Article ; Online: Qing-Xin-Jie-Yu Granule alleviates atherosclerosis by reshaping gut microbiota and metabolic homeostasis of ApoE-/- mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology
2022 Volume 103, Page(s) 154220
Abstract: ... characteristics of atherosclerotic CVD, Qing-Xin-Jie-Yu Granule (QXJYG) is a Chinese traditional decoction ...
| Abstract | Background: Atherosclerosis (AS) is a key pathological factor in cardiovascular disease (CVD) and is characterized by high mortality and morbidity worldwide. Metabolic disorders, including pathoglycemia and dyslipidemia that lead to chronic inflammation, represent the prominent pathological characteristics of atherosclerotic CVD, Qing-Xin-Jie-Yu Granule (QXJYG) is a Chinese traditional decoction that has been clinically proven to be effective for patients with CVD. However, the underlying mechanisms have not been completely elucidated. Purpose: To investigate the protective effects of QXJYG against AS and its potential mechanisms. Methods: QXJYG was orally administered at doses of 1.664 and 4.992 g·kg Results: QXJYG retarded HFD-induced weight gain and reduced the increased serum levels of total cholesterol, triglycerides, and low-density lipoprotein-cholesterol, whereas high-dose QXJYG increased the serum level of high-density lipoprotein-cholesterol in HFD-fed ApoE-/- mice. Meanwhile, QXJYG reduced the serum levels, as well as aortas mRNA levels of the inflammatory cytokines, IL-1β and IL-6, which indicates that QXJYG is effective against metaflammation. Mechanistically, QXJYG reshaped the gut microbiota and its associated bile acids (BAs) metabolomic phenotype, partly by increasing the levels of BA synthesis enzymes, hepatic CYP7A1, and CYP27A1, while decreasing ileal FGF15 and β-Klotho mRNA expression, favoring facilitated de novo BAs synthesis and thereby driving cholesterol catabolic excretion. Conclusion: Our findings indicate that QXJYG is effective against HFD-triggered chronic inflammation, and contributes to the alleviation of AS development, and the antiatherogenic properties of QXJYG may be partly due to the remodeling of the gut microbiota and BA metabolism. Although the results are encouraging, further clinical studies of anti-AS herbal medicines are required to elucidate the full potential of the gut microbiota and BA metabolism. |
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| MeSH term(s) | Animals ; Apolipoproteins E ; Atherosclerosis/metabolism ; Cholesterol/metabolism ; Diet, High-Fat/adverse effects ; Drugs, Chinese Herbal ; Gastrointestinal Microbiome ; Homeostasis ; Humans ; Inflammation/metabolism ; Liver ; Mice ; Mice, Inbred C57BL ; RNA, Messenger/metabolism ; RNA, Ribosomal, 16S |
| Chemical Substances | Apolipoproteins E ; Drugs, Chinese Herbal ; RNA, Messenger ; RNA, Ribosomal, 16S ; qing-xin-jie-yu granules ; Cholesterol (97C5T2UQ7J) |
| Language | English |
| Publishing date | 2022-06-01 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 1205240-1 |
| ISSN | 1618-095X ; 0944-7113 |
| ISSN (online) | 1618-095X |
| ISSN | 0944-7113 |
| DOI | 10.1016/j.phymed.2022.154220 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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