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Article: Correlation of intra operative specimen imaging with final histopathology in breast conserving surgery for breast cancer.

Javed, Nida / Afzal, Sidra / Parvaiz, Muhammad Asad / Rehman, Parvaiz / Khalid, Ibtissam Bin

JPMA. The Journal of the Pakistan Medical Association

2024 Volume 74, Issue 2, Page(s) 252–263

Abstract: Objectives: To determine the effectiveness of specimen mammography in breast conserving surgery cases with respect to reduction in margin positivity rate, and to see whether the rate of secondary surgeries is decreased by intra-operative excision based ... ...

Abstract	Objectives: To determine the effectiveness of specimen mammography in breast conserving surgery cases with respect to reduction in margin positivity rate, and to see whether the rate of secondary surgeries is decreased by intra-operative excision based on specimen mammography evaluation. Methods: The retrospective study was conducted at the Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, and comprised data from January 2018 to December 2019 related to all female breast cancer patients who underwent mastectomy or breast conserving surgery with the involvement of specimen mammography. Sensitivity, specificity, positive predictive value and negative predictive value of specimen mammography were calculated. Data was analysed using SPSS 20. Results: Of the 226 patients initially assessed, 65(28.7%) were excluded, and the final sample comprised 161(71.2%) women with mean age 46.71±10.47 years. The sensitivity, specificity, positive predictive value and negative predictive value of specimen mammography for the sample were 65.8%, 80.8%, 54% and 87.3%, respectively. Performing specimen mammography for intra-operative margin assessment in 12 patients was likely to spare one patient from re-excision. Conclusions: Intra-operative specimen mammography was found to be a reliable tool for assessing margin status.
MeSH term(s)	Female ; Humans ; Adult ; Middle Aged ; Male ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Mastectomy, Segmental/methods ; Retrospective Studies ; Mastectomy ; Breast/pathology ; Mammography/methods
Language	English
Publishing date	2024-02-29
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.8397
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Article ; Online: Consanguinity in northwest Pakistan: evidence of temporal decline.

Malik, Sajid / Bibi, Anisa / Farid, Rubbiya / Khan, Sidra / Awan, Javaid / Rehman, Atta Ur

Journal of biosocial science

2024 Volume 56, Issue 3, Page(s) 445–458

Abstract: Pakistan has a high burden of hereditary and congenital anomalies and their incidence rate almost doubles against the background of parental consanguinity. Consanguineous unions (CU) are customary in Pakistan and deeply rooted socio-cultural norms favour ...

Abstract	Pakistan has a high burden of hereditary and congenital anomalies and their incidence rate almost doubles against the background of parental consanguinity. Consanguineous unions (CU) are customary in Pakistan and deeply rooted socio-cultural norms favour CU. This study aimed to elucidate the determinants and temporal change in CU in four northwestern populations of Pakistan. In a cross-sectional study, data on marital union types, bio-demographic factors, and paternal consanguinity were collected from 6,323 ever-married individuals in four districts of northwest Pakistan: Haripur, Muzaffarabad, Mansehra, and Shangla. We used descriptive statistics and multivariable logistic regression analysis. The CU were calculated to be 55%, and inbreeding coefficient F (ICF) was estimated to be 0.029. Eight factors, including district, rural origin, age of husband, occupational group of husband, literacy of husband, parental consanguinity, exchange marriage, and extended family type, were found to be significant predictors of consanguinity in the multivariable logistic regression analysis. The rate of consanguinity decreased significantly in the younger age categories of individuals. The rate of CU was seen to be declining over time and in marriages that started 'before 1980' and 'after 2010', respectively, and there was a decline in ICF from 0.030 to 0.027. These analyses also showed that the literacy rate improved, the average age at marriage increased, and the frequency of exchange marriages decreased over time. This study employs a sizable first-hand dataset to demonstrate a lowering CU rate in northwest Pakistan. It is anticipated that the burden of inherited and congenital anomalies may likely to diminish in the study populations along with the fall in ICF.
MeSH term(s)	Male ; Humans ; Consanguinity ; Pakistan/epidemiology ; Cross-Sectional Studies ; Marriage ; Fathers
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	390961-x
ISSN	1469-7599 ; 0021-9320
ISSN (online)	1469-7599
ISSN	0021-9320
DOI	10.1017/S0021932024000026
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Article: Efficacy and safety of intravitreal injection of triamcinolone-moxifloxacin after cataract surgery in a low to middle income country - a one-year audit.

Jeeva, Irfan Kabiruddin / Masud, Sidra / Siddiqui, Muhammad Abdul Rehman

JPMA. The Journal of the Pakistan Medical Association

2023 Volume 73, Issue 1, Page(s) 92–97

Abstract: Objective: To evaluate the safety and efficacy of intravitreal injection of triamcinolone and moxifloxacin regime administered immediately following cataract surgery.: Methods: The retrospective study was conducted from January to June 2021 at a ... ...

Abstract	Objective: To evaluate the safety and efficacy of intravitreal injection of triamcinolone and moxifloxacin regime administered immediately following cataract surgery. Methods: The retrospective study was conducted from January to June 2021 at a tertiary care referral centre in Karachi and comprised record of all patients who underwent dropless cataract surgery from April 2018 to June 2019. Data included slit lamp examination, dilated fundal exam, uncorrected visual acuity, best corrected visual acuity, and intraocular pressure. Cataract assessment and anterior chamber reaction were graded according to the World Health Organisation cataract grouping system. Efficacy of the regime was defined as the ability to prevent postoperative endophthalmitis. Stratification analysis was done to note if gender has any role in terms of effectiveness. Data was analysed using Microsoft Excel version 16.0 and IBM SPSS version 27. Results: Of 240 eyes of 161 patients analysed, 114(47.5%) were of men who had a mean age of 57.89±14.32 years, and 126(52.5%) were of females with a mean age of 58.02±10.85 years. Overall, 2(1.75%) male subjects and 1(0.8%) female subject developed breakthrough inflammation within one week of the procedure. They were treated with anti-inflammatory drops and in 1(33%) of the cases antibiotic drop for 1 week. At day 90, no patient had residual inflammation or new onset inflammation. Also, 15(6.25%) patients developed raised intraocular pressure from day 7 to day 30. Most cases 10(66.7%) resolved within 1 week of using intraocular pressure-lowering drops. No patient developed endophthalmitis postoperatively. Conclusions: Dropless cataract regime was found to be an effective and safe alternative that was easy to administer.
MeSH term(s)	Humans ; Male ; Female ; Adult ; Middle Aged ; Aged ; Moxifloxacin/adverse effects ; Triamcinolone ; Intravitreal Injections ; Retrospective Studies ; Developing Countries ; Cataract Extraction ; Glucocorticoids/adverse effects ; Inflammation/drug therapy ; Endophthalmitis/epidemiology ; Endophthalmitis/etiology ; Endophthalmitis/prevention & control ; Cataract ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Eye Diseases
Chemical Substances	Moxifloxacin (U188XYD42P) ; Triamcinolone (1ZK20VI6TY) ; Glucocorticoids
Language	English
Publishing date	2023-02-25
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.5207
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Article ; Online: Sustainable finance, natural resource abundance, and energy poverty trap: the environmental challenges in the era of COVID-19

Baiwei, Xie / Hanif, Imran / Wasim, Sarah / Rehman, Sidra

Environ Sci Pollut Res. 2023 Feb., v. 30, no. 10 p.26535-26544

2023

Abstract: Energy poverty is a global challenge and the scarcity has been emerging as a global issue. Therefore, the relationship among energy scarcity, sustainable finance, and carbon emissions is analyzed with the help of global data from 40 developing countries ... ...

Abstract	Energy poverty is a global challenge and the scarcity has been emerging as a global issue. Therefore, the relationship among energy scarcity, sustainable finance, and carbon emissions is analyzed with the help of global data from 40 developing countries until the beginning of the COVID-19 era. For empirical results’ estimation, the study analyzed a panel data ranging from 2000 to 2019. To measure the energy poverty, some part of population that has no access to energy is considered, and empirical analysis based on augmented mean group (AMG) regression method was carried out. The findings of the study suggest the inverse relation among energy poverty and carbon emissions. Moreover, a negative relationship was also observed between sustainable finance and carbon emissions. These findings highlight that alleviation of energy poverty can intensify environmental pollution. While improvement in access to clean energy will benefit society by alleviating energy poverty and controlling carbon emissions. Moreover, improvement in the share of sustainable finance in total investment may improve the environment quality by reducing carbon emissions. Therefore, it is suggested that regional plans along with sustainable finance are required on a priority basis for the promotion of clean energy to control carbon emissions and alleviate energy poverty at the household level.
Keywords	COVID-19 infection ; carbon ; clean energy ; empirical research ; energy ; energy poverty ; finance ; pollution ; regression analysis ; society
Language	English
Dates of publication	2023-02
Size	p. 26535-26544.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-23986-7
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Article ; Online: Immunoglobulin A nephropathy associated with acute hepatitis E infection: First case report.

Cheema, Sidra Shafiq / Cheema, Manal Fatima / Gilani, Samreen / Cheema, Shafiqur Rehman

Clinical nephrology. Case studies

2023 Volume 11, Page(s) 95–98

Abstract: In this case report, we describe a young male patient who presented with gross hematuria and nephrotic syndrome a few weeks after serologically positive acute hepatitis E virus (HEV) infection. Histopathological examination of renal core biopsy revealed ... ...

Abstract	In this case report, we describe a young male patient who presented with gross hematuria and nephrotic syndrome a few weeks after serologically positive acute hepatitis E virus (HEV) infection. Histopathological examination of renal core biopsy revealed that the majority of the viable glomeruli had a predominantly mesangiopathic process characterized by mild to moderate diffuse increase in mesangial matrix and cellularity with segmental variation. Immunofluorescence microscopy depicted a strong (3+) granular mesangial and capillary loop staining for IgA, consistent with IgA nephropathy (IgAN). This pattern of mesangial and glomerular capillary loop staining of IgA is suggestive of secondary IgAN. Further research is required to explore the relationship between IgAN and acute HEV infection.
Language	English
Publishing date	2023-06-08
Publishing country	Germany
Document type	Case Reports
ISSN	2196-5293
ISSN (online)	2196-5293
DOI	10.5414/CNCS111100
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Article: Scutellaria petiolata

Mubin, Sidra / Rehman, Najeeb Ur / Murad, Waheed / Shah, Muddaser / Al-Harrasi, Ahmed / Afza, Rabia

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 8

Abstract: The recent investigation was designed to ... ...

Abstract	The recent investigation was designed to explore
Language	English
Publishing date	2022-07-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11081446
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Article ; Online: Sustainable finance, natural resource abundance, and energy poverty trap: the environmental challenges in the era of COVID-19.

Baiwei, Xie / Hanif, Imran / Wasim, Sarah / Rehman, Sidra

Environmental science and pollution research international

2022 Volume 30, Issue 10, Page(s) 26535–26544

Abstract	Energy poverty is a global challenge and the scarcity has been emerging as a global issue. Therefore, the relationship among energy scarcity, sustainable finance, and carbon emissions is analyzed with the help of global data from 40 developing countries until the beginning of the COVID-19 era. For empirical results' estimation, the study analyzed a panel data ranging from 2000 to 2019. To measure the energy poverty, some part of population that has no access to energy is considered, and empirical analysis based on augmented mean group (AMG) regression method was carried out. The findings of the study suggest the inverse relation among energy poverty and carbon emissions. Moreover, a negative relationship was also observed between sustainable finance and carbon emissions. These findings highlight that alleviation of energy poverty can intensify environmental pollution. While improvement in access to clean energy will benefit society by alleviating energy poverty and controlling carbon emissions. Moreover, improvement in the share of sustainable finance in total investment may improve the environment quality by reducing carbon emissions. Therefore, it is suggested that regional plans along with sustainable finance are required on a priority basis for the promotion of clean energy to control carbon emissions and alleviate energy poverty at the household level.
MeSH term(s)	Humans ; Economic Development ; COVID-19 ; Poverty ; Natural Resources ; Carbon ; Carbon Dioxide/analysis ; Renewable Energy
Chemical Substances	Carbon (7440-44-0) ; Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2022-11-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-23986-7
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Article: Toxicity Profiling and Antihyperuricemic Activity of Goubion: A Polyherbal Formulation.

Sadia, Halima / Naveed, Safila / Rehman, Hina / Usman, Rafia / Qamar, Fatima / Yasmeen, Sidra / Sana, Aisha / Mughal, Mahrukh / Asif, Saima / Razzaq, Ghulam

Evidence-based complementary and alternative medicine : eCAM

2023 Volume 2023, Page(s) 7088628

Abstract: The objective of the present study was to determine the acute and subacute toxicity profile of a polyherbal formulation called "Goubion" in addition to the in vivo antihyperuricemic study using fructose-induced hyperuricemia. Goubion is a combination ... ...

Abstract	The objective of the present study was to determine the acute and subacute toxicity profile of a polyherbal formulation called "Goubion" in addition to the in vivo antihyperuricemic study using fructose-induced hyperuricemia. Goubion is a combination of
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2023/7088628
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Article ; Online: Attention-based deep learning framework to recognize diabetes disease from cellular retinal images.

Kothadiya, Deep / Rehman, Amjad / Abbas, Sidra / Alamri, Faten S / Saba, Tanzila

Biochemistry and cell biology = Biochimie et biologie cellulaire

2023 Volume 101, Issue 6, Page(s) 550–561

Abstract: A medical disorder known as diabetic retinopathy (DR) affects people who suffer from diabetes. Many people are visually impaired due to DR. Primary cause of DR in patients is high blood sugar, and it affects blood vessels available in the retinal cell. ... ...

Abstract	A medical disorder known as diabetic retinopathy (DR) affects people who suffer from diabetes. Many people are visually impaired due to DR. Primary cause of DR in patients is high blood sugar, and it affects blood vessels available in the retinal cell. The recent advancement in deep learning and computer vision methods, and their automation applications can recognize the presence of DR in retinal cells and vessel images. Authors have proposed an attention-based hybrid model to recognize diabetes in early stage to prevent harmful clauses. Proposed methodology uses DenseNet121 architecture for convolution learning and then, the feature vector will be enhanced with channel and spatial attention model. The proposed architecture also simulates binary and multiclass classification to recognize the infection and the spreading of disease. Binary classification recognizes DR images either positive or negative, while multiclass classification represents an infection on a scale of 0-4. Simulation of the proposed methodology has achieved 98.57% and 99.01% accuracy for multiclass and binary classification, respectively. Simulation of the study also explored the impact of data augmentation to make the proposed model robust and generalized. Attention-based deep learning model has achieved remarkable accuracy to detect diabetic infection from retinal cellular images.
MeSH term(s)	Humans ; Deep Learning ; Diabetic Retinopathy/diagnostic imaging ; Automation ; Hyperglycemia ; Neurons ; Diabetes Mellitus
Language	English
Publishing date	2023-07-20
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	54104-7
ISSN	1208-6002 ; 0829-8211
ISSN (online)	1208-6002
ISSN	0829-8211
DOI	10.1139/bcb-2023-0151
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Article: Residual efficiency of iron-nanoparticles and different iron sources on growth, and antioxidants in maize plants under salts stress: life cycle study.

Alsamadany, Hameed / Anayatullah, Sidra / Zia-Ur-Rehman, Muhammad / Usman, Muhammad / Ameen, Talha / Alharby, Hesham F / Alharbi, Basmah M / Abdulmajeed, Awatif M / Yong, Jean Wan Hong / Rizwan, Muhammad

Heliyon

2024 Volume 10, Issue 7, Page(s) e28973

Abstract: Exogenous application of iron (Fe) may alleviate salinity stress in plants growing in saline soils. This comparative study evaluated the comparative residual effects of iron nanoparticles (FNp) with two other Fe sources including iron-sulphate (FS) and ... ...

Abstract	Exogenous application of iron (Fe) may alleviate salinity stress in plants growing in saline soils. This comparative study evaluated the comparative residual effects of iron nanoparticles (FNp) with two other Fe sources including iron-sulphate (FS) and iron-chelate (FC) on maize (
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28973
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