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Article ; Online: An Evaluation of the Impact of Air Pollution on the Lung Functions of High School Students Living in a Ceramic Industrial Park Zone.

Mizutani, Rafael Futoshi / de Paula Santos, Ubiratan / Arbex, Renata Ferlin / Arbex, Marcos Abdo / Terra-Filho, Mario

International journal of environmental research and public health

2023 Volume 20, Issue 21

Abstract: Santa Gertrudes (SG) and Rio Claro (RC), Sao Paulo, Brazil, are located in a ceramic industrial park zone, and their particulate matter with an aerodynamic diameter of less than 10 µm ( ... ...

Abstract	Santa Gertrudes (SG) and Rio Claro (RC), Sao Paulo, Brazil, are located in a ceramic industrial park zone, and their particulate matter with an aerodynamic diameter of less than 10 µm (PM
MeSH term(s)	Humans ; Air Pollutants/analysis ; Cross-Sectional Studies ; Environmental Exposure/analysis ; Brazil/epidemiology ; Air Pollution/analysis ; Lung ; Particulate Matter/analysis ; Forced Expiratory Volume ; Students ; Silicon Dioxide/analysis
Chemical Substances	Air Pollutants ; Particulate Matter ; Silicon Dioxide (7631-86-9)
Language	English
Publishing date	2023-10-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20216964
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Article ; Online: Environmental air pollution: respiratory effects.

Santos, Ubiratan de Paula / Arbex, Marcos Abdo / Braga, Alfésio Luis Ferreira / Mizutani, Rafael Futoshi / Cançado, José Eduardo Delfini / Terra-Filho, Mário / Chatkin, José Miguel

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

2021 Volume 47, Issue 1, Page(s) e20200267

Abstract: Environmental air pollution is a major risk factor for morbidity and mortality worldwide. Environmental air pollution has a direct impact on human health, being responsible for an increase in the incidence of and number of deaths due to cardiopulmonary, ... ...

Abstract	Environmental air pollution is a major risk factor for morbidity and mortality worldwide. Environmental air pollution has a direct impact on human health, being responsible for an increase in the incidence of and number of deaths due to cardiopulmonary, neoplastic, and metabolic diseases; it also contributes to global warming and the consequent climate change associated with extreme events and environmental imbalances. In this review, we present articles that show the impact that exposure to different sources and types of air pollutants has on the respiratory system; we present the acute effects-such as increases in symptoms and in the number of emergency room visits, hospitalizations, and deaths-and the chronic effects-such as increases in the incidence of asthma, COPD, and lung cancer, as well as a rapid decline in lung function. The effects of air pollution in more susceptible populations and the effects associated with physical exercise in polluted environments are also presented and discussed. Finally, we present the major studies on the subject conducted in Brazil. Health care and disease prevention services should be aware of this important risk factor in order to counsel more susceptible individuals about protective measures that can facilitate their treatment, as well as promoting the adoption of environmental measures that contribute to the reduction of such emissions.
MeSH term(s)	Air Pollutants/adverse effects ; Air Pollution/adverse effects ; Asthma ; Brazil ; Humans ; Respiratory System
Chemical Substances	Air Pollutants
Language	Portuguese
Publishing date	2021-02-08
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2223157-2
ISSN	1806-3756 ; 1806-3713
ISSN (online)	1806-3756
ISSN	1806-3713
DOI	10.36416/1806-3756/e20200267
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Article ; Online: Relationship between air pollution and hospitalizations for congestive heart failure in elderly people in the city of São Paulo.

de Aguiar Pontes Pamplona, Ysabely / Arbex, Marcos Abdo / Braga, Alfésio Luís Ferreira / Pereira, Luiz Alberto Amador / Martins, Lourdes Conceição

Environmental science and pollution research international

2020 Volume 27, Issue 15, Page(s) 18208–18220

Abstract: To evaluate the effects of air pollutants on hospitalizations of elderly people for congestive heart failure (CHF) in the city of São Paulo, stratified by sex, exploring lag structures, from 2000 to 2013. Ecological time series study using information on ...

Abstract	To evaluate the effects of air pollutants on hospitalizations of elderly people for congestive heart failure (CHF) in the city of São Paulo, stratified by sex, exploring lag structures, from 2000 to 2013. Ecological time series study using information on hospitalization of elderly patients for CHF (ICD-10th: I50) obtained from DATASUS for the city of São Paulo. Information on O
MeSH term(s)	Aged ; Air Pollutants/analysis ; Air Pollution/analysis ; Heart Failure ; Hospitalization ; Humans ; Particulate Matter/analysis ; Time Factors
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2020-03-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-020-08216-2
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Article ; Online: The challenge of managing extensively drug-resistant tuberculosis at a referral hospital in the state of São Paulo, Brazil: a report of three cases.

Arbex, Marcos Abdo / Siqueira, Hélio Ribeiro de / D'Ambrosio, Lia / Migliori, Giovanni Battista

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

2016 Volume 41, Issue 6, Page(s) 554–559

Abstract: Here, we report the cases of three patients diagnosed with extensively drug-resistant tuberculosis and admitted to a referral hospital in the state of São Paulo, Brazil, showing the clinical and radiological evolution, as well as laboratory test results, ...

Abstract	Here, we report the cases of three patients diagnosed with extensively drug-resistant tuberculosis and admitted to a referral hospital in the state of São Paulo, Brazil, showing the clinical and radiological evolution, as well as laboratory test results, over a one-year period. Treatment was based on the World Health Organization guidelines, with the inclusion of a new proposal for the use of a combination of antituberculosis drugs (imipenem and linezolid). In the cases studied, we show the challenge of creating an acceptable, effective treatment regimen including drugs that are more toxic, are more expensive, and are administered for longer periods. We also show that treatment costs are significantly higher for such patients, which could have an impact on health care systems, even after hospital discharge. We highlight the fact that in extreme cases, such as those reported here, hospitalization at a referral center seems to be the most effective strategy for providing appropriate treatment and increasing the chance of cure. In conclusion, health professionals and governments must make every effort to prevent cases of multidrug-resistant and extensively drug-resistant tuberculosis.
MeSH term(s)	Adult ; Antitubercular Agents/therapeutic use ; Brazil ; Extensively Drug-Resistant Tuberculosis/drug therapy ; Female ; Hospitalization ; Humans ; Imipenem/therapeutic use ; Linezolid/therapeutic use ; Male
Chemical Substances	Antitubercular Agents ; Imipenem (71OTZ9ZE0A) ; Linezolid (ISQ9I6J12J)
Language	Portuguese
Publishing date	2016-01-20
Publishing country	Brazil
Document type	Case Reports ; Journal Article
ZDB-ID	2223157-2
ISSN	1806-3756 ; 1806-3713
ISSN (online)	1806-3756
ISSN	1806-3713
DOI	10.1590/S1806-37562015000000299
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Article ; Online: Risk factors for tuberculosis: diabetes, smoking, alcohol use, and the use of other drugs.

Silva, Denise Rossato / Muñoz-Torrico, Marcela / Duarte, Raquel / Galvão, Tatiana / Bonini, Eduardo Henrique / Arbex, Flávio Ferlin / Arbex, Marcos Abdo / Augusto, Valéria Maria / Rabahi, Marcelo Fouad / Mello, Fernanda Carvalho de Queiroz

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

2018 Volume 44, Issue 2, Page(s) 145–152

Abstract: Tuberculosis continues to be a major public health problem. Although efforts to control the epidemic have reduced mortality and incidence, there are several predisposing factors that should be modified in order to reduce the burden of the disease. This ... ...

Abstract	Tuberculosis continues to be a major public health problem. Although efforts to control the epidemic have reduced mortality and incidence, there are several predisposing factors that should be modified in order to reduce the burden of the disease. This review article will address some of the risk factors associated with tuberculosis infection and active tuberculosis, including diabetes, smoking, alcohol use, and the use of other drugs, all of which can also contribute to poor tuberculosis treatment results. Tuberculosis can also lead to complications in the course and management of other diseases, such as diabetes. It is therefore important to identify these comorbidities in tuberculosis patients in order to ensure adequate management of both conditions.
MeSH term(s)	Alcohol Drinking/adverse effects ; Cocaine-Related Disorders/complications ; Diabetes Complications/complications ; Humans ; Risk Factors ; Smoking/adverse effects ; Tuberculosis/etiology
Language	English
Publishing date	2018-05-23
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2223157-2
ISSN	1806-3756 ; 1806-3713
ISSN (online)	1806-3756
ISSN	1806-3713
DOI	10.1590/s1806-37562017000000443
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Article ; Online: Pre-harvest cane burning and health: the association between school absences and burning sugarcane fields.

Mauro, Carla Cabrini / Ferrante, Vera Lúcia Silveira Bota / Arbex, Marcos Abdo / Ribeiro, Maria Lúcia / Magnani, Romeu

Revista de saude publica

2015 Volume 49, Page(s) 25

Abstract: The objective of this study was to investigate an association between pre-harvest sugarcane burning and respiratory diseases in children under five years of age. The following data were collected in five schools in the city of Araraquara, SP, ... ...

Abstract	The objective of this study was to investigate an association between pre-harvest sugarcane burning and respiratory diseases in children under five years of age. The following data were collected in five schools in the city of Araraquara, SP, Southeastern Brazil, between March and June 2009: daily records of absences and the reasons stated for these absences, total concentration of suspended particulate matter (µg/m3), and air humidity. The relationship between the percentage of school absences due to respiratory problems and the concentration of particulate matter in March and from April to June presented a distinct behavior: absences increased alongside the increase in particulate matter concentration. The use of school absences as indicators of this relationship is an innovative approach.
MeSH term(s)	Absenteeism ; Air Pollutants/analysis ; Air Pollutants/toxicity ; Air Pollution/adverse effects ; Air Pollution/analysis ; Air Pollution/statistics & numerical data ; Brazil ; Child, Preschool ; Humans ; Incineration ; Infant ; Infant, Newborn ; Particulate Matter/analysis ; Particulate Matter/toxicity ; Respiratory Tract Diseases/etiology ; Saccharum ; Smoke ; Students/statistics & numerical data
Chemical Substances	Air Pollutants ; Particulate Matter ; Smoke
Language	English
Publishing date	2015-04-28
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	732179-x
ISSN	1518-8787 ; 0034-8910
ISSN (online)	1518-8787
ISSN	0034-8910
DOI	10.1590/s0034-8910.2015049005641
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Article ; Online: [No title information]

Tiberi, Simon / Buchanan, Ruaridh / Caminero, José A / Centis, Rosella / Arbex, Marcos Abdo / Salazar, Miguel / Potter, Jessica / Migliori, Giovanni Battista

Presse medicale (Paris, France : 1983)

2017 Volume 46, Issue 2 Pt 2, Page(s) e41–e51

Abstract: Tuberculosis (TB) continues to cause more deaths worldwide than any other single infectious disease. Even though tuberculosis appears to be decreasing in incidence globally for some time, the proportion of drug resistance is increasing, contributing to ... ...

Title translation	The challenge of the new tuberculosis drugs.
Abstract	Tuberculosis (TB) continues to cause more deaths worldwide than any other single infectious disease. Even though tuberculosis appears to be decreasing in incidence globally for some time, the proportion of drug resistance is increasing, contributing to greater complexity, morbidity and mortality as well as cost. Since the advent of rifampicin in the 1960s, and the implementation of standard quadruple anti-tuberculosis regimen in the late 1970s, no new drugs have been changed the first line regimen. This regimen is effective however it is pill burden, and duration has not received investment and innovation. Drug-resistant regimens are long and frequently poorly tolerated due to significant toxicity. This review is an update on what is new in the treatment of drug-susceptible and drug-resistant tuberculosis, new TB drugs currently being used and studied in clinical trials are also mentioned. Fortunately, there have been many significant advances in this field in recent years. The horizon is changing with the new WHO shorter multidrug-resistant tuberculosis regimens and with the increasing availability of new or repurposed drugs like bedaquiline, delamanid, clofazimine and linezolid. These drugs pose new challenges relating to their rational use to prevent selection of resistant strains of Mycobacterium tuberculosis even before a new regimen has been studied. The availability of these new drugs is offering hope and new possibilities for saving patients who had few or no treatment options. Their use and combination into effective regimens need to be studied; trials are in progress. It is hoped that soon we will be able to treat sensitive and drug-resistant cases with a universal regimen, this would revolutionise treatment and take us another step closer towards elimination.
MeSH term(s)	Antitubercular Agents/administration & dosage ; Antitubercular Agents/adverse effects ; Antitubercular Agents/therapeutic use ; Disease Management ; Drug Repositioning ; Drug Resistance, Multiple, Bacterial/genetics ; Drug Therapy, Combination ; Forecasting ; Humans ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/genetics ; Practice Guidelines as Topic ; Selection, Genetic ; Therapies, Investigational ; Treatment Outcome ; Tuberculosis/drug therapy ; Tuberculosis, Multidrug-Resistant/drug therapy ; World Health Organization
Chemical Substances	Antitubercular Agents
Language	French
Publishing date	2017-02-28
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	120943-7
ISSN	2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0032-7867 ; 0755-4982 ; 0301-1518
DOI	10.1016/j.lpm.2017.01.016
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Article ; Online: The challenge of managing extensively drug-resistant tuberculosis at a referral hospital in the state of São Paulo, Brazil

Marcos Abdo Arbex / Hélio Ribeiro de Siqueira / Lia D'Ambrosio / Giovanni Battista Migliori

Jornal Brasileiro de Pneumologia, Vol 41, Iss 6, Pp 554-

a report of three cases

2015 Volume 559

Abstract: ABSTRACT Here, we report the cases of three patients diagnosed with extensively drug-resistant tuberculosis and admitted to a referral hospital in the state of São Paulo, Brazil, showing the clinical and radiological evolution, as well as laboratory test ...

Abstract	ABSTRACT Here, we report the cases of three patients diagnosed with extensively drug-resistant tuberculosis and admitted to a referral hospital in the state of São Paulo, Brazil, showing the clinical and radiological evolution, as well as laboratory test results, over a one-year period. Treatment was based on the World Health Organization guidelines, with the inclusion of a new proposal for the use of a combination of antituberculosis drugs (imipenem and linezolid). In the cases studied, we show the challenge of creating an acceptable, effective treatment regimen including drugs that are more toxic, are more expensive, and are administered for longer periods. We also show that treatment costs are significantly higher for such patients, which could have an impact on health care systems, even after hospital discharge. We highlight the fact that in extreme cases, such as those reported here, hospitalization at a referral center seems to be the most effective strategy for providing appropriate treatment and increasing the chance of cure. In conclusion, health professionals and governments must make every effort to prevent cases of multidrug-resistant and extensively drug-resistant tuberculosis.
Keywords	Tuberculose resistente a múltiplos medicamentos ; Tuberculose extensivamente resistente a drogas ; Antituberculosos ; Antibióticos antituberculose ; Diseases of the respiratory system ; RC705-779 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Subject code	360
Language	Portuguese
Publishing date	2015-12-01T00:00:00Z
Publisher	Sociedade Brasileira de Pneumologia e Tisiologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New and repurposed drugs to treat multidrug- and extensively drug-resistant tuberculosis.

Silva, Denise Rossato / Dalcolmo, Margareth / Tiberi, Simon / Arbex, Marcos Abdo / Munoz-Torrico, Marcela / Duarte, Raquel / D'Ambrosio, Lia / Visca, Dina / Rendon, Adrian / Gaga, Mina / Zumla, Alimuddin / Migliori, Giovanni Battista

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

2018 Volume 44, Issue 2, Page(s) 153–160

Abstract: Multidrug-resistant and extensively drug-resistant tuberculosis (MDR-TB and XDR-TB, respectively) continue to represent a challenge for clinicians and public health authorities. Unfortunately, although there have been encouraging reports of higher ... ...

Abstract	Multidrug-resistant and extensively drug-resistant tuberculosis (MDR-TB and XDR-TB, respectively) continue to represent a challenge for clinicians and public health authorities. Unfortunately, although there have been encouraging reports of higher success rates, the overall rate of favorable outcomes of M/XDR-TB treatment is only 54%, or much lower when the spectrum of drug resistance is beyond that of XDR-TB. Treating M/XDR-TB continues to be a difficult task, because of the high incidence of adverse events, the long duration of treatment, the high cost of the regimens used, and the drain on health care resources. Various trials and studies have recently been undertaken (some already published and others ongoing), all aimed at improving outcomes of M/XDR-TB treatment by changing the overall approach, shortening treatment duration, and developing a universal regimen. The objective of this review was to summarize what has been achieved to date, as far as new and repurposed drugs are concerned, with a special focus on delamanid, bedaquiline, pretomanid, clofazimine, carbapenems, and linezolid. After more than 40 years of neglect, greater attention has recently been paid to the need for new drugs to fight the "white plague", and promising results are being reported.
MeSH term(s)	Antitubercular Agents/classification ; Antitubercular Agents/therapeutic use ; Clinical Trials as Topic ; Diarylquinolines/therapeutic use ; Drug Repositioning ; Extensively Drug-Resistant Tuberculosis/drug therapy ; Humans ; Nitroimidazoles/therapeutic use ; Oxazoles/therapeutic use
Chemical Substances	Antitubercular Agents ; Diarylquinolines ; Nitroimidazoles ; OPC-67683 ; Oxazoles ; pretomanid ; bedaquiline (78846I289Y)
Language	English
Publishing date	2018-06-05
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2223157-2
ISSN	1806-3756 ; 1806-3713
ISSN (online)	1806-3756
ISSN	1806-3713
DOI	10.1590/s1806-37562017000000436
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Article ; Online: Pre-harvest cane burning and health

Carla Cabrini Mauro / Vera Lúcia Silveira Bota Ferrante / Marcos Abdo Arbex / Maria Lúcia Ribeiro / Romeu Magnani

Revista de Saúde Pública, Vol 49, Iss 0, Pp 1-

the association between school absences and burning sugarcane fields

2015 Volume 4

Abstract	The objective of this study was to investigate an association between pre-harvest sugarcane burning and respiratory diseases in children under five years of age. The following data were collected in five schools in the city of Araraquara, SP, Southeastern Brazil, between March and June 2009: daily records of absences and the reasons stated for these absences, total concentration of suspended particulate matter (µg/m3), and air humidity. The relationship between the percentage of school absences due to respiratory problems and the concentration of particulate matter in March and from April to June presented a distinct behavior: absences increased alongside the increase in particulate matter concentration. The use of school absences as indicators of this relationship is an innovative approach.
Keywords	Pré-Escolar ; Absenteísmo ; Doenças Respiratórias ; epidemiologia ; Fumaça ; efeitos adversos ; Saccharum ; Poluição do Ar ; Material Particulado ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Universidade de São Paulo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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