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  1. Article ; Online: Reduction of Dinitrogen to Ammonia and Hydrazine on Low-Valent Ruthenium Complexes.

    Field, Leslie D / Li, Hsiu L / Abeysinghe, P Manohari / Bhadbhade, Mohan / Dalgarno, Scott J / McIntosh, Ruaraidh D

    Inorganic chemistry

    2019  Volume 58, Issue 3, Page(s) 1929–1934

    Abstract: The ruthenium(0) dinitrogen complexes [Ru( ... ...

    Abstract The ruthenium(0) dinitrogen complexes [Ru(N
    Language English
    Publishing date 2019-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.8b02850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Antitumour bis(cyclopentadienyl) metal complexes: titanocene and molybdocene dichloride and derivatives.

    Abeysinghe, P Manohari / Harding, Margaret M

    Dalton transactions (Cambridge, England : 2003)

    2007  , Issue 32, Page(s) 3474–3482

    Abstract: This Perspective will focus on recent developments in the field of antitumour metallocenes structurally related to titanocene dichloride. Despite extensive testing of titanocene dichloride which culminated in phase I and II clinical trials, further ... ...

    Abstract This Perspective will focus on recent developments in the field of antitumour metallocenes structurally related to titanocene dichloride. Despite extensive testing of titanocene dichloride which culminated in phase I and II clinical trials, further trials have been abandoned. While DNA has been implicated as the major target related to anticancer activity, identification of the active species and mechanism of action has been poorly understood and hence the design of second generation titanocene derivatives has not been possible. Recent mechanistic studies have provided a plausible mechanism for delivery of Ti to cancer cells via transferrin mediated endocytosis. This mechanism requires the presence of labile Cp-Ti bonds that hydrolyse on a time scale to deliver Ti to transferrin. A large range of titanocene derivatives in which the cyclopentadienyl rings have been substituted by both electron withdrawing and donating groups, including aromatic, alkyl and cyclic amines, have been prepared and tested for activity in the last 5 years. These results have shown that subtle structural effects can have a significant effect on biological activity and that biological activity is highly cell line dependent. However, the biological chemistry and cellular studies required to determine the mechanism of action of these new titanocenes have not been reported. In contrast, the bioorganometallic chemistry and cellular studies of molybdocene dichloride have implicated interaction with cellular thiols as the key reaction related to biological activity. Tailoring of the pseudohalide ligands by tuning the strength of the Mo-S bonds provides the opportunity to enhance cell uptake. Further research is required to establish the origin of antitumour activity.
    MeSH term(s) Antineoplastic Agents/chemistry ; Ferrous Compounds/chemistry ; Molecular Structure ; Organometallic Compounds/chemistry ; Titanium/chemistry
    Chemical Substances Antineoplastic Agents ; Ferrous Compounds ; Organometallic Compounds ; ferrocifen ; molybdocene dichloride (12184-22-4) ; titanocene (1271-29-0) ; Titanium (D1JT611TNE)
    Language English
    Publishing date 2007-08-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1472887-4
    ISSN 1364-5447 ; 1477-9234 ; 1477-9226 ; 0300-9246
    ISSN (online) 1364-5447 ; 1477-9234
    ISSN 1477-9226 ; 0300-9246
    DOI 10.1039/b707440a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Inclusion complexes of the antitumour metallocenes Cp(2)MCl(2) (M = Mo, Ti) with cucurbit[n]urils.

    Buck, Damian P / Abeysinghe, P Manohari / Cullinane, Carleen / Day, Anthony I / Collins, J Grant / Harding, Margaret M

    Dalton transactions (Cambridge, England : 2003)

    2008  , Issue 17, Page(s) 2328–2334

    Abstract: The encapsulation of the aquated forms of molybdocene dichloride and titanocene dichloride by cucurbit[n]uril (Q[n], where n = 7 and 8) at different pD values has been studied by (1)H NMR spectroscopy and molecular modelling. (1)H NMR titration ... ...

    Abstract The encapsulation of the aquated forms of molybdocene dichloride and titanocene dichloride by cucurbit[n]uril (Q[n], where n = 7 and 8) at different pD values has been studied by (1)H NMR spectroscopy and molecular modelling. (1)H NMR titration experiments indicate that both metallocenes form 1 : 1 host-guest complexes with both Q[7] and Q[8]. In these complexes, both the cyclopentadienyl ligands and metal centre are positioned deep within the cucurbituril cavity. In vitro cell proliferation studies using the cancer cell lines MCF-7 and 2008 showed that the encapsulated molybdocene complex was more active than the corresponding free metallocene, with GI(50) values of 210 and 400 muM respectively. However, unexpectedly the encapsulation of Cp(2)MoCl(2(aq))at pD 7 catalysed significant degradation of the cucurbituril framework in the presence of oxygen. Encapsulation of Cp(2)TiCl(2(aq)) by Q[7] greatly slowed the protonolysis of the cyclopentadienyl ligands in aqueous phosphate buffer (pD 7), while encapsulation in Q[8] only slightly retarded the hydrolytic degradation of the metallocene.
    MeSH term(s) Antineoplastic Agents/chemistry ; Bridged-Ring Compounds/chemistry ; Cell Line, Tumor ; Humans ; Imidazoles/chemistry ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Models, Molecular ; Molecular Structure ; Molybdenum ; Organometallic Compounds/chemistry ; Titanium
    Chemical Substances Antineoplastic Agents ; Bridged-Ring Compounds ; Imidazoles ; Organometallic Compounds ; cucurbit(7)uril ; cucurbit(8)uril ; molybdocene dichloride (12184-22-4) ; Molybdenum (81AH48963U) ; Titanium (D1JT611TNE) ; titanocene dichloride (MJE0547U1U)
    Language English
    Publishing date 2008-05-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1364-5447 ; 1477-9234 ; 1477-9226 ; 0300-9246
    ISSN (online) 1364-5447 ; 1477-9234
    ISSN 1477-9226 ; 0300-9246
    DOI 10.1039/b718322d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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