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  1. Book ; Online ; E-Book: Covid-19 and foreign aid

    De Percy, Michael / Jakupec, Viktor / Kelly, Max

    nationalism and global development in a new world order

    (Rethinking development)

    2023  

    Abstract: This book provides a timely, critical, and thought-provoking analysis of the implications of the disruption of COVID-19 to the foreign aid and development system, and the extent to which the system is retaining a level of relevance, legitimacy, or ... ...

    Author's details edited by Viktor Jakupec, Max Kelly and Michael de Percy
    Series title Rethinking development
    Abstract This book provides a timely, critical, and thought-provoking analysis of the implications of the disruption of COVID-19 to the foreign aid and development system, and the extent to which the system is retaining a level of relevance, legitimacy, or coherence. Drawing on the expertise of key scholars from around the world in the fields of international development, political science, socioeconomics, history, and international relations, the book explores the impact of the COVID-19 pandemic on development aid within an environment of shifting national and regional priorities and interactions. The response is specifically focused on the interrelated themes of political analysis and soft power, the legitimation crisis, poverty, inequality, foreign aid, and the disruption and re-making of the world order. The book argues that complex and multidirectional linkages between politics, economics, society, and the environment are driving changes in the extant development aid system. COVID-19 and Foreign Aid provides a range of critical reflections to shifts in the world order, the rise of nationalism, the strange non-death of neoliberalism, shifts in globalisation, and the evolving impact of COVID as a cross-cutting crisis in the development aid system. This book will be of interest to researchers and students in the field of health and development studies, decision-makers at government level as well as to those working in or consulting to international aid institutions, regional and bilateral aid agencies, and non-governmental organisations.
    Keywords Economic assistance/Social aspects ; Economic assistance/Political aspects ; COVID-19 (Disease)/Social aspects
    Subject code 362.19624144
    Language English
    Size 1 online resource (361 pages)
    Edition 1st edition.
    Publisher Routledge, Taylor & Francis Group
    Publishing place London ; New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-000-78743-5 ; 1-00-327384-X ; 1-003-27384-X ; 1-000-78741-9 ; 1-03-222714-1 ; 1-03-222711-7 ; 978-1-000-78743-6 ; 978-1-00-327384-4 ; 978-1-003-27384-4 ; 978-1-000-78741-2 ; 978-1-03-222714-6 ; 978-1-03-222711-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Corrigendum to: Update of the Preclinical Situation of Anticancer Platinum Complexes: Novel Design Strategies and Innovative Analytical Approaches.

    Galanski, Mathea Sophia / Jakupec, Michael A / Keppler, Bernhard K

    Current medicinal chemistry

    2023  Volume 30, Issue 36, Page(s) 4167

    Abstract: An article was published in the journal "Current Medicinal Chemistry," Volume 12, No. 18, 2005, pp: 2075-2094 [1]. The first author is requesting an alteration in the name. Details of a correction are provided here. The original name published was Markus ...

    Abstract An article was published in the journal "Current Medicinal Chemistry," Volume 12, No. 18, 2005, pp: 2075-2094 [1]. The first author is requesting an alteration in the name. Details of a correction are provided here. The original name published was Markus Galanski. The request is to change the name to Mathea Sophia Galanski. The original article can be found online at: http://www.benthamscience.com/article/5874.
    Language English
    Publishing date 2023-02-21
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/092986733036230530164546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Investigating the anticancer potential of 4-phenylthiazole derived Ru(II) and Os(II) metalacycles.

    Getreuer, Paul / Marretta, Laura / Toyoglu, Emine / Dömötör, Orsolya / Hejl, Michaela / Prado-Roller, Alexander / Cseh, Klaudia / Legin, Anton A / Jakupec, Michael A / Barone, Giampaolo / Terenzi, Alessio / Keppler, Bernhard K / Kandioller, Wolfgang

    Dalton transactions (Cambridge, England : 2003)

    2024  Volume 53, Issue 12, Page(s) 5567–5579

    Abstract: In this contribution we report the synthesis, characterization ... ...

    Abstract In this contribution we report the synthesis, characterization and
    MeSH term(s) Humans ; Molecular Structure ; Models, Molecular ; Cell Line, Tumor ; Antineoplastic Agents/chemistry ; Cell Cycle ; Ruthenium/pharmacology ; Ruthenium/chemistry ; Coordination Complexes/chemistry
    Chemical Substances Antineoplastic Agents ; Ruthenium (7UI0TKC3U5) ; Coordination Complexes
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d4dt00245h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Combination of Drug Delivery Properties of PAMAM Dendrimers and Cytotoxicity of Platinum(IV) Complexes-A More Selective Anticancer Treatment?

    Lerchbammer-Kreith, Yvonne / Hejl, Michaela / Vician, Petra / Jakupec, Michael A / Berger, Walter / Galanski, Mathea S / Keppler, Bernhard K

    Pharmaceutics

    2023  Volume 15, Issue 5

    Abstract: Based on their drug delivery properties and activity against tumors, we combined PAMAM dendrimers with various platinum(IV) complexes in order to provide an improved approach of anticancer treatment. Platinum(IV) complexes were linked to terminal ... ...

    Abstract Based on their drug delivery properties and activity against tumors, we combined PAMAM dendrimers with various platinum(IV) complexes in order to provide an improved approach of anticancer treatment. Platinum(IV) complexes were linked to terminal NH
    Language English
    Publishing date 2023-05-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15051515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Not the usual suspect - an unexpected organometallic product during the synthesis of cytotoxic platinum(II) complexes.

    Maier, Thomas / Wutschitz, Judith / Gajic, Natalie / Hejl, Michaela / Cseh, Klaudia / Mai, Sebastian / Jakupec, Michael A / Galanski, Mathea S / Keppler, Bernhard K

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 44, Page(s) 16326–16335

    Abstract: The reaction of ( ... ...

    Abstract The reaction of (1
    MeSH term(s) Humans ; Platinum/chemistry ; Organoplatinum Compounds/chemistry ; Cell Line, Tumor ; Antineoplastic Agents/chemistry ; DNA ; Drug Screening Assays, Antitumor
    Chemical Substances Platinum (49DFR088MY) ; Organoplatinum Compounds ; Antineoplastic Agents ; DNA (9007-49-2)
    Language English
    Publishing date 2023-11-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt01736b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Comparative Study on the Complexation of the Anticancer Iron Chelator VLX600 with Essential Metal Ions.

    Pósa, Vivien / Federa, Anja / Cseh, Klaudia / Wenisch, Dominik / Spengler, Gabriella / May, Nóra V / Lihi, Norbert / Samu, Gergely F / Jakupec, Michael A / Keppler, Bernhard K / Kowol, Christian R / Enyedy, Éva A

    Inorganic chemistry

    2024  Volume 63, Issue 5, Page(s) 2401–2417

    Abstract: As cancer cells exhibit an increased uptake of iron, targeting the interaction with iron has become a straightforward strategy in the fight against cancer. This work comprehensively characterizes the chemical properties of 6-methyl-3-{( ... ...

    Abstract As cancer cells exhibit an increased uptake of iron, targeting the interaction with iron has become a straightforward strategy in the fight against cancer. This work comprehensively characterizes the chemical properties of 6-methyl-3-{(2
    MeSH term(s) Humans ; Ferric Compounds ; Copper/pharmacology ; Copper/chemistry ; Metals/chemistry ; Iron/chemistry ; Ions ; Coordination Complexes/pharmacology ; Coordination Complexes/chemistry ; Iron Chelating Agents/pharmacology ; Ferrous Compounds ; Hydrazones ; Triazoles
    Chemical Substances VLX600 ; Ferric Compounds ; Copper (789U1901C5) ; Metals ; Iron (E1UOL152H7) ; Ions ; Coordination Complexes ; Iron Chelating Agents ; Ferrous Compounds ; Hydrazones ; Triazoles
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c03259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Microplastics role in cell migration and distribution during cancer cell division.

    Brynzak-Schreiber, Ekaterina / Schögl, Elisabeth / Bapp, Carolin / Cseh, Klaudia / Kopatz, Verena / Jakupec, Michael A / Weber, Andreas / Lange, Tobias / Toca-Herrera, José L / Del Favero, Giorgia / Wadsak, Wolfgang / Kenner, Lukas / Pichler, Verena

    Chemosphere

    2024  Volume 353, Page(s) 141463

    Abstract: Amidst the global plastic pollution crisis, the gastrointestinal tract serves as the primary entry point for daily exposure to micro- and nanoplastics. We investigated the complex dynamics between polystyrene micro- and nanoplastics (PS-MNPs) and four ... ...

    Abstract Amidst the global plastic pollution crisis, the gastrointestinal tract serves as the primary entry point for daily exposure to micro- and nanoplastics. We investigated the complex dynamics between polystyrene micro- and nanoplastics (PS-MNPs) and four distinct human colorectal cancer cell lines (HT29, HCT116, SW480, and SW620). Our findings revealed a significant size- and concentration dependent uptake of 0.25, 1, and 10 μm PS-MNPs across all cell lines, with HCT116 cells exhibiting the highest uptake rates. During cell division, particles were distributed between mother and daughter cells. Interestingly, we observed no signs of elimination from the cells. Short-term exposure to 0.25 μm particles significantly amplified cell migration, potentially leading to pro-metastatic effects. Particles demonstrated high persistence in 2D and 3D cultures, and accumulation in non-proliferating parts of spheroids, without interfering with cell proliferation or division. Our study unveils the disturbing fact of the persistence and bioaccumulation of MNPs in colorectal cancer cell lines, key toxicological traits under REACH (Regulation concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals). Our observations underscore the potential of MNPs as hidden catalysts for tumor progression, particularly through enhancing cell migration and possibly fueling metastasis - a finding that sheds light on a significant and previously underexplored area of concern.
    MeSH term(s) Humans ; Microplastics/metabolism ; Plastics/toxicity ; Polystyrenes/metabolism ; Colorectal Neoplasms ; Cell Division ; Cell Movement ; Water Pollutants, Chemical/metabolism
    Chemical Substances Microplastics ; Plastics ; Polystyrenes ; Water Pollutants, Chemical
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.141463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Anticancer Tungstenocenes with a Diverse Set of (

    Cseh, Klaudia / Berasaluce, Iker / Fuchs, Valentin / Banc, Alexandra / Schweikert, Andreas / Prado-Roller, Alexander / Hejl, Michaela / Wernitznig, Debora / Koellensperger, Gunda / Jakupec, Michael A / Kandioller, Wolfgang / Malarek, Michael S / Keppler, Bernhard K

    Pharmaceutics

    2023  Volume 15, Issue 7

    Abstract: The synthesis, characterization and biological activity of tungstenocenes with varying biologically active ( ...

    Abstract The synthesis, characterization and biological activity of tungstenocenes with varying biologically active (
    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15071875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: KP772 overcomes multiple drug resistance in malignant lymphoma and leukemia cells in vitro by inducing Bcl-2-independent apoptosis and upregulation of Harakiri.

    Kater, Lisa / Kater, Benjamin / Jakupec, Michael A / Keppler, Bernhard K / Prokop, Aram

    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry

    2021  Volume 26, Issue 8, Page(s) 897–907

    Abstract: Despite high cure rates in pediatric patients with acute leukemia, development of resistance limits the efficacy of antileukemic therapy. Tris(1,10-phenanthroline)tris(thiocyanato-κN)lanthanum(III) (KP772) is an experimental antineoplastic agent to which ...

    Abstract Despite high cure rates in pediatric patients with acute leukemia, development of resistance limits the efficacy of antileukemic therapy. Tris(1,10-phenanthroline)tris(thiocyanato-κN)lanthanum(III) (KP772) is an experimental antineoplastic agent to which multidrug-resistant cell models have shown hypersensitivity. Antiproliferative and apoptotic activities of KP772 were tested in leukemia, lymphoma and solid tumor cell lines as well as primary leukemia cells (isolated from the bone marrow of a child with acute myeloid leukemia (AML). The ability to overcome drug resistances was investigated in doxorubicin- and vincristine-resistant cell lines. Real-time PCR was used to gain insight into the mechanism of apoptosis induction. KP772 inhibited proliferation and induced apoptosis in various leukemia and lymphoma cell lines in a concentration-dependent manner (LC
    MeSH term(s) Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis ; Child ; Drug Resistance, Multiple ; Drug Resistance, Neoplasm ; Humans ; Leukemia/drug therapy ; Lymphoma ; Proto-Oncogene Proteins c-bcl-2 ; Up-Regulation
    Chemical Substances Antineoplastic Agents ; Proto-Oncogene Proteins c-bcl-2
    Language English
    Publishing date 2021-10-06
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1464026-0
    ISSN 1432-1327 ; 0949-8257
    ISSN (online) 1432-1327
    ISSN 0949-8257
    DOI 10.1007/s00775-021-01900-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Systematic Study on the Cytotoxic Potency of Commonly Used Dimeric Metal Precursors in Human Cancer Cell Lines.

    Geisler, Heiko / Harringer, Sophia / Wenisch, Dominik / Urban, Richard / Jakupec, Michael A / Kandioller, Wolfgang / Keppler, Bernhard K

    ChemistryOpen

    2022  Volume 11, Issue 7, Page(s) e202200019

    Abstract: The cytotoxicities of seven dimeric metal species of the general formula [M(arene) ... ...

    Abstract The cytotoxicities of seven dimeric metal species of the general formula [M(arene)Cl
    MeSH term(s) Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Humans ; Iridium ; Neoplasms ; Osmium ; Rhodium/toxicity ; Ruthenium
    Chemical Substances Antineoplastic Agents ; Osmium (2E7M255OPY) ; Iridium (44448S9773) ; Ruthenium (7UI0TKC3U5) ; Rhodium (DMK383DSAC)
    Language English
    Publishing date 2022-02-24
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2655605-4
    ISSN 2191-1363 ; 2191-1363
    ISSN (online) 2191-1363
    ISSN 2191-1363
    DOI 10.1002/open.202200019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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