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  1. Article: Co-infection of the respiratory epithelium, scene of complex functional interactions between viral, bacterial, and human neuraminidases.

    Escuret, Vanessa / Terrier, Olivier

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1137336

    Abstract: The activity of sialic acids, known to play critical roles in biology and many pathological processes, is finely regulated by a class of enzymes called sialidases, also known as neuraminidases. These are present in mammals and many other biological ... ...

    Abstract The activity of sialic acids, known to play critical roles in biology and many pathological processes, is finely regulated by a class of enzymes called sialidases, also known as neuraminidases. These are present in mammals and many other biological systems, such as viruses and bacteria. This review focuses on the very particular situation of co-infections of the respiratory epithelium, the scene of complex functional interactions between viral, bacterial, and human neuraminidases. This intrinsically multidisciplinary topic combining structural biology, biochemistry, physiology, and the study of host-pathogen interactions, opens up exciting research perspectives that could lead to a better understanding of the mechanisms underlying virus-bacteria co-infections and their contribution to the aggravation of respiratory pathology, notably in the context of pre-existing pathological contexts. Strategies that mimic or inhibit the activity of the neuraminidases could constitute interesting treatment options for viral and bacterial infections.
    Language English
    Publishing date 2023-05-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1137336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Anti-Influenza Drug Discovery and Development: Targeting the Virus and Its Host by All Possible Means.

    Terrier, Olivier / Slama-Schwok, Anny

    Advances in experimental medicine and biology

    2021  Volume 1322, Page(s) 195–218

    Abstract: Infections by influenza virus constitute a major and recurrent threat for human health. Together with vaccines, antiviral drugs play a key role in the prevention and treatment of influenza virus infection and disease. Today, the number of antiviral ... ...

    Abstract Infections by influenza virus constitute a major and recurrent threat for human health. Together with vaccines, antiviral drugs play a key role in the prevention and treatment of influenza virus infection and disease. Today, the number of antiviral molecules approved for the treatment of influenza is relatively limited, and their use is threatened by the emergence of viral strains with resistance mutations. There is therefore a real need to expand the prophylactic and therapeutic arsenal. This chapter summarizes the state of the art in drug discovery and development for the treatment of influenza virus infections, with a focus on both virus-targeting and host cell-targeting strategies. Novel antiviral strategies targeting other viral proteins or targeting the host cell, some of which are based on drug repurposing, may be used in combination to strengthen our therapeutic arsenal against this major pathogen.
    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Drug Discovery ; Humans ; Influenza, Human/drug therapy ; Orthomyxoviridae ; Orthomyxoviridae Infections ; Virus Replication
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2021-07-13
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-16-0267-2_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Viral and Bacterial Co-Infections in the Lungs: Dangerous Liaisons.

    Oliva, Justine / Terrier, Olivier

    Viruses

    2021  Volume 13, Issue 9

    Abstract: Respiratory tract infections constitute a significant public health problem, with a therapeutic arsenal that remains relatively limited and that is threatened by the emergence of antiviral and/or antibiotic resistance. Viral-bacterial co-infections are ... ...

    Abstract Respiratory tract infections constitute a significant public health problem, with a therapeutic arsenal that remains relatively limited and that is threatened by the emergence of antiviral and/or antibiotic resistance. Viral-bacterial co-infections are very often associated with the severity of these respiratory infections and have been explored mainly in the context of bacterial superinfections following primary influenza infection. This review summarizes our current knowledge of the mechanisms underlying these co-infections between respiratory viruses (influenza viruses, RSV, and SARS-CoV-2) and bacteria, at both the physiological and immunological levels. This review also explores the importance of the microbiome and the pathological context in the evolution of these respiratory tract co-infections and presents the different in vitro and in vivo experimental models available. A better understanding of the complex functional interactions between viruses/bacteria and host cells will allow the development of new, specific, and more effective diagnostic and therapeutic approaches.
    MeSH term(s) Coinfection ; Disease Management ; Disease Susceptibility ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate ; Microbiota ; Pneumonia, Bacterial/epidemiology ; Pneumonia, Bacterial/etiology ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/etiology ; Superinfection
    Language English
    Publishing date 2021-08-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13091725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mutant UBA1 and Severe Adult-Onset Autoinflammatory Disease.

    Arlet, Jean-Benoit / Terrier, Benjamin / Kosmider, Olivier

    The New England journal of medicine

    2021  Volume 384, Issue 22, Page(s) 2163

    MeSH term(s) Hereditary Autoinflammatory Diseases/diagnosis ; Hereditary Autoinflammatory Diseases/genetics ; Humans ; Muscular Atrophy, Spinal ; Mutation
    Language English
    Publishing date 2021-06-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2102124
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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Visual Fixation on the Thorax Predicts Bystander Breathing Detection in Simulated Out-of-Hospital Cardiac Arrest, but Video Debriefing With Eye Tracking Gaze Overlay Does Not Enhance Postallocation Success Rate: A Randomized Controlled Trial.

    Pedrotti, Marco / Terrier, Philippe / Gelin, Louis / Stanek, Marc / Schirlin, Olivier

    Simulation in healthcare : journal of the Society for Simulation in Healthcare

    2022  Volume 17, Issue 6, Page(s) 377–384

    Abstract: Introduction: Bystander cardiopulmonary resuscitation in out-of-hospital cardiac arrest is associated with higher survival rates. Even trained health care staff cannot assess breathing well enough to detect cardiac arrest. Recognition of cardiac arrest ... ...

    Abstract Introduction: Bystander cardiopulmonary resuscitation in out-of-hospital cardiac arrest is associated with higher survival rates. Even trained health care staff cannot assess breathing well enough to detect cardiac arrest. Recognition of cardiac arrest by lay rescuers might be overlooked in adult basic life support resuscitation guidelines, which explain what to do, but not how to do it. The 2015 Adult Advanced Life Support Resuscitation Guidelines recommend to "look for chest movement." We hypothesize (1) that instructing lay rescuers to look for chest movement allows detecting breathing (or lack thereof); (2) that showing a person their own recorded gaze overlay during a video debriefing intervention enhances breathing detection at postallocation; and (3) that the more time spent looking at a cardiac arrest victim's chest, the greater the probability of detecting breathing (or lack thereof).
    Methods: Monocentric, blinded, prospective, 2-arm parallel randomized controlled trial with balanced randomization (1:1). The design entailed a preallocation simulation, an intervention (video debriefing with or without gaze overlay), and a postallocation simulation. A follow-up simulation took place after 6 months. The main outcome measured was success in detecting breathing. Participants were all prospective students of a bachelor's degree program in nursing.
    Results: All participants performed better at postallocation (success rate at preallocation = 59%, postallocation = 79%, χ 2 = 7.22, P < 0.01) regardless of viewing their own gaze overlay during video debriefing. We failed to obtain a sufficient number of participants for the follow-up simulation. Instructing lay rescuers to look for chest movement allows them to detect breathing (or lack thereof). Each second spent looking at the thorax increased the odds of successfully detecting breathing by 38%. Mean thorax gaze duration significantly increased by 5.95 seconds (95% confidence interval = 4.71-7.31) from preallocation (3.46 seconds, SD = 4.16) to postallocation (9.41 seconds, SD = 5.98). Laypersons' median diagnosis time was 15.5 seconds (range = 2-63 seconds), similar to another study (13 seconds, range = 5-40 seconds).
    Conclusions: This is the second study in which the median time to decision exceeded the maximum 10 seconds recommended. International guidelines should consider increasing the time allowed for the "check breathing" step of bystander cardiopulmonary resuscitation procedures.
    MeSH term(s) Adult ; Humans ; Out-of-Hospital Cardiac Arrest/diagnosis ; Out-of-Hospital Cardiac Arrest/therapy ; Eye-Tracking Technology ; Cardiopulmonary Resuscitation/education ; Thorax
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2223429-9
    ISSN 1559-713X ; 1559-2332
    ISSN (online) 1559-713X
    ISSN 1559-2332
    DOI 10.1097/SIH.0000000000000617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Viral and Bacterial Co-Infections in the Lungs: Dangerous Liaisons

    Oliva, Justine / Terrier, Olivier

    Viruses. 2021 Aug. 30, v. 13, no. 9

    2021  

    Abstract: Respiratory tract infections constitute a significant public health problem, with a therapeutic arsenal that remains relatively limited and that is threatened by the emergence of antiviral and/or antibiotic resistance. Viral–bacterial co-infections are ... ...

    Abstract Respiratory tract infections constitute a significant public health problem, with a therapeutic arsenal that remains relatively limited and that is threatened by the emergence of antiviral and/or antibiotic resistance. Viral–bacterial co-infections are very often associated with the severity of these respiratory infections and have been explored mainly in the context of bacterial superinfections following primary influenza infection. This review summarizes our current knowledge of the mechanisms underlying these co-infections between respiratory viruses (influenza viruses, RSV, and SARS-CoV-2) and bacteria, at both the physiological and immunological levels. This review also explores the importance of the microbiome and the pathological context in the evolution of these respiratory tract co-infections and presents the different in vitro and in vivo experimental models available. A better understanding of the complex functional interactions between viruses/bacteria and host cells will allow the development of new, specific, and more effective diagnostic and therapeutic approaches.
    Keywords Severe acute respiratory syndrome coronavirus 2 ; antibiotic resistance ; evolution ; influenza ; microbiome ; mixed infection ; public health ; therapeutics
    Language English
    Dates of publication 2021-0830
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13091725
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Un mécanisme inédit de détournement viro-induit de p53 dans le contexte de l’infection par les virus influenza.

    Dubois, Julia / Rosa-Calatrava, Manuel / Terrier, Olivier

    Medecine sciences : M/S

    2020  Volume 36, Issue 2, Page(s) 106–108

    Title translation A novel mechanism for virally-induced hijacking of p53 identified in the context of influenza virus infection.
    MeSH term(s) Animals ; Host-Pathogen Interactions/physiology ; Humans ; Influenza, Human/metabolism ; Influenza, Human/virology ; Orthomyxoviridae/metabolism ; Orthomyxoviridae/pathogenicity ; Orthomyxoviridae Infections/metabolism ; Orthomyxoviridae Infections/virology ; Protein Binding ; Tumor Suppressor Protein p53/metabolism ; Viral Nonstructural Proteins/metabolism
    Chemical Substances INS1 protein, influenza virus ; Tumor Suppressor Protein p53 ; Viral Nonstructural Proteins
    Language French
    Publishing date 2020-03-04
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2020004
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  8. Article ; Online: Subchondral bone attenuation coefficient utility of the sacroiliac margins to differentiate spondyloarthritis and osteitis condensans ilii

    Daniel Wendling / Clément Prati / Sébastien Aubry / Alexandre Terrier / Olivier Fakih / Mickaël Chouk / Frank Verhoeven

    RMD Open, Vol 8, Iss

    2022  Volume 1

    Keywords Medicine ; R
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Subchondral bone attenuation coefficient utility of the sacroiliac margins to differentiate spondyloarthritis and osteitis condensans ilii.

    Terrier, Alexandre / Fakih, Olivier / Chouk, Mickaël / Prati, Clément / Wendling, Daniel / Aubry, Sébastien / Verhoeven, Frank

    RMD open

    2022  Volume 8, Issue 1

    Abstract: Introduction: Differentiating ankylosing spondylitis (AS) from osteitis condensans ilii (OCI) remains challenging for clinicians. The aim of this study was to determine whether Subchondral Bone Attenuation Coefficient of the SacroIliac margins (SBAC-SI) ...

    Abstract Introduction: Differentiating ankylosing spondylitis (AS) from osteitis condensans ilii (OCI) remains challenging for clinicians. The aim of this study was to determine whether Subchondral Bone Attenuation Coefficient of the SacroIliac margins (SBAC-SI) is different in AS, OCI and diffuse idiopathic skeletal hyperostosis (DISH).
    Methods: A monocentric retrospective observational study was performed at the University Hospital of Besançon. Patients included were followed for AS, DISH or OCI and underwent CT scan including sacroiliac joint. Patients with tumour lesion of bone or a history of pelvic radiotherapy were excluded. AS and OCI patients were matched with a control of the same age and sex. SBAC-SI was evaluated by the sum of 24 identical circular regions of interest, 8 per slice (anterior, middle and posterior).
    Results: Thirty AS and AS controls, 31 DISH, 29 OCI and OCI controls were included. SBAC-SI score was 9727 (±2430) in the OCI group (p<0.001), 3563 (±1860) in the AS group, 3899 (±1937) in the DISH group, 4224 (±1693) in the AS control group and 5445 (±1205) in the OCI control group. A threshold of 7500 HU had the best discriminative value between OCI and AS (youden index: 0.89). In AS, disease duration is negatively associated with SBAC-SI (r: -0.623; p<0.01) and HLA B27 is associated with lower SBAC-SI (6523 (5198; 7137) vs 2809 (1568; 3371); p<0.001).
    Conclusion: SBAC-SI is significatively different between AS and OCI and could help to distinguish these two diseases.
    MeSH term(s) HLA-B27 Antigen ; Humans ; Osteitis/diagnostic imaging ; Sacroiliac Joint/diagnostic imaging ; Spondylarthritis/diagnosis ; Spondylitis, Ankylosing/diagnostic imaging
    Chemical Substances HLA-B27 Antigen
    Language English
    Publishing date 2022-05-17
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2812592-7
    ISSN 2056-5933 ; 2056-5933
    ISSN (online) 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2022-002275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Atypical splice-site mutations causing VEXAS syndrome.

    Templé, Marie / Duroyon, Eugénie / Croizier, Carolyne / Rossignol, Julien / Huet, Thomas / Friedrich, Chloé / Zalmai, Loria / Priollet, Pascal / Hayem, Gilles / Tournillhac, Olivier / Le Guenno, Guillaume / Hermine, Olivier / Terrier, Benjamin / Kosmider, Olivier

    Rheumatology (Oxford, England)

    2021  Volume 60, Issue 12, Page(s) e435–e437

    MeSH term(s) Aged ; DNA/genetics ; DNA Mutational Analysis ; Hereditary Autoinflammatory Diseases/diagnosis ; Hereditary Autoinflammatory Diseases/genetics ; Hereditary Autoinflammatory Diseases/metabolism ; Humans ; Male ; Mutation ; Ubiquitin-Activating Enzymes/genetics ; Ubiquitin-Activating Enzymes/metabolism
    Chemical Substances UBA1 protein, human ; DNA (9007-49-2) ; Ubiquitin-Activating Enzymes (EC 6.2.1.45)
    Language English
    Publishing date 2021-07-09
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keab524
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    In stock of ZB MED Cologne/Königswinter

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