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  1. Article ; Online: Antiviral Agents: Discovery to Resistance.

    Adamson, Catherine S

    Viruses

    2020  Volume 12, Issue 4

    Abstract: In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [ ... ]. ...

    Abstract In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [...].
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Drug Resistance, Viral ; Humans ; Virus Diseases/drug therapy ; Virus Diseases/virology
    Chemical Substances Antiviral Agents
    Keywords covid19
    Language English
    Publishing date 2020-04-07
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v12040406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Antiviral Agents

    Catherine S. Adamson

    Viruses ; Volume 12 ; Issue 4

    Discovery to Resistance

    2020  

    Abstract: In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [.] ...

    Abstract In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [.]
    Keywords n/a ; covid19
    Language English
    Publishing date 2020-04-07
    Publisher Multidisciplinary Digital Publishing Institute
    Publishing country ch
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Antiviral Agents: Discovery to Resistance

    Adamson, Catherine S

    Viruses

    Abstract: In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [ ... ]. ...

    Abstract In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [...].
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #35157
    Database COVID19

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  4. Article ; Online: Antiviral Agents

    Catherine S. Adamson

    Viruses, Vol 12, Iss 406, p

    Discovery to Resistance

    2020  Volume 406

    Abstract: In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [.] ...

    Abstract In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [.]
    Keywords n/a ; Microbiology ; QR1-502 ; covid19
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article: Antiviral Agents: Discovery to Resistance

    Adamson, Catherine S

    Viruses. 2020 Apr. 07, v. 12, no. 4

    2020  

    Abstract: In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [ ... ] ...

    Abstract In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [...]
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antiviral agents ; drug development ; drug resistance
    Language English
    Dates of publication 2020-0407
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v12040406
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Bright and Early: Inhibiting Human Cytomegalovirus by Targeting Major Immediate-Early Gene Expression or Protein Function.

    Adamson, Catherine S / Nevels, Michael M

    Viruses

    2020  Volume 12, Issue 1

    Abstract: The human cytomegalovirus (HCMV), one of eight human herpesviruses, establishes lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections cause severe disease in immunosuppressed patients and congenital defects in ... ...

    Abstract The human cytomegalovirus (HCMV), one of eight human herpesviruses, establishes lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections cause severe disease in immunosuppressed patients and congenital defects in children. There is no vaccine for HCMV, and the currently approved antivirals come with major limitations. Most approved HCMV antivirals target late molecular processes in the viral replication cycle including DNA replication and packaging. "Bright and early" events in HCMV infection have not been exploited for systemic prevention or treatment of disease. Initiation of HCMV replication depends on transcription from the viral major immediate-early (IE) gene. Alternative transcripts produced from this gene give rise to the IE1 and IE2 families of viral proteins, which localize to the host cell nucleus. The IE1 and IE2 proteins are believed to control all subsequent early and late events in HCMV replication, including reactivation from latency, in part by antagonizing intrinsic and innate immune responses. Here we provide an update on the regulation of major IE gene expression and the functions of IE1 and IE2 proteins. We will relate this insight to experimental approaches that target IE gene expression or protein function via molecular gene silencing and editing or small chemical inhibitors.
    MeSH term(s) Antiviral Agents/therapeutic use ; CRISPR-Cas Systems ; Cytomegalovirus/drug effects ; Cytomegalovirus/genetics ; Cytomegalovirus Infections/therapy ; Gene Expression Regulation, Viral ; Genes, Immediate-Early/genetics ; Humans ; Immediate-Early Proteins/drug effects ; Immediate-Early Proteins/genetics ; Immediate-Early Proteins/metabolism ; RNA Interference ; RNA, Catalytic/drug effects ; RNA, Catalytic/genetics ; Viral Proteins/drug effects ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Virus Replication/drug effects
    Chemical Substances Antiviral Agents ; Immediate-Early Proteins ; RNA, Catalytic ; Viral Proteins
    Language English
    Publishing date 2020-01-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v12010110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Specificity and sensitivity of an RNA targeting type III CRISPR complex coupled with a NucC endonuclease effector.

    Grüschow, Sabine / Adamson, Catherine S / White, Malcolm F

    Nucleic acids research

    2021  Volume 49, Issue 22, Page(s) 13122–13134

    Abstract: Type III CRISPR systems detect invading RNA, resulting in the activation of the enzymatic Cas10 subunit. The Cas10 cyclase domain generates cyclic oligoadenylate (cOA) second messenger molecules, activating a variety of effector nucleases that degrade ... ...

    Abstract Type III CRISPR systems detect invading RNA, resulting in the activation of the enzymatic Cas10 subunit. The Cas10 cyclase domain generates cyclic oligoadenylate (cOA) second messenger molecules, activating a variety of effector nucleases that degrade nucleic acids to provide immunity. The prophage-encoded Vibrio metoecus type III-B (VmeCmr) locus is uncharacterised, lacks the HD nuclease domain in Cas10 and encodes a NucC DNA nuclease effector that is also found associated with Cyclic-oligonucleotide-based anti-phage signalling systems (CBASS). Here we demonstrate that VmeCmr is activated by target RNA binding, generating cyclic-triadenylate (cA3) to stimulate a robust NucC-mediated DNase activity. The specificity of VmeCmr is probed, revealing the importance of specific nucleotide positions in segment 1 of the RNA duplex and the protospacer flanking sequence (PFS). We harness this programmable system to demonstrate the potential for a highly specific and sensitive assay for detection of the SARS-CoV-2 virus RNA with a limit of detection (LoD) of 2 fM using a commercial plate reader without any extrinsic amplification step. The sensitivity is highly dependent on the guide RNA used, suggesting that target RNA secondary structure plays an important role that may also be relevant in vivo.
    MeSH term(s) Animals ; COVID-19 ; CRISPR-Associated Proteins/genetics ; CRISPR-Cas Systems/genetics ; Cell Line ; Chlorocebus aethiops ; Endodeoxyribonucleases/metabolism ; Endoribonucleases/metabolism ; Humans ; Prophages/genetics ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; Vero Cells ; Vibrio/virology
    Chemical Substances CRISPR-Associated Proteins ; RNA, Viral ; Endodeoxyribonucleases (EC 3.1.-) ; Endoribonucleases (EC 3.1.-)
    Language English
    Publishing date 2021-12-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkab1190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1067: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Bright and Early: Inhibiting Human Cytomegalovirus by Targeting Major Immediate-Early Gene Expression or Protein Function

    Adamson, Catherine S / Nevels, Michael M

    Viruses. 2020 Jan. 16, v. 12, no. 1

    2020  

    Abstract: The human cytomegalovirus (HCMV), one of eight human herpesviruses, establishes lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections cause severe disease in immunosuppressed patients and congenital defects in ... ...

    Abstract The human cytomegalovirus (HCMV), one of eight human herpesviruses, establishes lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections cause severe disease in immunosuppressed patients and congenital defects in children. There is no vaccine for HCMV, and the currently approved antivirals come with major limitations. Most approved HCMV antivirals target late molecular processes in the viral replication cycle including DNA replication and packaging. “Bright and early” events in HCMV infection have not been exploited for systemic prevention or treatment of disease. Initiation of HCMV replication depends on transcription from the viral major immediate-early (IE) gene. Alternative transcripts produced from this gene give rise to the IE1 and IE2 families of viral proteins, which localize to the host cell nucleus. The IE1 and IE2 proteins are believed to control all subsequent early and late events in HCMV replication, including reactivation from latency, in part by antagonizing intrinsic and innate immune responses. Here we provide an update on the regulation of major IE gene expression and the functions of IE1 and IE2 proteins. We will relate this insight to experimental approaches that target IE gene expression or protein function via molecular gene silencing and editing or small chemical inhibitors.
    Keywords DNA replication ; animal viruses ; antiviral agents ; carrier state ; cell nucleus ; chemical inhibitors ; children ; congenital abnormalities ; disease severity ; gene expression ; gene silencing ; genes ; innate immunity ; messenger RNA ; patients ; transcription (genetics) ; vaccines ; viral proteins ; virus assembly
    Language English
    Dates of publication 2020-0116
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v12010110
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: The role of ion dissolution in metal and metal oxide surface inactivation of SARS-CoV-2.

    Hilton, Jane / Nanao, Yoshiko / Flokstra, Machiel / Askari, Meisam / Smith, Terry K / Di Falco, Andrea / King, Phil D C / Wahl, Peter / Adamson, Catherine S

    Applied and environmental microbiology

    2024  Volume 90, Issue 2, Page(s) e0155323

    Abstract: Anti-viral surface coatings are under development to prevent viral fomite transmission from high-traffic touch surfaces in public spaces. Copper's anti-viral properties have been widely documented, but the anti-viral mechanism of copper surfaces is not ... ...

    Abstract Anti-viral surface coatings are under development to prevent viral fomite transmission from high-traffic touch surfaces in public spaces. Copper's anti-viral properties have been widely documented, but the anti-viral mechanism of copper surfaces is not fully understood. We screened a series of metal and metal oxide surfaces for anti-viral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease (COVID-19). Copper and copper oxide surfaces exhibited superior anti-SARS-CoV-2 activity; however, the level of anti-viral activity was dependent on the composition of the carrier solution used to deliver virus inoculum. We demonstrate that copper ions released into solution from test surfaces can mediate virus inactivation, indicating a copper ion dissolution-dependent anti-viral mechanism. The level of anti-viral activity is, however, not dependent on the amount of copper ions released into solution
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Copper/pharmacology ; Antiviral Agents ; Oxides ; Ions
    Chemical Substances Copper (789U1901C5) ; Antiviral Agents ; Oxides ; Ions
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.01553-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 201: Show issues Location:
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  10. Article ; Online: Protease-Mediated Maturation of HIV: Inhibitors of Protease and the Maturation Process.

    Adamson, Catherine S

    Molecular biology international

    2012  Volume 2012, Page(s) 604261

    Abstract: Protease-mediated maturation of HIV-1 virus particles is essential for virus infectivity. Maturation occurs concomitant with immature virus particle release and is mediated by the viral protease (PR), which sequentially cleaves the Gag and Gag-Pol ... ...

    Abstract Protease-mediated maturation of HIV-1 virus particles is essential for virus infectivity. Maturation occurs concomitant with immature virus particle release and is mediated by the viral protease (PR), which sequentially cleaves the Gag and Gag-Pol polyproteins into mature protein domains. Maturation triggers a second assembly event that generates a condensed conical capsid core. The capsid core organizes the viral RNA genome and viral proteins to facilitate viral replication in the next round of infection. The fundamental role of proteolytic maturation in the generation of mature infectious particles has made it an attractive target for therapeutic intervention. Development of small molecules that target the PR active site has been highly successful and nine protease inhibitors (PIs) have been approved for clinical use. This paper provides an overview of their development and clinical use together with a discussion of problems associated with drug resistance. The second-half of the paper discusses a novel class of antiretroviral drug termed maturation inhibitors, which target cleavage sites in Gag not PR itself. The paper focuses on bevirimat (BVM) the first-in-class maturation inhibitor: its mechanism of action and the implications of naturally occurring polymorphisms that confer reduced susceptibility to BVM in phase II clinical trials.
    Language English
    Publishing date 2012-07-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573919-0
    ISSN 2090-2190 ; 2090-2190
    ISSN (online) 2090-2190
    ISSN 2090-2190
    DOI 10.1155/2012/604261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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