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Book ; Audio / Video: One of the mad ones, Daniel E. DeSole, M.D

Singer, Philip

2011

Abstract: One Of the Mad Ones is a documentary history of a boarded New York psychiatrist, beloved by his patients, who rejects modern psychopharmacology in favor of human interaction. He's shown with patients previously 'dumbed down' with drugs, using his own ... ...

Title variant	Daniel E. DeSole, M.D.
Author's details	a documenary by Philip Singer
Abstract	"One Of the Mad Ones is a documentary history of a boarded New York psychiatrist, beloved by his patients, who rejects modern psychopharmacology in favor of human interaction. He's shown with patients previously 'dumbed down' with drugs, using his own unique interpersonal techniques. After suffering a heart attack, he recapitulates his career and explains why he is living in a state of dread."--DVD container.
MeSH term(s)	Physicians ; Mental Disorders/therapy ; Psychiatry ; Mental Health Services
Keywords	United States
Language	English
Size	1 videodisc (99 min.) :, DVD video, color, sound ;, 4 3/4 in.
Document type	Book ; Audio / Video
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: Development and Validation of an Intracranial Hemorrhage Risk Score in Older Adults with Atrial Fibrillation Treated with Oral Anticoagulant.

Bessette, Lily G / Singer, Daniel E / Pawar, Ajinkya / Wong, Vincent / Kim, Dae Hyun / Lin, Kueiyu Joshua

Clinical epidemiology

2024 Volume 16, Page(s) 267–279

Abstract: Background: High risk of intracranial hemorrhage (ICH) is a leading reason for withholding anticoagulation in patients with atrial fibrillation (AF). We aimed to develop a claims-based ICH risk prediction model in older adults with AF initiating oral ... ...

Abstract	Background: High risk of intracranial hemorrhage (ICH) is a leading reason for withholding anticoagulation in patients with atrial fibrillation (AF). We aimed to develop a claims-based ICH risk prediction model in older adults with AF initiating oral anticoagulation (OAC). Methods: We used US Medicare claims data to identify new users of OAC aged ≥65 years with AF in 2010-2017. We used regularized Cox regression to select predictors of ICH. We compared our AF ICH risk score with the HAS-BLED bleed risk and Homer fall risk scores by area under the receiver operating characteristic curve (AUC) and assessed net reclassification improvement (NRI) when predicting 1-year risk of ICH. Results: Our study cohort comprised 840,020 patients (mean [SD] age 77.5 [7.4] years and female 52.2%) split geographically into training (3963 ICH events [0.6%] in 629,804 patients) and validation (1397 ICH events [0.7%] in 210,216 patients) sets. Our AF ICH risk score, including 50 predictors, had superior AUCs of 0.653 and 0.650 in the training and validation sets than the HAS-BLED score of 0.580 and 0.567 ( Conclusion: Our novel claims-based ICH risk prediction model outperformed the standard HAS-BLED score and can inform OAC prescribing decisions.
Language	English
Publishing date	2024-04-17
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494772-6
ISSN	1179-1349
ISSN	1179-1349
DOI	10.2147/CLEP.S438013
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Brain MRI microbleeds and risk of intracranial hemorrhage in atrial fibrillation patients: A Swedish case-control study.

Aspberg, Sara / Cheng, David / von Heijne, Anders / Gigante, Bruna / Singer, Daniel E

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2024 Volume 33, Issue 4, Page(s) 107629

Abstract: Objectives: Our goal was to quantify the independent association of brain microbleeds with future intracranial hemorrhage (ICrH). Microbleed findings on brain magnetic resonance imaging (MRI) may identify distinctive risk factors for ICrH which could ... ...

Abstract	Objectives: Our goal was to quantify the independent association of brain microbleeds with future intracranial hemorrhage (ICrH). Microbleed findings on brain magnetic resonance imaging (MRI) may identify distinctive risk factors for ICrH which could inform the anticoagulant therapy decision for atrial fibrillation (AF) patients. Our study design includes patients with MRIs for numerous reasons, not limited to evaluation of stroke. Materials and methods: The source population was all patients with AF from a nationwide Swedish health care register. Case patients had an ICrH between 2006 and 2013 and ≥1 brain MRI for an unrelated condition before the ICrH. Each case was matched to four controls who had a brain MRI without a subsequent ICrH. The MRIs were re-reviewed by neuroradiologists. Associations between MRI findings and subsequent ICrH were assessed using logistic regression, adjusting for comorbidities and antithrombotic medications. Results: A total of 78 cases and 312 matched controls were identified; 29 cases and 79 controls had MRI sequences suitable for analysis of microbleeds. Patients with ≥10 microbleeds had a markedly increased risk of ICrH (adjusted odds ratio 14.56; 95 % confidence interval: 2.86-74.16, p < 0.001). All patients with ≥10 microbleeds had microbleeds in the lobar region and ≥10 lobar microbleeds was associated with intracerebral hemorrhages, univariable OR 8.54 (2.01-36.33), p = 0.004. Conclusions: Leveraging a nationwide database with brain imaging obtained prior to ICrH, we identified a strong association between ≥10 microbleeds on brain MRI and subsequent ICrH among AF patients. Lobar brain regions were involved whenever there were ≥10 microbleeds. Brain MRIs may help optimize the anticoagulation decision in selected AF patients.
MeSH term(s)	Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/drug therapy ; Case-Control Studies ; Sweden/epidemiology ; Intracranial Hemorrhages/etiology ; Intracranial Hemorrhages/complications ; Brain/pathology ; Stroke/epidemiology ; Cerebral Hemorrhage/etiology ; Cerebral Hemorrhage/complications ; Magnetic Resonance Imaging/adverse effects ; Risk Factors
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1131675-5
ISSN	1532-8511 ; 1052-3057
ISSN (online)	1532-8511
ISSN	1052-3057
DOI	10.1016/j.jstrokecerebrovasdis.2024.107629
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Zs.A 3519: Show issues

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Article ; Online: Healthcare Resource Utilization Following Single-lead Electrocardiogram Screening for Atrial Fibrillation in Older Individuals at Primary Care Visits.

Atlas, Steven J / Borowsky, Leila H / Chang, Yuchiao / Ashburner, Jeffrey M / Ellinor, Patrick T / Lubitz, Steven A / Singer, Daniel E

Journal of general internal medicine

2024

Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Letter
ZDB-ID	639008-0
ISSN	1525-1497 ; 0884-8734
ISSN (online)	1525-1497
ISSN	0884-8734
DOI	10.1007/s11606-024-08733-7
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Zs.A 2205: Show issues

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Article ; Online: The power of public-private partnership in medical technology innovation: Lessons from the development of FDA-cleared medical devices for assessment of concussion.

Singer, Michael E / Hack, Dallas C / Hanley, Daniel F

Journal of clinical and translational science

2022 Volume 6, Issue 1, Page(s) e42

Abstract: Given the convergence of the long and challenging development path for medical devices with the need for diagnostic capabilities for mild traumatic brain injury (mTBI/concussion), the effective role of public-private partnership (PPP) can be demonstrated ...

Abstract	Given the convergence of the long and challenging development path for medical devices with the need for diagnostic capabilities for mild traumatic brain injury (mTBI/concussion), the effective role of public-private partnership (PPP) can be demonstrated to yield Food and Drug Administration (FDA) clearances and innovative product introductions. An overview of the mTBI problem and landscape was performed. A detailed situation analysis of an example of a PPP yielding an innovative product was further demonstrated. The example of PPP has led to multiple FDA clearances and product introductions in the TBI diagnostic product category where there was an urgent military and public need. Important lessons included defining the primary public and military health objective for new product introduction, the importance of the government-academia-industry PPP triad with a "collaboration towards solutions" Quality-by-Design (QbD) mindset to assure clinical validity with regulatory compliance, the development of device comparators and integration of measurements into a robust, evidence-based statistical and FDA pathway, and the utility of top-down, flexible, practical action while operating within governmental guidelines and patient safety.
Language	English
Publishing date	2022-03-10
Publishing country	England
Document type	Journal Article ; Review
ISSN	2059-8661
ISSN (online)	2059-8661
DOI	10.1017/cts.2022.373
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Lifestyle Modification Program for Secondary Prevention of Atrial Fibrillation: Introductory Findings.

Ashburner, Jeffrey M / Carmichael, Taylor D / Bhattacharya, Romit / Natarajan, Pradeep / Singer, Daniel E / Thorndike, Anne N

Journal of cardiopulmonary rehabilitation and prevention

2023 Volume 44, Issue 2, Page(s) 143–145

MeSH term(s)	Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/prevention & control ; Secondary Prevention ; Life Style ; Risk Factors ; Stroke/complications
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2272063-7
ISSN	1932-751X ; 1932-7501
ISSN (online)	1932-751X
ISSN	1932-7501
DOI	10.1097/HCR.0000000000000853
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1998: Show issues

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Article ; Online: Stroke Rate Variation and Anticoagulation Benefit in Atrial Fibrillation.

Shah, Sachin J / Singer, Daniel E

Annals of internal medicine

2019 Volume 170, Issue 11, Page(s) 818–819

MeSH term(s)	Anticoagulants ; Atrial Fibrillation ; Humans ; Stroke
Chemical Substances	Anticoagulants
Language	English
Publishing date	2019-06-04
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/L19-0130
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Ua VI Zs.178/2: Show issues

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Article ; Online: Prescribing Trends of Oral Anticoagulants in US Patients With Cirrhosis and Nonvalvular Atrial Fibrillation.

Simon, Tracey G / Schneeweiss, Sebastian / Singer, Daniel E / Sreedhara, Sushama Kattinakere / Lin, Kueiyu Joshua

Journal of the American Heart Association

2023 Volume 12, Issue 3, Page(s) e026863

Abstract: Background Many patients with cirrhosis have concurrent nonvalvular atrial fibrillation (NVAF). Data are lacking regarding recent oral anticoagulant (OAC) usage trends among US patients with cirrhosis and NVAF. Methods and Results Using MarketScan claims ...

Abstract	Background Many patients with cirrhosis have concurrent nonvalvular atrial fibrillation (NVAF). Data are lacking regarding recent oral anticoagulant (OAC) usage trends among US patients with cirrhosis and NVAF. Methods and Results Using MarketScan claims data (2012-2019), we identified patients with cirrhosis and NVAF eligible for OACs (CHA
MeSH term(s)	Aged ; Female ; Humans ; Male ; Administration, Oral ; Anticoagulants/therapeutic use ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/epidemiology ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/epidemiology ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Retrospective Studies ; Stroke/diagnosis ; Thrombocytopenia/epidemiology ; Warfarin/therapeutic use ; United States
Chemical Substances	Anticoagulants ; Warfarin (5Q7ZVV76EI)
Language	English
Publishing date	2023-01-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.122.026863
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prevalence and Incidence of Atrial Fibrillation Among Older Primary Care Patients.

Khurshid, Shaan / Ashburner, Jeffrey M / Ellinor, Patrick T / McManus, David D / Atlas, Steven J / Singer, Daniel E / Lubitz, Steven A

JAMA network open

2023 Volume 6, Issue 2, Page(s) e2255838

MeSH term(s)	Humans ; Atrial Fibrillation/epidemiology ; Incidence ; Prevalence ; Risk Factors ; Primary Health Care
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2022.55838
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The power of public–private partnership in medical technology innovation

Michael E. Singer / Dallas C. Hack / Daniel F. Hanley

Journal of Clinical and Translational Science, Vol

Lessons from the development of FDA-cleared medical devices for assessment of concussion

2022 Volume 6

Abstract	Given the convergence of the long and challenging development path for medical devices with the need for diagnostic capabilities for mild traumatic brain injury (mTBI/concussion), the effective role of public–private partnership (PPP) can be demonstrated to yield Food and Drug Administration (FDA) clearances and innovative product introductions. An overview of the mTBI problem and landscape was performed. A detailed situation analysis of an example of a PPP yielding an innovative product was further demonstrated. The example of PPP has led to multiple FDA clearances and product introductions in the TBI diagnostic product category where there was an urgent military and public need. Important lessons included defining the primary public and military health objective for new product introduction, the importance of the government–academia–industry PPP triad with a “collaboration towards solutions” Quality-by-Design (QbD) mindset to assure clinical validity with regulatory compliance, the development of device comparators and integration of measurements into a robust, evidence-based statistical and FDA pathway, and the utility of top-down, flexible, practical action while operating within governmental guidelines and patient safety.
Keywords	Medical technology ; concussion ; medical devices ; traumatic brain injury (TBI) ; medical technology innovation ; medical device development ; innovation ; development ; Medicine ; R
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Cambridge University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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