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  1. Article: Werkzeugkiste (51)

    Freimuth, Joachim / Stein, Nadine

    Organisationsentwicklung : Zeitschrift für Unternehmensentwicklung und Change Management Vol. 36, No. 2 , p. 88-93

    lösungsorientierte Beratung mit Skalenfragen

    2017  Volume 36, Issue 2, Page(s) 88–93

    Author's details Joachim Freimuth und Nadine Stein
    Language German
    Publisher Handelsblatt Fachmedien
    Publishing place Düsseldorf
    Document type Article
    ZDB-ID 625692-2
    ISSN 0724-6110
    ISSN 0724-6110
    Database ECONomics Information System

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  2. Article: Werkzeugkiste 51. Lösungsorientierte Beratung mit Skalenfragen

    Freimuth, Joachim / Stein, Nadine

    OrganisationsEntwicklung

    2017  Volume 36, Issue 2, Page(s) 88–93

    Abstract: Die Nutzung von Skalenfragen in der lösungsorientierten Beratung wird erläutert. Nach einer Darstellung des Kontextes der Methode wird ihre Wirkung aufgrund von Visualisierung, Spezifika der Fragestellung und Merkmalen der umgebenden Beratungsepisode ... ...

    Title translation Toolbox 51. Solution-focused counseling by scale questions
    Abstract Die Nutzung von Skalenfragen in der lösungsorientierten Beratung wird erläutert. Nach einer Darstellung des Kontextes der Methode wird ihre Wirkung aufgrund von Visualisierung, Spezifika der Fragestellung und Merkmalen der umgebenden Beratungsepisode verdeutlicht. Anhand von Beispielen wird der Einsatz von Skalenfragen illustriert. Schließlich wird auf Risiken der Methode und den Umgang mit ihnen eingegangen.
    Keywords Beratung ; Bildhafte Vorstellung ; Change Strategies ; Conflict Resolution ; Counseling ; Fragenstellen ; Imagery ; Konfliktlösung ; Lösungsorientierte Therapie ; Questioning ; Solution Focused Therapy ; Therapeutic Processes ; Therapeutische Prozesse ; Veränderungsstrategien
    Language German
    Document type Article
    ZDB-ID 625692-2
    ISSN 0724-6110
    ISSN 0724-6110
    Database PSYNDEX

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  3. Article ; Online: Antitumorigenic effects of cannabinoids beyond apoptosis.

    Freimuth, Nadine / Ramer, Robert / Hinz, Burkhard

    The Journal of pharmacology and experimental therapeutics

    2010  Volume 332, Issue 2, Page(s) 336–344

    Abstract: According to the World Health Organization, the cases of death caused by cancer will have been doubled until the year 2030. By 2010, cancer is expected to be the number one cause of death. Therefore, it is necessary to explore novel approaches for the ... ...

    Abstract According to the World Health Organization, the cases of death caused by cancer will have been doubled until the year 2030. By 2010, cancer is expected to be the number one cause of death. Therefore, it is necessary to explore novel approaches for the treatment of cancer. Over past years, the antitumorigenic effects of cannabinoids have emerged as an exciting field in cancer research. Apart from their proapoptotic and antiproliferative action, recent research has shown that cannabinoids may likewise affect tumor cell angiogenesis, migration, invasion, adhesion, and metastasization. This review will summarize the data concerning the influence of cannabinoids on these locomotive processes beyond modulation of cancer cell apoptosis and proliferation. The findings discussed here provide a new perspective on the antitumorigenic potential of cannabinoids.
    MeSH term(s) Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/therapeutic use ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Cannabinoids/pharmacology ; Cannabinoids/therapeutic use ; Cell Adhesion/drug effects ; Cell Movement/drug effects ; Humans ; Models, Biological ; Neoplasm Invasiveness/prevention & control ; Neoplasm Metastasis/drug therapy ; Neoplasms/drug therapy
    Chemical Substances Angiogenesis Inhibitors ; Antineoplastic Agents ; Cannabinoids
    Language English
    Publishing date 2010-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3106-9
    ISSN 1521-0103 ; 0022-3565
    ISSN (online) 1521-0103
    ISSN 0022-3565
    DOI 10.1124/jpet.109.157735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.

    Ramer, Robert / Bublitz, Katharina / Freimuth, Nadine / Merkord, Jutta / Rohde, Helga / Haustein, Maria / Borchert, Philipp / Schmuhl, Ellen / Linnebacher, Michael / Hinz, Burkhard

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2012  Volume 26, Issue 4, Page(s) 1535–1548

    Abstract: Cannabinoids inhibit cancer cell invasion via increasing tissue inhibitor of matrix metalloproteinases-1 (TIMP-1). This study investigates the role of intercellular adhesion molecule-1 (ICAM-1) within this action. In the lung cancer cell lines A549, H358, ...

    Abstract Cannabinoids inhibit cancer cell invasion via increasing tissue inhibitor of matrix metalloproteinases-1 (TIMP-1). This study investigates the role of intercellular adhesion molecule-1 (ICAM-1) within this action. In the lung cancer cell lines A549, H358, and H460, cannabidiol (CBD; 0.001-3 μM) elicited concentration-dependent ICAM-1 up-regulation compared to vehicle via cannabinoid receptors, transient receptor potential vanilloid 1, and p42/44 mitogen-activated protein kinase. Up-regulation of ICAM-1 mRNA by CBD in A549 was 4-fold at 3 μM, with significant effects already evident at 0.01 μM. ICAM-1 induction became significant after 2 h, whereas significant TIMP-1 mRNA increases were observed only after 48 h. Inhibition of ICAM-1 by antibody or siRNA approaches reversed the anti-invasive and TIMP-1-upregulating action of CBD and the likewise ICAM-1-inducing cannabinoids Δ(9)-tetrahydrocannabinol and R(+)-methanandamide when compared to isotype or nonsilencing siRNA controls. ICAM-1-dependent anti-invasive cannabinoid effects were confirmed in primary tumor cells from a lung cancer patient. In athymic nude mice, CBD elicited a 2.6- and 3.0-fold increase of ICAM-1 and TIMP-1 protein in A549 xenografts, as compared to vehicle-treated animals, and an antimetastatic effect that was fully reversed by a neutralizing antibody against ICAM-1 [% metastatic lung nodules vs. isotype control (100%): 47.7% for CBD + isotype antibody and 106.6% for CBD + ICAM-1 antibody]. Overall, our data indicate that cannabinoids induce ICAM-1, thereby conferring TIMP-1 induction and subsequent decreased cancer cell invasiveness.
    MeSH term(s) Aged ; Animals ; Cannabidiol/pharmacology ; Cannabidiol/therapeutic use ; Female ; Humans ; Intercellular Adhesion Molecule-1/genetics ; Intercellular Adhesion Molecule-1/metabolism ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Mice ; Mice, Nude ; Mitogen-Activated Protein Kinases/genetics ; Mitogen-Activated Protein Kinases/metabolism ; Neoplasm Invasiveness ; Neoplasm Metastasis/drug therapy ; Neoplasm Metastasis/pathology ; Neoplasm Transplantation ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Random Allocation ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism ; Tissue Inhibitor of Metalloproteinase-1/genetics ; Tissue Inhibitor of Metalloproteinase-1/metabolism ; Tumor Cells, Cultured ; Up-Regulation/drug effects
    Chemical Substances RNA, Small Interfering ; TRPV Cation Channels ; TRPV1 receptor ; Tissue Inhibitor of Metalloproteinase-1 ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Cannabidiol (19GBJ60SN5) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2012-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.11-198184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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