hirotaka / Inoue, Takeo

    Internal medicine (Tokyo, Japan)

    2024  

    Abstract: Objective Bronchoscopic lung volume reduction (BLVR) using a one-way endobronchial valve (EBV) can provide clinically meaningful benefits to chronic obstructive pulmonary disease (COPD) patients. Although the Japanese Pharmaceuticals and Medical Devices ... ...

    Abstract Objective Bronchoscopic lung volume reduction (BLVR) using a one-way endobronchial valve (EBV) can provide clinically meaningful benefits to chronic obstructive pulmonary disease (COPD) patients. Although the Japanese Pharmaceuticals and Medical Devices Agency approved EBVs in November 2022, information regarding the number of Japanese patients with severe COPD eligible for BLVR treatment is still lacking. We therefore screened computed tomography (CT) images of patients with severe COPD using a quantitative CT (QCT) analysis to estimate the proportion of candidates eligible for BLVR treatment with an EBV. Methods CT scans of COPD patients with Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 3 and 4 were retrospectively analyzed using QCT to evaluate fissure integrity and tissue destruction. The difference in volume-weighted percentage was measured using the density scores of the target lobe and ipsilateral non-target lobe at -910 Hounsfield units. The target lobe was defined as the most affected lobe, with an emphysema destruction score of >50% for each patient. Results High-resolution CT scans of 32 patients (GOLD 3=19, GOLD 4=13) were analyzed. The target lobe could not be identified in 1 patient, whereas the target lobes for 8 patients were not surrounded by fissures with ≥80% completeness. Conversely, in 13 patients, the target lobes were surrounded by fissures with >95% completeness. The remaining 10 patients had fissure completeness between 80% and 95% at the target lobes and were considered candidates for collateral ventilation assessment. Conclusion A QCT analysis showed that 23 of 32 patients with severe COPD could be considered for a thorough examination of BLVR treatment with EBV.
    Language English
    Publishing date 2024-01-02
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.2250-23
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Improvement of Broad-Spectrum Disease-Resistant Rice by the Overexpression of

    Maeda, Satoru / Goto, Shingo / Inoue, Haruhiko / Suwazono, Haruka / Takatsuji, Hiroshi / Mori, Masaki

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 8

    Abstract: Conferring crops with resistance to multiple diseases is crucial for stable food production. Genetic engineering is an effective means of achieving this. The rice receptor-like cytoplasmic kinase BSR1 mediates microbe-associated molecular pattern-induced ...

    Abstract Conferring crops with resistance to multiple diseases is crucial for stable food production. Genetic engineering is an effective means of achieving this. The rice receptor-like cytoplasmic kinase BSR1 mediates microbe-associated molecular pattern-induced immunity. In our previous study, we demonstrated that rice lines overexpressing
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13081138
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