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Article ; Online: Fish Oil, Se Yeast, and Micronutrient-Enriched Nutrition as Adjuvant Treatment during Target Therapy in a Murine Model of Lung Cancer

Hang Wang / Simon Hsia / Tsung-Han Wu / Chang-Jer Wu

Marine Drugs, Vol 19, Iss 262, p

2021 Volume 262

Abstract: Despite the effectiveness of primary treatment modalities for cancer, the side effects of treatments, medication resistance, and the deterioration of cachexia after disease progression lead to poor prognosis. A supportive treatment modality to overcome ... ...

Abstract	Despite the effectiveness of primary treatment modalities for cancer, the side effects of treatments, medication resistance, and the deterioration of cachexia after disease progression lead to poor prognosis. A supportive treatment modality to overcome these limitations would be considered a major breakthrough. Here, we used two different target drugs to demonstrate whether a nutraceutical formula (fish oil, Se yeast, and micronutrient-enriched nutrition; NuF) can interfere with cancer cachexia and improve drug efficacy. After Lewis lung cancer (LLC) tumor injection, the C57BL/6 mice were orally administered targeted therapy drugs Iressa and Sutent alone or combined with NuF for 27 days. Sutent administration effectively inhibited tumor size but increased the number of lung metastases in the long term. Sutent combined with NuF had no significant difference in tumor weight and metastasis compare with Sutent alone. However, NuF slightly attenuated metastases number in lung may via mesenchymal marker N-cadherin suppression. NuF otherwise increased epithelial-like marker E-cadherin expression and induce NO-mediated intrinsic apoptotic pathway in tumor cells, thereby strengthening the ability of the targeted therapy drug Iressa for inhibiting tumor progression. Our results demonstrate that NuF can promote the anticancer effect of lung cancer to targeted therapy, especially in Iressa, by inhibiting HIF-1α and epithelial-mesenchymal transition (EMT) and inducing the apoptosis of lung cancer cells. Furthermore, NuF attenuates cancer-related cachectic symptoms by inhibiting systemic oxidative stress.
Keywords	fish oil ; Se yeast ; nutraceutical formula ; target therapy ; adjuvant treatment ; lung cancer ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of hydroxyl group in cyclo(Pro-Tyr)-like cyclic dipeptides on their anti-QS activity and self-assembly.

Li, Li / Xu, Zuxian / Cao, Ruipin / Li, Jiaxin / Wu, Chang-Jer / Wang, Yinglu / Zhu, Hu

iScience

2023 Volume 26, Issue 7, Page(s) 107048

Abstract: We investigated the influence of hydroxyl groups on the anti-quorum-sensing (anti-QS) and anti-biofilm activity of structurally similar cyclic dipeptides, namely cyclo( ...

Abstract	We investigated the influence of hydroxyl groups on the anti-quorum-sensing (anti-QS) and anti-biofilm activity of structurally similar cyclic dipeptides, namely cyclo(
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.107048
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Synergistic Effects of

Huang, Tse-Hung / Liu, Bang-Hung / Hsu, Chia-Hui / Wu, Chang-Jer / Liao, Kuang-Wen / Lin, Chen-Si / Chan, Yi-Lin

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 12

Abstract: Osteoarthritis (OA) is a progressive disease that causes pain, stiffness, and inflammation in the affected joints. Currently, there are no effective treatments for preventing the worst outcomes, such as synovitis or cartilage degradation. ...

Abstract	Osteoarthritis (OA) is a progressive disease that causes pain, stiffness, and inflammation in the affected joints. Currently, there are no effective treatments for preventing the worst outcomes, such as synovitis or cartilage degradation.
Language	English
Publishing date	2023-12-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12122068
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Green Tea Polyphenol Catechins Inhibit Coronavirus Replication and Potentiate the Adaptive Immunity and Autophagy-Dependent Protective Mechanism to Improve Acute Lung Injury in Mice.

Yang, Chih-Ching / Wu, Chang-Jer / Chien, Chen-Yen / Chien, Chiang-Ting

Antioxidants (Basel, Switzerland)

2021 Volume 10, Issue 6

Abstract: Effective antiviral therapeutics are urgently required to fight severe acute respiratory syndrome (SARS) caused by a SARS coronavirus (SARS-CoV). Because polyphenol catechins could confer antioxidative, anti-inflammatory, antiviral, and antimicrobial ... ...

Abstract	Effective antiviral therapeutics are urgently required to fight severe acute respiratory syndrome (SARS) caused by a SARS coronavirus (SARS-CoV). Because polyphenol catechins could confer antioxidative, anti-inflammatory, antiviral, and antimicrobial activities, we assessed the therapeutic effects of catechins against SARS-CoV replication in Vero E6 cells, the preventive effect of catechins on CD25/CD69/CD94/CD8
Language	English
Publishing date	2021-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10060928
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fish Oil, Se Yeast, and Micronutrient-Enriched Nutrition as Adjuvant Treatment during Target Therapy in a Murine Model of Lung Cancer.

Wang, Hang / Hsia, Simon / Wu, Tsung-Han / Wu, Chang-Jer

Marine drugs

2021 Volume 19, Issue 5

Abstract	Despite the effectiveness of primary treatment modalities for cancer, the side effects of treatments, medication resistance, and the deterioration of cachexia after disease progression lead to poor prognosis. A supportive treatment modality to overcome these limitations would be considered a major breakthrough. Here, we used two different target drugs to demonstrate whether a nutraceutical formula (fish oil, Se yeast, and micronutrient-enriched nutrition; NuF) can interfere with cancer cachexia and improve drug efficacy. After Lewis lung cancer (LLC) tumor injection, the C57BL/6 mice were orally administered targeted therapy drugs Iressa and Sutent alone or combined with NuF for 27 days. Sutent administration effectively inhibited tumor size but increased the number of lung metastases in the long term. Sutent combined with NuF had no significant difference in tumor weight and metastasis compare with Sutent alone. However, NuF slightly attenuated metastases number in lung may via mesenchymal marker N-cadherin suppression. NuF otherwise increased epithelial-like marker E-cadherin expression and induce NO-mediated intrinsic apoptotic pathway in tumor cells, thereby strengthening the ability of the targeted therapy drug Iressa for inhibiting tumor progression. Our results demonstrate that NuF can promote the anticancer effect of lung cancer to targeted therapy, especially in Iressa, by inhibiting HIF-1α and epithelial-mesenchymal transition (EMT) and inducing the apoptosis of lung cancer cells. Furthermore, NuF attenuates cancer-related cachectic symptoms by inhibiting systemic oxidative stress.
MeSH term(s)	Administration, Oral ; Animals ; Apoptosis/drug effects ; Cachexia/drug therapy ; Cachexia/etiology ; Carcinoma, Lewis Lung/complications ; Carcinoma, Lewis Lung/diet therapy ; Carcinoma, Lewis Lung/drug therapy ; Cell Line, Tumor ; Chemotherapy, Adjuvant/methods ; Disease Models, Animal ; Epithelial-Mesenchymal Transition/drug effects ; Fish Oils/administration & dosage ; Fish Oils/pharmacology ; Gefitinib/administration & dosage ; Gefitinib/pharmacology ; Inflammation/drug therapy ; Male ; Mice, Inbred C57BL ; Micronutrients/administration & dosage ; Micronutrients/pharmacology ; Neoplasm Metastasis/prevention & control ; Oxidation-Reduction/drug effects ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/pharmacology ; Selenium/administration & dosage ; Selenium/pharmacology ; Sunitinib/administration & dosage ; Sunitinib/pharmacology ; Tumor Burden/drug effects ; Yeast, Dried/administration & dosage ; Yeast, Dried/pharmacology ; Mice
Chemical Substances	Fish Oils ; Micronutrients ; Protein Kinase Inhibitors ; Selenium (H6241UJ22B) ; Gefitinib (S65743JHBS) ; Sunitinib (V99T50803M)
Language	English
Publishing date	2021-05-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md19050262
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fucoidan from Sargassum hemiphyllum inhibits infection and inflammation of Helicobacter pylori.

Chen, Bo-Rui / Li, Wei-Ming / Li, Tsung-Lin / Chan, Yi-Lin / Wu, Chang-Jer

Scientific reports

2022 Volume 12, Issue 1, Page(s) 429

Abstract: Having infected by Helicobacter pylori, the infection often leads to gastritis, gastric ulcer, or even gastric cancer. The disease is typically treated with antibiotics as they used to effectively inhibit or kill H. pylori, thus reducing the incidence of ...

Abstract	Having infected by Helicobacter pylori, the infection often leads to gastritis, gastric ulcer, or even gastric cancer. The disease is typically treated with antibiotics as they used to effectively inhibit or kill H. pylori, thus reducing the incidence of gastric adenoma and cancer to significant extent. H. pylori, however, has developed drug resistance to many clinically used antibiotics over the years, highlighting the crisis of antibiotic failure during the H. pylori treatment. We report here that the fucoidan from Sargassum hemiphyllum can significantly reduce the infection of H. pylori without developing to drug resistance. Fucoidan appears to be a strong anti-inflammation agent as manifested by the RAW264.7 cell model examination. Fucoidan can prohibit H. pylori adhesion to host cells, thereby reducing the infection rate by 60%, especially in post treatment in the AGS cell model assay. Mechanistically, fucoidan intervenes the adhesion of BabA and AlpA of H. pylori significantly lowering the total count of H. pylori and the level of IL-6 and TNF-α in vivo. These results all converge on the same fact that fucoidan is an effective agent in a position to protect the stomach from the H. pylori infection by reducing both the total count and induced inflammation.
MeSH term(s)	Animals ; Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Cytokines/metabolism ; Drug Evaluation, Preclinical ; Helicobacter Infections/drug therapy ; Helicobacter pylori/drug effects ; Humans ; Mice ; Mice, Inbred BALB C ; Polysaccharides/isolation & purification ; Polysaccharides/pharmacology ; Polysaccharides/therapeutic use ; RAW 264.7 Cells ; Sargassum/chemistry ; Stomach/drug effects ; Stomach/immunology ; Stomach/metabolism
Chemical Substances	Antineoplastic Agents ; Cytokines ; Polysaccharides ; fucoidan (9072-19-9)
Language	English
Publishing date	2022-01-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-04151-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fucoidan from Sargassum hemiphyllum inhibits infection and inflammation of Helicobacter pylori

Bo-Rui Chen / Wei-Ming Li / Tsung-Lin Li / Yi-Lin Chan / Chang-Jer Wu

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 11

Abstract: Abstract Having infected by Helicobacter pylori, the infection often leads to gastritis, gastric ulcer, or even gastric cancer. The disease is typically treated with antibiotics as they used to effectively inhibit or kill H. pylori, thus reducing the ... ...

Abstract	Abstract Having infected by Helicobacter pylori, the infection often leads to gastritis, gastric ulcer, or even gastric cancer. The disease is typically treated with antibiotics as they used to effectively inhibit or kill H. pylori, thus reducing the incidence of gastric adenoma and cancer to significant extent. H. pylori, however, has developed drug resistance to many clinically used antibiotics over the years, highlighting the crisis of antibiotic failure during the H. pylori treatment. We report here that the fucoidan from Sargassum hemiphyllum can significantly reduce the infection of H. pylori without developing to drug resistance. Fucoidan appears to be a strong anti-inflammation agent as manifested by the RAW264.7 cell model examination. Fucoidan can prohibit H. pylori adhesion to host cells, thereby reducing the infection rate by 60%, especially in post treatment in the AGS cell model assay. Mechanistically, fucoidan intervenes the adhesion of BabA and AlpA of H. pylori significantly lowering the total count of H. pylori and the level of IL-6 and TNF-α in vivo. These results all converge on the same fact that fucoidan is an effective agent in a position to protect the stomach from the H. pylori infection by reducing both the total count and induced inflammation.
Keywords	Medicine ; R ; Science ; Q
Subject code	630
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Fish Oil, Se Yeast, and Micronutrient-Enriched Nutrition as Adjuvant Treatment during Target Therapy in a Murine Model of Lung Cancer

Wang, Hang / Hsia, Simon / Wu, Tsung-Han / Wu, Chang-Jer

Marine drugs. 2021 May 04, v. 19, no. 5

2021

Abstract	Despite the effectiveness of primary treatment modalities for cancer, the side effects of treatments, medication resistance, and the deterioration of cachexia after disease progression lead to poor prognosis. A supportive treatment modality to overcome these limitations would be considered a major breakthrough. Here, we used two different target drugs to demonstrate whether a nutraceutical formula (fish oil, Se yeast, and micronutrient-enriched nutrition; NuF) can interfere with cancer cachexia and improve drug efficacy. After Lewis lung cancer (LLC) tumor injection, the C57BL/6 mice were orally administered targeted therapy drugs Iressa and Sutent alone or combined with NuF for 27 days. Sutent administration effectively inhibited tumor size but increased the number of lung metastases in the long term. Sutent combined with NuF had no significant difference in tumor weight and metastasis compare with Sutent alone. However, NuF slightly attenuated metastases number in lung may via mesenchymal marker N-cadherin suppression. NuF otherwise increased epithelial-like marker E-cadherin expression and induce NO-mediated intrinsic apoptotic pathway in tumor cells, thereby strengthening the ability of the targeted therapy drug Iressa for inhibiting tumor progression. Our results demonstrate that NuF can promote the anticancer effect of lung cancer to targeted therapy, especially in Iressa, by inhibiting HIF-1α and epithelial-mesenchymal transition (EMT) and inducing the apoptosis of lung cancer cells. Furthermore, NuF attenuates cancer-related cachectic symptoms by inhibiting systemic oxidative stress.
Keywords	adjuvants ; animal models ; antineoplastic activity ; apoptosis ; cachexia ; cadherins ; dietary supplements ; drugs ; fish oils ; lung neoplasms ; lungs ; metastasis ; neoplasm progression ; oxidative stress ; prognosis ; yeasts
Language	English
Dates of publication	2021-0504
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2175190-0
ISSN	1660-3397
ISSN	1660-3397
DOI	10.3390/md19050262
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Retraction for Huang et al., "Use of the Antimicrobial Peptide Pardaxin (GE33) To Protect against Methicillin-Resistant Staphylococcus aureus Infection in Mice with Skin Injuries".

Huang, Han-Ning / Pan, Chieh-Yu / Chan, Yi-Lin / Chen, Jyh-Yih / Wu, Chang-Jer

Antimicrobial agents and chemotherapy

2020 Volume 64, Issue 6

Language	English
Publishing date	2020-05-21
Publishing country	United States
Document type	Journal Article ; Retraction of Publication
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.00484-20
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Green Tea Polyphenol Catechins Inhibit Coronavirus Replication and Potentiate the Adaptive Immunity and Autophagy-Dependent Protective Mechanism to Improve Acute Lung Injury in Mice

Yang, Chih-Ching / Wu, Chang-Jer / Chien, Chen-Yen / Chien, Chiang-Ting

Antioxidants. 2021 June 07, v. 10, no. 6

2021

Abstract	Effective antiviral therapeutics are urgently required to fight severe acute respiratory syndrome (SARS) caused by a SARS coronavirus (SARS-CoV). Because polyphenol catechins could confer antioxidative, anti-inflammatory, antiviral, and antimicrobial activities, we assessed the therapeutic effects of catechins against SARS-CoV replication in Vero E6 cells, the preventive effect of catechins on CD25/CD69/CD94/CD8⁺ cytotoxic T lymphocytes-mediated adaptive immunity, and the protective effect on lipopolysaccharide-induced acute lung injury (ALI) in mice. We found that catechins containing 32.8% epigallocatechin gallate, 15.2% epicatechin gallate, 13.2 epicatechin, 10.8% epigallocatechin, 10.4% gallocatechin, and 4.4% catechin directly inhibited SARS-CoV replication at sub-micromolecular concentrations. Four-week catechins ingestion increased CD8⁺ T cell percentage, upregulated CD69⁺/CD25⁺/CD94-NKG2A/CD8⁺ T lymphocytes-mediated adaptive immunity, and increased type I cytokines release responding to ovalbumin/alum. Catechins significantly reduced lipopolysaccharide-induced cytokine storm and oxidative stress and ALI by inhibiting PI3K/AKT/mTOR signaling to upregulate Beclin-1/Atg5-Atg12/LC3-II-mediated autophagy mechanism. Pretreatment of autophagy inhibitor 3-Methyladenine reversed the inhibiting effects of catechins on the cytokines and oxidative stress levels and ALI. In conclusion, our data indicated that catechins directly inhibited SARS-CoV replication, potentiated the CD25/CD69/CD94/CD8⁺ T lymphocytes-mediated adaptive immunity and attenuated lipopolysaccharide-induced ALI and cytokine storm by PI3K/AKT/mTOR-signaling-mediated autophagy, which may be applied to prevent and/or treat SARS-CoV infection.
Keywords	Orthocoronavirinae ; adaptive immunity ; alum ; autophagy ; catechin ; cytokines ; cytotoxicity ; epicatechin ; epigallocatechin gallate ; green tea ; ingestion ; lungs ; ovalbumin ; oxidative stress ; polyphenols ; protective effect ; therapeutics
Language	English
Dates of publication	2021-0607
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10060928
Database	NAL-Catalogue (AGRICOLA)

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